jia yi - Academia.edu (original) (raw)

Papers by jia yi

PloS one, 2018

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a wide spectrum of c... more Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a wide spectrum of clinical manifestations and degrees of severity. Few genomic biomarkers for SLE have been validated and employed to inform clinical classifications and decisions. To discover and assess the gene-expression based SLE predictors in published studies, we performed a meta-analysis using our established signature database and a data similarity-driven strategy. From 13 training data sets on SLE gene-expression studies, we identified a SLE meta-signature (SLEmetaSig100) containing 100 concordant genes that are involved in DNA sensors and the IFN signaling pathway. We rigorously examined SLEmetaSig100 with both retrospective and prospective validation in two independent data sets. Using unsupervised clustering, we retrospectively elucidated that SLEmetaSig100 could classify clinical samples into two groups that correlated with SLE disease status and disease activities. More importantly, SLEmetaSi...

Advanced Materials Research, 2014

The Auto-Proving-Ground test cant reveal all problems of testing vehicles. Establishing a more su... more The Auto-Proving-Ground test cant reveal all problems of testing vehicles. Establishing a more suitable and accurate test for reliability index of auto-mobiles has become an important issue. The operating states data of coaches that running from Hefei to Zhengzhou has been collected in this paper, principal component analysis, and clustering analysis were then used to obtain the main factors that necessary for researching intercity bus reliability. The road condition, the ratio of idling, acceleration, deceleration and constant velocity has been determined based on the real drive condition. The acceleration in the y direction also has been taken into consideration when the bus steer. Based on the factors we improve the effectiveness and rationality of tests, which is in favor of building the system of rapid detection and evaluation for vehicles reliability.

PLOS Genetics, 2017

The funders had no role in showed that replication stresses affect chromatin structure by expandi... more The funders had no role in showed that replication stresses affect chromatin structure by expanding of heterochromatin with locus specificity. Mechanistically, we provide evidence suggesting that excessive formation of single-stranded DNA might have correlation with the reduction in fidelity of centromeric chromatin duplication. Finally, we demonstrated replication stress perturb the development process by reducing the fidelity of chromatin organization duplication in fruit fly and worm, illustrating the broadness and the evolutionary conservation of the phenomenon. Together, our results shed light on the importance of replication stresses cause epigenetic instability in addition to genetic stability.

Environmental pollution (Barking, Essex : 1987), 2014

We investigated the effects of arsenic species on As accumulation, plant growth and rhizospheric ... more We investigated the effects of arsenic species on As accumulation, plant growth and rhizospheric changes in As-hyperaccumulator Pteris vittata (PV). PV was grown for 60-d in a soil spiked with 200 mg kg(-1) arsenate (AsV-soil) or arsenite (AsIII-soil). Diffusive gradients in thin-films technique (DGT) were used to monitor As uptake by PV. Interestingly AsIII-soil produced the highest PV biomass at 8.6 g plant(-1), 27% and 46% greater than AsV-soil and the control. Biomass increase was associated with As-induced P uptake by PV. Although AsIII was oxidized to AsV during the experiment, As species impacted As accumulation by PV, with 17.5% more As in AsIII-soil than AsV-soil (36 vs. 31 mg plant(-1)). As concentration in PV roots was 30% higher in AsV-soil whereas As concentration in PV fronds was 7.9% greater in AsIII-soil, suggesting more rapid translocation of AsIII than AsV. These findings were important to understand the mechanisms of As uptake, accumulation and translocation by PV.

Microchimica Acta, 2018

A method is described for fast identification of bacteria by combining (a) the enrichment of bact... more A method is described for fast identification of bacteria by combining (a) the enrichment of bacterial cells by using magnetite (Fe 3 O 4) magnetic beads modified with human IgG (IgG@Fe 3 O 4) and (b) MALDI-TOF MS analysis. IgG has affinity to protein A, protein G, protein L and glycans on the surface of bacterial cells, and IgG@Fe 3 O 4. It therefore is applicable to the preconcentration of a range of bacterial species. The feasibility of the method has been demonstrated by collecting six species of pathogenic bacteria (Gram-positives: Staphylococcus aureus and Kocuria rosea; Gram-negatives: Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae and Pseudomonas aeruginosa). Bacteria with concentrations as low as 10 CFU•mL −1 in spiked water samples were extracted by this sorbent with recovery rates of >50%. After enrichment, bacteria on the IgG@Fe 3 O 4 sorbent were further identified by MALDI-TOF MS. Bacteria in concentrations as low as 10 5 CFU in 100 μL of human whole blood can be identified by the method. Compared to other blood culture based tests, the culture time is shortened by 40% (from~10 h to~6 h), and the plate culture procedure (overnight) is avoided. After short blood culture, the enrichment and identification can be finished in one hour. The IgG@Fe 3 O 4 is of practical value in clinical diagnosis and may be combined with other identification methods, e.g. PCR, Raman spectroscopy, infrared spectroscopy, etc.

Advanced Materials Research, 2013

Due to its influence on iron corrosion and involvement in dechlorination reaction, the concentrat... more Due to its influence on iron corrosion and involvement in dechlorination reaction, the concentration of H+ is crucial to the reactivity and efficiency of nanosized Pd /Fe. In this study, PCP dechlorination by smectite-templated Pd/Fe was studied and the effect of pH on PCP dechlorination was investigated in detail. The reaction rate constant is critically dependant on the reaction pH over the range 6.0~10.0. The dechlorination rate increases rapidly with decreasing the reaction pH value when the pH is 6.0~8.0. The rate change is up to 3.346 folds with decreasing of per pH unit while it decreases down to 0.3338 when pH is in the range 8.0~10.0. The reductive efficiency of zero-valent iron (ZVI) was further investigated by spiking excess PCP in the reaction system. The maximal reaction efficiency of ZVI for PCP dechlorination attains to 78% when pH is 9.0. The difference between the dechlorination rate and reductive efficiency with respect to reaction pH suggest that ZVI could not be ...

Sensors, 2008

High temperature sensors capable of operating in harsh environments are needed in order to preven... more High temperature sensors capable of operating in harsh environments are needed in order to prevent disasters caused by structural or system functional failures due to increasing temperatures. Most existing temperature sensors do not satisfy the needs because they require either physical contact or a battery power supply for signal communication, and furthermore, neither of them can withstand high temperatures nor rotating applications. This paper presents a novel passive wireless temperature sensor, suitable for working in harsh environments for high temperature rotating component monitoring. A completely passive LC resonant telemetry scheme, relying on a frequency variation output, which has been applied successfully in pressure, humidity and chemical measurement, is integrated with a unique high-k temperature sensitive ceramic material, in order to measure the temperatures without contacts, active elements, or power supplies within the sensor. In this paper, the high temperature sensor design and performance analysis are conducted based on mechanical and electrical modeling, in order to maximize the sensing distance, the Q factor and the sensitivity. In the end, the sensor prototype is fabricated and calibrated successfully up to 235ºC, so that the concept of temperature sensing through passive wireless communication is proved.

Colloids and Surfaces B: Biointerfaces, 2003

One of the important fields in cell biology is physical stimulus on the growth of plant cells and... more One of the important fields in cell biology is physical stimulus on the growth of plant cells and organs. The effects of strong sound wave on thermodynamic properties, cell cycles and calcium ion signaling transduction of plants have been studied. In this work, chrysanthemum seedlings are treated by sound wave with a certain intensity (100 db) and frequency (1000 Hz)

Colloids and Surfaces B: Biointerfaces, 2003

ABSTRACT Plants and environment are dependent on each other and environmental factors can greatly... more ABSTRACT Plants and environment are dependent on each other and environmental factors can greatly influence the growth and development of plant. Plasmalemma takes an important role in the process of signal transduction. The physical state of plasmalemma lipid and second structure of membrane protein can change with the process of signal transduction. In this paper, the effect of sound stimulation on the microstructure of plasmalemma was studied to explore the mechanism of biological effect of sound stimulation.

Colloids and Surfaces B: Biointerfaces, 2003

Environmental factors can greatly influence the growth of plants. In this paper, the effect of so... more Environmental factors can greatly influence the growth of plants. In this paper, the effect of sound stimulation on the metabolism of chrysanthemum roots was studied and it was found that the growth of roots was not inhibited but accelerated under suitable sound stimulation. And the content of soluble sugar and protein and the activity of amylase all increased significantly, which

PloS one, 2018

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a wide spectrum of c... more Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a wide spectrum of clinical manifestations and degrees of severity. Few genomic biomarkers for SLE have been validated and employed to inform clinical classifications and decisions. To discover and assess the gene-expression based SLE predictors in published studies, we performed a meta-analysis using our established signature database and a data similarity-driven strategy. From 13 training data sets on SLE gene-expression studies, we identified a SLE meta-signature (SLEmetaSig100) containing 100 concordant genes that are involved in DNA sensors and the IFN signaling pathway. We rigorously examined SLEmetaSig100 with both retrospective and prospective validation in two independent data sets. Using unsupervised clustering, we retrospectively elucidated that SLEmetaSig100 could classify clinical samples into two groups that correlated with SLE disease status and disease activities. More importantly, SLEmetaSi...

Advanced Materials Research, 2014

The Auto-Proving-Ground test cant reveal all problems of testing vehicles. Establishing a more su... more The Auto-Proving-Ground test cant reveal all problems of testing vehicles. Establishing a more suitable and accurate test for reliability index of auto-mobiles has become an important issue. The operating states data of coaches that running from Hefei to Zhengzhou has been collected in this paper, principal component analysis, and clustering analysis were then used to obtain the main factors that necessary for researching intercity bus reliability. The road condition, the ratio of idling, acceleration, deceleration and constant velocity has been determined based on the real drive condition. The acceleration in the y direction also has been taken into consideration when the bus steer. Based on the factors we improve the effectiveness and rationality of tests, which is in favor of building the system of rapid detection and evaluation for vehicles reliability.

PLOS Genetics, 2017

The funders had no role in showed that replication stresses affect chromatin structure by expandi... more The funders had no role in showed that replication stresses affect chromatin structure by expanding of heterochromatin with locus specificity. Mechanistically, we provide evidence suggesting that excessive formation of single-stranded DNA might have correlation with the reduction in fidelity of centromeric chromatin duplication. Finally, we demonstrated replication stress perturb the development process by reducing the fidelity of chromatin organization duplication in fruit fly and worm, illustrating the broadness and the evolutionary conservation of the phenomenon. Together, our results shed light on the importance of replication stresses cause epigenetic instability in addition to genetic stability.

Environmental pollution (Barking, Essex : 1987), 2014

We investigated the effects of arsenic species on As accumulation, plant growth and rhizospheric ... more We investigated the effects of arsenic species on As accumulation, plant growth and rhizospheric changes in As-hyperaccumulator Pteris vittata (PV). PV was grown for 60-d in a soil spiked with 200 mg kg(-1) arsenate (AsV-soil) or arsenite (AsIII-soil). Diffusive gradients in thin-films technique (DGT) were used to monitor As uptake by PV. Interestingly AsIII-soil produced the highest PV biomass at 8.6 g plant(-1), 27% and 46% greater than AsV-soil and the control. Biomass increase was associated with As-induced P uptake by PV. Although AsIII was oxidized to AsV during the experiment, As species impacted As accumulation by PV, with 17.5% more As in AsIII-soil than AsV-soil (36 vs. 31 mg plant(-1)). As concentration in PV roots was 30% higher in AsV-soil whereas As concentration in PV fronds was 7.9% greater in AsIII-soil, suggesting more rapid translocation of AsIII than AsV. These findings were important to understand the mechanisms of As uptake, accumulation and translocation by PV.

Microchimica Acta, 2018

A method is described for fast identification of bacteria by combining (a) the enrichment of bact... more A method is described for fast identification of bacteria by combining (a) the enrichment of bacterial cells by using magnetite (Fe 3 O 4) magnetic beads modified with human IgG (IgG@Fe 3 O 4) and (b) MALDI-TOF MS analysis. IgG has affinity to protein A, protein G, protein L and glycans on the surface of bacterial cells, and IgG@Fe 3 O 4. It therefore is applicable to the preconcentration of a range of bacterial species. The feasibility of the method has been demonstrated by collecting six species of pathogenic bacteria (Gram-positives: Staphylococcus aureus and Kocuria rosea; Gram-negatives: Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae and Pseudomonas aeruginosa). Bacteria with concentrations as low as 10 CFU•mL −1 in spiked water samples were extracted by this sorbent with recovery rates of >50%. After enrichment, bacteria on the IgG@Fe 3 O 4 sorbent were further identified by MALDI-TOF MS. Bacteria in concentrations as low as 10 5 CFU in 100 μL of human whole blood can be identified by the method. Compared to other blood culture based tests, the culture time is shortened by 40% (from~10 h to~6 h), and the plate culture procedure (overnight) is avoided. After short blood culture, the enrichment and identification can be finished in one hour. The IgG@Fe 3 O 4 is of practical value in clinical diagnosis and may be combined with other identification methods, e.g. PCR, Raman spectroscopy, infrared spectroscopy, etc.

Advanced Materials Research, 2013

Due to its influence on iron corrosion and involvement in dechlorination reaction, the concentrat... more Due to its influence on iron corrosion and involvement in dechlorination reaction, the concentration of H+ is crucial to the reactivity and efficiency of nanosized Pd /Fe. In this study, PCP dechlorination by smectite-templated Pd/Fe was studied and the effect of pH on PCP dechlorination was investigated in detail. The reaction rate constant is critically dependant on the reaction pH over the range 6.0~10.0. The dechlorination rate increases rapidly with decreasing the reaction pH value when the pH is 6.0~8.0. The rate change is up to 3.346 folds with decreasing of per pH unit while it decreases down to 0.3338 when pH is in the range 8.0~10.0. The reductive efficiency of zero-valent iron (ZVI) was further investigated by spiking excess PCP in the reaction system. The maximal reaction efficiency of ZVI for PCP dechlorination attains to 78% when pH is 9.0. The difference between the dechlorination rate and reductive efficiency with respect to reaction pH suggest that ZVI could not be ...

Sensors, 2008

High temperature sensors capable of operating in harsh environments are needed in order to preven... more High temperature sensors capable of operating in harsh environments are needed in order to prevent disasters caused by structural or system functional failures due to increasing temperatures. Most existing temperature sensors do not satisfy the needs because they require either physical contact or a battery power supply for signal communication, and furthermore, neither of them can withstand high temperatures nor rotating applications. This paper presents a novel passive wireless temperature sensor, suitable for working in harsh environments for high temperature rotating component monitoring. A completely passive LC resonant telemetry scheme, relying on a frequency variation output, which has been applied successfully in pressure, humidity and chemical measurement, is integrated with a unique high-k temperature sensitive ceramic material, in order to measure the temperatures without contacts, active elements, or power supplies within the sensor. In this paper, the high temperature sensor design and performance analysis are conducted based on mechanical and electrical modeling, in order to maximize the sensing distance, the Q factor and the sensitivity. In the end, the sensor prototype is fabricated and calibrated successfully up to 235ºC, so that the concept of temperature sensing through passive wireless communication is proved.

Colloids and Surfaces B: Biointerfaces, 2003

One of the important fields in cell biology is physical stimulus on the growth of plant cells and... more One of the important fields in cell biology is physical stimulus on the growth of plant cells and organs. The effects of strong sound wave on thermodynamic properties, cell cycles and calcium ion signaling transduction of plants have been studied. In this work, chrysanthemum seedlings are treated by sound wave with a certain intensity (100 db) and frequency (1000 Hz)

Colloids and Surfaces B: Biointerfaces, 2003

ABSTRACT Plants and environment are dependent on each other and environmental factors can greatly... more ABSTRACT Plants and environment are dependent on each other and environmental factors can greatly influence the growth and development of plant. Plasmalemma takes an important role in the process of signal transduction. The physical state of plasmalemma lipid and second structure of membrane protein can change with the process of signal transduction. In this paper, the effect of sound stimulation on the microstructure of plasmalemma was studied to explore the mechanism of biological effect of sound stimulation.

Colloids and Surfaces B: Biointerfaces, 2003

Environmental factors can greatly influence the growth of plants. In this paper, the effect of so... more Environmental factors can greatly influence the growth of plants. In this paper, the effect of sound stimulation on the metabolism of chrysanthemum roots was studied and it was found that the growth of roots was not inhibited but accelerated under suitable sound stimulation. And the content of soluble sugar and protein and the activity of amylase all increased significantly, which