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Proyecto Fin de Master de Museologia. IV edicion 2007-08. Univ. Granada. Facultad de Bellas Artes
Psiquiatría Biológica, 2014
ABSTRACT Depressive episodes with psychotic symptoms are a clinical entity with serious risk to t... more ABSTRACT Depressive episodes with psychotic symptoms are a clinical entity with serious risk to the patient, thus the therapeutic response should be based on the severity of the illness. The main treatment guidelines for unipolar depressive disorder recommend using antidepressive agents with adjuvant antipsychotic agents as first-line of treatment. The efficacy of electroconvulsive therapy in acute episode with severe forms, or less severe treatment resistant forms, has also been well-established. The case is presented of a patient suffering from a unipolar depressive episode, and who developed nihilistic psychotic symptoms (Cotard's delusion). Her therapeutic management, with the use of electroconvulsive therapy combined with drug treatment based on antidepressive and antipsychotics agents, led to a quick and marked clinical improvement with restitutio ad integrum of the patient, despite the resistance to clinical treatment presented in previous treatments of the current episode.
Psiquiatría Biológica, 2010
Dentro del diagnó stico diferencial de los cuadros psicó ticos de debut agudo debemos considerar ... more Dentro del diagnó stico diferencial de los cuadros psicó ticos de debut agudo debemos considerar los cuadros inducidos farmacoló gicamente y las enfermedades mé dicas. En nuestro caso, observamos una paciente que presentó sintomatología compatible con un episodio psicó tico tras haber estado en tratamiento con metronidazol. La ausencia de antecedentes psiquiá tricos previos personales o familiares, ni otra condició n física que justificara el cuadro, y la rá pida resolució n de este tras la suspensió n del tratamiento apoyan la relació n entre el metronidazol y la psicosis.
Endocrine, 1995
A higher specific binding of GLP-1(7-36)amide is found in skeletal muscle plasma membranes from a... more A higher specific binding of GLP-1(7-36)amide is found in skeletal muscle plasma membranes from adult streptozotocin (STZ)-treated rats (insulin-dependent diabetes mellitus model) and from neonatal STZ-treated rats (non insulin-dependent diabetes mellitus model), as compared to that in normal controls; no apparent change in the affinity was observed, that indicating the presence in both diabetic models of an increased number of high affinity binding sites for the peptide. The maximal specific GLP-1(7-16)amide binding in the non insulin-dependent diabetes mellitus model was found to be significantly higher than that in the insulin-dependent diabetes mellitus model. As GLP-1(7-36)amide exerts a glycogenic effect in the rat skeletal muscle, the present data suggest that the action of the peptide in the muscle glucose metabolism may be increased in states of insulin deficiency accompanied or not by insulin resistance.
Diabetes, 1997
To search if biological effects of GLP-I on glucose metabolism in extrapancreatic tissue are pres... more To search if biological effects of GLP-I on glucose metabolism in extrapancreatic tissue are present in diabetic states, we have studied the action of GLP-I and insulin on glycogen-enzyme activity, glycogen synthesis, and glucose metabolism in isolated hepatocytes and soleus muscle from adult streptozotocin (STZ)-and neonatal STZtreated diabetic rats. This work confirms the previously reported insulin-like effects of GLP-I on glucose metabolism in both muscle and liver tissue from normal rats (control). The present study extends those observations to the muscle and liver tissue of diabetic animals. In both muscle and liver tissue, the metabolism of D-glucose, in the absence of added peptides, was more severely affected in adult STZ (IDDM model) than in neonatal STZ (nSTZ; NIDDM model) rats, and the magnitude of hormonal effect on metabolic variables was lower in diabetic rats than in control rats, as a rule. Nevertheless, in liver and muscle tissue of diabetic rats, GLP-I was able to increase glycogen synthase activity, augment the net rate of D-[U-CJglucose incorporation into glycogen, and increase D-[5-3 H]glucose utilization, D-[U-14 C]glucose oxidation, and lactate production. In conclusion, GLP-I exerts insulin-like effects on D-glucose metabolism in both muscle and liver tissue in IDDM or NIDDM animal models, and present observations reinforce the view that GLP-I may represent a most promising tool in the treatment of diabetic patients. Diabetes 46:1264-1269, 1997 T he glucagon-like peptide 1(7-36) amide (GLP-I) is secreted by the intestinal L-cells in response to carbohydrate and fat meals. GLP-I has a glucosedependent insulinotropic effect, inhibits glucagon release, and is considered as a physiological incretin. On the other hand, Gutniak et al. (1) show that glucose disappear-From the Department of Metabolism, Nutrition, and Hormones (M.
Archives of Biochemistry and Biophysics, 1997
crease in glycogen synthase a activity, as is known The GLP-1 structurally related peptides exend... more crease in glycogen synthase a activity, as is known The GLP-1 structurally related peptides exendin-4 for insulin (5, 6). These insulin-like effects of GLP-1 and exendin(9-39)amide were found to act, in rat liver on glucose metabolism in liver and muscle could be and skeletal muscle, as agonist and antagonist, respecmediated by specific receptors (7-11), their presence tively, of the GLP-1(7-36)amide effects on glucose mebeing documented by reverse transcription polymertabolism. Thus, like GLP-1(7-36)amide, exendin-4 inase chain reaction in rat liver and skeletal muscle (7) creased glycogen synthase a activity and glucose inand in mouse liver (8), as well as by Northern blot corporation into glycogen in both tissues and also (9) and binding studies (10, 11) in both tissues from stimulated exogenous D-glucose utilization and oxidarats. The exact nature of the GLP-1 receptors present tion in muscle. These effects of GLP-1(7-36)amide and in liver and in skeletal muscle has not been clarified, exendin-4 were inhibited by exendin(9-39)amide. Our but apparently they are not of the G-protein-linked findings provide further support to the proposed use type such as those found in the pancreatic b cell (12) of GLP-1, or exendin-4, as a tool in the treatment of since, in those two tissues, the peptide does not indiabetes mellitus. Thus, in addition to the well-known crease adenylate cyclase activity (10, 11, 13). insulinotropic action of the peptides, they act both in Exendin-4 (Ex-4) is a peptide 53% structurally reliver and in muscle in a manner most suitable for restolated to GLP-1(7-36)amide, isolated from Heloderma ration of glucose homeostasis, with emphasis on their suspectum venom (14), which was found to increase positive effects upon glycogen synthesis in the two tisinsulin release in rat pancreatic islets and in rat and sues and on the stimulation of exogenous glucose camouse insulinoma B-cells (15) and to stimulate sotabolism in muscle.
Proyecto Fin de Master de Museologia. IV edicion 2007-08. Univ. Granada. Facultad de Bellas Artes
Psiquiatría Biológica, 2014
ABSTRACT Depressive episodes with psychotic symptoms are a clinical entity with serious risk to t... more ABSTRACT Depressive episodes with psychotic symptoms are a clinical entity with serious risk to the patient, thus the therapeutic response should be based on the severity of the illness. The main treatment guidelines for unipolar depressive disorder recommend using antidepressive agents with adjuvant antipsychotic agents as first-line of treatment. The efficacy of electroconvulsive therapy in acute episode with severe forms, or less severe treatment resistant forms, has also been well-established. The case is presented of a patient suffering from a unipolar depressive episode, and who developed nihilistic psychotic symptoms (Cotard's delusion). Her therapeutic management, with the use of electroconvulsive therapy combined with drug treatment based on antidepressive and antipsychotics agents, led to a quick and marked clinical improvement with restitutio ad integrum of the patient, despite the resistance to clinical treatment presented in previous treatments of the current episode.
Psiquiatría Biológica, 2010
Dentro del diagnó stico diferencial de los cuadros psicó ticos de debut agudo debemos considerar ... more Dentro del diagnó stico diferencial de los cuadros psicó ticos de debut agudo debemos considerar los cuadros inducidos farmacoló gicamente y las enfermedades mé dicas. En nuestro caso, observamos una paciente que presentó sintomatología compatible con un episodio psicó tico tras haber estado en tratamiento con metronidazol. La ausencia de antecedentes psiquiá tricos previos personales o familiares, ni otra condició n física que justificara el cuadro, y la rá pida resolució n de este tras la suspensió n del tratamiento apoyan la relació n entre el metronidazol y la psicosis.
Endocrine, 1995
A higher specific binding of GLP-1(7-36)amide is found in skeletal muscle plasma membranes from a... more A higher specific binding of GLP-1(7-36)amide is found in skeletal muscle plasma membranes from adult streptozotocin (STZ)-treated rats (insulin-dependent diabetes mellitus model) and from neonatal STZ-treated rats (non insulin-dependent diabetes mellitus model), as compared to that in normal controls; no apparent change in the affinity was observed, that indicating the presence in both diabetic models of an increased number of high affinity binding sites for the peptide. The maximal specific GLP-1(7-16)amide binding in the non insulin-dependent diabetes mellitus model was found to be significantly higher than that in the insulin-dependent diabetes mellitus model. As GLP-1(7-36)amide exerts a glycogenic effect in the rat skeletal muscle, the present data suggest that the action of the peptide in the muscle glucose metabolism may be increased in states of insulin deficiency accompanied or not by insulin resistance.
Diabetes, 1997
To search if biological effects of GLP-I on glucose metabolism in extrapancreatic tissue are pres... more To search if biological effects of GLP-I on glucose metabolism in extrapancreatic tissue are present in diabetic states, we have studied the action of GLP-I and insulin on glycogen-enzyme activity, glycogen synthesis, and glucose metabolism in isolated hepatocytes and soleus muscle from adult streptozotocin (STZ)-and neonatal STZtreated diabetic rats. This work confirms the previously reported insulin-like effects of GLP-I on glucose metabolism in both muscle and liver tissue from normal rats (control). The present study extends those observations to the muscle and liver tissue of diabetic animals. In both muscle and liver tissue, the metabolism of D-glucose, in the absence of added peptides, was more severely affected in adult STZ (IDDM model) than in neonatal STZ (nSTZ; NIDDM model) rats, and the magnitude of hormonal effect on metabolic variables was lower in diabetic rats than in control rats, as a rule. Nevertheless, in liver and muscle tissue of diabetic rats, GLP-I was able to increase glycogen synthase activity, augment the net rate of D-[U-CJglucose incorporation into glycogen, and increase D-[5-3 H]glucose utilization, D-[U-14 C]glucose oxidation, and lactate production. In conclusion, GLP-I exerts insulin-like effects on D-glucose metabolism in both muscle and liver tissue in IDDM or NIDDM animal models, and present observations reinforce the view that GLP-I may represent a most promising tool in the treatment of diabetic patients. Diabetes 46:1264-1269, 1997 T he glucagon-like peptide 1(7-36) amide (GLP-I) is secreted by the intestinal L-cells in response to carbohydrate and fat meals. GLP-I has a glucosedependent insulinotropic effect, inhibits glucagon release, and is considered as a physiological incretin. On the other hand, Gutniak et al. (1) show that glucose disappear-From the Department of Metabolism, Nutrition, and Hormones (M.
Archives of Biochemistry and Biophysics, 1997
crease in glycogen synthase a activity, as is known The GLP-1 structurally related peptides exend... more crease in glycogen synthase a activity, as is known The GLP-1 structurally related peptides exendin-4 for insulin (5, 6). These insulin-like effects of GLP-1 and exendin(9-39)amide were found to act, in rat liver on glucose metabolism in liver and muscle could be and skeletal muscle, as agonist and antagonist, respecmediated by specific receptors (7-11), their presence tively, of the GLP-1(7-36)amide effects on glucose mebeing documented by reverse transcription polymertabolism. Thus, like GLP-1(7-36)amide, exendin-4 inase chain reaction in rat liver and skeletal muscle (7) creased glycogen synthase a activity and glucose inand in mouse liver (8), as well as by Northern blot corporation into glycogen in both tissues and also (9) and binding studies (10, 11) in both tissues from stimulated exogenous D-glucose utilization and oxidarats. The exact nature of the GLP-1 receptors present tion in muscle. These effects of GLP-1(7-36)amide and in liver and in skeletal muscle has not been clarified, exendin-4 were inhibited by exendin(9-39)amide. Our but apparently they are not of the G-protein-linked findings provide further support to the proposed use type such as those found in the pancreatic b cell (12) of GLP-1, or exendin-4, as a tool in the treatment of since, in those two tissues, the peptide does not indiabetes mellitus. Thus, in addition to the well-known crease adenylate cyclase activity (10, 11, 13). insulinotropic action of the peptides, they act both in Exendin-4 (Ex-4) is a peptide 53% structurally reliver and in muscle in a manner most suitable for restolated to GLP-1(7-36)amide, isolated from Heloderma ration of glucose homeostasis, with emphasis on their suspectum venom (14), which was found to increase positive effects upon glycogen synthesis in the two tisinsulin release in rat pancreatic islets and in rat and sues and on the stimulation of exogenous glucose camouse insulinoma B-cells (15) and to stimulate sotabolism in muscle.