joel joseph - Academia.edu (original) (raw)
Papers by joel joseph
This thesis aimed to develop a mathematical model using a Petri net to simulate the traffic flow ... more This thesis aimed to develop a mathematical model using a Petri net to simulate the traffic flow inside the road tunnel. The purpose was to create a single-lane tunnel that could simulate the flow while also including an event, which slows down a vehicle to cause congestion. The program uses modules to divided the tunnel into smaller segments and compute the vehicle distance inside these segments. Three different simulations using four tunnel segments yield an expected outcome, except for higher vehicle numbers due to the tunnel segment being too long. The program is still not usable and requires further development before put into practice.2021-09-29T16:26:21
The purpose of this study is to provide an assessment of the key health behaviors, determinants, ... more The purpose of this study is to provide an assessment of the key health behaviors, determinants, and exposure to PSI-Caribbean programming among sexually active youth 16 to 24 years in Suriname, where PSI-Caribbean is implementing a KFW-funded project (CARISMA II) targeting sexually active youth. The survey was conducted in three (3) project targeted districts â Nickerie, Paramaribo and Wanica. Time-location sampling (TLS) was used to recruit sexually active males and females 16 to 24 years at known hot spots in this baseline study. A total of 742 interviews were conducted. Analyses consisted of logistic regression and anovas to examine trends over time, to ascertain which determinants are correlated with key behaviors, and to examine the association between program exposure and changes in health behaviors and determinants. Socio-demographic characteristics and hot spots where youth hang out were controlled for in the analyses
BACKGROUND St. Lucia is a Caribbean island located between the Caribbean Sea and the North Atlant... more BACKGROUND St. Lucia is a Caribbean island located between the Caribbean Sea and the North Atlantic Ocean, north of Trinidad & Tobago. With a land span of 616 sq. km, St. Lucia is volcanic and mountainous with some broad fertile valleys. Based on reports from the CIA World Fact Book, St. Lucia's population as of July 2012 is estimated at 162,178 persons, with a male to female ration of 1.06. Of the total population, 67.5% are between the ages of 15 to 64 years, 22.8% are between the ages of 0 to 14 years, and 9.7% are 65 years and older. According to St. Lucia Statistics Office, approximately 20% of the population i s between the ages of 15 and 24 years (around 30,000 people) and of this, 80% of these youth are sexually active. Ninety percent (90%) of this last subgroup has been sexually active within the past month. This leads to an estimated target population size of 22,000 for Population Services International. Saint Lucia is mostly a rural country (only 28% of the population is described as urbanized). Tourism is the main driver of the economy and the manufacturing sector is described as the most diverse in the eastern Caribbean. According to the 2010 St. Lucia UNGASS report, the country'Âs HIV/AIDS status is described as a concentrated, low prevalence epidemic. The report also indicates that while current HIV infections continue to be characterized by heterosexual intercourse, in the Saint Lucian context drivers of the epidemic broadly include: transactional sex where no cash is exchanged but gifts are given and support suppl ied; sex for drugs (crack, cocaine) and traditional sex work (exchange of sex for money) primarily by both foreign and local women. Foreign women primarily work in brothels and strip-clubs while local women are known to work in areas frequented by tourists. Trends in HIV transmission have also been linked to increased poverty and social disintegration. The UNGASS report continues to state that further to these broad drivers, there is a hidden but believed to be substantial population of men having sex with men exclusively (MSM) and men having sex with both men and women (MSMW). This is thought to be exacerbating the HIV epidemic and statistical evidence suggests that the behaviors of MSMW have contributed to the feminization of the HIV epidemic in St. Lucia STUDY OBJECTIVES The purpose of the Tracking Results Continuously (TRaC) survey among sexually active youth 16-24 years in St. Lucia is to provide evidence for monitoring and implementation of PSI/SFH HIV prevention Program. The data gathered through the 2012 TRaC survey will be analyzed according to PSI's Performance Framework DESIGN/METHODOLOGY This study design calls for a time location sampling approach. The total sample size will be 530 youth 16 to 24. Data will be aggregated to create dashboard tables. Information from the St. Lucia Government Statistics Department was used to estimate the target population size of 22,000 (this estimate is based on a population size of approximately 30,000 youth 15-24 years with 80% of these youth who are sexually active and 90% of this population sexually active within the past month). ÂHot spots (i.e. specific locations where youth 16-24 years are known to congregate e.g. community blocks, beaches, clubs, bars, shopping areas, sporting events) will be identified within St. Lucian communities. Personnel at the National AIDS Program and the St. Lucia Planned Parenthood who have worked extensively with the target population will identify all locations and the time that youth are generally found to be congregating at these locations. These well-informed persons will make estimates of the number of youth at each location. St. Lucia is divided into ten (10) parishes both urban and rural. Despite these divisions there are no real distinctions between where the urban and rural youth congregate. Young people in St. Lucia are found at popular community blocks, residential houses, bars, clubs, shopping areas, and sporting events at specific times. Youth who congregate at selected locations will be approached by interviewers and using a systematic random process to participate in the study. For instance, if an interviewer visits a Âhot spot and there are 13 youth at that location the interviewer will assign a number to all persons within the target population age group and select every nth person to interview after choosing a random starting number. If the selected individual does not meet the inclusion criteria which includes being between 16-24 years, has had sexual intercourse in last 30 days and has had more than one sexual partner in the last three (3) months, then another member from the group will be randomly selected. Youth on the street will be selected rather than youth at their homes because information obtained from youth at home may be negatively skewed. A young person at home in St. Lucia would usually be in the presence of their parent or guardian and therefore would be less…
SCIENCE DILIMAN is published semi-annually (June and December) by the University of the Philippin... more SCIENCE DILIMAN is published semi-annually (June and December) by the University of the Philippines Diliman through the Off ice of the Vice-Chancellor for Research and Development. The journal features articles of pure and applied sciences.
PSI conducted the first round of the TRaC (Tracking Results Continuoulsy) survey in June 2008 amo... more PSI conducted the first round of the TRaC (Tracking Results Continuoulsy) survey in June 2008 among male youth on the block (MYOB). The aim of this study was to provide evidence for monitoring and implementation of PSI Caribbean's HIV Prevention Program. The data gathered also served to monitor the levels and trends evident in key behavior, risk, OAM constructs and exposure to PSI activities youth on the block over time
Abalone are herbivorous marine gastropods and are nocturnal-that is, they hide during the day amo... more Abalone are herbivorous marine gastropods and are nocturnal-that is, they hide during the day amongst rocks and at night time, they go out in search of food. Its fishery provides a significant source of employment and income to coastal people. From a socioeconomic perspective, the long-term sustainability of abalone fisheries is of great importance. Unfortunately, abalone stocks have been overfished in many areas where they are found as a result of ever-increasing market demand, uncontrolled exploitation and/or inadequate or lack of fisheries management. One possible option for resource management is to educate local fishers to develop a corps of local resource managers who would promote sustainable fishing practices and conservation of this valuable resource (see Capinpin, this issue). Photo courtesy of E.C. Capinpin, Jr.
2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 2021
We investigate the cross coupling between parallel operating thermo-magnetic generators (TMGs) on... more We investigate the cross coupling between parallel operating thermo-magnetic generators (TMGs) on their dynamic performance and power output. TMGs are an emerging technology for waste heat recovery. Here, TMG operation relies on the abrupt drop of magnetization at the Curie temperature of a magnetic shape memory (MSMA) film of Ni-Mn-Ga mounted at the front of a cantilever and on rapid heat transfer due to the film's large surface-to-volume ratio. Parallel designs are highly demanded to increase power output. When exposed to heat source temperatures Ts of 110-170 °C, resonant self-oscillation of each cantilever is excited in the range of 50-70 Hz resulting in a power output up to 30textmW/textcm330\ \text{mW}/\text{cm}^{3}30textmW/textcm3 for each TMG. At low Ts, oscillations remain stable even for a small distance DDD of 0.4 mm between cantilevers, while at textTsgeq150circmathrmC\text{Ts}\ \geq\ 150^{\circ}\mathrm{C}textTsgeq150circmathrmC, instabilities occur below D=1D=1D=1 mm affecting power output.
Pharmacognosy Magazine, 2019
Background:Easy availability, relatively low cost with fewer side effects, has made the herbal ex... more Background:Easy availability, relatively low cost with fewer side effects, has made the herbal extracts/fractions/pure compounds as prominent source of medicinally important molecules. Dioscorea villosa L. commonly known as wild yam belongs to the family Dioscoreaceae and has been used in various parts of India to treat joint pain, arthritis, and various other diseases. However, its role in wound healing has not been documented so far. In the current study, the in vitro wound healing capabilities of D. villosa were examined using L929 cells. Materials and Methods:Methanolic extraction of D. villosa leaves was prepared by applying inexpensive maceration method. 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to analyze the cytotoxicity of D. villosa extract and in vitro wound healing capabilities were investigated by applying scratch assay. The qualitative measurement of different secondary metabolites was determined by standard biochemical assays. Gas chromatography-mass spectrometry (GC-MS) was performed to identify the possible wound healing components present in the methanolic leaf extract of D. villosa, and the antioxidant properties of the plant extract were evaluated by α,α-diphenyl-β-picrylhydrazyl and ferric reducing antioxidant power assays. Furthermore, the possible molecular factors involved in the proliferation and migration of fibroblast in the presence of D. villosa extract was determined by flow cytometry technique. Results:The experiments to analyze the cytotoxic effect of D. villosa on L929 cells revealed that at the highest concentration used, i.e., 500 μg/mL after 48 h of incubation, 96.06% ± 0.42% of the cells were viable. The results of the scratch assay revealed that 125 μg/mL of plant extract induced the migration in 88.58% of fibroblast cells. Through GC-MS analysis, antioxidant and anti-inflammatory molecules such as 1 H-Indole-2,3-dione (Isatin) and Dexamethasone have been identified. In addition, flow cytometry data showed the influence of plant extract on the expression of Collagen-1 and transforming growth factor (TGF)-beta, which play a major role in the wound healing processes. 125 μg/mL of plant extract induced Collagen-1 in 22.18% cells and TGF-beta in 80.77% of cells, respectively. Conclusion:The presence of potent antioxidant and anti-inflammatory molecules and capability to induce the expression of fundamental wound healing molecular factors TGF-beta and collagen-1 in fibroblast cells, endorsed D. villosa as a potential wound healing agent. Abbreviations used:DA: Dioscorea villosa; LDH: Lactate dehydrogenase; ECM: Extra Cellular matrix; DMSO: Dimethyl sulfoxide; DMEM: Dulbecco's Modified Eagle's Medium; FBS: Fetal bovine serum; FITC: Fluorescein isothiocyanate. D-PBS: Dulbecco's phosphate-buffered saline; FACS: Fluorescent activated cell sorter; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; μg: Micrograms; ng: Nanogram; mL: milliliter; SD: Standard Deviation; hEGF: Human epidermal growth factor.
For most of the experiments concerning the main claim of the paper, the code was enough from the ... more For most of the experiments concerning the main claim of the paper, the code was enough from the official repo provided by the authors on Github. However, reproducing some of the figures and the tables involving Gradient Alignment and Catastrophic Forgetting visualization proved to be difficult due to those parts not being published. We were able to contact the authors and received help for those experiments.
Gastrointestinal Endoscopy, 2021
American Journal of Gastroenterology, 2021
Encyclopedia of Smart Materials, 2022
Nucleic Acids Research, 2021
We introduce a new online database of nucleic acid nanostructures for the field of DNA and RNA na... more We introduce a new online database of nucleic acid nanostructures for the field of DNA and RNA nanotechnology. The database implements an upload interface, searching and database browsing. Each deposited nanostructures includes an image of the nanostructure, design file, an optional 3D view, and additional metadata such as experimental data, protocol or literature reference. The database accepts nanostructures in any preferred format used by the uploader for the nanostructure design. We further provide a set of conversion tools that encourage design file conversion into common formats (oxDNA and PDB) that can be used for setting up simulations, interactive editing or 3D visualization. The aim of the repository is to provide to the DNA/RNA nanotechnology community a resource for sharing their designs for further reuse in other systems and also to function as an archive of the designs that have been achieved in the field so far. Nanobase.org is available at https://nanobase.org/.
Journal of Natural Science, Biology and Medicine, 2021
Background: Insulin resistance (IR) is the major underlying mechanism responsible for metabolic s... more Background: Insulin resistance (IR) is the major underlying mechanism responsible for metabolic syndrome and HOMA-IR2 is a validated marker of IR. Fasting lipid profile, including triglyceride (TG) and high-density lipoprotein (HDL) cholesterol routinely feature in the outpatient investigation list. Utility of TG/HDL ratio as a surrogate marker for IR was thus studied in healthy young males. Materials and Methods: This cross-sectional study involved 71 young males aged 18–35 years who came for a routine health check in a fasting state. Height, weight, waist circumference were recorded. Fasting plasma glucose (FPG) and lipid profile reports were collected from the laboratory database. Fasting insulin (FI) was estimated by enzyme-linked immunosorbent assay. Body mass index (kg/m2), TG/HDL, TC/HDL, and HOMA-IR2 were calculated. Results: Mean TG/HDL ratio was 3.73 ± 2.03 and HOMA IR2 was above the standard cut off of ≥2.5 units. Subjects were further divided into two groups based on FPG values. TG, low-density lipoprotein, total cholesterol, TG/HDL, TC/HDL, FI and HOMA-IR2 were found to be higher in the pre-diabetes with impaired fasting glycemic subjects. Overall, a statistically significant positive correlation was seen (P = 0.01, r = 0.284) between TG/HDL and HOMA-IR2. Conclusion: TG/HDL ratio was significantly associated with IR and it could be used as an indicator of IR especially in prediabetic subjects having impaired fasting glucose.
Materials, 2021
This paper presents a lumped element model (LEM) to describe the coupled dynamic properties of th... more This paper presents a lumped element model (LEM) to describe the coupled dynamic properties of thermomagnetic generators (TMGs) based on magnetic shape memory alloy (MSMA) films. The TMG generators make use of the concept of resonant self-actuation of a freely movable cantilever, caused by a large abrupt temperature-dependent change of magnetization and rapid heat transfer inherent to the MSMA films. The LEM is validated for the case of a Ni-Mn-Ga film with Curie temperature TC of 375 K. For a heat source temperature of 443 K, the maximum power generated is 3.1 µW corresponding to a power density with respect to the active material’s volume of 80 mW/cm3. Corresponding LEM simulations allow for a detailed study of the time-resolved temperature change of the MSMA film, the change of magnetic field at the position of the film and of the corresponding film magnetization. Resonant self-actuation is observed at 114 Hz, while rapid temperature changes of about 10 K occur within 1 ms during...
Joule, 2020
Conclusion: Overall, Our findings suggest that catechin hydrate inhibits B(a)P-induced lung tumor... more Conclusion: Overall, Our findings suggest that catechin hydrate inhibits B(a)P-induced lung tumor formation by modulating hyperproliferation, inflammation, apoptosis and ALDH1 expression.
This thesis aimed to develop a mathematical model using a Petri net to simulate the traffic flow ... more This thesis aimed to develop a mathematical model using a Petri net to simulate the traffic flow inside the road tunnel. The purpose was to create a single-lane tunnel that could simulate the flow while also including an event, which slows down a vehicle to cause congestion. The program uses modules to divided the tunnel into smaller segments and compute the vehicle distance inside these segments. Three different simulations using four tunnel segments yield an expected outcome, except for higher vehicle numbers due to the tunnel segment being too long. The program is still not usable and requires further development before put into practice.2021-09-29T16:26:21
The purpose of this study is to provide an assessment of the key health behaviors, determinants, ... more The purpose of this study is to provide an assessment of the key health behaviors, determinants, and exposure to PSI-Caribbean programming among sexually active youth 16 to 24 years in Suriname, where PSI-Caribbean is implementing a KFW-funded project (CARISMA II) targeting sexually active youth. The survey was conducted in three (3) project targeted districts â Nickerie, Paramaribo and Wanica. Time-location sampling (TLS) was used to recruit sexually active males and females 16 to 24 years at known hot spots in this baseline study. A total of 742 interviews were conducted. Analyses consisted of logistic regression and anovas to examine trends over time, to ascertain which determinants are correlated with key behaviors, and to examine the association between program exposure and changes in health behaviors and determinants. Socio-demographic characteristics and hot spots where youth hang out were controlled for in the analyses
BACKGROUND St. Lucia is a Caribbean island located between the Caribbean Sea and the North Atlant... more BACKGROUND St. Lucia is a Caribbean island located between the Caribbean Sea and the North Atlantic Ocean, north of Trinidad & Tobago. With a land span of 616 sq. km, St. Lucia is volcanic and mountainous with some broad fertile valleys. Based on reports from the CIA World Fact Book, St. Lucia's population as of July 2012 is estimated at 162,178 persons, with a male to female ration of 1.06. Of the total population, 67.5% are between the ages of 15 to 64 years, 22.8% are between the ages of 0 to 14 years, and 9.7% are 65 years and older. According to St. Lucia Statistics Office, approximately 20% of the population i s between the ages of 15 and 24 years (around 30,000 people) and of this, 80% of these youth are sexually active. Ninety percent (90%) of this last subgroup has been sexually active within the past month. This leads to an estimated target population size of 22,000 for Population Services International. Saint Lucia is mostly a rural country (only 28% of the population is described as urbanized). Tourism is the main driver of the economy and the manufacturing sector is described as the most diverse in the eastern Caribbean. According to the 2010 St. Lucia UNGASS report, the country'Âs HIV/AIDS status is described as a concentrated, low prevalence epidemic. The report also indicates that while current HIV infections continue to be characterized by heterosexual intercourse, in the Saint Lucian context drivers of the epidemic broadly include: transactional sex where no cash is exchanged but gifts are given and support suppl ied; sex for drugs (crack, cocaine) and traditional sex work (exchange of sex for money) primarily by both foreign and local women. Foreign women primarily work in brothels and strip-clubs while local women are known to work in areas frequented by tourists. Trends in HIV transmission have also been linked to increased poverty and social disintegration. The UNGASS report continues to state that further to these broad drivers, there is a hidden but believed to be substantial population of men having sex with men exclusively (MSM) and men having sex with both men and women (MSMW). This is thought to be exacerbating the HIV epidemic and statistical evidence suggests that the behaviors of MSMW have contributed to the feminization of the HIV epidemic in St. Lucia STUDY OBJECTIVES The purpose of the Tracking Results Continuously (TRaC) survey among sexually active youth 16-24 years in St. Lucia is to provide evidence for monitoring and implementation of PSI/SFH HIV prevention Program. The data gathered through the 2012 TRaC survey will be analyzed according to PSI's Performance Framework DESIGN/METHODOLOGY This study design calls for a time location sampling approach. The total sample size will be 530 youth 16 to 24. Data will be aggregated to create dashboard tables. Information from the St. Lucia Government Statistics Department was used to estimate the target population size of 22,000 (this estimate is based on a population size of approximately 30,000 youth 15-24 years with 80% of these youth who are sexually active and 90% of this population sexually active within the past month). ÂHot spots (i.e. specific locations where youth 16-24 years are known to congregate e.g. community blocks, beaches, clubs, bars, shopping areas, sporting events) will be identified within St. Lucian communities. Personnel at the National AIDS Program and the St. Lucia Planned Parenthood who have worked extensively with the target population will identify all locations and the time that youth are generally found to be congregating at these locations. These well-informed persons will make estimates of the number of youth at each location. St. Lucia is divided into ten (10) parishes both urban and rural. Despite these divisions there are no real distinctions between where the urban and rural youth congregate. Young people in St. Lucia are found at popular community blocks, residential houses, bars, clubs, shopping areas, and sporting events at specific times. Youth who congregate at selected locations will be approached by interviewers and using a systematic random process to participate in the study. For instance, if an interviewer visits a Âhot spot and there are 13 youth at that location the interviewer will assign a number to all persons within the target population age group and select every nth person to interview after choosing a random starting number. If the selected individual does not meet the inclusion criteria which includes being between 16-24 years, has had sexual intercourse in last 30 days and has had more than one sexual partner in the last three (3) months, then another member from the group will be randomly selected. Youth on the street will be selected rather than youth at their homes because information obtained from youth at home may be negatively skewed. A young person at home in St. Lucia would usually be in the presence of their parent or guardian and therefore would be less…
SCIENCE DILIMAN is published semi-annually (June and December) by the University of the Philippin... more SCIENCE DILIMAN is published semi-annually (June and December) by the University of the Philippines Diliman through the Off ice of the Vice-Chancellor for Research and Development. The journal features articles of pure and applied sciences.
PSI conducted the first round of the TRaC (Tracking Results Continuoulsy) survey in June 2008 amo... more PSI conducted the first round of the TRaC (Tracking Results Continuoulsy) survey in June 2008 among male youth on the block (MYOB). The aim of this study was to provide evidence for monitoring and implementation of PSI Caribbean's HIV Prevention Program. The data gathered also served to monitor the levels and trends evident in key behavior, risk, OAM constructs and exposure to PSI activities youth on the block over time
Abalone are herbivorous marine gastropods and are nocturnal-that is, they hide during the day amo... more Abalone are herbivorous marine gastropods and are nocturnal-that is, they hide during the day amongst rocks and at night time, they go out in search of food. Its fishery provides a significant source of employment and income to coastal people. From a socioeconomic perspective, the long-term sustainability of abalone fisheries is of great importance. Unfortunately, abalone stocks have been overfished in many areas where they are found as a result of ever-increasing market demand, uncontrolled exploitation and/or inadequate or lack of fisheries management. One possible option for resource management is to educate local fishers to develop a corps of local resource managers who would promote sustainable fishing practices and conservation of this valuable resource (see Capinpin, this issue). Photo courtesy of E.C. Capinpin, Jr.
2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 2021
We investigate the cross coupling between parallel operating thermo-magnetic generators (TMGs) on... more We investigate the cross coupling between parallel operating thermo-magnetic generators (TMGs) on their dynamic performance and power output. TMGs are an emerging technology for waste heat recovery. Here, TMG operation relies on the abrupt drop of magnetization at the Curie temperature of a magnetic shape memory (MSMA) film of Ni-Mn-Ga mounted at the front of a cantilever and on rapid heat transfer due to the film's large surface-to-volume ratio. Parallel designs are highly demanded to increase power output. When exposed to heat source temperatures Ts of 110-170 °C, resonant self-oscillation of each cantilever is excited in the range of 50-70 Hz resulting in a power output up to 30textmW/textcm330\ \text{mW}/\text{cm}^{3}30textmW/textcm3 for each TMG. At low Ts, oscillations remain stable even for a small distance DDD of 0.4 mm between cantilevers, while at textTsgeq150circmathrmC\text{Ts}\ \geq\ 150^{\circ}\mathrm{C}textTsgeq150circmathrmC, instabilities occur below D=1D=1D=1 mm affecting power output.
Pharmacognosy Magazine, 2019
Background:Easy availability, relatively low cost with fewer side effects, has made the herbal ex... more Background:Easy availability, relatively low cost with fewer side effects, has made the herbal extracts/fractions/pure compounds as prominent source of medicinally important molecules. Dioscorea villosa L. commonly known as wild yam belongs to the family Dioscoreaceae and has been used in various parts of India to treat joint pain, arthritis, and various other diseases. However, its role in wound healing has not been documented so far. In the current study, the in vitro wound healing capabilities of D. villosa were examined using L929 cells. Materials and Methods:Methanolic extraction of D. villosa leaves was prepared by applying inexpensive maceration method. 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to analyze the cytotoxicity of D. villosa extract and in vitro wound healing capabilities were investigated by applying scratch assay. The qualitative measurement of different secondary metabolites was determined by standard biochemical assays. Gas chromatography-mass spectrometry (GC-MS) was performed to identify the possible wound healing components present in the methanolic leaf extract of D. villosa, and the antioxidant properties of the plant extract were evaluated by α,α-diphenyl-β-picrylhydrazyl and ferric reducing antioxidant power assays. Furthermore, the possible molecular factors involved in the proliferation and migration of fibroblast in the presence of D. villosa extract was determined by flow cytometry technique. Results:The experiments to analyze the cytotoxic effect of D. villosa on L929 cells revealed that at the highest concentration used, i.e., 500 μg/mL after 48 h of incubation, 96.06% ± 0.42% of the cells were viable. The results of the scratch assay revealed that 125 μg/mL of plant extract induced the migration in 88.58% of fibroblast cells. Through GC-MS analysis, antioxidant and anti-inflammatory molecules such as 1 H-Indole-2,3-dione (Isatin) and Dexamethasone have been identified. In addition, flow cytometry data showed the influence of plant extract on the expression of Collagen-1 and transforming growth factor (TGF)-beta, which play a major role in the wound healing processes. 125 μg/mL of plant extract induced Collagen-1 in 22.18% cells and TGF-beta in 80.77% of cells, respectively. Conclusion:The presence of potent antioxidant and anti-inflammatory molecules and capability to induce the expression of fundamental wound healing molecular factors TGF-beta and collagen-1 in fibroblast cells, endorsed D. villosa as a potential wound healing agent. Abbreviations used:DA: Dioscorea villosa; LDH: Lactate dehydrogenase; ECM: Extra Cellular matrix; DMSO: Dimethyl sulfoxide; DMEM: Dulbecco's Modified Eagle's Medium; FBS: Fetal bovine serum; FITC: Fluorescein isothiocyanate. D-PBS: Dulbecco's phosphate-buffered saline; FACS: Fluorescent activated cell sorter; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; μg: Micrograms; ng: Nanogram; mL: milliliter; SD: Standard Deviation; hEGF: Human epidermal growth factor.
For most of the experiments concerning the main claim of the paper, the code was enough from the ... more For most of the experiments concerning the main claim of the paper, the code was enough from the official repo provided by the authors on Github. However, reproducing some of the figures and the tables involving Gradient Alignment and Catastrophic Forgetting visualization proved to be difficult due to those parts not being published. We were able to contact the authors and received help for those experiments.
Gastrointestinal Endoscopy, 2021
American Journal of Gastroenterology, 2021
Encyclopedia of Smart Materials, 2022
Nucleic Acids Research, 2021
We introduce a new online database of nucleic acid nanostructures for the field of DNA and RNA na... more We introduce a new online database of nucleic acid nanostructures for the field of DNA and RNA nanotechnology. The database implements an upload interface, searching and database browsing. Each deposited nanostructures includes an image of the nanostructure, design file, an optional 3D view, and additional metadata such as experimental data, protocol or literature reference. The database accepts nanostructures in any preferred format used by the uploader for the nanostructure design. We further provide a set of conversion tools that encourage design file conversion into common formats (oxDNA and PDB) that can be used for setting up simulations, interactive editing or 3D visualization. The aim of the repository is to provide to the DNA/RNA nanotechnology community a resource for sharing their designs for further reuse in other systems and also to function as an archive of the designs that have been achieved in the field so far. Nanobase.org is available at https://nanobase.org/.
Journal of Natural Science, Biology and Medicine, 2021
Background: Insulin resistance (IR) is the major underlying mechanism responsible for metabolic s... more Background: Insulin resistance (IR) is the major underlying mechanism responsible for metabolic syndrome and HOMA-IR2 is a validated marker of IR. Fasting lipid profile, including triglyceride (TG) and high-density lipoprotein (HDL) cholesterol routinely feature in the outpatient investigation list. Utility of TG/HDL ratio as a surrogate marker for IR was thus studied in healthy young males. Materials and Methods: This cross-sectional study involved 71 young males aged 18–35 years who came for a routine health check in a fasting state. Height, weight, waist circumference were recorded. Fasting plasma glucose (FPG) and lipid profile reports were collected from the laboratory database. Fasting insulin (FI) was estimated by enzyme-linked immunosorbent assay. Body mass index (kg/m2), TG/HDL, TC/HDL, and HOMA-IR2 were calculated. Results: Mean TG/HDL ratio was 3.73 ± 2.03 and HOMA IR2 was above the standard cut off of ≥2.5 units. Subjects were further divided into two groups based on FPG values. TG, low-density lipoprotein, total cholesterol, TG/HDL, TC/HDL, FI and HOMA-IR2 were found to be higher in the pre-diabetes with impaired fasting glycemic subjects. Overall, a statistically significant positive correlation was seen (P = 0.01, r = 0.284) between TG/HDL and HOMA-IR2. Conclusion: TG/HDL ratio was significantly associated with IR and it could be used as an indicator of IR especially in prediabetic subjects having impaired fasting glucose.
Materials, 2021
This paper presents a lumped element model (LEM) to describe the coupled dynamic properties of th... more This paper presents a lumped element model (LEM) to describe the coupled dynamic properties of thermomagnetic generators (TMGs) based on magnetic shape memory alloy (MSMA) films. The TMG generators make use of the concept of resonant self-actuation of a freely movable cantilever, caused by a large abrupt temperature-dependent change of magnetization and rapid heat transfer inherent to the MSMA films. The LEM is validated for the case of a Ni-Mn-Ga film with Curie temperature TC of 375 K. For a heat source temperature of 443 K, the maximum power generated is 3.1 µW corresponding to a power density with respect to the active material’s volume of 80 mW/cm3. Corresponding LEM simulations allow for a detailed study of the time-resolved temperature change of the MSMA film, the change of magnetic field at the position of the film and of the corresponding film magnetization. Resonant self-actuation is observed at 114 Hz, while rapid temperature changes of about 10 K occur within 1 ms during...
Joule, 2020
Conclusion: Overall, Our findings suggest that catechin hydrate inhibits B(a)P-induced lung tumor... more Conclusion: Overall, Our findings suggest that catechin hydrate inhibits B(a)P-induced lung tumor formation by modulating hyperproliferation, inflammation, apoptosis and ALDH1 expression.