jorge mena - Academia.edu (original) (raw)

Papers by jorge mena

The authors of this impressive volume argue that globalization is making it harder for democracie... more The authors of this impressive volume argue that globalization is making it harder for democracies to operate effectively as nation-states. Instead, countries must find new ways to expand political participation and accountability across borders; democratic order can no longer function ...

Aims: To determine whether the implementation of alcohol control policies was associated with cha... more Aims: To determine whether the implementation of alcohol control policies was associated with changes in the incidence of road traffic deaths. Design: Ecologic study conducted using an interrupted time series analysis. Full restrictive polices banned alcohol between 6 p.m. and 6 a.m. Most restrictive polices prohibited alcohol between 1 a.m. and 10 a.m. Restrictive policies prohibited alcohol between 2 a.m. and 10 a.m. Moderately restrictive policies banned alcohol between 3 a.m. and 10 a.m. Lax policies prohibited alcohol between 4 a.m. and 10 a.m. Setting: We used data of road traffic mortality in the population of Cali, Colombia from 1998 to 2008. Participants: The population of Cali in 2008 was 2,184,753 inhabitants; 47 % were male. Measures: Aggregated daily counts of road traffic deaths. Restrictive policies were compared with lax policies to estimate the effect of reducing hours of alcohol availability using multiple negative binomial regressions. Findings: There was a decrea...

With the current technology, wireless devices have found their place in the life of the average p... more With the current technology, wireless devices have found their place in the life of the average person. These devices are present in almost every aspect of people’s lives to such a degree that they have become indispensable for business. One important capability that the user demands is the ability to transmit data in real-time when these devices have limited re- sources such as short battery life, limited bandwidth, low computational resources and short transmission ranges. When the usage for such devices increases, a large amount of traffic is generated to the point that the user experiences long delays and/or response times that he or she may find uncomfortable or unacceptable; the shared transmission medium becomes over- loaded and congestion results. One solution to the congestion problem is the placement of wireless relays that use distinct portions of the radio spectrum currently unused to divert the traffic to a different direction. We present an on-demand algorithm that att...

2018 IEEE Wireless Communications and Networking Conference (WCNC)

Current mobile devices may reach the Internet via their multiple interfaces, i.e., WiFi and LTE. ... more Current mobile devices may reach the Internet via their multiple interfaces, i.e., WiFi and LTE. MPTCP is an ideal candidate to leverage these interfaces and make the network connectivity more robust. However, priority is given to battery conservation and turning off an energy consuming interface such as LTE while WiFi coverage is available is often the case. Even though MPTCP handles well under such conditions, it is vulnerable to handovers onto poorly performing new paths. In those scenarios, an MPTCP would be better off if the handover would not have occurred. In this paper we propose a proactive measurement of newly discovered paths as MPTCP hands over. Our algorithms leverage CapProbe to estimate the capacity in the new path and qualify its performance. We identify two metrics based on CapProbe partial measurements that declare the viability of a path to continue with the handover or revert back to the backup interface. We study our metrics and algorithm under a small test bed and real situations and show cases of MPTCP connections recovering from failed handovers.

International Journal of Molecular Sciences, 2020

Carotid atherosclerotic plaque rupture can lead to cerebrovascular accident (CVA). By comparing R... more Carotid atherosclerotic plaque rupture can lead to cerebrovascular accident (CVA). By comparing RNA-Seq data from vascular smooth muscle cells (VSMC) extracted from carotid atheroma surgically excised from a group of asymptomatic and symptomatic subjects, we identified more than 700 genomic variants associated with symptomatology (p < 0.05). From these, twelve single nucleotide polymorphisms (SNPs) were selected for further validation. Comparing genotypes of a hospital-based cohort of asymptomatic with symptomatic patients, an exonic SNP in the BIRC6 (BRUCE/Apollon) gene, rs35286811, emerged as significantly associated with CVA symptomatology (p = 0.002; OR = 2.24). Moreover, BIRC6 mRNA levels were significantly higher in symptomatic than asymptomatic subjects upon measurement by qPCR in excised carotid atherosclerotic tissue (p < 0.0001), and significantly higher in carriers of the rs35286811 risk allele (p < 0.0001). rs35286811 is a proxy of a GWAS SNP reported to be asso...

Naval Battlefield Network communications rely on various wireless network technologies for data d... more Naval Battlefield Network communications rely on various wireless network technologies for data delivery between different entities such as ships and shore nodes. A critical problem in current military wireless networks is that a loss of network connectivity due to wireless link outage or entity mobility takes relatively long time to recover. In this paper, we propose an alternative solution by applying Multi-path TCP and SoftwareDefined Networking on military wireless network to maximize the total throughput and minimize the traffic delay and jitter for the communication between ships and shore nodes. According to the Mininet-WiFi emulation experiment results, compared to current single-path TCP communication, our proposed approach provides almost no-cost network handover, more reliable network connectivity and higher end-to-end throughput. In addition, our designed SDN centralized controller is able to balance the traffic flows dynamically to effectively eliminate link congestion ...

This chapter contains sections titled: General Induction motor Synchronous motor Motor locked rot... more This chapter contains sections titled: General Induction motor Synchronous motor Motor locked rotor information (adapted from NEC??????) IEEE Std 45-2002 recommendations for motors Motor controls??????-??????general IEEE Std 45-2002 recommendations for control apparatus Motor starter comparison??????-??????direct on line (DOL), reduced voltage, and soft starter ]]>

Currently the Internet infrastructure is dominated by the transport protocols TCP and UDP. While ... more Currently the Internet infrastructure is dominated by the transport protocols TCP and UDP. While TCP provides strict sequencing and reliable delivery and UDP provides plain fast transmission, there exists applications that occupy the best out of the two worlds, such as telephony signaling. Moreover, since the emergence of the Internet, the industry is seeing converge the two largest networks in the world: the IP Network and the Public Switched Telephony Network, making the need of more suitable protocol more apparent. SCTP is a protocol that has been proposed by the IETF in 2000, and defined initially in the RFC 2960. With this situation in mind and after analyzing the current market conditions, the authors of this paper present an analysis of SCTP as a viable solution to the current situation and provide their own perspective and predictions about the future of SCTP.

International Journal of Mechanical Engineering and Robotics Research, 2020

Through the use of structural topological optimization applied to the redesign of the front suspe... more Through the use of structural topological optimization applied to the redesign of the front suspension components of the Formula SAE FESPE 2012 racing prototype and the implementation of materials such as aluminum Al 6061T6 and Al 7075T6 will improve vehicle maneuverability and stability. Analysis: The front and lateral geometry of the front suspension was redesigned, later on by means of a kinematic analysis to obtain the system's dynamic behavior curves and with the development of components through CAD/CAE software (Autodesk Inventor Professional), and supported by a FEA analysis (ANSYS), the maximum stress values in critical operating conditions of the suspension are obtained. Results: The results indicated a mass reduction of about 20.96% for the entire front suspension system, the use of materials such as Al 6061-T6 aluminum axles with an elastic yield stress Sy=276 MPa and Al 7075-T6 aluminum blocks (Sy=503), for CNC machining have a high mechanical resistance capable of withstanding the maximum stresses generated in the movement of the suspension and through the redesign of the geometry, the correct configuration of the camber and caster angles and the height of the rolling center was determined to obtain the maximum grip of the tyre that will provide reliability to the prototype. New/Improvement: A topological optimization study is carried out to improve the structural shape of the component and thus obtain an adequate reduction in the mass of the component, in order to achieve better results in terms of the safety factor of the dynamic design (fatigue). 

Cells, 2020

The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are ... more The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are yet to be determined. In a single nucleotide polymorphism (SNP) screen of this locus in a Basque population, rs28385692, a rare coding variant substituting Leu for Pro at position 16 emerged significantly (p = 0.02). This variant is located in the signal peptide (SP) shared by the three secreted protein isoforms produced by IL22RA2 (IL-22 binding protein-1(IL-22BPi1), IL-22BPi2 and IL-22BPi3). Genotyping was extended to a Europe-wide case-control dataset and yielded high significance in the full dataset (p = 3.17 × 10−4). Importantly, logistic regression analyses conditioning on the main known MS-associated SNP at this locus, rs17066096, revealed that this association was independent from the primary association signal in the full case-control dataset. In silico analysis predicted both disruption of the alpha helix of the H-region of the SP and decreased hydrophobicity of this region, ul...

PLOS Genetics, 2019

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by... more Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and neuronal dysfunction. Although the majority of patients do not present familial aggregation, Mendelian forms have been described. We performed wholeexome sequencing analysis in 132 patients from 34 multi-incident families, which nominated likely pathogenic variants for MS in 12 genes of the innate immune system that regulate the transcription and activation of inflammatory mediators.

International Journal of Molecular Sciences, 2019

Of the three interleukin-22 binding protein (IL-22BP) isoforms produced by the human IL22RA2 gene... more Of the three interleukin-22 binding protein (IL-22BP) isoforms produced by the human IL22RA2 gene, IL-22BPi2 and IL-22BPi3 are capable of neutralizing IL-22. The longest isoform, IL-22BPi1, does not bind IL-22, is poorly secreted, and its retention within the endoplasmic reticulum (ER) is associated with induction of an unfolded protein response (UPR). Therapeutic modulation of IL-22BPi2 and IL-22BPi3 production may be beneficial in IL-22-dependent disorders. Recently, we identified the ER chaperones GRP94 and cyclophilin B in the interactomes of both IL-22BPi1 and IL-22BPi2. In this study, we investigated whether secretion of the IL-22BP isoforms could be modulated by pharmacological targeting of GRP94 and cyclophilin B, either by means of geldanamycin, that binds to the ADP/ATP pocket shared by HSP90 paralogs, or by cyclosporin A, which causes depletion of ER cyclophilin B levels through secretion. We found that geldanamycin and its analogs did not influence secretion of IL-22BPi2...

1980 International Electron Devices Meeting, 1980

The performance of VDMOS power devices for high frequency linear applications is investigated in ... more The performance of VDMOS power devices for high frequency linear applications is investigated in this paper. In particular a model relating technology and layout parameters is developed to optimize device design. The model is used to predict the performance of an experimental high frequency VDMOST as well as to establish ultimate performance limitations of optimized devices.

Annals of the Entomological Society of America, 1956

In the course of fly collecting on mountain summits in 1952, some of the commonest species taken ... more In the course of fly collecting on mountain summits in 1952, some of the commonest species taken were of the Sarcophaga " sima-idonea group." Fourteen species of this group were recognized in the summit material, of which nine were considered to be undescribed. This revision is based on that material, plus rather limited material from other sources, primarily the U.

ACM SIGMETRICS Performance Evaluation Review, 2017

Highly dynamic vehicular networks use long-range radio technologies such as DSRC, WiMAX, and Cell... more Highly dynamic vehicular networks use long-range radio technologies such as DSRC, WiMAX, and Cellular networks to maintain connectivity. Multipath TCP offers the possibility to combine these radio technologies to improve network performance, allow robust handoffs, and maintain vehicle connectivity at all times. The proliferation of mobile devices with dual interfaces and the manufacturers' interest to make their vehicles smarter and more competitive create the ideal scenario for MPTCP on VANETs. In this paper, we study the performance of MPTCP on two VANET scenarios: Vehicle-to-Infrastructure (V2I), and Vehicle-to-Vehicle, (V2V) under distinct velocities.

Scientific reports, Jan 23, 2017

Mounting evidence suggests that TGFβ/BMP signaling pathway is most likely involved in shell biomi... more Mounting evidence suggests that TGFβ/BMP signaling pathway is most likely involved in shell biomineralization in molluscs, but the function of pathway receptors is poorly studied. Here, we cloned and identified two homologous BMP receptor genes, PfBMPR1B and PfBAMBI, from the pearl oyster Pinctada fucata. Real-time quantitative PCR and in situ hybridization revealed that these genes were expressed in mantle edge and pallial, specifically located at the outer epithelia. Knockdown of PfBMPR1B by RNA interference (RNAi) significantly decreased the expression levels of matrix protein (MP) genes and induced the abnormal ultrastructure of prismatic and nacreous layers. Conversely, knockdown of PfBAMBI significantly increased the expression levels of a portion of MP genes and induced the overgrowth of nacreous layer crystals. In the RNAi and shell notching experiments, MP gene expressions were competitively regulated by PfBMPR1B and PfBAMBI. In addition, the receptor inhibitor LDN193189 re...

MILCOM 2016 - 2016 IEEE Military Communications Conference, 2016

Satellite systems such as Low Earth Orbiting (LEO) networks play an important role in the next ge... more Satellite systems such as Low Earth Orbiting (LEO) networks play an important role in the next generation 5G networks. To facilitate the integration of satellite and terrestrial networks, software-defined networking (SDN) is embraced which brings flexibility, user-customized services and reduces the cost of network configurations. However, it has been long known that communications via LEO satellite network suffer from long delay and frequent ground-satellite handovers, both are problematic for TCP connections. The emergence of Multipath TCP (MPTCP) provides a new solution to these challenges. In this paper, we study the performance of MPTCP over SDN-enabled LEO satellite networks. MPTCP maintains multiple simultaneous subflows in space to increase throughput. In anticipation of handover, MPTCP creates subflows that run in backup mode and shifts traffic smoothly. To support MPTCP, we design an SDN controller that identifies MPTCP subflows attached to the same MPTCP session and splits them to disjoint paths. The SDN architecture centralizes the routing logic, so the system is more scalable and on-board processing is minimized. Simulations are run to evaluate the proposed MPTCP-SDN framework. It is shown that compared to previous solutions, our strategy significantly improves throughput performance and prevents the interruption of transmission during handover.