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Research paper thumbnail of Electrophysiologic studies after Mustard's operation for d-transposition of the great vessels

American Journal of Cardiology, 1978

Electrophysiologic studies were performed in 16 patients after Mustard's operation for d-transpos... more Electrophysiologic studies were performed in 16 patients after Mustard's operation for d-transposition of the great vessels. Standard 12 lead electrocardiograms showed the following rhythms: "sinus" (10 patients), junctional (4 patients), atrial flutter (1 patient) and alternating sinus and junctlonal(1 patient). Overdrive atrial stimulation was used to determine sinus nodal recovery time in the 16 patients. Atrial and atrioventricular (A-V) nodal effective refractory periods were determined in 12 patients utilizing the atrial extrastimulus technique. Twenty-four hour Holter electrocardiographic monitoring was performed in 15 patients. Ten (63 percent) of the 16 patients had abnormal sinus nodal recovery time. The atria1 effective refractory period was prolonged in 4 (33 percent) of the 12 patients in whom it was measured. All 12 patients had a normal A-V nodal effective refractory period. Prevtousty undetected arrhythmias were found in all patients when the 24 hour Holter electrocardiogram was compared with the standard electrocardiogram. Atropine shortened the sinus nodal recovery time, atrial effective refractory period and A-V nodal effective refractory period in all patients studied. One patient, whose junctional pacemaker was first to recover after termination of atrial pacing, had conversion to sinus rhythm and normal sinus nodal recovery time after administration of atropine.

Research paper thumbnail of Prevalence of selected viral infections among blood donors deferred for potential risk to blood safety

Transfusion, 2006

BACKGROUND: Health history questions identify blood donors believed to pose a higher risk of tran... more BACKGROUND: Health history questions identify blood donors believed to pose a higher risk of transmission of infectious diseases. This study assesses the current impact of some of these questions on blood safety as reflected by infectious disease markers.STUDY DESIGN AND METHODS: Donors who were deferred from donating blood due to health history question(s) were recruited at four different regions of the American Red Cross Blood Services. A blood sample was tested for serologic markers of blood-borne infections as performed for accepted blood donors.RESULTS: Of 497 deferred donors enrolled, 29 donors were deferred for having had “yellow jaundice, liver disease, or hepatitis since the age of 11” (Question 3), 1 of whom had hepatitis C virus antibodies (anti-HCV) and hepatitis B core antigen antibodies (anti-HBc), 2 had anti-HBc, and 1 had anti-HCV (p < 0.05 for both markers). Among 37 donors deferred for having “ever tested positive for hepatitis” (Question 4), 1 had hepatitis B surface antigen and anti-HBc and 3 had anti-HBc (p < 0.05 for both markers). Of 14 donors deferred for “having ever used a needle, even once, to take any illegal or nonprescription drug” (Question 12), 1 had anti-HCV, human T-lymphotropic virus-I antibodies and anti-HBc, 1 had anti-HCV and anti-HBc, and 2 had anti-HCV (p < 0.05 for all three markers).CONCLUSIONS: Blood donors deferred for standard blood donor questions regarding risk of viral hepatitis as well as those with a history of intravenous drug use were more likely to have higher hepatitis marker rates than those who were not deferred. No significant findings were identified for other markers or questions.

Research paper thumbnail of Marginal recruitment impact of potential alterations to FDA deferral criteria for men who have sex with men

Transfusion, 2006

We read with interest the article by Sanchez and colleagues 1 reporting the prevalence of male-to... more We read with interest the article by Sanchez and colleagues 1 reporting the prevalence of male-to-male sexual experience (MSM) in blood donors that went unreported at the time of donation. Using an anonymous, postdonation survey of accepted blood donors, the authors estimated that the donors with unreported MSM within a 5-year period before donating, but not earlier, had a higher prevalence of infectious disease screening markers than did male donors with no history of MSM.

Research paper thumbnail of ESTUDIANTE DOCENTE ES GUIADO POR EL PRESENTADAS POR EL

Research paper thumbnail of Electrophysiologic studies after Mustard's operation for d-transposition of the great vessels

American Journal of Cardiology, 1978

Electrophysiologic studies were performed in 16 patients after Mustard's operation for d-transpos... more Electrophysiologic studies were performed in 16 patients after Mustard's operation for d-transposition of the great vessels. Standard 12 lead electrocardiograms showed the following rhythms: "sinus" (10 patients), junctional (4 patients), atrial flutter (1 patient) and alternating sinus and junctlonal(1 patient). Overdrive atrial stimulation was used to determine sinus nodal recovery time in the 16 patients. Atrial and atrioventricular (A-V) nodal effective refractory periods were determined in 12 patients utilizing the atrial extrastimulus technique. Twenty-four hour Holter electrocardiographic monitoring was performed in 15 patients. Ten (63 percent) of the 16 patients had abnormal sinus nodal recovery time. The atria1 effective refractory period was prolonged in 4 (33 percent) of the 12 patients in whom it was measured. All 12 patients had a normal A-V nodal effective refractory period. Prevtousty undetected arrhythmias were found in all patients when the 24 hour Holter electrocardiogram was compared with the standard electrocardiogram. Atropine shortened the sinus nodal recovery time, atrial effective refractory period and A-V nodal effective refractory period in all patients studied. One patient, whose junctional pacemaker was first to recover after termination of atrial pacing, had conversion to sinus rhythm and normal sinus nodal recovery time after administration of atropine.

Research paper thumbnail of Prevalence of selected viral infections among blood donors deferred for potential risk to blood safety

Transfusion, 2006

BACKGROUND: Health history questions identify blood donors believed to pose a higher risk of tran... more BACKGROUND: Health history questions identify blood donors believed to pose a higher risk of transmission of infectious diseases. This study assesses the current impact of some of these questions on blood safety as reflected by infectious disease markers.STUDY DESIGN AND METHODS: Donors who were deferred from donating blood due to health history question(s) were recruited at four different regions of the American Red Cross Blood Services. A blood sample was tested for serologic markers of blood-borne infections as performed for accepted blood donors.RESULTS: Of 497 deferred donors enrolled, 29 donors were deferred for having had “yellow jaundice, liver disease, or hepatitis since the age of 11” (Question 3), 1 of whom had hepatitis C virus antibodies (anti-HCV) and hepatitis B core antigen antibodies (anti-HBc), 2 had anti-HBc, and 1 had anti-HCV (p < 0.05 for both markers). Among 37 donors deferred for having “ever tested positive for hepatitis” (Question 4), 1 had hepatitis B surface antigen and anti-HBc and 3 had anti-HBc (p < 0.05 for both markers). Of 14 donors deferred for “having ever used a needle, even once, to take any illegal or nonprescription drug” (Question 12), 1 had anti-HCV, human T-lymphotropic virus-I antibodies and anti-HBc, 1 had anti-HCV and anti-HBc, and 2 had anti-HCV (p < 0.05 for all three markers).CONCLUSIONS: Blood donors deferred for standard blood donor questions regarding risk of viral hepatitis as well as those with a history of intravenous drug use were more likely to have higher hepatitis marker rates than those who were not deferred. No significant findings were identified for other markers or questions.

Research paper thumbnail of Marginal recruitment impact of potential alterations to FDA deferral criteria for men who have sex with men

Transfusion, 2006

We read with interest the article by Sanchez and colleagues 1 reporting the prevalence of male-to... more We read with interest the article by Sanchez and colleagues 1 reporting the prevalence of male-to-male sexual experience (MSM) in blood donors that went unreported at the time of donation. Using an anonymous, postdonation survey of accepted blood donors, the authors estimated that the donors with unreported MSM within a 5-year period before donating, but not earlier, had a higher prevalence of infectious disease screening markers than did male donors with no history of MSM.

Research paper thumbnail of ESTUDIANTE DOCENTE ES GUIADO POR EL PRESENTADAS POR EL

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