juan rodriguez - Academia.edu (original) (raw)
Papers by juan rodriguez
Journal of microencapsulation, Jan 24, 2015
Mercury is one of the most toxic pollutants, with high capacity of accumulation in living organis... more Mercury is one of the most toxic pollutants, with high capacity of accumulation in living organism, causing important human health problems. Therefore, the mercury removal from water is an important research goal. In a previous work, an extractant agent [di(2-ethylhexyl)phosphoric acid] was microencapsulated in poly(styrene-co-divinylbenzene) by means of suspension polymerisation using toluene as diluent. In this study, this recipe has been modified changing the toluene by heptane and extended to four additional extractants (trioctylamine, trioctylmethylammonium chloride [TOMAC], tributyl phosphate and trioctylphosphine oxide). The polluting potential of the waste liquid from the process was measured by total organic carbon and chemical oxygen demand analyses. The morphology, particle size and distribution were studied by scanning electron microscopy and low angle laser light scattering. The amount of extractant agent into the microcapsules and the microencapsulation efficiency were...
Environmental technology, Jan 5, 2015
Several methods for evaluating the toxicity and biodegradability of hazardous pollutants (chlorin... more Several methods for evaluating the toxicity and biodegradability of hazardous pollutants (chlorinated compounds, chemical additives and pharmaceuticals) have been studied in this work. Different bioassays using representative bacteria of marine and terrestrial ecosystems such as Vibrio fischeri and Pseudomonas putida have been used to assess the ecotoxicity. Activated sludge was used to analyze the effect of those pollutants in a biological reactor of a sewage treatment plant (STP). The results demonstrate that none of the compounds is toxic to activated sludge and only ofloxacin to P. putida. The additives tested can be considered moderately toxic according to the more sensitive V. fischeri assays, whereas the EC50 values of the pharmaceuticals depend on the specific microorganism used in each test. Regarding the biodegradability, respirometric measurements were carried out for fast biodegradability assessment and the Zahn-Wellens test for inherent biodegradability. The evolution o...
The present work reports the results of the first evaluation of monitored data from selected sola... more The present work reports the results of the first evaluation of monitored data from selected solar heating and cooling systems by means of the unified monitoring procedure developed under the IEA Task 38. At the beginning the main aspects of the procedure is explained. Afterwards results of the evaluation of monitoring data of 5 systems including absorption, adsorption and DEC
The judgment of the Court of First Instance of July 11, 2007 awarding damages to Schneider Electr... more The judgment of the Court of First Instance of July 11, 2007 awarding damages to Schneider Electric is unlikely to lead to a flood of merger-related damages litigation against the European Commission.
Computer Aided Chemical Engineering, 2002
Proceedings (Baylor University. Medical Center), 2015
British journal of cancer, Jan 2, 2010
Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer rese... more Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development. An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs 1, 2, 7, 9, 11, 13, 14, and their tissue inhibitors, TIMPs 1, 2 and 3. More than 2600 determinations on cancer specimens from 133 patients with clinically localised prostate carcinoma, 20 patients with prostatic intraepithelial neoplasia and 50 patients with benign prostate hyperplasia and controls, were performed. When compared with benign pathologies, prostate carcinomas had higher expression of all MMPs and TIMPs. Dendogram shows a first-order division of tumours into two distinct MMPs/TIMPs molecular profiles, one of them with high MMPs/TIMs expression profile (n=70; 52.6%). Tumours with high expression of MMP-11 or -13, or c...
In the present work 4 different energy supply systems are compared. Two solar thermal assisted sy... more In the present work 4 different energy supply systems are compared. Two solar thermal assisted systems, one conventional system and a photovoltaic assisted system have been considered. The energy load curves and the available roof area of a large scale office building located in northern Italy have been taken as a starting point. The energy system has to supply electrical
This paper presents the results of the monitoring activities carried out at EURAC Research, a bui... more This paper presents the results of the monitoring activities carried out at EURAC Research, a building office which is energy supplied by a CHCP system including a large solar thermal installation, an absorption chiller and an AHU. Monitored values have resulted well different from the design values. The control strategy has emerged to play a crucial rule on the performance
Journal of clinical microbiology, 1999
The presence of a 500-bp fragment which amplifies a region from the genome of Mycobacterium bovis... more The presence of a 500-bp fragment which amplifies a region from the genome of Mycobacterium bovis (J. G. Rodriguez, G. A. Meija, P. Del Portillo, M. E. Patarroyo, and L. A. Murillo, Microbiology 141:2131-2138, 1995) was evaluated by carrying out PCR on 121 M. bovis isolates. The M. bovis strains, previously characterized by culture and biochemical tests, were isolated from cattle in different regions of Argentina, Mexico, and Colombia. Four additional strains isolated from sea lions that belong to the M. tuberculosis complex were also included in the study. All of the isolates tested were PCR positive, rendering the expected 500-bp band and giving a correlation of 100% with previous microbiological characterization. Southern blot analysis revealed a common band of 1, 800 bp and a polymorphic high-molecular-mass hybridization pattern. The results show that this assay may be useful for diagnosis and identification of M. bovis in cattle.
The Journal of nutrition, 1982
An experiment was conducted in the highlands (Altiplano) of Bolivia to establish the specific min... more An experiment was conducted in the highlands (Altiplano) of Bolivia to establish the specific mineral status for growing llamas compared to sheep grazing unfertilized, native pastures. Animal tissues (plasma, liver and bone), forage and soil samples were collected during the wet and dry seasons and analyzed for mineral contents. During the wet season, forages were higher (P less than 0.05) in Ca, K, Fe and protein. Percent borderline to deficient forage concentrations during the wet and dry seasons, respectively, were found as follows: protein (less than 7.0%) 20 and 53; CCa (less than 0.30%) 10 and 40; Cu (less than 5 ppm) 20 and 47; K (less than 0.5%) 10 and 20; Mg (less than 0.08%) 10 and 20; Na (less than 0.1%) 30 and 69; P (less than 0.25%) 100 and 100; Zn (less than 30 ppm) 60 and 80; and Se (less than 0.1 ppm) 90 and 93% of the total forages, respectively. Concentrations of liver Mg, Co, Mn, Mo, Se and Zn, plasma Mg and Cu and rib (percent ash) Ca, Mg and P were all higher (P...
Organic Process Research & Development, 1999
The aim of this study was to develop a crystallization process for the removal of the alkaline ca... more The aim of this study was to develop a crystallization process for the removal of the alkaline catalyst (potassium hydroxide) from crude polyether-polyols. The process involves a first step of neutralization with an aqueous solution of phosphoric acid and subsequently the removal of water to reach supersaturation and crystal growth. Finally, the crystals formed are removed by filtration. Different amounts of phosphoric acid and water were investigated in order to establish a suitable recipe for this process. Different depressurization vs time profiles for the water evaporation were used to produce an uniform and narrow crystal size distribution with a large mean crystal size in this kind of experimental device.
Current opinion in genetics & development, 2014
The application of the principles of evolutionary biology into medicine was suggested long ago an... more The application of the principles of evolutionary biology into medicine was suggested long ago and is already providing insight into the ultimate causes of disease. However, a full systematic integration of medical genomics and evolutionary medicine is still missing. Here, we briefly review some cases where the combination of the two fields has proven profitable and highlight two of the main issues hindering the development of evolutionary genomic medicine as a mature field, namely the dissociation between fitness and health and the still considerable difficulties in predicting phenotypes from genotypes. We use publicly available data to illustrate both problems and conclude that new approaches are needed for evolutionary genomic medicine to overcome these obstacles.
This experimental study focused on fuel droplet combustion characteristics for various liquids du... more This experimental study focused on fuel droplet combustion characteristics for various liquids during exposure to external acoustical perturbations. Emphasis in the present study was placed on the combustion of a number of alternative liquid fuels, including ethanol, methanol, aviation fuels, and blends of aviation fuel and liquid synthetic fuel derived from coal gasification via the Fischer-Tropsch process. The study examined
Industrial & Engineering Chemistry Research, 2008
This work reports a study of the the use of supercritical fluid technology coupled with pretreatm... more This work reports a study of the the use of supercritical fluid technology coupled with pretreatment processes for the valorization of brewer's spent grain (BSG), a beer production residue, to design a global management process producing valuable extracts and raffinate stabilization. The SC-CO 2 extraction of BSG was performed at temperatures of 313, 333, and 353 K and at pressures from 10 to 35 MPa using raw and milled BSG. Optimal extraction conditions were selected considering the criterion of maximum yield: 313 K temperature, 35 MPa pressure, and milled BSG. Equilibrium and mass-transfer parameters were determined for use in the development of scale-up procedures. A preliminary economic study was performed to determine that the proposed process is economically feasible.
Revista Española de Medicina Nuclear, 2003
Resumen.-Objetivo: Cuantificar el contenido del receptor del factor de crecimiento epidérmico (EG... more Resumen.-Objetivo: Cuantificar el contenido del receptor del factor de crecimiento epidérmico (EGFR) mediante técnica de radioligando en el cáncer de mama, y analizar su relación con las características de las pacientes y de sus tumores así como su significado pronóstico.
In Galicia can be found around 280 quarries and open pits excavated in rock, most of them are orn... more In Galicia can be found around 280 quarries and open pits excavated in rock, most of them are ornamental rock and construction aggregates exploitations. 6100 people work in these mines and 35% are exposed to rock fall accidents; this percentage increases up 80% for the case of aggregates quarries. This phenomenon is now in the work safety statistics. The present
Genetics in Medicine, 2014
Journal of microencapsulation, Jan 24, 2015
Mercury is one of the most toxic pollutants, with high capacity of accumulation in living organis... more Mercury is one of the most toxic pollutants, with high capacity of accumulation in living organism, causing important human health problems. Therefore, the mercury removal from water is an important research goal. In a previous work, an extractant agent [di(2-ethylhexyl)phosphoric acid] was microencapsulated in poly(styrene-co-divinylbenzene) by means of suspension polymerisation using toluene as diluent. In this study, this recipe has been modified changing the toluene by heptane and extended to four additional extractants (trioctylamine, trioctylmethylammonium chloride [TOMAC], tributyl phosphate and trioctylphosphine oxide). The polluting potential of the waste liquid from the process was measured by total organic carbon and chemical oxygen demand analyses. The morphology, particle size and distribution were studied by scanning electron microscopy and low angle laser light scattering. The amount of extractant agent into the microcapsules and the microencapsulation efficiency were...
Environmental technology, Jan 5, 2015
Several methods for evaluating the toxicity and biodegradability of hazardous pollutants (chlorin... more Several methods for evaluating the toxicity and biodegradability of hazardous pollutants (chlorinated compounds, chemical additives and pharmaceuticals) have been studied in this work. Different bioassays using representative bacteria of marine and terrestrial ecosystems such as Vibrio fischeri and Pseudomonas putida have been used to assess the ecotoxicity. Activated sludge was used to analyze the effect of those pollutants in a biological reactor of a sewage treatment plant (STP). The results demonstrate that none of the compounds is toxic to activated sludge and only ofloxacin to P. putida. The additives tested can be considered moderately toxic according to the more sensitive V. fischeri assays, whereas the EC50 values of the pharmaceuticals depend on the specific microorganism used in each test. Regarding the biodegradability, respirometric measurements were carried out for fast biodegradability assessment and the Zahn-Wellens test for inherent biodegradability. The evolution o...
The present work reports the results of the first evaluation of monitored data from selected sola... more The present work reports the results of the first evaluation of monitored data from selected solar heating and cooling systems by means of the unified monitoring procedure developed under the IEA Task 38. At the beginning the main aspects of the procedure is explained. Afterwards results of the evaluation of monitoring data of 5 systems including absorption, adsorption and DEC
The judgment of the Court of First Instance of July 11, 2007 awarding damages to Schneider Electr... more The judgment of the Court of First Instance of July 11, 2007 awarding damages to Schneider Electric is unlikely to lead to a flood of merger-related damages litigation against the European Commission.
Computer Aided Chemical Engineering, 2002
Proceedings (Baylor University. Medical Center), 2015
British journal of cancer, Jan 2, 2010
Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer rese... more Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development. An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs 1, 2, 7, 9, 11, 13, 14, and their tissue inhibitors, TIMPs 1, 2 and 3. More than 2600 determinations on cancer specimens from 133 patients with clinically localised prostate carcinoma, 20 patients with prostatic intraepithelial neoplasia and 50 patients with benign prostate hyperplasia and controls, were performed. When compared with benign pathologies, prostate carcinomas had higher expression of all MMPs and TIMPs. Dendogram shows a first-order division of tumours into two distinct MMPs/TIMPs molecular profiles, one of them with high MMPs/TIMs expression profile (n=70; 52.6%). Tumours with high expression of MMP-11 or -13, or c...
In the present work 4 different energy supply systems are compared. Two solar thermal assisted sy... more In the present work 4 different energy supply systems are compared. Two solar thermal assisted systems, one conventional system and a photovoltaic assisted system have been considered. The energy load curves and the available roof area of a large scale office building located in northern Italy have been taken as a starting point. The energy system has to supply electrical
This paper presents the results of the monitoring activities carried out at EURAC Research, a bui... more This paper presents the results of the monitoring activities carried out at EURAC Research, a building office which is energy supplied by a CHCP system including a large solar thermal installation, an absorption chiller and an AHU. Monitored values have resulted well different from the design values. The control strategy has emerged to play a crucial rule on the performance
Journal of clinical microbiology, 1999
The presence of a 500-bp fragment which amplifies a region from the genome of Mycobacterium bovis... more The presence of a 500-bp fragment which amplifies a region from the genome of Mycobacterium bovis (J. G. Rodriguez, G. A. Meija, P. Del Portillo, M. E. Patarroyo, and L. A. Murillo, Microbiology 141:2131-2138, 1995) was evaluated by carrying out PCR on 121 M. bovis isolates. The M. bovis strains, previously characterized by culture and biochemical tests, were isolated from cattle in different regions of Argentina, Mexico, and Colombia. Four additional strains isolated from sea lions that belong to the M. tuberculosis complex were also included in the study. All of the isolates tested were PCR positive, rendering the expected 500-bp band and giving a correlation of 100% with previous microbiological characterization. Southern blot analysis revealed a common band of 1, 800 bp and a polymorphic high-molecular-mass hybridization pattern. The results show that this assay may be useful for diagnosis and identification of M. bovis in cattle.
The Journal of nutrition, 1982
An experiment was conducted in the highlands (Altiplano) of Bolivia to establish the specific min... more An experiment was conducted in the highlands (Altiplano) of Bolivia to establish the specific mineral status for growing llamas compared to sheep grazing unfertilized, native pastures. Animal tissues (plasma, liver and bone), forage and soil samples were collected during the wet and dry seasons and analyzed for mineral contents. During the wet season, forages were higher (P less than 0.05) in Ca, K, Fe and protein. Percent borderline to deficient forage concentrations during the wet and dry seasons, respectively, were found as follows: protein (less than 7.0%) 20 and 53; CCa (less than 0.30%) 10 and 40; Cu (less than 5 ppm) 20 and 47; K (less than 0.5%) 10 and 20; Mg (less than 0.08%) 10 and 20; Na (less than 0.1%) 30 and 69; P (less than 0.25%) 100 and 100; Zn (less than 30 ppm) 60 and 80; and Se (less than 0.1 ppm) 90 and 93% of the total forages, respectively. Concentrations of liver Mg, Co, Mn, Mo, Se and Zn, plasma Mg and Cu and rib (percent ash) Ca, Mg and P were all higher (P...
Organic Process Research & Development, 1999
The aim of this study was to develop a crystallization process for the removal of the alkaline ca... more The aim of this study was to develop a crystallization process for the removal of the alkaline catalyst (potassium hydroxide) from crude polyether-polyols. The process involves a first step of neutralization with an aqueous solution of phosphoric acid and subsequently the removal of water to reach supersaturation and crystal growth. Finally, the crystals formed are removed by filtration. Different amounts of phosphoric acid and water were investigated in order to establish a suitable recipe for this process. Different depressurization vs time profiles for the water evaporation were used to produce an uniform and narrow crystal size distribution with a large mean crystal size in this kind of experimental device.
Current opinion in genetics & development, 2014
The application of the principles of evolutionary biology into medicine was suggested long ago an... more The application of the principles of evolutionary biology into medicine was suggested long ago and is already providing insight into the ultimate causes of disease. However, a full systematic integration of medical genomics and evolutionary medicine is still missing. Here, we briefly review some cases where the combination of the two fields has proven profitable and highlight two of the main issues hindering the development of evolutionary genomic medicine as a mature field, namely the dissociation between fitness and health and the still considerable difficulties in predicting phenotypes from genotypes. We use publicly available data to illustrate both problems and conclude that new approaches are needed for evolutionary genomic medicine to overcome these obstacles.
This experimental study focused on fuel droplet combustion characteristics for various liquids du... more This experimental study focused on fuel droplet combustion characteristics for various liquids during exposure to external acoustical perturbations. Emphasis in the present study was placed on the combustion of a number of alternative liquid fuels, including ethanol, methanol, aviation fuels, and blends of aviation fuel and liquid synthetic fuel derived from coal gasification via the Fischer-Tropsch process. The study examined
Industrial & Engineering Chemistry Research, 2008
This work reports a study of the the use of supercritical fluid technology coupled with pretreatm... more This work reports a study of the the use of supercritical fluid technology coupled with pretreatment processes for the valorization of brewer's spent grain (BSG), a beer production residue, to design a global management process producing valuable extracts and raffinate stabilization. The SC-CO 2 extraction of BSG was performed at temperatures of 313, 333, and 353 K and at pressures from 10 to 35 MPa using raw and milled BSG. Optimal extraction conditions were selected considering the criterion of maximum yield: 313 K temperature, 35 MPa pressure, and milled BSG. Equilibrium and mass-transfer parameters were determined for use in the development of scale-up procedures. A preliminary economic study was performed to determine that the proposed process is economically feasible.
Revista Española de Medicina Nuclear, 2003
Resumen.-Objetivo: Cuantificar el contenido del receptor del factor de crecimiento epidérmico (EG... more Resumen.-Objetivo: Cuantificar el contenido del receptor del factor de crecimiento epidérmico (EGFR) mediante técnica de radioligando en el cáncer de mama, y analizar su relación con las características de las pacientes y de sus tumores así como su significado pronóstico.
In Galicia can be found around 280 quarries and open pits excavated in rock, most of them are orn... more In Galicia can be found around 280 quarries and open pits excavated in rock, most of them are ornamental rock and construction aggregates exploitations. 6100 people work in these mines and 35% are exposed to rock fall accidents; this percentage increases up 80% for the case of aggregates quarries. This phenomenon is now in the work safety statistics. The present
Genetics in Medicine, 2014