juhi sharma - Academia.edu (original) (raw)

Papers by juhi sharma

Canadian Journal of Infectious Diseases and Medical Microbiology

Colistin resistance is a globalized sensible issue because it has been considered a drug of the l... more Colistin resistance is a globalized sensible issue because it has been considered a drug of the last-line resort to treat drug-resistant bacterial infections. The product of the mobilized colistin resistance (mcr) gene and its variants are the significant causes of colistin resistance, which is emerging due to the frequent colistin use in veterinary, and these genes circulate among the bacterial community. Apart from mcr genes, some other intrinsic genes and proteins are also involved in colistin resistance. Researchers focus on the most advanced genomics (whole genome sequencing), proteomics, and bioinformatics approaches to explore the question of colistin resistance. To combat colistin resistance, researchers developed various strategies such as the development of newer drugs, the repurposing of existing drugs, combinatorial treatment by colistin with other drugs, a nano-based approach, photodynamic therapy, a CRISPRi-based strategy, and a phage-based strategy. In this timeline r...

Research and Reports in Tropical Medicine

As the infectivity of the SARS-CoV-2 virus is higher compared with other coronaviruses reported s... more As the infectivity of the SARS-CoV-2 virus is higher compared with other coronaviruses reported so far, so effective therapeutics and vaccines are the best way to control the proliferation of this infection The COVID-19 mortality rate is lower compared with other similar viral diseases such as severe acute respiratory Ssndrome (SARS) and Middle East respiratory syndrome (MERS). However, due to the evolution of SARS-CoV-2 mutants that are responsible for the subsequent waves, mortality due to COVID-19 has increased across the globe. Currently, the magnitude of SARS-CoV-2 infection is highly severe and is leading to a tremendously increased number of deaths globally. Scientists expect that SARS-CoV-2 has the potential to become a seasonal disease like influenza and may persist with humanity in the future. Currently, preventive strategies such as sanitation, social distancing, use of masks, potential chemotherapies (pathogen-centric and host-centric), and vaccines are the only option to fight against COVID-19. Many groups of Indian government-public private consortia had set up different strategies (development of multiple vaccines) for combat of this unique threat through stepssuch as an increase in vaccinations and sample testing per day. In this focused review, we have discussed the challenges faced and success stories employed to manage COVID-19.

International Journal of Current Pharmaceutical Research, 2021

State of symbiosis is created among the species that are found in naturally existing biofilms. Bi... more State of symbiosis is created among the species that are found in naturally existing biofilms. Biofilm formation provides protection against toxic shocks, mechanical stress, and predation. Biofilm can play an important role in wastewater treatment technologies and on the other hand could also lead to plague water. Biofilm-based treatments have been traditionally used for the treatment of water but the recent development in the stream has boosted the use of biofilm in various strategies of waste water treatment especially for strategies related to BOD and nutrients. However, the blueprint and execution of this idea is still being worked on due to the problems which arise in the implementation such as corroding pipes, increasing head loss, allowing pathogens to persist in distribution systems, and fouling membrane processes. Design for choice of species for biofilm processes in particular techniques is important wastewater treatment. All these data are essential to develop the perform...

Nanotechnology for Agriculture: Crop Production & Protection

To augment the nutritional values and yields for which agricultural sector come across various pr... more To augment the nutritional values and yields for which agricultural sector come across various problem, solution to this can be provided by narrative and enhanced strategies unrehearsed by nanotechnology. To recover the safety of agricultural products as well as diminish the pollution, new Nano technological techniques with controlled delivery of pesticides, herbicides and fertilizers could be functional. Important aspects in novel agriculture include development of nanodevices such as smart delivery systems to target specific sites and also nanocarriers for chemical controlled release. Agricultural production can be revolutionized using nanotechnology involving on-farm applications to deliver drugs or pesticides to livestock or crops and smart-sensing devices for agriculture-environment interactions. This study emphasizes upon bionanotechnology awareness in agriculture which is an emergent field having enormous prospective.

Indian journal of experimental biology, 2014

The present study describes a novel and simple vaccination strategy that involve culturing of M. ... more The present study describes a novel and simple vaccination strategy that involve culturing of M. tuberculosis in the macrophage cells. Isolation of phagosome from macrophage (cell line J774) infected with M. tuberculosis (H37) and M. bovis (BCG) at early and late phase of infection was done ensuing the identification and characterization of these phagosome. In vitro study of apoptosis induced by phagosome infected with (H37) and (BCG) was performed. The vaccine candidate with H1137 MOI- 1:10 at 3 h, MOI- 1:20 at 1, 1.5, 2.5 and 3 h and BCG MOI- 1:20 at 3.5 h showed percentage apoptosis as 38.64, 39.93, 34.66, 22.56,34.59 and 37.81% respectively. The results designates that macrophages provide cellular niche during infection and illustrate considerable immunogenic property. Novel antigens expressed or secreted by H37 in infected macrophages can provide evidence to be a successful vaccine candidate as it endures enhanced immune response than BCG.

Microbial Rejuvenation of Polluted Environment

The Lactic Acid Bacteria (LAB) has extensivelybeen used in food industry for the production of va... more The Lactic Acid Bacteria (LAB) has extensivelybeen used in food industry for the production of varied fermented products such as yoghurt, cheese etc. These are also been used as probioticsfor animal as well as human welfare in terms of health and well being. also The present review focuses on available literature, current market status and on the characteristics of Lactic Acid Bacteria with a special emphasis on the probiotic properties of the genus Lactobacillus.The industrial scale development of Lactobacillus as commercial products has benefited the market in several facets.

Microbial Rejuvenation of Polluted Environment

Contemporary scientific progress in applying biotechnological tools for environmental management ... more Contemporary scientific progress in applying biotechnological tools for environmental management is the emerging field of bioremediation (assisted with microbes) to mitigate the hazardous effluents from the world. The detrimental marvels have resulted in serious environmental and social problems around the world; these problems must be looked after for solutions elsewhere than the

The different microorganisms such as bacteria, fungus has ability to treat water contaminated wit... more The different microorganisms such as bacteria, fungus has ability to treat water contaminated with heavy metal. The study carried out for heavy metal, removed by bacteria isolated from infected area to treat contaminated water collected from effluent of industries. Characterization of isolated bacteria showed resistance to heavy metal. The total 73 bacterial isolate were screened, using LB agar. Three resistant bacteria were selected using different agar media containing different concentration of Ar, Cu, and Zn. These bacteria showed optimum growth when incubated for 24 hour at 30 c̊. The isolates were further examined using different heavy metal concentration.The selected organisms which show higher resistance to metal was identified as Bacillus, Staphylococcus and Klebsiella .antibiotic resistance of heavy metal tolerance was analyzed in detail showing resistance against Ampicillin and ciprofloxacin and minimum inhibitory concentration at 100μg/ml and 120μg/ml for Klebsiella and ...

Microbial Proteomics: Development in Technologies and Applications

Nanotechnology for Agriculture: Crop Production & Protection, 2019

To augment the nutritional values and yields for which agricultural sector come across various pr... more To augment the nutritional values and yields for which agricultural sector come across various problem, solution to this can be provided by narrative and enhanced strategies unrehearsed by nanotechnology. To recover the safety of agricultural products as well as diminish the pollution, new Nano technological techniques with controlled delivery of pesticides, herbicides and fertilizers could be functional. Important aspects in novel agriculture include development of nanodevices such as smart delivery systems to target specific sites and also nanocarriers for chemical controlled release. Agricultural production can be revolutionized using nanotechnology involving on-farm applications to deliver drugs or pesticides to livestock or crops and smart-sensing devices for agriculture-environment interactions. This study emphasizes upon bionanotechnology awareness in agriculture which is an emergent field having enormous prospective.

Contemporary scientific progress in applying biotechnological tools for environmental management ... more Contemporary scientific progress in applying biotechnological tools for environmental management is the emerging field of bioremediation (assisted with microbes) to mitigate the hazardous effluents from the world. The detrimental marvels have resulted in serious environmental and social problems around the world; these problems must be looked after for solutions elsewhere than the

The nutrients required for good health, longevity, and well-being come from the different complex... more The nutrients required for good health, longevity, and well-being come from the different complex food system. The constant growth of the world population increased the demand for better technologies to enhance the agricultural yields, production of healthier food, and combat with pathogens to reduce the damage. In medical fields, nanotechnology shows promising therapeutic effects as it overcomes the biological barriers and improves the targeting of the diseased tissues, while application of nanotechnology in agricultural fields has received little attention in contrast to the human health system. Phyto-nanotechnology has tremendous potential to alter the plant production by allowing the target-specific delivery of nutrients and biomolecules, and it also allows the controlled release of fertilizers, herbicides, and pesticides to reduce environmental damage. A better understanding of the relationship between plants response and nanoparticles may improve the uptake of agricultural ele...

Coronaviruses

COVID-19 is currently threatening the globe. SARS-CoV-2 is the cause of COVID-19, which spreads v... more COVID-19 is currently threatening the globe. SARS-CoV-2 is the cause of COVID-19, which spreads via droplets/airborne and direct contact. Health care workers (HCWs) are the frontline workers, which are directly involved in taking care of patients affected by COVID-19. HCWs are at a higher risk of infection during the caring of COVID-19 patients. This focused review highlighted the higher risk for COVID-19 infection among health care professionals during close contact with patients and their preventive management in COVID-19 pandemic.

Frontiers in Cardiovascular Medicine

Journal of the Renin-Angiotensin-Aldosterone System

COVID-19 is the newly born pandemic caused by the SARS-CoV-2 virus, which is the recently emerged... more COVID-19 is the newly born pandemic caused by the SARS-CoV-2 virus, which is the recently emerged betacoronavirus that crosses the species barrier. It predominantly infects pneumocytes of the respiratory tract, but due to the presence of angiotensin-converting enzyme II (ACE2) on other cells like surface enterocytes of the upper esophagus and colon, these are also considered as the primary sites of infection. ACE2 receptor served as a cellular entry point for SARS-CoV-2. The expression of the ACE2 receptors is regulated by several factors such as age, tobacco smoking, inflammatory signaling, ACE inhibitors, angiotensin receptor blockers, and comorbidities (chronic obstructive pulmonary disease (COPD), tuberculosis, cerebrovascular disease, coronary heart disease, hypertension, and diabetes). Therefore, scientists are trying to explore the in-depth knowledge of ACE2 and considered it as a potential indirect target for COVID-19 therapeutics. In this focused review, we discussed in det...

Environmental Technology & Innovation

Abstract A novel, neutral and heat-tolerant tyrosinase produced from Pleurotus djamor (P. djamor)... more Abstract A novel, neutral and heat-tolerant tyrosinase produced from Pleurotus djamor (P. djamor) using biomimetic calcium carbonate which was further used for the biodegradation of the phenolic waste of industrial effluents. Carbon-dioxide was sequestered/captured into calcium carbonate (CaCO3) using carbonic anhydrase (2.1 U/mg protein) of Oceanobacillus with sequestration capacity as 24.7 CaCO3/mg protein in 25 s. This CaCO3 was used as a substrate for cultivation of P. djamor (a mushroom) which was the potential source of tyrosinase. Mushroom tyrosinase was purified up to 51.7 folds purity which shown a molecular weight ∼ 90 kDa on SDS-PAGE. The optimal thermal and pH activity of the tyrosinase was observed at 50 °C and 7.0, respectively. The tyrosinase was stable within a pH range of 6.0-8.0, temperature 35 °C-55 °C and showed high substrate specificity for L-DOPA. Tyrosinase activity was drastically enhanced by Cu 2 + , Ca2＋ and Mn 2 + metal ions. K + ions were also found to inhibit the tyrosinase activity up to the moderate level. Mushroom tyrosinase was used to degrade phenol from industry effluents with 90% removal in 6 hrs. Extracellular nature as well as tyrosinase stability in the extreme conditions (temperature, pH, and presence of heavy metals) makes it preferable candidate for phenol bioremediation from industrial effluents.

Environmental and Microbial Biotechnology

Journal of Global Antimicrobial Resistance

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Microbial Pathogenesis

In the last two decades, tuberculosis (TB) have threatened the public across the globe and contin... more In the last two decades, tuberculosis (TB) have threatened the public across the globe and continuing new TB cases and their transmission pooled with the global emergence of drug-resistant strains present an enduring occupational risk for health care workers (HCWs). Since last decade, government and funding agencies has given a significant amount of funds to tackle the problem of TB infection among medical staff or HCW in hospitals of developing countries, but the effects of these efforts have not yet been reported. Working environments are the major risk factors for TB infections among the HCW in hospital settings. Twenty-two high burden countries endorsed to the preponderance of worldwide tuberculosis cases in 2015. Urgent preventive strategies and mediations are needed to ensure the safety and sustained availability of these exquisite healthcare resources. This timeline review will provide the theoretical basis of high TB burden among the HCW which can be used for further improvement in strategies for the prevention of TB infections in hospital settings and provide a reliable basis for improving the personal health of HCW or medical staff.

Canadian Journal of Infectious Diseases and Medical Microbiology

Colistin resistance is a globalized sensible issue because it has been considered a drug of the l... more Colistin resistance is a globalized sensible issue because it has been considered a drug of the last-line resort to treat drug-resistant bacterial infections. The product of the mobilized colistin resistance (mcr) gene and its variants are the significant causes of colistin resistance, which is emerging due to the frequent colistin use in veterinary, and these genes circulate among the bacterial community. Apart from mcr genes, some other intrinsic genes and proteins are also involved in colistin resistance. Researchers focus on the most advanced genomics (whole genome sequencing), proteomics, and bioinformatics approaches to explore the question of colistin resistance. To combat colistin resistance, researchers developed various strategies such as the development of newer drugs, the repurposing of existing drugs, combinatorial treatment by colistin with other drugs, a nano-based approach, photodynamic therapy, a CRISPRi-based strategy, and a phage-based strategy. In this timeline r...

Research and Reports in Tropical Medicine

As the infectivity of the SARS-CoV-2 virus is higher compared with other coronaviruses reported s... more As the infectivity of the SARS-CoV-2 virus is higher compared with other coronaviruses reported so far, so effective therapeutics and vaccines are the best way to control the proliferation of this infection The COVID-19 mortality rate is lower compared with other similar viral diseases such as severe acute respiratory Ssndrome (SARS) and Middle East respiratory syndrome (MERS). However, due to the evolution of SARS-CoV-2 mutants that are responsible for the subsequent waves, mortality due to COVID-19 has increased across the globe. Currently, the magnitude of SARS-CoV-2 infection is highly severe and is leading to a tremendously increased number of deaths globally. Scientists expect that SARS-CoV-2 has the potential to become a seasonal disease like influenza and may persist with humanity in the future. Currently, preventive strategies such as sanitation, social distancing, use of masks, potential chemotherapies (pathogen-centric and host-centric), and vaccines are the only option to fight against COVID-19. Many groups of Indian government-public private consortia had set up different strategies (development of multiple vaccines) for combat of this unique threat through stepssuch as an increase in vaccinations and sample testing per day. In this focused review, we have discussed the challenges faced and success stories employed to manage COVID-19.

International Journal of Current Pharmaceutical Research, 2021

State of symbiosis is created among the species that are found in naturally existing biofilms. Bi... more State of symbiosis is created among the species that are found in naturally existing biofilms. Biofilm formation provides protection against toxic shocks, mechanical stress, and predation. Biofilm can play an important role in wastewater treatment technologies and on the other hand could also lead to plague water. Biofilm-based treatments have been traditionally used for the treatment of water but the recent development in the stream has boosted the use of biofilm in various strategies of waste water treatment especially for strategies related to BOD and nutrients. However, the blueprint and execution of this idea is still being worked on due to the problems which arise in the implementation such as corroding pipes, increasing head loss, allowing pathogens to persist in distribution systems, and fouling membrane processes. Design for choice of species for biofilm processes in particular techniques is important wastewater treatment. All these data are essential to develop the perform...

Nanotechnology for Agriculture: Crop Production & Protection

To augment the nutritional values and yields for which agricultural sector come across various pr... more To augment the nutritional values and yields for which agricultural sector come across various problem, solution to this can be provided by narrative and enhanced strategies unrehearsed by nanotechnology. To recover the safety of agricultural products as well as diminish the pollution, new Nano technological techniques with controlled delivery of pesticides, herbicides and fertilizers could be functional. Important aspects in novel agriculture include development of nanodevices such as smart delivery systems to target specific sites and also nanocarriers for chemical controlled release. Agricultural production can be revolutionized using nanotechnology involving on-farm applications to deliver drugs or pesticides to livestock or crops and smart-sensing devices for agriculture-environment interactions. This study emphasizes upon bionanotechnology awareness in agriculture which is an emergent field having enormous prospective.

Indian journal of experimental biology, 2014

The present study describes a novel and simple vaccination strategy that involve culturing of M. ... more The present study describes a novel and simple vaccination strategy that involve culturing of M. tuberculosis in the macrophage cells. Isolation of phagosome from macrophage (cell line J774) infected with M. tuberculosis (H37) and M. bovis (BCG) at early and late phase of infection was done ensuing the identification and characterization of these phagosome. In vitro study of apoptosis induced by phagosome infected with (H37) and (BCG) was performed. The vaccine candidate with H1137 MOI- 1:10 at 3 h, MOI- 1:20 at 1, 1.5, 2.5 and 3 h and BCG MOI- 1:20 at 3.5 h showed percentage apoptosis as 38.64, 39.93, 34.66, 22.56,34.59 and 37.81% respectively. The results designates that macrophages provide cellular niche during infection and illustrate considerable immunogenic property. Novel antigens expressed or secreted by H37 in infected macrophages can provide evidence to be a successful vaccine candidate as it endures enhanced immune response than BCG.

Microbial Rejuvenation of Polluted Environment

The Lactic Acid Bacteria (LAB) has extensivelybeen used in food industry for the production of va... more The Lactic Acid Bacteria (LAB) has extensivelybeen used in food industry for the production of varied fermented products such as yoghurt, cheese etc. These are also been used as probioticsfor animal as well as human welfare in terms of health and well being. also The present review focuses on available literature, current market status and on the characteristics of Lactic Acid Bacteria with a special emphasis on the probiotic properties of the genus Lactobacillus.The industrial scale development of Lactobacillus as commercial products has benefited the market in several facets.

Microbial Rejuvenation of Polluted Environment

Contemporary scientific progress in applying biotechnological tools for environmental management ... more Contemporary scientific progress in applying biotechnological tools for environmental management is the emerging field of bioremediation (assisted with microbes) to mitigate the hazardous effluents from the world. The detrimental marvels have resulted in serious environmental and social problems around the world; these problems must be looked after for solutions elsewhere than the

The different microorganisms such as bacteria, fungus has ability to treat water contaminated wit... more The different microorganisms such as bacteria, fungus has ability to treat water contaminated with heavy metal. The study carried out for heavy metal, removed by bacteria isolated from infected area to treat contaminated water collected from effluent of industries. Characterization of isolated bacteria showed resistance to heavy metal. The total 73 bacterial isolate were screened, using LB agar. Three resistant bacteria were selected using different agar media containing different concentration of Ar, Cu, and Zn. These bacteria showed optimum growth when incubated for 24 hour at 30 c̊. The isolates were further examined using different heavy metal concentration.The selected organisms which show higher resistance to metal was identified as Bacillus, Staphylococcus and Klebsiella .antibiotic resistance of heavy metal tolerance was analyzed in detail showing resistance against Ampicillin and ciprofloxacin and minimum inhibitory concentration at 100μg/ml and 120μg/ml for Klebsiella and ...

Microbial Proteomics: Development in Technologies and Applications

Nanotechnology for Agriculture: Crop Production & Protection, 2019

To augment the nutritional values and yields for which agricultural sector come across various pr... more To augment the nutritional values and yields for which agricultural sector come across various problem, solution to this can be provided by narrative and enhanced strategies unrehearsed by nanotechnology. To recover the safety of agricultural products as well as diminish the pollution, new Nano technological techniques with controlled delivery of pesticides, herbicides and fertilizers could be functional. Important aspects in novel agriculture include development of nanodevices such as smart delivery systems to target specific sites and also nanocarriers for chemical controlled release. Agricultural production can be revolutionized using nanotechnology involving on-farm applications to deliver drugs or pesticides to livestock or crops and smart-sensing devices for agriculture-environment interactions. This study emphasizes upon bionanotechnology awareness in agriculture which is an emergent field having enormous prospective.

Contemporary scientific progress in applying biotechnological tools for environmental management ... more Contemporary scientific progress in applying biotechnological tools for environmental management is the emerging field of bioremediation (assisted with microbes) to mitigate the hazardous effluents from the world. The detrimental marvels have resulted in serious environmental and social problems around the world; these problems must be looked after for solutions elsewhere than the

The nutrients required for good health, longevity, and well-being come from the different complex... more The nutrients required for good health, longevity, and well-being come from the different complex food system. The constant growth of the world population increased the demand for better technologies to enhance the agricultural yields, production of healthier food, and combat with pathogens to reduce the damage. In medical fields, nanotechnology shows promising therapeutic effects as it overcomes the biological barriers and improves the targeting of the diseased tissues, while application of nanotechnology in agricultural fields has received little attention in contrast to the human health system. Phyto-nanotechnology has tremendous potential to alter the plant production by allowing the target-specific delivery of nutrients and biomolecules, and it also allows the controlled release of fertilizers, herbicides, and pesticides to reduce environmental damage. A better understanding of the relationship between plants response and nanoparticles may improve the uptake of agricultural ele...

Coronaviruses

COVID-19 is currently threatening the globe. SARS-CoV-2 is the cause of COVID-19, which spreads v... more COVID-19 is currently threatening the globe. SARS-CoV-2 is the cause of COVID-19, which spreads via droplets/airborne and direct contact. Health care workers (HCWs) are the frontline workers, which are directly involved in taking care of patients affected by COVID-19. HCWs are at a higher risk of infection during the caring of COVID-19 patients. This focused review highlighted the higher risk for COVID-19 infection among health care professionals during close contact with patients and their preventive management in COVID-19 pandemic.

Frontiers in Cardiovascular Medicine

Journal of the Renin-Angiotensin-Aldosterone System

COVID-19 is the newly born pandemic caused by the SARS-CoV-2 virus, which is the recently emerged... more COVID-19 is the newly born pandemic caused by the SARS-CoV-2 virus, which is the recently emerged betacoronavirus that crosses the species barrier. It predominantly infects pneumocytes of the respiratory tract, but due to the presence of angiotensin-converting enzyme II (ACE2) on other cells like surface enterocytes of the upper esophagus and colon, these are also considered as the primary sites of infection. ACE2 receptor served as a cellular entry point for SARS-CoV-2. The expression of the ACE2 receptors is regulated by several factors such as age, tobacco smoking, inflammatory signaling, ACE inhibitors, angiotensin receptor blockers, and comorbidities (chronic obstructive pulmonary disease (COPD), tuberculosis, cerebrovascular disease, coronary heart disease, hypertension, and diabetes). Therefore, scientists are trying to explore the in-depth knowledge of ACE2 and considered it as a potential indirect target for COVID-19 therapeutics. In this focused review, we discussed in det...

Environmental Technology & Innovation

Abstract A novel, neutral and heat-tolerant tyrosinase produced from Pleurotus djamor (P. djamor)... more Abstract A novel, neutral and heat-tolerant tyrosinase produced from Pleurotus djamor (P. djamor) using biomimetic calcium carbonate which was further used for the biodegradation of the phenolic waste of industrial effluents. Carbon-dioxide was sequestered/captured into calcium carbonate (CaCO3) using carbonic anhydrase (2.1 U/mg protein) of Oceanobacillus with sequestration capacity as 24.7 CaCO3/mg protein in 25 s. This CaCO3 was used as a substrate for cultivation of P. djamor (a mushroom) which was the potential source of tyrosinase. Mushroom tyrosinase was purified up to 51.7 folds purity which shown a molecular weight ∼ 90 kDa on SDS-PAGE. The optimal thermal and pH activity of the tyrosinase was observed at 50 °C and 7.0, respectively. The tyrosinase was stable within a pH range of 6.0-8.0, temperature 35 °C-55 °C and showed high substrate specificity for L-DOPA. Tyrosinase activity was drastically enhanced by Cu 2 + , Ca2＋ and Mn 2 + metal ions. K + ions were also found to inhibit the tyrosinase activity up to the moderate level. Mushroom tyrosinase was used to degrade phenol from industry effluents with 90% removal in 6 hrs. Extracellular nature as well as tyrosinase stability in the extreme conditions (temperature, pH, and presence of heavy metals) makes it preferable candidate for phenol bioremediation from industrial effluents.

Environmental and Microbial Biotechnology

Journal of Global Antimicrobial Resistance

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Microbial Pathogenesis

In the last two decades, tuberculosis (TB) have threatened the public across the globe and contin... more In the last two decades, tuberculosis (TB) have threatened the public across the globe and continuing new TB cases and their transmission pooled with the global emergence of drug-resistant strains present an enduring occupational risk for health care workers (HCWs). Since last decade, government and funding agencies has given a significant amount of funds to tackle the problem of TB infection among medical staff or HCW in hospitals of developing countries, but the effects of these efforts have not yet been reported. Working environments are the major risk factors for TB infections among the HCW in hospital settings. Twenty-two high burden countries endorsed to the preponderance of worldwide tuberculosis cases in 2015. Urgent preventive strategies and mediations are needed to ensure the safety and sustained availability of these exquisite healthcare resources. This timeline review will provide the theoretical basis of high TB burden among the HCW which can be used for further improvement in strategies for the prevention of TB infections in hospital settings and provide a reliable basis for improving the personal health of HCW or medical staff.