julia sanchez - Academia.edu (original) (raw)

Papers by julia sanchez

Research paper thumbnail of Venous Thromboembolism in Patients With Ischemic and Hemorrhagic Stroke

American Journal of Cardiology, 2005

The rates of pulmonary embolism (PE), deep venous thrombosis (DVT), and their combination, venous... more The rates of pulmonary embolism (PE), deep venous thrombosis (DVT), and their combination, venous thromboembolism (VTE), in hospitalized patients with stroke from 1979 to 2003 were determined from the National Hospital Discharge Survey. Of 14,109,000 patients hospitalized with ischemic stroke, PE occurred in 72,000 (0.51%), DVT in 104,000 (0.74%), and VTE in 165,000 (1.17%). Of 1,606,000 patients hospitalized with hemorrhagic stroke, rates were higher: PE occurred in 11,000 (0.68%), DVT in 22,000 (1.37%), and VTE in 31,000 (1.93%). The rates of VTE with ischemic stroke and with hemorrhagic stroke did not change over the 25-year period of observation.

Research paper thumbnail of Multidetector Computed Tomography for the Diagnosis of Coronary Artery Disease: A Systematic Review

American Journal of Medicine, 2006

The study’s purpose was to determine the sensitivity and specificity of contrast-enhanced multide... more The study’s purpose was to determine the sensitivity and specificity of contrast-enhanced multidetector computed tomography (CT) for the detection of coronary artery disease.A search of the literature in all languages was performed incorporating both electronic and manual components. Manual reference checks of recent reviews and all original investigations supplemented the electronic searches.Average sensitivity for patient-based detection of significant (>50% or ≥50%) stenosis was 61 of 64 (95%) with 4-slice CT, 276 of 292 (95%) with 16-slice CT, and 47 of 47 (100%) with 64-slice CT. Average specificity was 84% for 4-slice CT, 84% for 16-slice CT, and 100% for 64-slice CT. The sensitivity for a significant stenosis in evaluable segments was 307 of 372 (83%) with 4-slice CT, 1023 of 1160 (88%) with 16-slice CT, and 165 of 176 (94%) with 64-slice CT. Average specificity was 93% or greater with all multidetector CT. Seventy-eight percent of segments were evaluable with 4-slice CT, 91% with 16-slice CT, and 100% with 64-slice CT. Stenoses in proximal and mid-segments were shown with a higher sensitivity than distal segments. Left main stenosis was identified with high sensitivity with all multidetector CT, but sensitivity in other vessels increased with an increasing number of detectors.Multidetector CT has the potential to be used as a screening test in appropriate patients. Contrast-enhanced 16-slice CT seems to be reasonably sensitive and specific for the detection of significant coronary artery disease but has shortcomings. Preliminary data with 64-slice CT suggest that it is more sensitive and specific.

Research paper thumbnail of Fatal Pulmonary Embolism and Stroke

American Journal of Cardiology, 2006

Death from pulmonary embolism (PE) in patients with ischemic stroke was determined from the Unite... more Death from pulmonary embolism (PE) in patients with ischemic stroke was determined from the United States Census Bureau’s Compressed Mortality File, which is based on all death certificates throughout the United States. Among patients with ischemic stroke who died over a 19-year study period, PE was the listed cause of death in 11,101 of 2,000,963 individuals (0.55%). On the basis of an assumed sensitivity of death certificates for fatal PE of 26.7% to 37.2%, the corrected rate of fatal PE was 1.5% to 2.1%. Death rates from PE in patients with ischemic stroke decreased from 1980 to 1998. A decrease over 2 decades in the rate of deaths from PE in patients with ischemic stroke is compatible with the increasing and effective use of antithrombotic prophylaxis.

Research paper thumbnail of Incidence of Venous Thromboembolism in Patients Hospitalized with Cancer

American Journal of Medicine, 2006

Research paper thumbnail of Venous Thromboembolism in Patients With Ischemic and Hemorrhagic Stroke

American Journal of Cardiology, 2005

The rates of pulmonary embolism (PE), deep venous thrombosis (DVT), and their combination, venous... more The rates of pulmonary embolism (PE), deep venous thrombosis (DVT), and their combination, venous thromboembolism (VTE), in hospitalized patients with stroke from 1979 to 2003 were determined from the National Hospital Discharge Survey. Of 14,109,000 patients hospitalized with ischemic stroke, PE occurred in 72,000 (0.51%), DVT in 104,000 (0.74%), and VTE in 165,000 (1.17%). Of 1,606,000 patients hospitalized with hemorrhagic stroke, rates were higher: PE occurred in 11,000 (0.68%), DVT in 22,000 (1.37%), and VTE in 31,000 (1.93%). The rates of VTE with ischemic stroke and with hemorrhagic stroke did not change over the 25-year period of observation.

Research paper thumbnail of Multidetector Computed Tomography for the Diagnosis of Coronary Artery Disease: A Systematic Review

American Journal of Medicine, 2006

The study’s purpose was to determine the sensitivity and specificity of contrast-enhanced multide... more The study’s purpose was to determine the sensitivity and specificity of contrast-enhanced multidetector computed tomography (CT) for the detection of coronary artery disease.A search of the literature in all languages was performed incorporating both electronic and manual components. Manual reference checks of recent reviews and all original investigations supplemented the electronic searches.Average sensitivity for patient-based detection of significant (>50% or ≥50%) stenosis was 61 of 64 (95%) with 4-slice CT, 276 of 292 (95%) with 16-slice CT, and 47 of 47 (100%) with 64-slice CT. Average specificity was 84% for 4-slice CT, 84% for 16-slice CT, and 100% for 64-slice CT. The sensitivity for a significant stenosis in evaluable segments was 307 of 372 (83%) with 4-slice CT, 1023 of 1160 (88%) with 16-slice CT, and 165 of 176 (94%) with 64-slice CT. Average specificity was 93% or greater with all multidetector CT. Seventy-eight percent of segments were evaluable with 4-slice CT, 91% with 16-slice CT, and 100% with 64-slice CT. Stenoses in proximal and mid-segments were shown with a higher sensitivity than distal segments. Left main stenosis was identified with high sensitivity with all multidetector CT, but sensitivity in other vessels increased with an increasing number of detectors.Multidetector CT has the potential to be used as a screening test in appropriate patients. Contrast-enhanced 16-slice CT seems to be reasonably sensitive and specific for the detection of significant coronary artery disease but has shortcomings. Preliminary data with 64-slice CT suggest that it is more sensitive and specific.

Research paper thumbnail of Fatal Pulmonary Embolism and Stroke

American Journal of Cardiology, 2006

Death from pulmonary embolism (PE) in patients with ischemic stroke was determined from the Unite... more Death from pulmonary embolism (PE) in patients with ischemic stroke was determined from the United States Census Bureau’s Compressed Mortality File, which is based on all death certificates throughout the United States. Among patients with ischemic stroke who died over a 19-year study period, PE was the listed cause of death in 11,101 of 2,000,963 individuals (0.55%). On the basis of an assumed sensitivity of death certificates for fatal PE of 26.7% to 37.2%, the corrected rate of fatal PE was 1.5% to 2.1%. Death rates from PE in patients with ischemic stroke decreased from 1980 to 1998. A decrease over 2 decades in the rate of deaths from PE in patients with ischemic stroke is compatible with the increasing and effective use of antithrombotic prophylaxis.

Research paper thumbnail of Incidence of Venous Thromboembolism in Patients Hospitalized with Cancer

American Journal of Medicine, 2006