julio castillo - Academia.edu (original) (raw)
Papers by julio castillo
Industrial & Engineering Chemistry Analytical Edition, 1946
of the concentration of methyl chloride present in a given sample of air may be expected by the m... more of the concentration of methyl chloride present in a given sample of air may be expected by the method. Therefore this correction factor is included in the calculation to compensate for the systematic error. It is believed that the systematic error is attributable to the retention in the reactor of combusion products that are not completely removed by rinsing 7%-ith chloride-free air.
Survey of Anesthesiology, 1964
Page 1. THE NEUROMUSCULAR BLOCKING ACTION OF SUCCINYLCHOLINE (DIACETYLCHOLINE)&#x... more Page 1. THE NEUROMUSCULAR BLOCKING ACTION OF SUCCINYLCHOLINE (DIACETYLCHOLINE)' JULIO C. CASTILLO AND EDWIN J. DE BEER The Welicome Research Laboratories, Tuckahoe, New York Received for publication May 8, 1950 ...
Lecture Notes in Computer Science, 2010
A. Kuri-Morales and GR Simari (Eds.): IBERAMIA 2010, LNAI 6433, pp. 366375, 2010. © Springer-Ver... more A. Kuri-Morales and GR Simari (Eds.): IBERAMIA 2010, LNAI 6433, pp. 366375, 2010. © Springer-Verlag Berlin Heidelberg 2010 ... Using Sentence Semantic Similarity Based on WordNet in ... Julio J. Castillo1,2 and Marina E. Cardenas2 ... 1 National University of Cordoba-...
Lecture Notes in Computer Science, 2010
Abstract. This paper explores how to increase the size of Textual Entailment Corpus by using Mach... more Abstract. This paper explores how to increase the size of Textual Entailment Corpus by using Machine Translation systems to generate additional ht, pairs. We also analyze the theoretical upper bound of a Corpus expanded by machine translation systems, and propose how it ...
Lecture Notes in Computer Science, 2010
Abstract. In this paper, we present a Recognizing Textual Entailment system which uses semantic s... more Abstract. In this paper, we present a Recognizing Textual Entailment system which uses semantic similarity metrics to sentence level only using WordNet as source of knowledge. We show how the widely used semantic measures Word-Net-based can be generalized to build ...
2010 International Conference on Intelligent Computing and Cognitive Informatics, 2010
Page 1. Textual Entailment Search Task An Initial Approach Based on Coreference Resolution Julio ... more Page 1. Textual Entailment Search Task An Initial Approach Based on Coreference Resolution Julio Javier Castillo FaMAF, National University of Cordoba FRC, National Technological University Cordoba, Argentina jotacastillo@gmail.com ...
Advances in Intelligent and Soft Computing, 2010
This paper presents how the size of Textual Entailment Corpus could be increased by using Transla... more This paper presents how the size of Textual Entailment Corpus could be increased by using Translators to generate additional〈 t, h〉 pairs. Also, we show the theoretical upper bound of a Corpus expanded by translators. Then, we propose an algorithm to expand the corpus ...
International Journal of Machine Learning and Cybernetics, 2011
In this paper we explain how to build a recognizing textual entailment (RTE) system which only us... more In this paper we explain how to build a recognizing textual entailment (RTE) system which only uses semantic similarity measures based on WordNet. We show how the widely used WordNet-based semantic measures can be generalized to build sentence level semantic metrics in order to be used in both mono-lingual and cross-lingual textual entailment. We experiment with a wide variety of RTE datasets and evaluate the contribution of an algorithm which expands the RTE monolingual corpus. Results achieved with this method yielded significant statistical differences when predicting RTE test sets. We provide an efficiency analysis of these metrics drawing some conclusions about their practical utility in recognizing textual entailment. We also analyze the cross-lingual textual entailment task, we create a bilingual English-Spanish corpus, and propose a procedure to create a cross-lingual textual entailment corpus for any pair of languages. Finally, we show that the proposed method is enough to build an average score RTE system in both monolingual and cross-lingual textual entailment, that uses semantic information from WordNet as the only source of lexicalsemantic knowledge.
Virulence, 2012
Drosophila has been established as an excellent genetic and genomic model to investigate host-pat... more Drosophila has been established as an excellent genetic and genomic model to investigate host-pathogen interactions and innate immune defense mechanisms. To date, most information on the Drosophila immune response derives from studies that involve bacterial, fungal or viral pathogens. However, immune reactions to insect parasitic nematodes are still not well characterized. The nematodes Heterorhabditis bacteriophora live in symbiosis with the entomopathogenic bacteria Photorhabdus luminescens, and they are able to invade and kill insects. Interestingly, Heterorhabditis nematodes are viable in the absence of Photorhabdus. Techniques for infecting Drosophila larvae with these nematodes have been previously reported. Here, we have developed a method for infecting Drosophila adult flies with Heterorhabditis nematodes carrying (symbiotic worms) or lacking (axenic worms) their associated bacteria. The protocol we present can be readily adapted for studying parasitic strategies of other in...
PloS one, 2010
Assemblages associated with intertidal rocky shores were examined for large scale distribution pa... more Assemblages associated with intertidal rocky shores were examined for large scale distribution patterns with specific emphasis on identifying latitudinal trends of species richness and taxonomic distinctiveness. Seventy-two sites distributed around the globe were evaluated following the standardized sampling protocol of the Census of Marine Life NaGISA project (www.nagisa.coml.org). There were no clear patterns of standardized estimators of species richness along latitudinal gradients or among Large Marine Ecosystems (LMEs); however, a strong latitudinal gradient in taxonomic composition (i.e., proportion of different taxonomic groups in a given sample) was observed. Environmental variables related to natural influences were strongly related to the distribution patterns of the assemblages on the LME scale, particularly photoperiod, sea surface temperature (SST) and rainfall. In contrast, no environmental variables directly associated with human influences (with the exception of the ...
Frontiers in Physiology, 2013
Insects have evolved obligate, mutualistic interactions with bacteria without further transmissio... more Insects have evolved obligate, mutualistic interactions with bacteria without further transmission to other eukaryotic organisms. Such long-term obligate partnerships between insects and bacteria have a profound effect on various physiological functions of the host. Here we provide an overview of the effects of endosymbiotic bacteria on the insect immune system as well as on the immune response of insects to pathogenic infections. Potential mechanisms through which endosymbionts can affect the ability of their host to resist an infection are discussed in the light of recent findings. We finally point out unresolved questions for future research and speculate how the current knowledge can be employed to design and implement measures for the effective control of agricultural insect pests and vectors of diseases.
Journal of Visualized Experiments, 2012
Insect hemocytes (equivalent to mammalian white blood cells) play an important role in several ph... more Insect hemocytes (equivalent to mammalian white blood cells) play an important role in several physiological processes throughout an insect's life cycle 1
International Journal of Molecular Sciences, 2012
Aging is a complex process that involves the accumulation of deleterious changes resulting in ove... more Aging is a complex process that involves the accumulation of deleterious changes resulting in overall decline in several vital functions, leading to the progressive deterioration in physiological condition of the organism and eventually causing disease and death. The immune system is the most important host-defense mechanism in humans and is also highly conserved in insects. Extensive research in vertebrates has concluded that aging of the immune function results in increased susceptibility to infectious disease and chronic inflammation. Over the years, interest has grown in studying the molecular interaction between aging and the immune response to pathogenic infections. The fruit fly Drosophila melanogaster is an excellent model system for dissecting the genetic and genomic basis of important biological processes, such as aging and the innate immune system, and deciphering parallel mechanisms in vertebrate animals. Here, we review the recent advances in the identification of key players modulating the relationship between molecular aging networks and immune signal transduction pathways in the fly. Understanding the details of the molecular events involved in aging and immune system regulation will potentially lead to the development of strategies for decreasing the impact of age-related diseases, thus improving human health and life span.
Trends in Parasitology, 2011
Transplantation, 1996
Wolters Kluwer Health may email you for journal alerts and information, but is committed to maint... more Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home > July 15, ...
PLoS Pathogens, 2011
All vector mosquito species must feed on the blood of a vertebrate host to produce eggs. Multiple... more All vector mosquito species must feed on the blood of a vertebrate host to produce eggs. Multiple cycles of blood feeding also promote frequent contacts with hosts, which enhance the risk of exposure to infectious agents and disease transmission. Blood feeding triggers the release of insulin-like peptides (ILPs) from the brain of the mosquito Aedes aegypti, which regulate blood meal digestion and egg formation. In turn, hemocytes serve as the most important constitutive defense in mosquitoes against pathogens that enter the hemocoel. Prior studies indicated that blood feeding stimulates hemocytes to increase in abundance, but how this increase in abundance is regulated is unknown. Here, we determined that phagocytic granulocytes and oenocytoids express the A. aegypti insulin receptor (AaMIR). We then showed that: 1) decapitation of mosquitoes after blood feeding inhibited hemocyte proliferation, 2) a single dose of insulin-like peptide 3 (ILP3) sufficient to stimulate egg production rescued proliferation, and 3) knockdown of the AaMIR inhibited ILP3 rescue activity. Infection studies indicated that increased hemocyte abundance enhanced clearance of the bacterium Escherichia coli at lower levels of infection. Surprisingly, however, non-blood fed females better survived intermediate and high levels of E. coli infection than blood fed females. Taken together, our results reveal a previously unrecognized role for the insulin signaling pathway in regulating hemocyte proliferation. Our results also indicate that blood feeding enhances resistance to E. coli at lower levels of infection but reduces tolerance at higher levels of infection. Citation: Castillo J, Brown MR, Strand MR (2011) Blood Feeding and Insulin-like Peptide 3 Stimulate Proliferation of Hemocytes in the Mosquito Aedes aegypti. PLoS Pathog 7(10): e1002274.
Industrial & Engineering Chemistry Analytical Edition, 1946
of the concentration of methyl chloride present in a given sample of air may be expected by the m... more of the concentration of methyl chloride present in a given sample of air may be expected by the method. Therefore this correction factor is included in the calculation to compensate for the systematic error. It is believed that the systematic error is attributable to the retention in the reactor of combusion products that are not completely removed by rinsing 7%-ith chloride-free air.
Survey of Anesthesiology, 1964
Page 1. THE NEUROMUSCULAR BLOCKING ACTION OF SUCCINYLCHOLINE (DIACETYLCHOLINE)&#x... more Page 1. THE NEUROMUSCULAR BLOCKING ACTION OF SUCCINYLCHOLINE (DIACETYLCHOLINE)' JULIO C. CASTILLO AND EDWIN J. DE BEER The Welicome Research Laboratories, Tuckahoe, New York Received for publication May 8, 1950 ...
Lecture Notes in Computer Science, 2010
A. Kuri-Morales and GR Simari (Eds.): IBERAMIA 2010, LNAI 6433, pp. 366375, 2010. © Springer-Ver... more A. Kuri-Morales and GR Simari (Eds.): IBERAMIA 2010, LNAI 6433, pp. 366375, 2010. © Springer-Verlag Berlin Heidelberg 2010 ... Using Sentence Semantic Similarity Based on WordNet in ... Julio J. Castillo1,2 and Marina E. Cardenas2 ... 1 National University of Cordoba-...
Lecture Notes in Computer Science, 2010
Abstract. This paper explores how to increase the size of Textual Entailment Corpus by using Mach... more Abstract. This paper explores how to increase the size of Textual Entailment Corpus by using Machine Translation systems to generate additional ht, pairs. We also analyze the theoretical upper bound of a Corpus expanded by machine translation systems, and propose how it ...
Lecture Notes in Computer Science, 2010
Abstract. In this paper, we present a Recognizing Textual Entailment system which uses semantic s... more Abstract. In this paper, we present a Recognizing Textual Entailment system which uses semantic similarity metrics to sentence level only using WordNet as source of knowledge. We show how the widely used semantic measures Word-Net-based can be generalized to build ...
2010 International Conference on Intelligent Computing and Cognitive Informatics, 2010
Page 1. Textual Entailment Search Task An Initial Approach Based on Coreference Resolution Julio ... more Page 1. Textual Entailment Search Task An Initial Approach Based on Coreference Resolution Julio Javier Castillo FaMAF, National University of Cordoba FRC, National Technological University Cordoba, Argentina jotacastillo@gmail.com ...
Advances in Intelligent and Soft Computing, 2010
This paper presents how the size of Textual Entailment Corpus could be increased by using Transla... more This paper presents how the size of Textual Entailment Corpus could be increased by using Translators to generate additional〈 t, h〉 pairs. Also, we show the theoretical upper bound of a Corpus expanded by translators. Then, we propose an algorithm to expand the corpus ...
International Journal of Machine Learning and Cybernetics, 2011
In this paper we explain how to build a recognizing textual entailment (RTE) system which only us... more In this paper we explain how to build a recognizing textual entailment (RTE) system which only uses semantic similarity measures based on WordNet. We show how the widely used WordNet-based semantic measures can be generalized to build sentence level semantic metrics in order to be used in both mono-lingual and cross-lingual textual entailment. We experiment with a wide variety of RTE datasets and evaluate the contribution of an algorithm which expands the RTE monolingual corpus. Results achieved with this method yielded significant statistical differences when predicting RTE test sets. We provide an efficiency analysis of these metrics drawing some conclusions about their practical utility in recognizing textual entailment. We also analyze the cross-lingual textual entailment task, we create a bilingual English-Spanish corpus, and propose a procedure to create a cross-lingual textual entailment corpus for any pair of languages. Finally, we show that the proposed method is enough to build an average score RTE system in both monolingual and cross-lingual textual entailment, that uses semantic information from WordNet as the only source of lexicalsemantic knowledge.
Virulence, 2012
Drosophila has been established as an excellent genetic and genomic model to investigate host-pat... more Drosophila has been established as an excellent genetic and genomic model to investigate host-pathogen interactions and innate immune defense mechanisms. To date, most information on the Drosophila immune response derives from studies that involve bacterial, fungal or viral pathogens. However, immune reactions to insect parasitic nematodes are still not well characterized. The nematodes Heterorhabditis bacteriophora live in symbiosis with the entomopathogenic bacteria Photorhabdus luminescens, and they are able to invade and kill insects. Interestingly, Heterorhabditis nematodes are viable in the absence of Photorhabdus. Techniques for infecting Drosophila larvae with these nematodes have been previously reported. Here, we have developed a method for infecting Drosophila adult flies with Heterorhabditis nematodes carrying (symbiotic worms) or lacking (axenic worms) their associated bacteria. The protocol we present can be readily adapted for studying parasitic strategies of other in...
PloS one, 2010
Assemblages associated with intertidal rocky shores were examined for large scale distribution pa... more Assemblages associated with intertidal rocky shores were examined for large scale distribution patterns with specific emphasis on identifying latitudinal trends of species richness and taxonomic distinctiveness. Seventy-two sites distributed around the globe were evaluated following the standardized sampling protocol of the Census of Marine Life NaGISA project (www.nagisa.coml.org). There were no clear patterns of standardized estimators of species richness along latitudinal gradients or among Large Marine Ecosystems (LMEs); however, a strong latitudinal gradient in taxonomic composition (i.e., proportion of different taxonomic groups in a given sample) was observed. Environmental variables related to natural influences were strongly related to the distribution patterns of the assemblages on the LME scale, particularly photoperiod, sea surface temperature (SST) and rainfall. In contrast, no environmental variables directly associated with human influences (with the exception of the ...
Frontiers in Physiology, 2013
Insects have evolved obligate, mutualistic interactions with bacteria without further transmissio... more Insects have evolved obligate, mutualistic interactions with bacteria without further transmission to other eukaryotic organisms. Such long-term obligate partnerships between insects and bacteria have a profound effect on various physiological functions of the host. Here we provide an overview of the effects of endosymbiotic bacteria on the insect immune system as well as on the immune response of insects to pathogenic infections. Potential mechanisms through which endosymbionts can affect the ability of their host to resist an infection are discussed in the light of recent findings. We finally point out unresolved questions for future research and speculate how the current knowledge can be employed to design and implement measures for the effective control of agricultural insect pests and vectors of diseases.
Journal of Visualized Experiments, 2012
Insect hemocytes (equivalent to mammalian white blood cells) play an important role in several ph... more Insect hemocytes (equivalent to mammalian white blood cells) play an important role in several physiological processes throughout an insect's life cycle 1
International Journal of Molecular Sciences, 2012
Aging is a complex process that involves the accumulation of deleterious changes resulting in ove... more Aging is a complex process that involves the accumulation of deleterious changes resulting in overall decline in several vital functions, leading to the progressive deterioration in physiological condition of the organism and eventually causing disease and death. The immune system is the most important host-defense mechanism in humans and is also highly conserved in insects. Extensive research in vertebrates has concluded that aging of the immune function results in increased susceptibility to infectious disease and chronic inflammation. Over the years, interest has grown in studying the molecular interaction between aging and the immune response to pathogenic infections. The fruit fly Drosophila melanogaster is an excellent model system for dissecting the genetic and genomic basis of important biological processes, such as aging and the innate immune system, and deciphering parallel mechanisms in vertebrate animals. Here, we review the recent advances in the identification of key players modulating the relationship between molecular aging networks and immune signal transduction pathways in the fly. Understanding the details of the molecular events involved in aging and immune system regulation will potentially lead to the development of strategies for decreasing the impact of age-related diseases, thus improving human health and life span.
Trends in Parasitology, 2011
Transplantation, 1996
Wolters Kluwer Health may email you for journal alerts and information, but is committed to maint... more Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home > July 15, ...
PLoS Pathogens, 2011
All vector mosquito species must feed on the blood of a vertebrate host to produce eggs. Multiple... more All vector mosquito species must feed on the blood of a vertebrate host to produce eggs. Multiple cycles of blood feeding also promote frequent contacts with hosts, which enhance the risk of exposure to infectious agents and disease transmission. Blood feeding triggers the release of insulin-like peptides (ILPs) from the brain of the mosquito Aedes aegypti, which regulate blood meal digestion and egg formation. In turn, hemocytes serve as the most important constitutive defense in mosquitoes against pathogens that enter the hemocoel. Prior studies indicated that blood feeding stimulates hemocytes to increase in abundance, but how this increase in abundance is regulated is unknown. Here, we determined that phagocytic granulocytes and oenocytoids express the A. aegypti insulin receptor (AaMIR). We then showed that: 1) decapitation of mosquitoes after blood feeding inhibited hemocyte proliferation, 2) a single dose of insulin-like peptide 3 (ILP3) sufficient to stimulate egg production rescued proliferation, and 3) knockdown of the AaMIR inhibited ILP3 rescue activity. Infection studies indicated that increased hemocyte abundance enhanced clearance of the bacterium Escherichia coli at lower levels of infection. Surprisingly, however, non-blood fed females better survived intermediate and high levels of E. coli infection than blood fed females. Taken together, our results reveal a previously unrecognized role for the insulin signaling pathway in regulating hemocyte proliferation. Our results also indicate that blood feeding enhances resistance to E. coli at lower levels of infection but reduces tolerance at higher levels of infection. Citation: Castillo J, Brown MR, Strand MR (2011) Blood Feeding and Insulin-like Peptide 3 Stimulate Proliferation of Hemocytes in the Mosquito Aedes aegypti. PLoS Pathog 7(10): e1002274.