julio cesar arroyo - Academia.edu (original) (raw)
Uploads
Papers by julio cesar arroyo
Life Sciences, 1984
The slow intravenous infusion of amphotericin B (amB) induced a moderate, partially dose-dependen... more The slow intravenous infusion of amphotericin B (amB) induced a moderate, partially dose-dependent fever in male adult rabbits, whereas the iv bolus injection of the drug was less pyrogenic and only at higher doses. Higher, more sustained fevers occurred with doses of 2.5 and 5.0 mg of amB. The threshold pyrogenic dose of amB in the rabbits tested approached 0.16 mg per Kg (delta T greater than 0.4 degrees C). Endotoxin-tolerant rabbits had a lower increase in rectal temperature when challenged with amB. No fever occurred in mice treated with amB.
Journal of the South Carolina Medical Association (1975), 2011
Infectious Diseases in Clinical Practice, 2004
Page 1. Safety/Tolerability and Efficacy of Abacavir-Containing Combination Therapy in HIV-1-Infe... more Page 1. Safety/Tolerability and Efficacy of Abacavir-Containing Combination Therapy in HIV-1-Infected Adults in a Clinical Practice Setting: Results of ZORRO Peter J. Ruane, MD,* Marshall K. Kubota, MD,y Arthur L. Williams ...
Southern Medical Journal, 1987
Clinical Infectious Diseases, 2012
Antimicrobial Agents and Chemotherapy, 1977
A patient with Mycobacterium chelonei infection was treated with erythromycin stearate and strept... more A patient with Mycobacterium chelonei infection was treated with erythromycin stearate and streptomycin. The choice of antibiotics was based on a rapid radiometric susceptibility test developed in our laboratory.
The American Journal of Medicine, 1977
Disseminated Nocardia caviae infection occurs only rarely. To date, two cases have been recorded ... more Disseminated Nocardia caviae infection occurs only rarely. To date, two cases have been recorded in the literature. We describe a third case of systemic N. caviae infection in a compromised host and compare it with the first two cases. Postmortem, microbiologic and antibiotic sensitivity data are included.
The American Journal of Medicine, 1989
American Journal of Infection Control, 1988
Southern Medical Journal, 1986
To determine whether serum aminoglycoside assays aided clinicians in treating infections and avoi... more To determine whether serum aminoglycoside assays aided clinicians in treating infections and avoiding aminoglycoside nephrotoxicity, we reviewed the charts of patients treated with aminoglycoside antibiotics parenterally. We compared 78 episodes of aminoglycoside-treated infections during which serum assays were done (group B) to 51 episodes without serum assays (group A). The groups of patients were comparable in age, outcome of infection, incidence of aminoglycoside nephrotoxicity, mean total dose of aminoglycosides given, and number of courses. Toxic trough levels of tobramycin (the most frequently used aminoglycoside) were seldom detected before the onset of nephrotoxicity, and peak tobramycin levels were frequently suboptimal. While 71% of decisions to increase or decrease the aminoglycoside dose after serum assays were considered appropriate, only 57% of noninterventions were appropriate. At our hospital, serum aminoglycoside assays did not help improve the outcome of infection or the incidence of nephrotoxicity. Their major clinical contribution was to alert the physician that serum concentrations were low.
Life Sciences, 1984
The slow intravenous infusion of amphotericin B (amB) induced a moderate, partially dose-dependen... more The slow intravenous infusion of amphotericin B (amB) induced a moderate, partially dose-dependent fever in male adult rabbits, whereas the iv bolus injection of the drug was less pyrogenic and only at higher doses. Higher, more sustained fevers occurred with doses of 2.5 and 5.0 mg of amB. The threshold pyrogenic dose of amB in the rabbits tested approached 0.16 mg per Kg (delta T greater than 0.4 degrees C). Endotoxin-tolerant rabbits had a lower increase in rectal temperature when challenged with amB. No fever occurred in mice treated with amB.
Journal of the South Carolina Medical Association (1975), 2011
Infectious Diseases in Clinical Practice, 2004
Page 1. Safety/Tolerability and Efficacy of Abacavir-Containing Combination Therapy in HIV-1-Infe... more Page 1. Safety/Tolerability and Efficacy of Abacavir-Containing Combination Therapy in HIV-1-Infected Adults in a Clinical Practice Setting: Results of ZORRO Peter J. Ruane, MD,* Marshall K. Kubota, MD,y Arthur L. Williams ...
Southern Medical Journal, 1987
Clinical Infectious Diseases, 2012
Antimicrobial Agents and Chemotherapy, 1977
A patient with Mycobacterium chelonei infection was treated with erythromycin stearate and strept... more A patient with Mycobacterium chelonei infection was treated with erythromycin stearate and streptomycin. The choice of antibiotics was based on a rapid radiometric susceptibility test developed in our laboratory.
The American Journal of Medicine, 1977
Disseminated Nocardia caviae infection occurs only rarely. To date, two cases have been recorded ... more Disseminated Nocardia caviae infection occurs only rarely. To date, two cases have been recorded in the literature. We describe a third case of systemic N. caviae infection in a compromised host and compare it with the first two cases. Postmortem, microbiologic and antibiotic sensitivity data are included.
The American Journal of Medicine, 1989
American Journal of Infection Control, 1988
Southern Medical Journal, 1986
To determine whether serum aminoglycoside assays aided clinicians in treating infections and avoi... more To determine whether serum aminoglycoside assays aided clinicians in treating infections and avoiding aminoglycoside nephrotoxicity, we reviewed the charts of patients treated with aminoglycoside antibiotics parenterally. We compared 78 episodes of aminoglycoside-treated infections during which serum assays were done (group B) to 51 episodes without serum assays (group A). The groups of patients were comparable in age, outcome of infection, incidence of aminoglycoside nephrotoxicity, mean total dose of aminoglycosides given, and number of courses. Toxic trough levels of tobramycin (the most frequently used aminoglycoside) were seldom detected before the onset of nephrotoxicity, and peak tobramycin levels were frequently suboptimal. While 71% of decisions to increase or decrease the aminoglycoside dose after serum assays were considered appropriate, only 57% of noninterventions were appropriate. At our hospital, serum aminoglycoside assays did not help improve the outcome of infection or the incidence of nephrotoxicity. Their major clinical contribution was to alert the physician that serum concentrations were low.