kadir yalçın - Academia.edu (original) (raw)
Papers by kadir yalçın
Journal of Clinical and Experimental Investigations, Mar 13, 2012
Amaç: Koroner arter hastalarında oksidatif/ antioksidatif dengenin oksidatif taraf lehine kaydığı... more Amaç: Koroner arter hastalarında oksidatif/ antioksidatif dengenin oksidatif taraf lehine kaydığı bilinmektedir. Bu çalışmanın amacı, total antioksidan durum, oksidatif yük ve koroner arter hastalığı arasındaki ilişkiyi incelemektir. Gereç ve yöntem: Çalışma grubu, koroner Anjiyografi yapmak için hastaneye yatırılan ardışık 87 hastadan oluşmaktadır. Plazma total oksidatif durum (TOD) ve total antioksidan kapasite (TAK) seviyeleri ölçüldü ve oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Dördüncü gruptaki TAK değerleri ilk grup (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) ile karşılaştırıldığında istatistiksel olarak anlamlı derecede artmıştı ve birinci gruptaki hastalar ile karşılaştırıldığında, dördüncü gruptaki (5.2 ± 2.8 vs 7.2 ± 5.4 µmol H 2 O 2 Eq/l) TOD değerlerindeki azalma anlamlı değildi. Hastalıklı damar sayısına göre, plazma oksidatif özellikleri üç grup arasında farklı bulunmadı. Sonuç: Plazma TAK düzeyleri koroner arter hastalığı olan kişilerde artmıştır ve koroner aterosklerozun ağırlığı TAK ile ilişkilidir. Anahtar kelimeler: Koroner arter hastalığı, total antioksidan kapasite, oksidatif yük ABSTRACT Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index. Materials and methods: The study group consisted of 87 consecutive patients who were hospitalized for coronary angiography. Plasma total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and oxidative stress index (OSI) was calculated. Results: The TAC values increased statistically significant in the four tertile compared with the first tertile (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS values decreased non-significantly in the four tertile (5.2 ± 2.8 vs 7.2 ± 5.4 µmol H 2 O 2 Eq/l) as compared to the patients in the first tertile. According to the number of diseased vessels, plasma oxidative characteristics did not differ between the three groups. Conclusions: Plasma TAC levels increased in subjects with coronary atherosclerosis and severity of coronary atherosclerosis is related with TAC.
Blood Coagulation & Fibrinolysis, Dec 1, 2020
Coronavirus disease is a highly contagious disease caused by systemic acute respiratory syndrome ... more Coronavirus disease is a highly contagious disease caused by systemic acute respiratory syndrome coronavirus 2 with high mortality rates. We aimed to evaluate the relationship between serum d-dimer levels and tomography findings at the time of admission in patients diagnosed with coronavirus disease 2019 (COVID-19). This study included 94 patients, 48 women (51%) and 46 men (49%), diagnosed by PCR method. Patients without any suspicious findings on thorax tomography and having oxygen saturation above 90% at the time of presentation were included as the first group. Patients with suspicious tomography findings but having oxygen saturation above 90% were designed as the second group, and patients with both suspicious tomography findings for COVID-19 and low oxygen saturation levels (<90%) at the time of admission were taken as the third group. Patients with oxygen desaturation were significantly older than the patients with normal oxygen saturations (P = 0.001). Patients with thorax tomography findings were having significantly higher d-dimer levels (P = 0.001). Patients with oxygen desaturation were having significantly higher d-dimer levels than the patients with normal oxygen saturations (P = 0.001). There was a significant negative correlation between oxygen saturation and d-dimer levels in all patients with and without tomography findings (r = −0.301, P = 0.016). Similarly, there was a significant positive correlation between the oxygen saturation and the lymphocyte count (r = 0.300, P < 0.017). Thorax tomography and d-dimer levels significantly correlate in patients with suspected COVID-19 admission. It should be kept in mind that patients with low oxygen saturation and high d-dimer levels may have serious lung involvement.
Journal of health sciences and medicine, Jul 20, 2022
Aim: To determine the effect of lactose intolerance on serum glucose levels and related biochemic... more Aim: To determine the effect of lactose intolerance on serum glucose levels and related biochemical parameters in the adult population who refrain from consuming milk and milk products. Material and Method: This retrospective, observational study was conducted in a tertiary care hospital between January 2016 and December 2019 with 296 participants. Plasma glucose, calcium, 25-hydroxyvitamin D3, folate, vitamin B12, thyroidstimulating hormone (TSH), and ferritin levels were controlled. Patients with positive lactose intolerance test results were accepted as the study group and negative results were accepted as the control group, and data of two groups were compared. Results: Of the total 296 participants 212 (71.7%) were found to have lactose intolerance and 84 (28.3%) were found to be normal. In the lactose intolerant group, blood glucose levels were significantly lower than the control group (5.14±0.53 mmol/L versus 5.47±0.54 mmol/L, p<0.001). In the lactose intolerant group, 29 (13.7%) patients, and in the control group 18 (21.4%) patients were having type 2 diabetes mellitus. In diabetic patients, both fasting blood glucose (5.68±0.49 mmol/L versus 6.30±0.59 mmol/L, p<0.001) and glycated hemoglobin levels were also significantly lower than the control group in the study group (6.78±1.08 versus 7.62±0.96, p<0.001). Conclusions: In this study, based upon the findings of people with insufficient milk consumption, any decrease in blood calcium or vitamin D levels was not observed. Lactose intolerant people may have lower blood glucose levels compared to lactase persistent people. Larger-scale and long-term studies are needed to demonstrate that persistence of lactase is an independent risk factor for the development of diabetes.
Turkish Journal of Medical Sciences, Aug 30, 2021
Background and aim: The aim of this study is to evaluate whether the long-term (≥4 weeks) use of ... more Background and aim: The aim of this study is to evaluate whether the long-term (≥4 weeks) use of proton pump inhibitors (PPIs) is a risk factor for intubation requirement and mortality in patients hospitalized for COVID-19. Materials and methods: In this multicentric retrospective study, a total of 382 adult patients (≥18 years of age) with confirmed COVID-19 who were hospitalized for treatment were enrolled. The patients were divided into two groups according to the periods during which they used PPIs: the first group included patients who were not on PPI treatment, and the second group included those who have used PPIs for more than 4 weeks. Results: The study participants were grouped according to their PPI usage history over the last 6 months. In total, 291 patients did not use any type of PPI over the last 6 months, and 91 patients used PPIs for more than 4 weeks. Older age (HR: 1.047, 95% CI: 1.026-1.068), current smoking (HR: 2.590, 95% CI: 1.334-5.025), and PPI therapy for more than 4 weeks (HR: 1.83, 95% CI: 1.06-2.41) were found to be independent risk factors for mortality. Conclusion: The results obtained in this study show that using PPIs for more than 4 weeks is associated with negative outcomes for patients with COVID-19. Patients receiving PPI therapy should be evaluated more carefully if they are hospitalized for COVID-19 treatment.
Dicle Medical Journal, Sep 1, 2012
İnflamasyon patolojik etkenlere karşı canlı dokular tarafından oluşturulan, patojeni uzaklaştırma... more İnflamasyon patolojik etkenlere karşı canlı dokular tarafından oluşturulan, patojeni uzaklaştırmaya yarayan ve iyileşme sürecini başlatan son derece önemli bir olaydır. Mikroorganizmalar, fiziksel ve kimyasal travmalar, termal yaralanma, iskemi ve immün reaksiyonlar inflamasyon nedeni olarak gösterilebilir. Plateletler, nükleusa sahip olmayan ve kemik iliğinde megakaryositlerden üretilen hücreler olup kanamanın durdurulması ve hemostazın devamında rol almasının yanısıra inflamasyonda da önemli rol almaktadır. Nötrofil ve makrofajlara benzer şekilde, inflamasyon mekanizmasına etki edecek çeşitli sitokin üretimi ve salınımı yaparlar. Bu derlemede inflamasyonda plateletlerin rolleri ve inflamasyonun plateletler üzerine etkileri tartışılacaktır.
Indian Journal of Medical Research, 2016
Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is an important cause of eleva... more Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is an important cause of elevated liver functions. There is evidence showing an association between NAFLD and subclinical atherosclerosis independent of traditional risk factors. We undertook this retrospective study to determine the association of Framingham cardiovascular risk scoring system with liver function tests and inflammatory markers and to find the role of liver function tests in determination of CVD risk among non-obese and nondiabetic subjects with non-alcoholic fatty liver disease. Methods: A total of 2058 patients were included in the study. Framingham cardiovascular risk scoring was done of all patients according to the age, gender, systolic blood pressure, serum total cholesterol and HDL cholesterol levels, smoking and antihypertensive medication history. Liver function test, lipid profile, insulin, uric acid, ferritin levels, etc. were determined. Results: According to the ultrasonography findings, patients were grouped as without any fatty infiltration of the liver (control group) (n=982), mild (n= 473), moderate (n=363) and severe fatty liver disease (n= 240) groups. In severe fatty liver disease group, the mean Framingham cardiovascular risk score was significantly higher than that of other groups. There was a positive correlation between GGT, uric acid and ferritin levels with Framingham cardiovascular score. In multivariate analysis, high GGT levels were positively associated with high-risk disease presence (OR: 3.02, 95% CI: 2.62-3.42) compared to low GGT levels independent of the age and sex. Interpretation & conclusions: Cardiovascular disease risk increases with the presence and stage of fatty liver disease. Our findings showed a positive correlation between elevated GGT levels and Framingham cardiovascular risk scoring system among non-diabetic, non-obese adults which could be important in clinical practice. Though in normal limits, elevated GGT levels among patients with fatty liver disease should be regarded as a sign of increased cardiovascular disease risk. Larger studies are warranted to elucidate the role of GGT in prediction of cardiovascular risk.
Selçuk Üniversitesi Tıp Fakültesi dergisi, Sep 1, 2021
Amaç: Bu çalışmada, karaciğer yağlanması ile hastaların demografik özellikleri, kan değerleri ve ... more Amaç: Bu çalışmada, karaciğer yağlanması ile hastaların demografik özellikleri, kan değerleri ve özellikle yüksek dansiteli dışı lipoproteinin yüksek dansiteli lipoproteine oranı (Non-HDL/HDL) arasında bir ilişki olup olmadığını araştırmak hedeflenmiştir. Hastalar ve Yöntem: Şubat 2020 ile Eylül 2020 tarihleri arasında ultrasonografi ile karaciğer yağlanması saptanan 164 hasta ile saptanmayan 188 hastanın laboratuvar ve ultrasonografi sonuçları prospektif olarak değerlendirildi. Hastaların; boy, ağırlık, karaciğer enzimleri, vitamin d düzeyleri ve lipid değerleri karşılaştırıldı. Bulgular: Karaciğer yağlanması varlığı ile; ağırlık, ALT, AST, vücut kitle indeksi, trigliserid, yüksek dansiteli dışı lipoprotein düzeyleri ve Non-HDL/HDL arasında anlamlı bir ilişki saptandı. Yağlanma şiddeti ile ağırlık, ALT, vücut kitle indeksi ve Non-HDL/HDL arasında anlamlı bir ilişki saptandı. Monosit sayısının yüksek dansiteli lipoproteine oranı ve vitamin D düzeyi ile karaciğer yağlanması varlığı arasında bir ilişki saptanmadı. Non-HDL/HDL oranı ile non-alkolik karaciğer yağlanması arasında ilişki saptanmıştır (r=0.158). Non-HDL/HDL oranının, non-alkolik karaciğer yağlanması tanısındaki pozitif ve negatif prediktif değerleri sırasıyla %56,3 ve %60,9 olarak bulunmuştur. Sonuç: Non-HDL/HDL oranı ile karaciğer yağlanması arasında anlamlı bir ilişki saptandı. Non-HDL/HDL oranı; karaciğer yağlanmasında kullanılabilecek yeni, kullanışlı ve kolay ulaşılabilen bir belirteçtir.
Journal of Clinical and Experimental Investigations, Dec 12, 2011
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clona... more Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clonal expansion of B lymphocytes. Richter Transformation (RT) must be considered if CLL patient had fever, weight loss, cytopenia and resistance to standard therapy. Despite CLL usually transforms to diffuse large cell lymphoma, some rare lymphomas may occur as RT such as Hodgkin variants, lymphoblastic lymphoma nad mantle cell lymphoma. Here, we report a case of Mantle cell lymphoma has become secondary to chronic lymphocytic leukemia due to its being a rare entity.
Turkish journal of hematology, Mar 1, 2013
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that presents with serosal... more Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that presents with serosal effusion in body cavities, without obvious tumor masses. Although PEL occurs in immunocompromised patients that are human immunodeficiency virus (HIV) positive, it also occurs in immunocompetent human herpes virus-8 (HHV-8)-positive patients. Herein we present an immunocompetent, HIV-negative, CD-20-negative, HHV-8-positive patient with pleural effusion that was diagnosed as PEL. The CHOP protocol and talc pleurodesis were administered. HHV-8 plays a causative role in PEL and is important for differentiating PEL from other types of lymphoma. As such, in addition to pleurodesis antiviral treatment should be considered for optimal treatment outcome.
Dicle Medical Journal, May 10, 2015
Bu çalışmanın amacı, büyük trokanter bölgesinde ağrısı olan hastalardaki trokanterik bursit ve gl... more Bu çalışmanın amacı, büyük trokanter bölgesinde ağrısı olan hastalardaki trokanterik bursit ve gluteus medius tendinopati prevelansını ultrasonografi kullanarak belirlemek ve gluteus medius tendinopatisi tanısının konulmasında, dirençli kalça abduksiyonu ve iç rotasyonunda ağrı varlığının değerlendirilmesinin önemini belirlemektir. Yöntemler: Bu çalışma büyük trokanterde ağrısı olan 75 hasta üzerinde retrospektif analiz ile gerçekleştirilmiştir. Hastaların fizik muayene kayıtlarında dirençli kalça abduksiyon ve iç rotasyonda ağrı varlığı araştırılmıştır. Fizik muayene kayıtlarının analizinden sonra hastaların kas iskelet sistemi ultrasonografi görüntüleme kayıtları incelenmiş olup, trokanterik bursit ve gluteus medius tendinopati varlığı değerlendirilmiştir. Bulgular: Büyük trokanterde ağrısı olan 75 hastanın; %41,4'ünde trokanterik bursit, %20'sinde gluteus medius tendinopatisi saptanmıştır. Dirençli kalça abduksiyonu ve iç rotasyonunda ağrı varlığı, gluteus mediusta tendinopati saptanan ve saptanmayan hastalarda gluteus mediusta tendinopati lehine, istatistiksel olarak belirgin farklı bulunmuştur. Sonuç: Hastalarda büyük trokanter ağrısının etyolojisinin aydınlatabilmesinde fizik muayene ve ultrasonografi ile görüntüleme önemlidir, özellikle dirençli kalça abduksiyonu ve iç rotasyonunda ağrı varlığının değerlendirilmesi, gluteus mediusta tendinopati varlığının saptanmasında gereklidir.
Clinical Medicine, Jun 1, 2015
Common genetic mutations encountered in folate metabolism may result in increased homocysteine (H... more Common genetic mutations encountered in folate metabolism may result in increased homocysteine (Hcy) levels. It has been reported that increased serum Hcy levels may affect the intracellular fat metabolism and may cause enhanced fatty infi ltration in the liver resulting in non-alcoholic fatty liver disease (NAFLD). In total, 150 patients diagnosed with FLD by ultrasound examination and 136 healthy control patients that do not have any fatty infi ltration in the liver were included in the study. Patients were grouped as mild (n=88), moderate (n=38) or severe (n=24) according to the stage of fatty liver in ultrasound. Serum liver function tests, Hcy, folic acid and vitamin B12 levels of the patients were studied. The genetic MTHFR C677T and A1298C polymorphisms of the patients were also evaluated. Although there was no signifi cant difference in vitamin B12 and folic acid levels, in the severe group, Hcy levels were signifi cantly higher than that of control and mild groups (p<0.001). By contrast, there was no signifi cant difference in heterozygote MTHFR 677C/T and 1298A/C mutations, both MTHFR 677C/T and MTHFR 1298A/C mutations were more common in NAFLD groups compared with the control patients (p<0.001). We have determined increased Hcy levels and increased prevalence of homozygote MTHFR 677C/T and MTHFR 1298A/C mutations in patients with NAFLD compared with healthy controls. Larger studies are warranted to clarify the etiological role of the MTHFR mutations and Hcy levels in FLD.
Journal of Medicine and Palliative Care
Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease with and without heredi... more Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease with and without hereditary thrombophilia. Material and Method: Factor V Leiden (G1691A) mutation, methylene tetrahydrofolate gene mutation (C677T, A1298C), and PAI-1 (4G-5G) and FXIII (V34L) gene mutations were examined in all patients included in the study for various reasons such as recurrent miscarriage and venous embolism. Patients with any mutation were included in the hereditary thrombophilia group, while patients without mutations were included in the control group. D-dimer levels of the patients were also analyzed for the second time at least 25 days after admission. All included patients had received previously at least two doses of the BioNTech-Pfizer or CoronaVac vaccines. Results: A total of 158 patients, 46 (29.1%) male and 112 (70.9%) female, were included in the study. The mean age of the patients included in the study was 39.08 ± 9.09 years. A total of 121 patients, 33 (27.3%) men and 88 (72.7...
DergiPark (Istanbul University), Jul 4, 2022
Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease with and without heredi... more Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease with and without hereditary thrombophilia. Material and Method: Factor V Leiden (G1691A) mutation, methylene tetrahydrofolate gene mutation (C677T, A1298C), and PAI-1 (4G-5G) and FXIII (V34L) gene mutations were examined in all patients included in the study for various reasons such as recurrent miscarriage and venous embolism. Patients with any mutation were included in the hereditary thrombophilia group, while patients without mutations were included in the control group. D-dimer levels of the patients were also analyzed for the second time at least 25 days after admission. All included patients had received previously at least two doses of the BioNTech-Pfizer or CoronaVac vaccines. Results: A total of 158 patients, 46 (29.1%) male and 112 (70.9%) female, were included in the study. The mean age of the patients included in the study was 39.08 ± 9.09 years. A total of 121 patients, 33 (27.3%) men and 88 (72.7) women, with hereditary thrombophilia were in the first group. A total of 37 patients, 13 (35.1%) male and 24 (64.9%) female, who did not have any mutations, were taken as the control group. Of the patients with hereditary thrombophilia, 47 (38.8%) had Factor V Leiden, 63 (52.1%) had MTHFR gene mutations, 32 (26.4%) had PAI-1 and 12 (9.9%) had FXIII gene mutations. When the D-dimer values of both groups were examined 20-35 days after admission to the hospital, the D-dimer level of the hereditary thrombophilia group was 667.26 ±354.11 while the D-dimer level of the control group was 369.76±173.45 (P=0.031). The D-dimer level of 23 patients in the hereditary thrombophilia group and 2 patients without thrombophilia were found to be above 1000ng/ml when they came for control. Conclusion: It should be kept in mind that if there is prolonged or newly emerging D-dimer elevation in patients who had COVID-19 disease with mild-moderate symptoms, these patients may have hereditary thrombophilia.
Aim: The aim of this study was to investigate concordance between polymerase chain reaction (PCR)... more Aim: The aim of this study was to investigate concordance between polymerase chain reaction (PCR) test results and early thorax computed tomography (CT) findings of the patients in whom coronavirus disease 2019 (COVID-19) was suspected after evaluation of their complaints and physical examination findings. Material and Methods: One hundred and fourteen patients with suspicion of COVID-19, evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) existence with PCR test and performed thorax CT in the first 48 hours, between April and July 2020, were enrolled in this study retrospectively. Demographic characteristics, laboratory parameters and thorax CT findings of PCR positive and negative patients were compared. If patients had negative PCR test results, but clinical suspicion for COVID-19 persisted, additional PCR samples were tested at 48-hour intervals. Results: Interlobular septal thickening was more frequent in PCR positive patients (p=0.043). There was no significant thorax CT finding in 16 (28.6%) PCR positive and 14 (24.1%) PCR negative patients. Bilateral, peripheral and multilobar ground glass opacifications, consolidation and interlobular septal thickening were the most frequent findings in both groups. Neutrophil (p<0.001) and platelet counts (p=0.038) were significantly lower in PCR positive group. Conclusion: The thorax CT findings of the patients whose PCR tests were positive or negative were greatly similar except for interlobular septal thickening, thus thorax CT should not be used alone in the diagnosis of COVID-19 especially in early stages. In decision making, symptoms, laboratory and CT findings and PCR tests of patients must be evaluated all together. © 2020, Duzce University Medical School. All rights reserved
Lokman Hekim Health Sciences, 2021
Introduction: To determine the changes in mean platelet volume (MPV) and the neutrophil/lymphocyt... more Introduction: To determine the changes in mean platelet volume (MPV) and the neutrophil/lymphocyte ratio (NLR) in activation period among patients with ulcerative colitis (UC). Methods: Overall, 83 patients (49 female and 34 male) diagnosed with UC were retrospectively screened and includ- ed in this study. The complete blood count results, including hemoglobin, white blood cell (WBC) count, NLR, platelet count, and MPV, of all patients were recorded in both activation and remission periods. The serum C-reactive protein (CRP) and sedimentation levels of all patients were also recorded. Endoscopic disease activities (endoscopic activity index (EAI)) were also noted. Results: Compared with the remission periods, MPV values were statistically significantly lower (p=0.023) and NLR values were statistically significantly higher (p=0.011) in activation periods. In the correlation analysis, MPV levels were correlated with disease age (p=0.019), hemoglobin (p=0.012), WBC count (p=0.009), pl...
Hitit Medical Journal, 2021
Amaç: Uzun yıllardır kullanılan ucuz, kolay ve hızlı bir test olan sedimantasyon hala birçok duru... more Amaç: Uzun yıllardır kullanılan ucuz, kolay ve hızlı bir test olan sedimantasyon hala birçok durumda tanıya yardımcı olmaktadır. Bu çalışmada, sağlıklı bireylerde sedimantasyon, kolesterol değerleri ve monosit yüksek dansiteli lipoprotein oranı (MHR) ile vücut kitle indeksi arasındaki ilişki değerlendirilmiştir. Gereç ve Yöntem: Ocak 2020 ile Aralık 2020 tarihleri arasında; iç hastalıkları kliniğine belirgin şikayeti olmadan, rutin sağlık kontrolü ve checkup için başvuran 689 sağlıklı bireylerin sonuçları retrospektif olarak değerlendirilmiştir. Hastaların demografik özellikleri, vücut kitle indeksi ve kan parametreleri değerlendirilmiştir. Katılımcılar; vücut kitle indeksine göre; Grup 1 (normal kilolu), Grup 2 (aşırı kilolu) ve Grup 3 (obez) olarak sınıflandırılmıştır. Bulgular: Gruplar arasında; vücut kitle indeksi ile; boy, kilo, sedimantasyon değeri, glikoz, monosit sayısı, total kolesterol, düşük dansiteli lipoprotein, yüksek dansiteli lipoprotein dışı kolesterol ve MHR arasında anlamlı bir ilişki saptanmıştır. Kadınların sedimantasyon değeri erkeklerden anlamlı olarak fazla saptanmıştır. Vücut kitle indeksi ile sedimantasyon değeri (r=0.346, p=0.001), glikoz (r=0.239, p=0.001) ve monosit sayısı (r=0.096, p=0.013) arasında anlamlı bir korelasyon bulunmuştur. Sonuç: Bu çalışmanın neticelerine göre sedimantasyon hızı sağlıklı bireylerde VKI ile ilişkili bir parametre olarak sağlıklı bireylerde inflamasyon şiddetini göstermek için kullanılabilir. Sedimantasyon değeri yüzyıl önce bulunmasına rağmen kullanışlılığını devam ettirmektedir.
Lokman Hekim Health Sciences, 2021
Introduction: To determine the Helicobacter pylori (H. pylori) eradication rates with a quadruple... more Introduction: To determine the Helicobacter pylori (H. pylori) eradication rates with a quadruple treatment regimen consisted of pantoprazole, bismuth subcitrate, metronidazole, and amoxicillin for 14 days in a country with high metronidazole and clarithromycin resistance rates. Methods: All patients were prescribed 14-day quadruple therapy (pantoprazole 40 mg twice daily, bismuth subcitrate 600 mg 2 × 1, amoxicillin 1 g twice daily, and Metronidazole 500 mg three times a day, for 14 days). The success rates of eradication treatment were investigated with stool H. pylori antigen test performed 2 months after eradication. Results: Among 132 H. pylori-infected treatment-naive patients, 8 (6.0%) patients could not complete the study due to adverse events or lost from the follow up. Among 124 patients who completed the study, 10 patients presented with a positive result on stool H. pylori antigen testing at 8 th week, while in remaining 114 cases, the test result was negative. In intention to treat analysis, the eradication rate was determined as 86.4% (95% confidence interval [CI]=81.2%-92.3%), while in per-protocol analysis, the eradication rate was 91.9% (95% CI=88.2%-96.1%). Discussion and Conclusion: With low adverse events and high compliance rates, this treatment modality should be kept in mind for H. pylori eradication especially in regions with high clarithromycin resistance.
American Journal of Clinical Pathology, 2009
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor derived from interdigitating dendri... more Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor derived from interdigitating dendritic cells. Three cases of IDCS associated with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have been described, but no clonal relationship between the 2 neoplasms was demonstrated. We present a detailed case analysis of a CLL/SLL with metachronous IDCS and demonstrate that these 2 neoplasms are clonally related. The IDCS and CLL cells had trisomy 12 and identical monoclonal immunoglobulin heavy chain gene rearrangements. Analysis of transcription factors with a role in myeloid differentiation demonstrated PU.1 up-regulation and C/EBPα down-regulation in IDCS compared with CLL. High-density array comparative genomic hybridization also identified gains in part of chromosome 16q in IDCS. Our study demonstrates for the first time clonal transformation of CLL/SLL into IDCS. This phenomenon may be triggered by alterations in lineage-determining transcription programs, whi...
Journal of Clinical and Experimental Investigations, Mar 13, 2012
Amaç: Koroner arter hastalarında oksidatif/ antioksidatif dengenin oksidatif taraf lehine kaydığı... more Amaç: Koroner arter hastalarında oksidatif/ antioksidatif dengenin oksidatif taraf lehine kaydığı bilinmektedir. Bu çalışmanın amacı, total antioksidan durum, oksidatif yük ve koroner arter hastalığı arasındaki ilişkiyi incelemektir. Gereç ve yöntem: Çalışma grubu, koroner Anjiyografi yapmak için hastaneye yatırılan ardışık 87 hastadan oluşmaktadır. Plazma total oksidatif durum (TOD) ve total antioksidan kapasite (TAK) seviyeleri ölçüldü ve oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Dördüncü gruptaki TAK değerleri ilk grup (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) ile karşılaştırıldığında istatistiksel olarak anlamlı derecede artmıştı ve birinci gruptaki hastalar ile karşılaştırıldığında, dördüncü gruptaki (5.2 ± 2.8 vs 7.2 ± 5.4 µmol H 2 O 2 Eq/l) TOD değerlerindeki azalma anlamlı değildi. Hastalıklı damar sayısına göre, plazma oksidatif özellikleri üç grup arasında farklı bulunmadı. Sonuç: Plazma TAK düzeyleri koroner arter hastalığı olan kişilerde artmıştır ve koroner aterosklerozun ağırlığı TAK ile ilişkilidir. Anahtar kelimeler: Koroner arter hastalığı, total antioksidan kapasite, oksidatif yük ABSTRACT Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index. Materials and methods: The study group consisted of 87 consecutive patients who were hospitalized for coronary angiography. Plasma total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and oxidative stress index (OSI) was calculated. Results: The TAC values increased statistically significant in the four tertile compared with the first tertile (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS values decreased non-significantly in the four tertile (5.2 ± 2.8 vs 7.2 ± 5.4 µmol H 2 O 2 Eq/l) as compared to the patients in the first tertile. According to the number of diseased vessels, plasma oxidative characteristics did not differ between the three groups. Conclusions: Plasma TAC levels increased in subjects with coronary atherosclerosis and severity of coronary atherosclerosis is related with TAC.
Blood Coagulation & Fibrinolysis, Dec 1, 2020
Coronavirus disease is a highly contagious disease caused by systemic acute respiratory syndrome ... more Coronavirus disease is a highly contagious disease caused by systemic acute respiratory syndrome coronavirus 2 with high mortality rates. We aimed to evaluate the relationship between serum d-dimer levels and tomography findings at the time of admission in patients diagnosed with coronavirus disease 2019 (COVID-19). This study included 94 patients, 48 women (51%) and 46 men (49%), diagnosed by PCR method. Patients without any suspicious findings on thorax tomography and having oxygen saturation above 90% at the time of presentation were included as the first group. Patients with suspicious tomography findings but having oxygen saturation above 90% were designed as the second group, and patients with both suspicious tomography findings for COVID-19 and low oxygen saturation levels (<90%) at the time of admission were taken as the third group. Patients with oxygen desaturation were significantly older than the patients with normal oxygen saturations (P = 0.001). Patients with thorax tomography findings were having significantly higher d-dimer levels (P = 0.001). Patients with oxygen desaturation were having significantly higher d-dimer levels than the patients with normal oxygen saturations (P = 0.001). There was a significant negative correlation between oxygen saturation and d-dimer levels in all patients with and without tomography findings (r = −0.301, P = 0.016). Similarly, there was a significant positive correlation between the oxygen saturation and the lymphocyte count (r = 0.300, P < 0.017). Thorax tomography and d-dimer levels significantly correlate in patients with suspected COVID-19 admission. It should be kept in mind that patients with low oxygen saturation and high d-dimer levels may have serious lung involvement.
Journal of health sciences and medicine, Jul 20, 2022
Aim: To determine the effect of lactose intolerance on serum glucose levels and related biochemic... more Aim: To determine the effect of lactose intolerance on serum glucose levels and related biochemical parameters in the adult population who refrain from consuming milk and milk products. Material and Method: This retrospective, observational study was conducted in a tertiary care hospital between January 2016 and December 2019 with 296 participants. Plasma glucose, calcium, 25-hydroxyvitamin D3, folate, vitamin B12, thyroidstimulating hormone (TSH), and ferritin levels were controlled. Patients with positive lactose intolerance test results were accepted as the study group and negative results were accepted as the control group, and data of two groups were compared. Results: Of the total 296 participants 212 (71.7%) were found to have lactose intolerance and 84 (28.3%) were found to be normal. In the lactose intolerant group, blood glucose levels were significantly lower than the control group (5.14±0.53 mmol/L versus 5.47±0.54 mmol/L, p<0.001). In the lactose intolerant group, 29 (13.7%) patients, and in the control group 18 (21.4%) patients were having type 2 diabetes mellitus. In diabetic patients, both fasting blood glucose (5.68±0.49 mmol/L versus 6.30±0.59 mmol/L, p<0.001) and glycated hemoglobin levels were also significantly lower than the control group in the study group (6.78±1.08 versus 7.62±0.96, p<0.001). Conclusions: In this study, based upon the findings of people with insufficient milk consumption, any decrease in blood calcium or vitamin D levels was not observed. Lactose intolerant people may have lower blood glucose levels compared to lactase persistent people. Larger-scale and long-term studies are needed to demonstrate that persistence of lactase is an independent risk factor for the development of diabetes.
Turkish Journal of Medical Sciences, Aug 30, 2021
Background and aim: The aim of this study is to evaluate whether the long-term (≥4 weeks) use of ... more Background and aim: The aim of this study is to evaluate whether the long-term (≥4 weeks) use of proton pump inhibitors (PPIs) is a risk factor for intubation requirement and mortality in patients hospitalized for COVID-19. Materials and methods: In this multicentric retrospective study, a total of 382 adult patients (≥18 years of age) with confirmed COVID-19 who were hospitalized for treatment were enrolled. The patients were divided into two groups according to the periods during which they used PPIs: the first group included patients who were not on PPI treatment, and the second group included those who have used PPIs for more than 4 weeks. Results: The study participants were grouped according to their PPI usage history over the last 6 months. In total, 291 patients did not use any type of PPI over the last 6 months, and 91 patients used PPIs for more than 4 weeks. Older age (HR: 1.047, 95% CI: 1.026-1.068), current smoking (HR: 2.590, 95% CI: 1.334-5.025), and PPI therapy for more than 4 weeks (HR: 1.83, 95% CI: 1.06-2.41) were found to be independent risk factors for mortality. Conclusion: The results obtained in this study show that using PPIs for more than 4 weeks is associated with negative outcomes for patients with COVID-19. Patients receiving PPI therapy should be evaluated more carefully if they are hospitalized for COVID-19 treatment.
Dicle Medical Journal, Sep 1, 2012
İnflamasyon patolojik etkenlere karşı canlı dokular tarafından oluşturulan, patojeni uzaklaştırma... more İnflamasyon patolojik etkenlere karşı canlı dokular tarafından oluşturulan, patojeni uzaklaştırmaya yarayan ve iyileşme sürecini başlatan son derece önemli bir olaydır. Mikroorganizmalar, fiziksel ve kimyasal travmalar, termal yaralanma, iskemi ve immün reaksiyonlar inflamasyon nedeni olarak gösterilebilir. Plateletler, nükleusa sahip olmayan ve kemik iliğinde megakaryositlerden üretilen hücreler olup kanamanın durdurulması ve hemostazın devamında rol almasının yanısıra inflamasyonda da önemli rol almaktadır. Nötrofil ve makrofajlara benzer şekilde, inflamasyon mekanizmasına etki edecek çeşitli sitokin üretimi ve salınımı yaparlar. Bu derlemede inflamasyonda plateletlerin rolleri ve inflamasyonun plateletler üzerine etkileri tartışılacaktır.
Indian Journal of Medical Research, 2016
Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is an important cause of eleva... more Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is an important cause of elevated liver functions. There is evidence showing an association between NAFLD and subclinical atherosclerosis independent of traditional risk factors. We undertook this retrospective study to determine the association of Framingham cardiovascular risk scoring system with liver function tests and inflammatory markers and to find the role of liver function tests in determination of CVD risk among non-obese and nondiabetic subjects with non-alcoholic fatty liver disease. Methods: A total of 2058 patients were included in the study. Framingham cardiovascular risk scoring was done of all patients according to the age, gender, systolic blood pressure, serum total cholesterol and HDL cholesterol levels, smoking and antihypertensive medication history. Liver function test, lipid profile, insulin, uric acid, ferritin levels, etc. were determined. Results: According to the ultrasonography findings, patients were grouped as without any fatty infiltration of the liver (control group) (n=982), mild (n= 473), moderate (n=363) and severe fatty liver disease (n= 240) groups. In severe fatty liver disease group, the mean Framingham cardiovascular risk score was significantly higher than that of other groups. There was a positive correlation between GGT, uric acid and ferritin levels with Framingham cardiovascular score. In multivariate analysis, high GGT levels were positively associated with high-risk disease presence (OR: 3.02, 95% CI: 2.62-3.42) compared to low GGT levels independent of the age and sex. Interpretation & conclusions: Cardiovascular disease risk increases with the presence and stage of fatty liver disease. Our findings showed a positive correlation between elevated GGT levels and Framingham cardiovascular risk scoring system among non-diabetic, non-obese adults which could be important in clinical practice. Though in normal limits, elevated GGT levels among patients with fatty liver disease should be regarded as a sign of increased cardiovascular disease risk. Larger studies are warranted to elucidate the role of GGT in prediction of cardiovascular risk.
Selçuk Üniversitesi Tıp Fakültesi dergisi, Sep 1, 2021
Amaç: Bu çalışmada, karaciğer yağlanması ile hastaların demografik özellikleri, kan değerleri ve ... more Amaç: Bu çalışmada, karaciğer yağlanması ile hastaların demografik özellikleri, kan değerleri ve özellikle yüksek dansiteli dışı lipoproteinin yüksek dansiteli lipoproteine oranı (Non-HDL/HDL) arasında bir ilişki olup olmadığını araştırmak hedeflenmiştir. Hastalar ve Yöntem: Şubat 2020 ile Eylül 2020 tarihleri arasında ultrasonografi ile karaciğer yağlanması saptanan 164 hasta ile saptanmayan 188 hastanın laboratuvar ve ultrasonografi sonuçları prospektif olarak değerlendirildi. Hastaların; boy, ağırlık, karaciğer enzimleri, vitamin d düzeyleri ve lipid değerleri karşılaştırıldı. Bulgular: Karaciğer yağlanması varlığı ile; ağırlık, ALT, AST, vücut kitle indeksi, trigliserid, yüksek dansiteli dışı lipoprotein düzeyleri ve Non-HDL/HDL arasında anlamlı bir ilişki saptandı. Yağlanma şiddeti ile ağırlık, ALT, vücut kitle indeksi ve Non-HDL/HDL arasında anlamlı bir ilişki saptandı. Monosit sayısının yüksek dansiteli lipoproteine oranı ve vitamin D düzeyi ile karaciğer yağlanması varlığı arasında bir ilişki saptanmadı. Non-HDL/HDL oranı ile non-alkolik karaciğer yağlanması arasında ilişki saptanmıştır (r=0.158). Non-HDL/HDL oranının, non-alkolik karaciğer yağlanması tanısındaki pozitif ve negatif prediktif değerleri sırasıyla %56,3 ve %60,9 olarak bulunmuştur. Sonuç: Non-HDL/HDL oranı ile karaciğer yağlanması arasında anlamlı bir ilişki saptandı. Non-HDL/HDL oranı; karaciğer yağlanmasında kullanılabilecek yeni, kullanışlı ve kolay ulaşılabilen bir belirteçtir.
Journal of Clinical and Experimental Investigations, Dec 12, 2011
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clona... more Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clonal expansion of B lymphocytes. Richter Transformation (RT) must be considered if CLL patient had fever, weight loss, cytopenia and resistance to standard therapy. Despite CLL usually transforms to diffuse large cell lymphoma, some rare lymphomas may occur as RT such as Hodgkin variants, lymphoblastic lymphoma nad mantle cell lymphoma. Here, we report a case of Mantle cell lymphoma has become secondary to chronic lymphocytic leukemia due to its being a rare entity.
Turkish journal of hematology, Mar 1, 2013
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that presents with serosal... more Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that presents with serosal effusion in body cavities, without obvious tumor masses. Although PEL occurs in immunocompromised patients that are human immunodeficiency virus (HIV) positive, it also occurs in immunocompetent human herpes virus-8 (HHV-8)-positive patients. Herein we present an immunocompetent, HIV-negative, CD-20-negative, HHV-8-positive patient with pleural effusion that was diagnosed as PEL. The CHOP protocol and talc pleurodesis were administered. HHV-8 plays a causative role in PEL and is important for differentiating PEL from other types of lymphoma. As such, in addition to pleurodesis antiviral treatment should be considered for optimal treatment outcome.
Dicle Medical Journal, May 10, 2015
Bu çalışmanın amacı, büyük trokanter bölgesinde ağrısı olan hastalardaki trokanterik bursit ve gl... more Bu çalışmanın amacı, büyük trokanter bölgesinde ağrısı olan hastalardaki trokanterik bursit ve gluteus medius tendinopati prevelansını ultrasonografi kullanarak belirlemek ve gluteus medius tendinopatisi tanısının konulmasında, dirençli kalça abduksiyonu ve iç rotasyonunda ağrı varlığının değerlendirilmesinin önemini belirlemektir. Yöntemler: Bu çalışma büyük trokanterde ağrısı olan 75 hasta üzerinde retrospektif analiz ile gerçekleştirilmiştir. Hastaların fizik muayene kayıtlarında dirençli kalça abduksiyon ve iç rotasyonda ağrı varlığı araştırılmıştır. Fizik muayene kayıtlarının analizinden sonra hastaların kas iskelet sistemi ultrasonografi görüntüleme kayıtları incelenmiş olup, trokanterik bursit ve gluteus medius tendinopati varlığı değerlendirilmiştir. Bulgular: Büyük trokanterde ağrısı olan 75 hastanın; %41,4'ünde trokanterik bursit, %20'sinde gluteus medius tendinopatisi saptanmıştır. Dirençli kalça abduksiyonu ve iç rotasyonunda ağrı varlığı, gluteus mediusta tendinopati saptanan ve saptanmayan hastalarda gluteus mediusta tendinopati lehine, istatistiksel olarak belirgin farklı bulunmuştur. Sonuç: Hastalarda büyük trokanter ağrısının etyolojisinin aydınlatabilmesinde fizik muayene ve ultrasonografi ile görüntüleme önemlidir, özellikle dirençli kalça abduksiyonu ve iç rotasyonunda ağrı varlığının değerlendirilmesi, gluteus mediusta tendinopati varlığının saptanmasında gereklidir.
Clinical Medicine, Jun 1, 2015
Common genetic mutations encountered in folate metabolism may result in increased homocysteine (H... more Common genetic mutations encountered in folate metabolism may result in increased homocysteine (Hcy) levels. It has been reported that increased serum Hcy levels may affect the intracellular fat metabolism and may cause enhanced fatty infi ltration in the liver resulting in non-alcoholic fatty liver disease (NAFLD). In total, 150 patients diagnosed with FLD by ultrasound examination and 136 healthy control patients that do not have any fatty infi ltration in the liver were included in the study. Patients were grouped as mild (n=88), moderate (n=38) or severe (n=24) according to the stage of fatty liver in ultrasound. Serum liver function tests, Hcy, folic acid and vitamin B12 levels of the patients were studied. The genetic MTHFR C677T and A1298C polymorphisms of the patients were also evaluated. Although there was no signifi cant difference in vitamin B12 and folic acid levels, in the severe group, Hcy levels were signifi cantly higher than that of control and mild groups (p<0.001). By contrast, there was no signifi cant difference in heterozygote MTHFR 677C/T and 1298A/C mutations, both MTHFR 677C/T and MTHFR 1298A/C mutations were more common in NAFLD groups compared with the control patients (p<0.001). We have determined increased Hcy levels and increased prevalence of homozygote MTHFR 677C/T and MTHFR 1298A/C mutations in patients with NAFLD compared with healthy controls. Larger studies are warranted to clarify the etiological role of the MTHFR mutations and Hcy levels in FLD.
Journal of Medicine and Palliative Care
Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease with and without heredi... more Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease with and without hereditary thrombophilia. Material and Method: Factor V Leiden (G1691A) mutation, methylene tetrahydrofolate gene mutation (C677T, A1298C), and PAI-1 (4G-5G) and FXIII (V34L) gene mutations were examined in all patients included in the study for various reasons such as recurrent miscarriage and venous embolism. Patients with any mutation were included in the hereditary thrombophilia group, while patients without mutations were included in the control group. D-dimer levels of the patients were also analyzed for the second time at least 25 days after admission. All included patients had received previously at least two doses of the BioNTech-Pfizer or CoronaVac vaccines. Results: A total of 158 patients, 46 (29.1%) male and 112 (70.9%) female, were included in the study. The mean age of the patients included in the study was 39.08 ± 9.09 years. A total of 121 patients, 33 (27.3%) men and 88 (72.7...
DergiPark (Istanbul University), Jul 4, 2022
Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease with and without heredi... more Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease with and without hereditary thrombophilia. Material and Method: Factor V Leiden (G1691A) mutation, methylene tetrahydrofolate gene mutation (C677T, A1298C), and PAI-1 (4G-5G) and FXIII (V34L) gene mutations were examined in all patients included in the study for various reasons such as recurrent miscarriage and venous embolism. Patients with any mutation were included in the hereditary thrombophilia group, while patients without mutations were included in the control group. D-dimer levels of the patients were also analyzed for the second time at least 25 days after admission. All included patients had received previously at least two doses of the BioNTech-Pfizer or CoronaVac vaccines. Results: A total of 158 patients, 46 (29.1%) male and 112 (70.9%) female, were included in the study. The mean age of the patients included in the study was 39.08 ± 9.09 years. A total of 121 patients, 33 (27.3%) men and 88 (72.7) women, with hereditary thrombophilia were in the first group. A total of 37 patients, 13 (35.1%) male and 24 (64.9%) female, who did not have any mutations, were taken as the control group. Of the patients with hereditary thrombophilia, 47 (38.8%) had Factor V Leiden, 63 (52.1%) had MTHFR gene mutations, 32 (26.4%) had PAI-1 and 12 (9.9%) had FXIII gene mutations. When the D-dimer values of both groups were examined 20-35 days after admission to the hospital, the D-dimer level of the hereditary thrombophilia group was 667.26 ±354.11 while the D-dimer level of the control group was 369.76±173.45 (P=0.031). The D-dimer level of 23 patients in the hereditary thrombophilia group and 2 patients without thrombophilia were found to be above 1000ng/ml when they came for control. Conclusion: It should be kept in mind that if there is prolonged or newly emerging D-dimer elevation in patients who had COVID-19 disease with mild-moderate symptoms, these patients may have hereditary thrombophilia.
Aim: The aim of this study was to investigate concordance between polymerase chain reaction (PCR)... more Aim: The aim of this study was to investigate concordance between polymerase chain reaction (PCR) test results and early thorax computed tomography (CT) findings of the patients in whom coronavirus disease 2019 (COVID-19) was suspected after evaluation of their complaints and physical examination findings. Material and Methods: One hundred and fourteen patients with suspicion of COVID-19, evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) existence with PCR test and performed thorax CT in the first 48 hours, between April and July 2020, were enrolled in this study retrospectively. Demographic characteristics, laboratory parameters and thorax CT findings of PCR positive and negative patients were compared. If patients had negative PCR test results, but clinical suspicion for COVID-19 persisted, additional PCR samples were tested at 48-hour intervals. Results: Interlobular septal thickening was more frequent in PCR positive patients (p=0.043). There was no significant thorax CT finding in 16 (28.6%) PCR positive and 14 (24.1%) PCR negative patients. Bilateral, peripheral and multilobar ground glass opacifications, consolidation and interlobular septal thickening were the most frequent findings in both groups. Neutrophil (p<0.001) and platelet counts (p=0.038) were significantly lower in PCR positive group. Conclusion: The thorax CT findings of the patients whose PCR tests were positive or negative were greatly similar except for interlobular septal thickening, thus thorax CT should not be used alone in the diagnosis of COVID-19 especially in early stages. In decision making, symptoms, laboratory and CT findings and PCR tests of patients must be evaluated all together. © 2020, Duzce University Medical School. All rights reserved
Lokman Hekim Health Sciences, 2021
Introduction: To determine the changes in mean platelet volume (MPV) and the neutrophil/lymphocyt... more Introduction: To determine the changes in mean platelet volume (MPV) and the neutrophil/lymphocyte ratio (NLR) in activation period among patients with ulcerative colitis (UC). Methods: Overall, 83 patients (49 female and 34 male) diagnosed with UC were retrospectively screened and includ- ed in this study. The complete blood count results, including hemoglobin, white blood cell (WBC) count, NLR, platelet count, and MPV, of all patients were recorded in both activation and remission periods. The serum C-reactive protein (CRP) and sedimentation levels of all patients were also recorded. Endoscopic disease activities (endoscopic activity index (EAI)) were also noted. Results: Compared with the remission periods, MPV values were statistically significantly lower (p=0.023) and NLR values were statistically significantly higher (p=0.011) in activation periods. In the correlation analysis, MPV levels were correlated with disease age (p=0.019), hemoglobin (p=0.012), WBC count (p=0.009), pl...
Hitit Medical Journal, 2021
Amaç: Uzun yıllardır kullanılan ucuz, kolay ve hızlı bir test olan sedimantasyon hala birçok duru... more Amaç: Uzun yıllardır kullanılan ucuz, kolay ve hızlı bir test olan sedimantasyon hala birçok durumda tanıya yardımcı olmaktadır. Bu çalışmada, sağlıklı bireylerde sedimantasyon, kolesterol değerleri ve monosit yüksek dansiteli lipoprotein oranı (MHR) ile vücut kitle indeksi arasındaki ilişki değerlendirilmiştir. Gereç ve Yöntem: Ocak 2020 ile Aralık 2020 tarihleri arasında; iç hastalıkları kliniğine belirgin şikayeti olmadan, rutin sağlık kontrolü ve checkup için başvuran 689 sağlıklı bireylerin sonuçları retrospektif olarak değerlendirilmiştir. Hastaların demografik özellikleri, vücut kitle indeksi ve kan parametreleri değerlendirilmiştir. Katılımcılar; vücut kitle indeksine göre; Grup 1 (normal kilolu), Grup 2 (aşırı kilolu) ve Grup 3 (obez) olarak sınıflandırılmıştır. Bulgular: Gruplar arasında; vücut kitle indeksi ile; boy, kilo, sedimantasyon değeri, glikoz, monosit sayısı, total kolesterol, düşük dansiteli lipoprotein, yüksek dansiteli lipoprotein dışı kolesterol ve MHR arasında anlamlı bir ilişki saptanmıştır. Kadınların sedimantasyon değeri erkeklerden anlamlı olarak fazla saptanmıştır. Vücut kitle indeksi ile sedimantasyon değeri (r=0.346, p=0.001), glikoz (r=0.239, p=0.001) ve monosit sayısı (r=0.096, p=0.013) arasında anlamlı bir korelasyon bulunmuştur. Sonuç: Bu çalışmanın neticelerine göre sedimantasyon hızı sağlıklı bireylerde VKI ile ilişkili bir parametre olarak sağlıklı bireylerde inflamasyon şiddetini göstermek için kullanılabilir. Sedimantasyon değeri yüzyıl önce bulunmasına rağmen kullanışlılığını devam ettirmektedir.
Lokman Hekim Health Sciences, 2021
Introduction: To determine the Helicobacter pylori (H. pylori) eradication rates with a quadruple... more Introduction: To determine the Helicobacter pylori (H. pylori) eradication rates with a quadruple treatment regimen consisted of pantoprazole, bismuth subcitrate, metronidazole, and amoxicillin for 14 days in a country with high metronidazole and clarithromycin resistance rates. Methods: All patients were prescribed 14-day quadruple therapy (pantoprazole 40 mg twice daily, bismuth subcitrate 600 mg 2 × 1, amoxicillin 1 g twice daily, and Metronidazole 500 mg three times a day, for 14 days). The success rates of eradication treatment were investigated with stool H. pylori antigen test performed 2 months after eradication. Results: Among 132 H. pylori-infected treatment-naive patients, 8 (6.0%) patients could not complete the study due to adverse events or lost from the follow up. Among 124 patients who completed the study, 10 patients presented with a positive result on stool H. pylori antigen testing at 8 th week, while in remaining 114 cases, the test result was negative. In intention to treat analysis, the eradication rate was determined as 86.4% (95% confidence interval [CI]=81.2%-92.3%), while in per-protocol analysis, the eradication rate was 91.9% (95% CI=88.2%-96.1%). Discussion and Conclusion: With low adverse events and high compliance rates, this treatment modality should be kept in mind for H. pylori eradication especially in regions with high clarithromycin resistance.
American Journal of Clinical Pathology, 2009
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor derived from interdigitating dendri... more Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor derived from interdigitating dendritic cells. Three cases of IDCS associated with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have been described, but no clonal relationship between the 2 neoplasms was demonstrated. We present a detailed case analysis of a CLL/SLL with metachronous IDCS and demonstrate that these 2 neoplasms are clonally related. The IDCS and CLL cells had trisomy 12 and identical monoclonal immunoglobulin heavy chain gene rearrangements. Analysis of transcription factors with a role in myeloid differentiation demonstrated PU.1 up-regulation and C/EBPα down-regulation in IDCS compared with CLL. High-density array comparative genomic hybridization also identified gains in part of chromosome 16q in IDCS. Our study demonstrates for the first time clonal transformation of CLL/SLL into IDCS. This phenomenon may be triggered by alterations in lineage-determining transcription programs, whi...