kamuran tekin - Academia.edu (original) (raw)

Papers by kamuran tekin

Kardiologia Polska, 2014

Background: Optimisation of atrioventricular (AV) delay time has positive effects on left ventric... more Background: Optimisation of atrioventricular (AV) delay time has positive effects on left ventricular (LV) functions in patients with a DDD pacemaker. However, the method used for optimisation is still debated. Aim: To evaluate the effect of different AV delay times on various LV systolic performances by using automated functional imaging (AFI) in patients with a DDD pacemaker and preserved LV systolic function. Methods: The study population consisted of 40 patients with a DDD pacemaker implanted for third degree AV block and preserved LV systolic function (19 men; mean age 64.3 ± 10.9 years). During each pacing period, blood samples were taken for the measurement of B-type natriuretic peptide (BNP) levels, and telemetric and echocardiographic evaluations were performed to all patients. Also peak systolic global longitudinal strain (PSGLS) was calculated using the AFI method. Results: No significant differences except for LV outflow tract-velocity time integral (LVOT-VTI) were observed in pulse wave Doppler parameters with different AV delay times. PSGLS were better at 150 and 200 ms AV delay times compared to 100 ms (p < 0.001 for 100-150 ms and 100-200 ms). Similarly, LVOT-VTI values were significantly higher at 150 and 200 ms AV delay times compared to 100 ms (for 100-150 ms, p = 0.017 and for 100-200 ms, p = 0.013). Also there was a significant reduction in BNP levels at 150 ms and 200 ms compared to 100 ms AV delay time (for 100-150 ms, p = 0.001, and for 100-200 ms, p < 0.001). Conclusions: In patients with an implanted DDD pacemaker and preserved LV systolic function, increasing AV delay time has beneficial effects on LV systolic performance in the acute phase, as shown by the AFI method in our study.

Korean Circulation Journal, 2013

Background and Objectives: We have intended to investigate the influence of the timing of invasiv... more Background and Objectives: We have intended to investigate the influence of the timing of invasive procedures on all-cause mortality, recurrent myocardial infarction (MI), re-hospitalization due to cardiac causes and left ventricular function over a 3-month period among patients with Non-ST-elevation myocardial infarction (NSTEMI). Subjects and Methods: A total of 131 NSTEMI patients with moderate-high Thrombolysis in Myocardial Infarction risk scores, who had been admitted to our department between July 2011-December 2011 were included in our study. They had been randomized into 2 groups according to the timing of the percutaneous coronary intervention (PCI). Patient undergoing PCI in the first 24 hours of hospitalization were named the "Early Invasive Group" and those undergoing PCI between 24-72 hours of hospitalization were named the "Delayed Invasive Group". All patients were followed up for 3 months. Results: Third month left ventricular ejection fraction (LVEF) values were higher in the early invasive group (59.9±6.0% vs. 54.1±8.7%; p<0.001). Recurrent MI rates were lower in the early invasive group (2.9% vs. 14.5%; p=0.016). Similarly, hospitalization rates due to cardiac events were lower in the early invasive group (8.7% vs. 30.6%; p=0.001). All cause mortality appeared to be lower in the early invasive group, although not to a statistically significant degree (0% vs. 4.8%; p=0.065). Conclusion: The early invasive strategy appears to be more effective for the reduction of recurrent MI, re-hospitalization due to cardiac events, and the preservation of 3rd month LVEF in patients with moderate-high risk NSTEMI when compared to a delayed invasive strategy.

Neutrophil-to-Lymphocyte Ratio is Associated With Severity of Coronary Artery Ectasia

Angiology, 2013

We investigated the association between coronary artery ectasia (CAE) and Neutrophil-to-lymphocyt... more We investigated the association between coronary artery ectasia (CAE) and Neutrophil-to-lymphocyte ratio (NLR), an indicator of the inflammatory state. The study population included 434 patients (247 males, mean age 62 ± 10 years) including 230 patients with isolated CAE and 104 patients with coronary artery disease and 100 patientss with normal coronary arteries. The NLR was measured at admission and 30 days after coronary angiography in all the patients. The NLR was significantly higher in patients with CAE than those with normal coronary arteries (2.2 ± 0.6-1.3 ± 0.6, P < .001). Linear regression analyses revealed that NLR (coefficient β = −.61, P < .001) was significantly associated with severity of CAE. The NLR is significantly higher in patients with CAE compared to controls with normal coronary arteries, and NLR is associated with severity of CAE.

Relation Between Serum Uric Acid Levels and Severity of Coronary Artery Disease in Patients with Stable Coronary Artery Disease

Urik asit (UA), kardiyovaskuler hastalik icin bagimsiz risk faktorudur. Bu calismanin amaci koron... more Urik asit (UA), kardiyovaskuler hastalik icin bagimsiz risk faktorudur. Bu calismanin amaci koroner arter hastaligi siddeti (KAH) ile serum UA arasindaki iliskiyi arastirmaktir. Koroner anjiyografiye giden stabl KAH olan 106 hasta (yas ortalamasi ± S.D: 57.6±9.5 yil) ve saglikli 30 hasta kontrol grubu (ortalama) yas ± SD: 56.7±6.6 yil) bu calismaya dahil edildi. Islem oncesi her hastaya UA ve kreatinin duzeyi, aclik lipid profili ve kan sekeri olculdu. KAH siddeti syntax skoru (SS) ile tayin edildi. SS yonun- den hastalar 3 gruba ayrildi (en dusuk, orta ve en yuksek SS). En yuksek SSli hastalarda UA duzeyleri, orta (en dusuk ve kontrol gruplarina gore) ile mukayese de daha yuksekti (her biri icin p<0.001). Orta SSli hastalarin UA duzeyleri, en dusuk SS lilere benzerdi (P=0.521) fakat kontrol grubu ile mukayesede cok daha yuksekti (p<0.001). En dusuk SS li hastalarin UA duzeyleri kontrol grubundan daha yuksekti (P<0.001). SS degeri, bivariate analizde UA ile korrele idi (P&l...

Association Between Uric Acid and Coronary Collateral Circulation in Patients With Stable Coronary Artery Disease

Angiology, 2014

Serum uric acid (SUA) levels have been proposed as a biomarker of coronary artery disease (CAD) a... more Serum uric acid (SUA) levels have been proposed as a biomarker of coronary artery disease (CAD) and coronary collateral circulation (CCC). We investigated the association between SUA levels and development of CCC in patients with stable CAD. Consecutive patients (n = 480) with stable CAD who underwent coronary angiography and documented total occlusion in 1 of the major coronary arteries were included in this study. Levels of fasting blood glucose, white blood cell (WBC), creatinine, platelet count, and SUA were significantly higher in patients with poor CCC than in those with good CCC. After multivariate analysis, high levels of SUA were an independent predictor of CCC together with levels of fasting blood glucose and WBC. The receiver-operating characteristic analysis provided a cutoff value of 5.65 mg/dL for SUA to predict poor CCC with 60% sensitivity and 66% specificity. High levels of SUA may be associated with poor CCC in patients with stable CAD.

Kardiologia Polska, 2014

Background: Optimisation of atrioventricular (AV) delay time has positive effects on left ventric... more Background: Optimisation of atrioventricular (AV) delay time has positive effects on left ventricular (LV) functions in patients with a DDD pacemaker. However, the method used for optimisation is still debated. Aim: To evaluate the effect of different AV delay times on various LV systolic performances by using automated functional imaging (AFI) in patients with a DDD pacemaker and preserved LV systolic function. Methods: The study population consisted of 40 patients with a DDD pacemaker implanted for third degree AV block and preserved LV systolic function (19 men; mean age 64.3 ± 10.9 years). During each pacing period, blood samples were taken for the measurement of B-type natriuretic peptide (BNP) levels, and telemetric and echocardiographic evaluations were performed to all patients. Also peak systolic global longitudinal strain (PSGLS) was calculated using the AFI method. Results: No significant differences except for LV outflow tract-velocity time integral (LVOT-VTI) were observed in pulse wave Doppler parameters with different AV delay times. PSGLS were better at 150 and 200 ms AV delay times compared to 100 ms (p < 0.001 for 100-150 ms and 100-200 ms). Similarly, LVOT-VTI values were significantly higher at 150 and 200 ms AV delay times compared to 100 ms (for 100-150 ms, p = 0.017 and for 100-200 ms, p = 0.013). Also there was a significant reduction in BNP levels at 150 ms and 200 ms compared to 100 ms AV delay time (for 100-150 ms, p = 0.001, and for 100-200 ms, p < 0.001). Conclusions: In patients with an implanted DDD pacemaker and preserved LV systolic function, increasing AV delay time has beneficial effects on LV systolic performance in the acute phase, as shown by the AFI method in our study.

Korean Circulation Journal, 2013

Background and Objectives: We have intended to investigate the influence of the timing of invasiv... more Background and Objectives: We have intended to investigate the influence of the timing of invasive procedures on all-cause mortality, recurrent myocardial infarction (MI), re-hospitalization due to cardiac causes and left ventricular function over a 3-month period among patients with Non-ST-elevation myocardial infarction (NSTEMI). Subjects and Methods: A total of 131 NSTEMI patients with moderate-high Thrombolysis in Myocardial Infarction risk scores, who had been admitted to our department between July 2011-December 2011 were included in our study. They had been randomized into 2 groups according to the timing of the percutaneous coronary intervention (PCI). Patient undergoing PCI in the first 24 hours of hospitalization were named the "Early Invasive Group" and those undergoing PCI between 24-72 hours of hospitalization were named the "Delayed Invasive Group". All patients were followed up for 3 months. Results: Third month left ventricular ejection fraction (LVEF) values were higher in the early invasive group (59.9±6.0% vs. 54.1±8.7%; p<0.001). Recurrent MI rates were lower in the early invasive group (2.9% vs. 14.5%; p=0.016). Similarly, hospitalization rates due to cardiac events were lower in the early invasive group (8.7% vs. 30.6%; p=0.001). All cause mortality appeared to be lower in the early invasive group, although not to a statistically significant degree (0% vs. 4.8%; p=0.065). Conclusion: The early invasive strategy appears to be more effective for the reduction of recurrent MI, re-hospitalization due to cardiac events, and the preservation of 3rd month LVEF in patients with moderate-high risk NSTEMI when compared to a delayed invasive strategy.

Neutrophil-to-Lymphocyte Ratio is Associated With Severity of Coronary Artery Ectasia

Angiology, 2013

We investigated the association between coronary artery ectasia (CAE) and Neutrophil-to-lymphocyt... more We investigated the association between coronary artery ectasia (CAE) and Neutrophil-to-lymphocyte ratio (NLR), an indicator of the inflammatory state. The study population included 434 patients (247 males, mean age 62 ± 10 years) including 230 patients with isolated CAE and 104 patients with coronary artery disease and 100 patientss with normal coronary arteries. The NLR was measured at admission and 30 days after coronary angiography in all the patients. The NLR was significantly higher in patients with CAE than those with normal coronary arteries (2.2 ± 0.6-1.3 ± 0.6, P < .001). Linear regression analyses revealed that NLR (coefficient β = −.61, P < .001) was significantly associated with severity of CAE. The NLR is significantly higher in patients with CAE compared to controls with normal coronary arteries, and NLR is associated with severity of CAE.

Relation Between Serum Uric Acid Levels and Severity of Coronary Artery Disease in Patients with Stable Coronary Artery Disease

Urik asit (UA), kardiyovaskuler hastalik icin bagimsiz risk faktorudur. Bu calismanin amaci koron... more Urik asit (UA), kardiyovaskuler hastalik icin bagimsiz risk faktorudur. Bu calismanin amaci koroner arter hastaligi siddeti (KAH) ile serum UA arasindaki iliskiyi arastirmaktir. Koroner anjiyografiye giden stabl KAH olan 106 hasta (yas ortalamasi ± S.D: 57.6±9.5 yil) ve saglikli 30 hasta kontrol grubu (ortalama) yas ± SD: 56.7±6.6 yil) bu calismaya dahil edildi. Islem oncesi her hastaya UA ve kreatinin duzeyi, aclik lipid profili ve kan sekeri olculdu. KAH siddeti syntax skoru (SS) ile tayin edildi. SS yonun- den hastalar 3 gruba ayrildi (en dusuk, orta ve en yuksek SS). En yuksek SSli hastalarda UA duzeyleri, orta (en dusuk ve kontrol gruplarina gore) ile mukayese de daha yuksekti (her biri icin p<0.001). Orta SSli hastalarin UA duzeyleri, en dusuk SS lilere benzerdi (P=0.521) fakat kontrol grubu ile mukayesede cok daha yuksekti (p<0.001). En dusuk SS li hastalarin UA duzeyleri kontrol grubundan daha yuksekti (P<0.001). SS degeri, bivariate analizde UA ile korrele idi (P&l...

Association Between Uric Acid and Coronary Collateral Circulation in Patients With Stable Coronary Artery Disease

Angiology, 2014

Serum uric acid (SUA) levels have been proposed as a biomarker of coronary artery disease (CAD) a... more Serum uric acid (SUA) levels have been proposed as a biomarker of coronary artery disease (CAD) and coronary collateral circulation (CCC). We investigated the association between SUA levels and development of CCC in patients with stable CAD. Consecutive patients (n = 480) with stable CAD who underwent coronary angiography and documented total occlusion in 1 of the major coronary arteries were included in this study. Levels of fasting blood glucose, white blood cell (WBC), creatinine, platelet count, and SUA were significantly higher in patients with poor CCC than in those with good CCC. After multivariate analysis, high levels of SUA were an independent predictor of CCC together with levels of fasting blood glucose and WBC. The receiver-operating characteristic analysis provided a cutoff value of 5.65 mg/dL for SUA to predict poor CCC with 60% sensitivity and 66% specificity. High levels of SUA may be associated with poor CCC in patients with stable CAD.