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Cancer Prevention Research, 2015
Importance: In recent years, several studies have suggested effectiveness of green tea catechins ... more Importance: In recent years, several studies have suggested effectiveness of green tea catechins in prostate cancer (PCa) chemoprevention. With the exception of one trial from Italy, this has not been further tested in a randomized trial setting in high-risk men with atypical small acinar proliferation (ASAP) or high grade prostatic intraepithelial neoplasia (HGPIN). Objective: To determine whether the daily consumption of a standardized formulation of green tea catechins (Polyphenon E) supplement for 1 year reduces the rate of progression to PCa in men, diagnosed with HGPIN or ASAP. Additional objectives were to evaluate tolerance, lower urinary tract symptoms (LUTS) and quality of life (QOL). Design, setting and participants: A randomized, double-blinded trial was conducted from September 2008 to March 2014 at medical centers in the US targeting 97 men diagnosed HGPIN or ASAP, randomized to treatment (n=49) or control arm (n=48). Supplement or placebo was initiated within 3 months...
Cancer prevention research (Philadelphia, Pa.), Jan 14, 2015
Preclinical, epidemiological and prior clinical trial data suggest that green tea catechins (GTCs... more Preclinical, epidemiological and prior clinical trial data suggest that green tea catechins (GTCs) may reduce prostate cancer (PCa) risk. We conducted a placebo-controlled, randomized clinical trial of Polyphenon E® (PolyE), a proprietary mixture of GTCs, containing 400 mg (-)-epigallocatechin-3-gallate (EGCG) per day, in 97 men with high-grade prostatic intraepithelial neoplasia (HGPIN) and/or atypical small acinar proliferation (ASAP). The primary study endpoint was a comparison of the cumulative one-year PCa rates on the two study arms. No differences in the number of PCa cases were observed: 5/49 (PolyE) versus 9/48 (placebo), P=0.25. A secondary endpoint comparing the cumulative rate of PCa plus ASAP among men with HGPIN without ASAP at baseline, revealed a decrease in this composite endpoint: 3/26 (PolyE) versus 10/25 (placebo), P<0.024. This finding was driven by a decrease in ASAP diagnoses on the Poly E (0/26) compared to the placebo arm (5/25). A decrease in serum prost...
Reference and User Services Quarterly, 2000
You've heard the pitch about how big the Web is-some 380 million pages and counting. But did you ... more You've heard the pitch about how big the Web is-some 380 million pages and counting. But did you know that there is a virtual treasure trove of information that is not visible through the traditional search engines? Did you know that there are thousands of searchable databases, archives, and other information sources delivering highly targeted information for a much improved searching experience?-The Invisible Web Catalog on the Lycos Network Search engines Find Web sites, Web pages, and in some cases, specified types of documents. Some provide more comprehensive results while others provide more precise results. However, what most search engines rarely find are records in databases. increasingly, valuable sorts of information reside in databases and remain out of reach of standard search tools. This reality is becoming more apparent and getting increasing press among would-be power searchers. Web sites are popping up to address the issue and point researchers in the right direction. Conferences are offering workshops on ''The Invisible Web.
Cancer Prevention Research, 2015
Importance: In recent years, several studies have suggested effectiveness of green tea catechins ... more Importance: In recent years, several studies have suggested effectiveness of green tea catechins in prostate cancer (PCa) chemoprevention. With the exception of one trial from Italy, this has not been further tested in a randomized trial setting in high-risk men with atypical small acinar proliferation (ASAP) or high grade prostatic intraepithelial neoplasia (HGPIN). Objective: To determine whether the daily consumption of a standardized formulation of green tea catechins (Polyphenon E) supplement for 1 year reduces the rate of progression to PCa in men, diagnosed with HGPIN or ASAP. Additional objectives were to evaluate tolerance, lower urinary tract symptoms (LUTS) and quality of life (QOL). Design, setting and participants: A randomized, double-blinded trial was conducted from September 2008 to March 2014 at medical centers in the US targeting 97 men diagnosed HGPIN or ASAP, randomized to treatment (n=49) or control arm (n=48). Supplement or placebo was initiated within 3 months...
Cancer prevention research (Philadelphia, Pa.), Jan 14, 2015
Preclinical, epidemiological and prior clinical trial data suggest that green tea catechins (GTCs... more Preclinical, epidemiological and prior clinical trial data suggest that green tea catechins (GTCs) may reduce prostate cancer (PCa) risk. We conducted a placebo-controlled, randomized clinical trial of Polyphenon E® (PolyE), a proprietary mixture of GTCs, containing 400 mg (-)-epigallocatechin-3-gallate (EGCG) per day, in 97 men with high-grade prostatic intraepithelial neoplasia (HGPIN) and/or atypical small acinar proliferation (ASAP). The primary study endpoint was a comparison of the cumulative one-year PCa rates on the two study arms. No differences in the number of PCa cases were observed: 5/49 (PolyE) versus 9/48 (placebo), P=0.25. A secondary endpoint comparing the cumulative rate of PCa plus ASAP among men with HGPIN without ASAP at baseline, revealed a decrease in this composite endpoint: 3/26 (PolyE) versus 10/25 (placebo), P<0.024. This finding was driven by a decrease in ASAP diagnoses on the Poly E (0/26) compared to the placebo arm (5/25). A decrease in serum prost...
Reference and User Services Quarterly, 2000
You've heard the pitch about how big the Web is-some 380 million pages and counting. But did you ... more You've heard the pitch about how big the Web is-some 380 million pages and counting. But did you know that there is a virtual treasure trove of information that is not visible through the traditional search engines? Did you know that there are thousands of searchable databases, archives, and other information sources delivering highly targeted information for a much improved searching experience?-The Invisible Web Catalog on the Lycos Network Search engines Find Web sites, Web pages, and in some cases, specified types of documents. Some provide more comprehensive results while others provide more precise results. However, what most search engines rarely find are records in databases. increasingly, valuable sorts of information reside in databases and remain out of reach of standard search tools. This reality is becoming more apparent and getting increasing press among would-be power searchers. Web sites are popping up to address the issue and point researchers in the right direction. Conferences are offering workshops on ''The Invisible Web.