kashif ali - Academia.edu (original) (raw)

Papers by kashif ali

Indian Journal of Forensic and Community Medicine

Ars Combinatoria -Waterloo then Winnipeg-

2009 IEEE 34th Conference on Local Computer Networks, 2009

Abstract—Intelligent Transportation Systems (ITS) in the form of Vehicular Adhoc NETworks (VANETs... more Abstract—Intelligent Transportation Systems (ITS) in the form of Vehicular Adhoc NETworks (VANETs) have engaged sig-nificant interest from the academic, industry and government sectors. Data dissemination is of the utmost importance for the day-to-day operation of ITS ...

Successful Strategies to Generate and Analyze Metabolic Data, 2013

32nd IEEE Conference on Local Computer Networks (LCN 2007), 2007

Abstract—Denial of Service (DoS) attacks impose an increas-ingly growing threat to the Internet. ... more Abstract—Denial of Service (DoS) attacks impose an increas-ingly growing threat to the Internet. These attacks result in wastage of scarce Internet resources and service disruptions. Existing packet filtering schemes are deployable at either source, ...

Tumor Biology, 2014

Your article is protected by copyright and all rights are held exclusively by International Socie... more Your article is protected by copyright and all rights are held exclusively by International Society of Oncology and BioMarkers (ISOBM). This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com".

Plant Physiology and Biochemistry, 2014

Grapes are economically the most important fruit worldwide. However, the complexity of biological... more Grapes are economically the most important fruit worldwide. However, the complexity of biological events that lead to ripening of nonclimacteric fruits is not fully understood, particularly the role of polyamines' catabolism. The transcriptional and metabolic profilings complemented with biochemical data were studied during ripening of Trincadeira grapes submitted to guazatine treatment, a potent inhibitor of polyamine oxidase activity. The mRNA expression profiles of one time point (EL 38) corresponding to harvest stage was compared between mock and guazatine treatments using Affymetrix GrapeGen(®) genome array. A total of 2113 probesets (1880 unigenes) were differentially expressed between these samples. Quantitative RT-PCR validated microarrays results being carried out for EL 35 (véraison berries), EL 36 (ripe berries) and EL 38 (harvest stage berries). Metabolic profiling using HPLC and (1)H NMR spectroscopy showed increase of putrescine, proline, threonine and 1-O-ethyl-β-glucoside in guazatine treated samples. Genes involved in amino acid, carbohydrate and water transport were down-regulated in guazatine treated samples suggesting that the strong dehydrated phenotype obtained in guazatine treated samples may be due to impaired transport mechanisms. Genes involved in terpenes' metabolism were differentially expressed between guazatine and mock treated samples. Altogether, results support an important role of polyamine catabolism in grape ripening namely in cell expansion and aroma development.

Metabolomics, 2013

ABSTRACT Marine sponges are relatively less explored for their chemical features but highly antic... more ABSTRACT Marine sponges are relatively less explored for their chemical features but highly anticipated resource for bioactive compounds. In this paper we report the screening of marine sponges crude extracts for their potential to bind the adenosine A1 receptor. Many samples showed very promising activity and in order to identify the active components, a metabolomics-chemometrics approach is employed. Nuclear magnetic resonance spectroscopy is used for the metabolic profiling of the marine sponges and partial least squares (PLS) and orthogonal PLS (OPLS) algorithms are used to correlate the metabolomics with bioactivity data. Using several two dimensional-NMR techniques, the resonances responsible for the separation of high activity samples from the medium and low activity samples were identified as associated to metabolites like halisulfate 1, halisulfate 3–5, and suvanine (1–5), all belongs to sesterterpenes class. The reference compounds for these metabolites are also tested for the activity, which endorse the findings of the applied methodology.

Metabolomics, 2012

The identification of active ingredients in crude plant extracts offers great advantages. In this... more The identification of active ingredients in crude plant extracts offers great advantages. In this study, nuclear magnetic resonance and chemometrics were used for the screening of in vitro anti-TNFa activity in different berry types. Solid phase extraction was applied and the resulting water, methanol-water (1:1), and methanol fractions were tested for the activity. The methanol-water fraction contained most of the phenolics and showed significantly higher activity than the other two fractions. In the second phase of this study, grapes from 'Trincadeira', 'Touriga Nacional', and 'Aragonês', at four developmental stages were metabolically classified and tested for the TNFa inhibition. The initial stages of grape development, green and veraison, were found more active against TNFa production as compared to the later ripe and harvest stages. Among the cultivars, 'Touriga Nacional' was found to be the most potent inhibitor. Different multivariate data analyses algorithms based on projections to latent structures were applied to correlate the NMR and TNFa inhibition data. The variable importance in the projections plot showed that phenolics like quercetin, myricetin, (?)catechin, (-)-epicatechin, caftarate, and coutarate, were positively correlated with high activity. This work demonstrates the great potential of NMR spectroscopy in combination with chemometrics for the screening of large set of crude extracts, to study the effects of different variables on the activity, and identifying active compounds in complex mixtures like plant extracts. Keywords Grapes Á Developmental stages Á NMR spectroscopy Á Chemometrics Á Anti-TNFa activity Á PLS modeling Kashif Ali and Muzamal Iqbal are considered as the co-first authors.

IET Computers & Digital Techniques, 2008

Modern microprocessors dedicate a large portion of the chip area to the cache. Decreasing the ene... more Modern microprocessors dedicate a large portion of the chip area to the cache. Decreasing the energy consumption of the microprocessor, which is a very important design goal especially for small, battery powered, devices, depends on decreasing the energy consumption of the memory/cache system in the microprocessor. The authors investigate the energy consumption in caches and present a novel cache architecture for reduced energy instruction caches. Our cache architecture consists of the L1 cache, multiple line buffers and a prediction mechanism to predict which line buffer, or L1 cache, to access next. In the proposed technique, the authors use the multiple line buffers as a continuous small filter cache that can catch most of the cache access but they access only a single line buffer, thus reducing the energy consumption of the cache. They used simulation to evaluate the proposed architecture and to compare it with the HotSpot cache, filter cache and single line buffer cache. Simulation results show that the approach is slightly faster than the above mentioned caches, and it consumes considerably less energy than any of these cache architectures.

Ethiopian Journal of …, 1997

For given graphs G and H, the Ramsey number R(G, H) is the least natural number n such that for e... more For given graphs G and H, the Ramsey number R(G, H) is the least natural number n such that for every graph F of order n the following condition holds: either F contains G or the complement of F contains H. Beaded wheel BW2,m is a graph of order 2m + 1 which is obtained by inserting a new vertex in each spoke of the wheel W m. In this paper, we determine the Ramsey number of paths versus Beaded wheels: R(P n , BW 2,m) = 2n − 1 or 2n if m ≥ 3 is even or odd, respectively, provided n ≥ 2m 2 − 5m + 4.

The study of classical Ramsey numbers R(mn) shows little progress in the last two decades. Only n... more The study of classical Ramsey numbers R(mn) shows little progress in the last two decades. Only nine classical Ramsey numbers are known. This diculty ofnding the classical Ramsey numbers has inspired many people to study generalizations of classical Ramsey number. One of ...

research.cs.queensu.ca

Tag collisions can impose a major delay in Radio Frequency IDentifi-cation (RFID) systems. Such c... more Tag collisions can impose a major delay in Radio Frequency IDentifi-cation (RFID) systems. Such collisions are hard to overcome with passive tags due to their limited capabilities. In this paper, we look into the problem of minimizing the time required to read ...

Pakistan Journal of Botany, 2007

Croton (Codiaeum variegatum) with its amazing colors and leathery leaves is regarded as a beautif... more Croton (Codiaeum variegatum) with its amazing colors and leathery leaves is regarded as a beautiful foliage plant. The plant is native of South East Asia. Generally crotons are multiplied vegetatively by means of cuttings and air layering. This process is slow in response and ...

Food Chemistry, 2011

1H nuclear magnetic resonance (NMR) was applied for the metabolic profiling of grapes from three ... more 1H nuclear magnetic resonance (NMR) was applied for the metabolic profiling of grapes from three Portuguese cultivars including ‘Trincadeira’, ‘Aragonês’, and ‘Touriga Nacional’, at four developmental stages. Two kinds of extraction methods including deuterated NMR solvent extraction and solid phase extraction (SPE) were used for the metabolomic analysis and all the metabolites detected in 1H NMR were elucidated by two-dimensional

Indian Journal of Forensic and Community Medicine

Ars Combinatoria -Waterloo then Winnipeg-

2009 IEEE 34th Conference on Local Computer Networks, 2009

Abstract—Intelligent Transportation Systems (ITS) in the form of Vehicular Adhoc NETworks (VANETs... more Abstract—Intelligent Transportation Systems (ITS) in the form of Vehicular Adhoc NETworks (VANETs) have engaged sig-nificant interest from the academic, industry and government sectors. Data dissemination is of the utmost importance for the day-to-day operation of ITS ...

Successful Strategies to Generate and Analyze Metabolic Data, 2013

32nd IEEE Conference on Local Computer Networks (LCN 2007), 2007

Abstract—Denial of Service (DoS) attacks impose an increas-ingly growing threat to the Internet. ... more Abstract—Denial of Service (DoS) attacks impose an increas-ingly growing threat to the Internet. These attacks result in wastage of scarce Internet resources and service disruptions. Existing packet filtering schemes are deployable at either source, ...

Tumor Biology, 2014

Your article is protected by copyright and all rights are held exclusively by International Socie... more Your article is protected by copyright and all rights are held exclusively by International Society of Oncology and BioMarkers (ISOBM). This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com".

Plant Physiology and Biochemistry, 2014

Grapes are economically the most important fruit worldwide. However, the complexity of biological... more Grapes are economically the most important fruit worldwide. However, the complexity of biological events that lead to ripening of nonclimacteric fruits is not fully understood, particularly the role of polyamines' catabolism. The transcriptional and metabolic profilings complemented with biochemical data were studied during ripening of Trincadeira grapes submitted to guazatine treatment, a potent inhibitor of polyamine oxidase activity. The mRNA expression profiles of one time point (EL 38) corresponding to harvest stage was compared between mock and guazatine treatments using Affymetrix GrapeGen(®) genome array. A total of 2113 probesets (1880 unigenes) were differentially expressed between these samples. Quantitative RT-PCR validated microarrays results being carried out for EL 35 (véraison berries), EL 36 (ripe berries) and EL 38 (harvest stage berries). Metabolic profiling using HPLC and (1)H NMR spectroscopy showed increase of putrescine, proline, threonine and 1-O-ethyl-β-glucoside in guazatine treated samples. Genes involved in amino acid, carbohydrate and water transport were down-regulated in guazatine treated samples suggesting that the strong dehydrated phenotype obtained in guazatine treated samples may be due to impaired transport mechanisms. Genes involved in terpenes' metabolism were differentially expressed between guazatine and mock treated samples. Altogether, results support an important role of polyamine catabolism in grape ripening namely in cell expansion and aroma development.

Metabolomics, 2013

ABSTRACT Marine sponges are relatively less explored for their chemical features but highly antic... more ABSTRACT Marine sponges are relatively less explored for their chemical features but highly anticipated resource for bioactive compounds. In this paper we report the screening of marine sponges crude extracts for their potential to bind the adenosine A1 receptor. Many samples showed very promising activity and in order to identify the active components, a metabolomics-chemometrics approach is employed. Nuclear magnetic resonance spectroscopy is used for the metabolic profiling of the marine sponges and partial least squares (PLS) and orthogonal PLS (OPLS) algorithms are used to correlate the metabolomics with bioactivity data. Using several two dimensional-NMR techniques, the resonances responsible for the separation of high activity samples from the medium and low activity samples were identified as associated to metabolites like halisulfate 1, halisulfate 3–5, and suvanine (1–5), all belongs to sesterterpenes class. The reference compounds for these metabolites are also tested for the activity, which endorse the findings of the applied methodology.

Metabolomics, 2012

The identification of active ingredients in crude plant extracts offers great advantages. In this... more The identification of active ingredients in crude plant extracts offers great advantages. In this study, nuclear magnetic resonance and chemometrics were used for the screening of in vitro anti-TNFa activity in different berry types. Solid phase extraction was applied and the resulting water, methanol-water (1:1), and methanol fractions were tested for the activity. The methanol-water fraction contained most of the phenolics and showed significantly higher activity than the other two fractions. In the second phase of this study, grapes from 'Trincadeira', 'Touriga Nacional', and 'Aragonês', at four developmental stages were metabolically classified and tested for the TNFa inhibition. The initial stages of grape development, green and veraison, were found more active against TNFa production as compared to the later ripe and harvest stages. Among the cultivars, 'Touriga Nacional' was found to be the most potent inhibitor. Different multivariate data analyses algorithms based on projections to latent structures were applied to correlate the NMR and TNFa inhibition data. The variable importance in the projections plot showed that phenolics like quercetin, myricetin, (?)catechin, (-)-epicatechin, caftarate, and coutarate, were positively correlated with high activity. This work demonstrates the great potential of NMR spectroscopy in combination with chemometrics for the screening of large set of crude extracts, to study the effects of different variables on the activity, and identifying active compounds in complex mixtures like plant extracts. Keywords Grapes Á Developmental stages Á NMR spectroscopy Á Chemometrics Á Anti-TNFa activity Á PLS modeling Kashif Ali and Muzamal Iqbal are considered as the co-first authors.

IET Computers & Digital Techniques, 2008

Modern microprocessors dedicate a large portion of the chip area to the cache. Decreasing the ene... more Modern microprocessors dedicate a large portion of the chip area to the cache. Decreasing the energy consumption of the microprocessor, which is a very important design goal especially for small, battery powered, devices, depends on decreasing the energy consumption of the memory/cache system in the microprocessor. The authors investigate the energy consumption in caches and present a novel cache architecture for reduced energy instruction caches. Our cache architecture consists of the L1 cache, multiple line buffers and a prediction mechanism to predict which line buffer, or L1 cache, to access next. In the proposed technique, the authors use the multiple line buffers as a continuous small filter cache that can catch most of the cache access but they access only a single line buffer, thus reducing the energy consumption of the cache. They used simulation to evaluate the proposed architecture and to compare it with the HotSpot cache, filter cache and single line buffer cache. Simulation results show that the approach is slightly faster than the above mentioned caches, and it consumes considerably less energy than any of these cache architectures.

Ethiopian Journal of …, 1997

For given graphs G and H, the Ramsey number R(G, H) is the least natural number n such that for e... more For given graphs G and H, the Ramsey number R(G, H) is the least natural number n such that for every graph F of order n the following condition holds: either F contains G or the complement of F contains H. Beaded wheel BW2,m is a graph of order 2m + 1 which is obtained by inserting a new vertex in each spoke of the wheel W m. In this paper, we determine the Ramsey number of paths versus Beaded wheels: R(P n , BW 2,m) = 2n − 1 or 2n if m ≥ 3 is even or odd, respectively, provided n ≥ 2m 2 − 5m + 4.

The study of classical Ramsey numbers R(mn) shows little progress in the last two decades. Only n... more The study of classical Ramsey numbers R(mn) shows little progress in the last two decades. Only nine classical Ramsey numbers are known. This diculty ofnding the classical Ramsey numbers has inspired many people to study generalizations of classical Ramsey number. One of ...

research.cs.queensu.ca

Tag collisions can impose a major delay in Radio Frequency IDentifi-cation (RFID) systems. Such c... more Tag collisions can impose a major delay in Radio Frequency IDentifi-cation (RFID) systems. Such collisions are hard to overcome with passive tags due to their limited capabilities. In this paper, we look into the problem of minimizing the time required to read ...

Pakistan Journal of Botany, 2007

Croton (Codiaeum variegatum) with its amazing colors and leathery leaves is regarded as a beautif... more Croton (Codiaeum variegatum) with its amazing colors and leathery leaves is regarded as a beautiful foliage plant. The plant is native of South East Asia. Generally crotons are multiplied vegetatively by means of cuttings and air layering. This process is slow in response and ...

Food Chemistry, 2011

1H nuclear magnetic resonance (NMR) was applied for the metabolic profiling of grapes from three ... more 1H nuclear magnetic resonance (NMR) was applied for the metabolic profiling of grapes from three Portuguese cultivars including ‘Trincadeira’, ‘Aragonês’, and ‘Touriga Nacional’, at four developmental stages. Two kinds of extraction methods including deuterated NMR solvent extraction and solid phase extraction (SPE) were used for the metabolomic analysis and all the metabolites detected in 1H NMR were elucidated by two-dimensional