Tejal kaur - Academia.edu (original) (raw)

Papers by Tejal kaur

Research paper thumbnail of 0345 Olfactory Dysfunction in Individuals at Risk for Schizophrenia and in First Episode Subjects: A Cross-Sectional Analysis

Schizophrenia Research, Oct 1, 2006

Research paper thumbnail of Attention‐Deficit Hyperactivity Disorder

Research paper thumbnail of Treatment Implications of the Schizophrenia Prodrome

Behavioral Neurobiology of Schizophrenia and Its Treatment, 2010

Research paper thumbnail of Attention‐Deficit Hyperactivity Disorder

Clinical Child Psychiatry, 2012

Research paper thumbnail of Social functioning in young people at risk for schizophrenia

Psychiatry Research, 2007

Deficits in social functioning are potential risk factors for schizophrenia. Social functioning w... more Deficits in social functioning are potential risk factors for schizophrenia. Social functioning was assessed in 55 individuals "at risk" for schizophrenia, 16 first episode patients with schizophrenia and 45 normal comparison subjects. The Social Adjustment Inventory for Children and Adolescents (SAICA) was administered to adolescents <18 and the Social Adjustment Scale (SAS-SR) to young adults >17. The at risk and first episode groups significantly differed from the normal subjects on measures of social functioning in the domains of peer, family, work and school relationships. Individuals at risk for schizophrenia have significant functional deficits which may be potential indicators of increased vulnerability for psychosis.

Research paper thumbnail of New Onset of Psychotic Symptoms in an Adolescent with Pervasive Developmental Disorder, Not Otherwise Specified

Journal of Child and Adolescent Psychopharmacology, 2011

... Full Text: • HTML • PDF for printing (85.7 KB) • PDF w/ links (91 KB). Tejal Kaur, MD, 1, 2. ... more ... Full Text: • HTML • PDF for printing (85.7 KB) • PDF w/ links (91 KB). Tejal Kaur, MD, 1, 2. Zana Dobroshi, MD, Ph.D ... Treatment in Children and Adolescents with Disruptive Behavior Disorders. Gabriele Masi, Azzurra Manfredi, Annarita Milone, Pietro Muratori, Lisa Polidori, Laura ...

Research paper thumbnail of Tricyclic Antidepressants and Monoamine Oxidase Inhibitors

Archives of General Psychiatry, 1971

The combination of a tricyclic and a monoamine oxidase inhibitor (MAOI) has been reported effecti... more The combination of a tricyclic and a monoamine oxidase inhibitor (MAOI) has been reported effective in the treatment of depression but is avoided in this country due to concern over adverse reactions. A review of the case reports on which this concern with morbidity is based reveals no convincing evidence that the antidepressant combination taken in therapeutic doses was responsible for the illness reported. An informal review of 350 outpatients, a record examination of 50 inpatients, and a drug trial with 10 current patients has shown no drug-related morbidity. We conclude that the present evidence does not indicate the combined drug regimen unsafe. A suggestion is made for controlled clinical trials of MAOI-tricyclic antidepressant therapy to evaluate better its clinical effectiveness.

Research paper thumbnail of Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia

Frontiers in Cellular Neuroscience, Feb 23, 2023

Research paper thumbnail of Morphological Biomarkers in the Amygdala and Hippocampus of Children and Adults at High Familial Risk for Depression

Diagnostics, May 12, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia

Frontiers in Cellular Neuroscience

BackgroundWorking memory deficits are thought to be a primary disturbance in schizophrenia. We ai... more BackgroundWorking memory deficits are thought to be a primary disturbance in schizophrenia. We aimed to identify differences in morphology of the hippocampus and amygdala in patients with schizophrenia compared with healthy controls (HCs), and in patients who were either neuropsychologically near normal (NPNN) or neuropsychologically impaired (NPI). Morphological disturbances in the same subfields of the hippocampus and amygdala, but of greater magnitude in those with NPI, would strengthen evidence for the centrality of these limbic regions and working memory deficits in the pathogenesis of schizophrenia.MethodsWe acquired anatomical MRIs in 69 patients with schizophrenia (18 NPNN, 46 NPI) and 63 age-matched HC participants. We compared groups in hippocampus and amygdala surface morphologies and correlated morphological measures with clinical symptoms and working memory scores.ResultsSchizophrenia was associated with inward deformations of the head and tail of the hippocampus, protr...

Research paper thumbnail of Morphological Biomarkers in the Amygdala and Hippocampus of Children and Adults at High Familial Risk for Depression

Diagnostics

Major Depressive Disorder (MDD) is highly familial, and the hippocampus and amygdala are importan... more Major Depressive Disorder (MDD) is highly familial, and the hippocampus and amygdala are important in the pathophysiology of MDD. Whether morphological markers of risk for familial depression are present in the hippocampus or amygdala is unknown. We imaged the brains of 148 individuals, aged 6 to 54 years, who were members of a three-generation family cohort study and who were at either high or low familial risk for MDD. We compared surface morphological features of the hippocampus and amygdala across risk groups and assessed their associations with depression severity. High- compared with low-risk individuals had inward deformations of the head of both hippocampi and the medial surface of the left amygdala. The hippocampus findings persisted in analyses that included only those participants who had never had MDD, suggesting that these are true endophenotypic biomarkers for familial MDD. Posterior extension of the inward deformations was associated with more severe depressive sympto...

Research paper thumbnail of Annual Research Review: Current limitations and future directions in MRI studies of child‐ and adult‐onset developmental psychopathologies

Journal of Child Psychology and Psychiatry, 2014

BackgroundThe widespread use of Magnetic Resonance Imaging (MRI) in the study of child‐ and adult... more BackgroundThe widespread use of Magnetic Resonance Imaging (MRI) in the study of child‐ and adult‐onset developmental psychopathologies has generated many investigations that have measured brain structure and function in vivo throughout development, often generating great excitement over our ability to visualize the living, developing brain using the attractive, even seductive images that these studies produce. Often lost in this excitement is the recognition that brain imaging generally, and MRI in particular, is simply a technology, one that does not fundamentally differ from any other technology, be it a blood test, a genotyping assay, a biochemical assay, or behavioral test. No technology alone can generate valid scientific findings. Rather, it is only technology coupled with a strong experimental design that can generate valid and reproducible findings that lead to new insights into the mechanisms of disease and therapeutic response.MethodsIn this review we discuss selected stu...

Research paper thumbnail of 0345 Olfactory Dysfunction in Individuals at Risk for Schizophrenia and in First Episode Subjects: A Cross-Sectional Analysis

Schizophrenia Research, Oct 1, 2006

Research paper thumbnail of Attention‐Deficit Hyperactivity Disorder

Research paper thumbnail of Treatment Implications of the Schizophrenia Prodrome

Behavioral Neurobiology of Schizophrenia and Its Treatment, 2010

Research paper thumbnail of Attention‐Deficit Hyperactivity Disorder

Clinical Child Psychiatry, 2012

Research paper thumbnail of Social functioning in young people at risk for schizophrenia

Psychiatry Research, 2007

Deficits in social functioning are potential risk factors for schizophrenia. Social functioning w... more Deficits in social functioning are potential risk factors for schizophrenia. Social functioning was assessed in 55 individuals "at risk" for schizophrenia, 16 first episode patients with schizophrenia and 45 normal comparison subjects. The Social Adjustment Inventory for Children and Adolescents (SAICA) was administered to adolescents <18 and the Social Adjustment Scale (SAS-SR) to young adults >17. The at risk and first episode groups significantly differed from the normal subjects on measures of social functioning in the domains of peer, family, work and school relationships. Individuals at risk for schizophrenia have significant functional deficits which may be potential indicators of increased vulnerability for psychosis.

Research paper thumbnail of New Onset of Psychotic Symptoms in an Adolescent with Pervasive Developmental Disorder, Not Otherwise Specified

Journal of Child and Adolescent Psychopharmacology, 2011

... Full Text: • HTML • PDF for printing (85.7 KB) • PDF w/ links (91 KB). Tejal Kaur, MD, 1, 2. ... more ... Full Text: • HTML • PDF for printing (85.7 KB) • PDF w/ links (91 KB). Tejal Kaur, MD, 1, 2. Zana Dobroshi, MD, Ph.D ... Treatment in Children and Adolescents with Disruptive Behavior Disorders. Gabriele Masi, Azzurra Manfredi, Annarita Milone, Pietro Muratori, Lisa Polidori, Laura ...

Research paper thumbnail of Tricyclic Antidepressants and Monoamine Oxidase Inhibitors

Archives of General Psychiatry, 1971

The combination of a tricyclic and a monoamine oxidase inhibitor (MAOI) has been reported effecti... more The combination of a tricyclic and a monoamine oxidase inhibitor (MAOI) has been reported effective in the treatment of depression but is avoided in this country due to concern over adverse reactions. A review of the case reports on which this concern with morbidity is based reveals no convincing evidence that the antidepressant combination taken in therapeutic doses was responsible for the illness reported. An informal review of 350 outpatients, a record examination of 50 inpatients, and a drug trial with 10 current patients has shown no drug-related morbidity. We conclude that the present evidence does not indicate the combined drug regimen unsafe. A suggestion is made for controlled clinical trials of MAOI-tricyclic antidepressant therapy to evaluate better its clinical effectiveness.

Research paper thumbnail of Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia

Frontiers in Cellular Neuroscience, Feb 23, 2023

Research paper thumbnail of Morphological Biomarkers in the Amygdala and Hippocampus of Children and Adults at High Familial Risk for Depression

Diagnostics, May 12, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia

Frontiers in Cellular Neuroscience

BackgroundWorking memory deficits are thought to be a primary disturbance in schizophrenia. We ai... more BackgroundWorking memory deficits are thought to be a primary disturbance in schizophrenia. We aimed to identify differences in morphology of the hippocampus and amygdala in patients with schizophrenia compared with healthy controls (HCs), and in patients who were either neuropsychologically near normal (NPNN) or neuropsychologically impaired (NPI). Morphological disturbances in the same subfields of the hippocampus and amygdala, but of greater magnitude in those with NPI, would strengthen evidence for the centrality of these limbic regions and working memory deficits in the pathogenesis of schizophrenia.MethodsWe acquired anatomical MRIs in 69 patients with schizophrenia (18 NPNN, 46 NPI) and 63 age-matched HC participants. We compared groups in hippocampus and amygdala surface morphologies and correlated morphological measures with clinical symptoms and working memory scores.ResultsSchizophrenia was associated with inward deformations of the head and tail of the hippocampus, protr...

Research paper thumbnail of Morphological Biomarkers in the Amygdala and Hippocampus of Children and Adults at High Familial Risk for Depression

Diagnostics

Major Depressive Disorder (MDD) is highly familial, and the hippocampus and amygdala are importan... more Major Depressive Disorder (MDD) is highly familial, and the hippocampus and amygdala are important in the pathophysiology of MDD. Whether morphological markers of risk for familial depression are present in the hippocampus or amygdala is unknown. We imaged the brains of 148 individuals, aged 6 to 54 years, who were members of a three-generation family cohort study and who were at either high or low familial risk for MDD. We compared surface morphological features of the hippocampus and amygdala across risk groups and assessed their associations with depression severity. High- compared with low-risk individuals had inward deformations of the head of both hippocampi and the medial surface of the left amygdala. The hippocampus findings persisted in analyses that included only those participants who had never had MDD, suggesting that these are true endophenotypic biomarkers for familial MDD. Posterior extension of the inward deformations was associated with more severe depressive sympto...

Research paper thumbnail of Annual Research Review: Current limitations and future directions in MRI studies of child‐ and adult‐onset developmental psychopathologies

Journal of Child Psychology and Psychiatry, 2014

BackgroundThe widespread use of Magnetic Resonance Imaging (MRI) in the study of child‐ and adult... more BackgroundThe widespread use of Magnetic Resonance Imaging (MRI) in the study of child‐ and adult‐onset developmental psychopathologies has generated many investigations that have measured brain structure and function in vivo throughout development, often generating great excitement over our ability to visualize the living, developing brain using the attractive, even seductive images that these studies produce. Often lost in this excitement is the recognition that brain imaging generally, and MRI in particular, is simply a technology, one that does not fundamentally differ from any other technology, be it a blood test, a genotyping assay, a biochemical assay, or behavioral test. No technology alone can generate valid scientific findings. Rather, it is only technology coupled with a strong experimental design that can generate valid and reproducible findings that lead to new insights into the mechanisms of disease and therapeutic response.MethodsIn this review we discuss selected stu...