navroop kaur - Academia.edu (original) (raw)

Papers by navroop kaur

Research paper thumbnail of Multidrug resistance in Pseudomonas aeruginosa isolated from nosocomial respiratory and urinary infections in Aleppo, Syria

The Journal of Infection in Developing Countries, 2015

Introduction: Pseudomonas aeruginosa represents a serious clinical challenge due to its frequent ... more Introduction: Pseudomonas aeruginosa represents a serious clinical challenge due to its frequent involvement in nosocomial infections and its tendency towards multidrug resistance. Methodology: This study uncovered antibiotic susceptibility patterns in 177 isolates from inpatients in three key hospitals in Aleppo, the largest city in Syria. Results: Exceptionally low susceptibility to most routinely used antibiotics was uncovered; resistance to ciprofloxacin and gentamicin was 64.9% and 70.3%, respectively. Contrarily, susceptibility to colistin was the highest (89.1%). Conclusions: Multidrug resistance was rife, found at a rate of 53.67% among studied P. aeruginosa isolates.

Research paper thumbnail of A pandemic associated with novel coronavirus of probable animal origin

Research in Pharmacy and Health Sciences, 2020

Emerging infectious diseases, such as (SARS) Severe Acute Respiratory Syndrome coronavirus and (M... more Emerging infectious diseases, such as (SARS) Severe Acute Respiratory Syndrome coronavirus and (MERS) Middle East Respiratory Syndrome coronavirus, it is the third extremely pathogenic coronavirus which is emerged in the last two decades. Epidemiological investigation recommended that coronavirus outbreak was associated with seafood marked in Wuhan, China. The patient suffering from coronavirus experience various respiratory syndrome symptoms including temperature, faintness and cough. Since, the cause of coronavirus was unknown. The analysis of pneumonia was unidentified, and pneumonia was identifying depending on clinical characteristics, ruling out of common bacterial, viral pathogens and chest imaging that causes pneumonia. Some more cases were confirmed in China, Japan, USA and India. In todays, Wuhan, China there is possibility of SARS-CoV outbreak without any earlier notice. To prevent this epidemic various case from different countries should implement better triage schemes ...

Research paper thumbnail of ACE-2 receptors blockers: A novel therapeutic line of attack against COVID-19

INTERNATIONAL JOURNAL OF PHARMACOLOGY AND THERAPEUTICS, 2020

A novel infectious severe acute respiratory syndrome-like coronavirus (SARS-CoV 2) has caused an ... more A novel infectious severe acute respiratory syndrome-like coronavirus (SARS-CoV 2) has caused an outbreak in Wuhan city, Hubei province, China, starting from December 2019 that swiftly spread across all nations around the world. Comprehending how SARS-CoV-2 enters humans is the first preference for perceiving its enigma and restraining its spread. Coronavirus is a positive-stranded enveloped, pleiomorphic viruses whose surface transmembrane spike protein mediates SARS-CoV2 entry into cells. To attain its purposes, SARS-CoV2 spike binds to its receptor hACE2(human angiotensin-converting enzyme 2) through its receptor-binding domain. But as per the phylogenetic analysis, the coronaviruses has revealed that SARS-CoV2 is a member of the Betacoronavirus genus, which encompasses SARS-CoV, MERS-CoV, SARSr-CoV and as well as others identified in humans and animal species.Bat coronavirus seems to be the closest relative of SARS-CoV2 sharing more than 93.1% sequence identity in the spike (S) gene. SARS-CoV2 shares less than 80% sequence identity with SARS-CoV and SARSr-CoV. Based on crystal structure analysis, the SARS-CoV spike proteins have a strong binding affinity to the human ACE2 receptor.SARS-CoV2 and SARS-CoV spike proteins share 76.5% identity in amino acid sequence, and hence importantly, the SARS-CoV and SARS-CoV2 spike proteins have a high degree of homology. According to the cell entry mechanisms of SARS-CoV2, first, to aid entry into host cells, coronaviruses first bind to the cell surface receptor for viral attachment and ultimately fuse viral and lysosomal membranes to enter the endosomes consequently. The interplay initiates infection when a virus surface anchored homotrimeric spike protein mediates coronavirus entry. However, as per the cell entry mechanisms, the S1 protein consists of RBD(receptor binding domain) that concedes explicitly (ACE-2) receptor. These coronavirus cell entry mechanisms depend upon cellular proteases, which include cell surface proteases TMPRSS2, lysosomal proteases cathepsins and human airway-trypsin like proteases (HAT). These are the features of SARS-CoV-2 entry which contribute to its severe symptoms and high pathogenicity.

Research paper thumbnail of Multidrug resistance in Pseudomonas aeruginosa isolated from nosocomial respiratory and urinary infections in Aleppo, Syria

The Journal of Infection in Developing Countries, 2015

Introduction: Pseudomonas aeruginosa represents a serious clinical challenge due to its frequent ... more Introduction: Pseudomonas aeruginosa represents a serious clinical challenge due to its frequent involvement in nosocomial infections and its tendency towards multidrug resistance. Methodology: This study uncovered antibiotic susceptibility patterns in 177 isolates from inpatients in three key hospitals in Aleppo, the largest city in Syria. Results: Exceptionally low susceptibility to most routinely used antibiotics was uncovered; resistance to ciprofloxacin and gentamicin was 64.9% and 70.3%, respectively. Contrarily, susceptibility to colistin was the highest (89.1%). Conclusions: Multidrug resistance was rife, found at a rate of 53.67% among studied P. aeruginosa isolates.

Research paper thumbnail of A pandemic associated with novel coronavirus of probable animal origin

Research in Pharmacy and Health Sciences, 2020

Emerging infectious diseases, such as (SARS) Severe Acute Respiratory Syndrome coronavirus and (M... more Emerging infectious diseases, such as (SARS) Severe Acute Respiratory Syndrome coronavirus and (MERS) Middle East Respiratory Syndrome coronavirus, it is the third extremely pathogenic coronavirus which is emerged in the last two decades. Epidemiological investigation recommended that coronavirus outbreak was associated with seafood marked in Wuhan, China. The patient suffering from coronavirus experience various respiratory syndrome symptoms including temperature, faintness and cough. Since, the cause of coronavirus was unknown. The analysis of pneumonia was unidentified, and pneumonia was identifying depending on clinical characteristics, ruling out of common bacterial, viral pathogens and chest imaging that causes pneumonia. Some more cases were confirmed in China, Japan, USA and India. In todays, Wuhan, China there is possibility of SARS-CoV outbreak without any earlier notice. To prevent this epidemic various case from different countries should implement better triage schemes ...

Research paper thumbnail of ACE-2 receptors blockers: A novel therapeutic line of attack against COVID-19

INTERNATIONAL JOURNAL OF PHARMACOLOGY AND THERAPEUTICS, 2020

A novel infectious severe acute respiratory syndrome-like coronavirus (SARS-CoV 2) has caused an ... more A novel infectious severe acute respiratory syndrome-like coronavirus (SARS-CoV 2) has caused an outbreak in Wuhan city, Hubei province, China, starting from December 2019 that swiftly spread across all nations around the world. Comprehending how SARS-CoV-2 enters humans is the first preference for perceiving its enigma and restraining its spread. Coronavirus is a positive-stranded enveloped, pleiomorphic viruses whose surface transmembrane spike protein mediates SARS-CoV2 entry into cells. To attain its purposes, SARS-CoV2 spike binds to its receptor hACE2(human angiotensin-converting enzyme 2) through its receptor-binding domain. But as per the phylogenetic analysis, the coronaviruses has revealed that SARS-CoV2 is a member of the Betacoronavirus genus, which encompasses SARS-CoV, MERS-CoV, SARSr-CoV and as well as others identified in humans and animal species.Bat coronavirus seems to be the closest relative of SARS-CoV2 sharing more than 93.1% sequence identity in the spike (S) gene. SARS-CoV2 shares less than 80% sequence identity with SARS-CoV and SARSr-CoV. Based on crystal structure analysis, the SARS-CoV spike proteins have a strong binding affinity to the human ACE2 receptor.SARS-CoV2 and SARS-CoV spike proteins share 76.5% identity in amino acid sequence, and hence importantly, the SARS-CoV and SARS-CoV2 spike proteins have a high degree of homology. According to the cell entry mechanisms of SARS-CoV2, first, to aid entry into host cells, coronaviruses first bind to the cell surface receptor for viral attachment and ultimately fuse viral and lysosomal membranes to enter the endosomes consequently. The interplay initiates infection when a virus surface anchored homotrimeric spike protein mediates coronavirus entry. However, as per the cell entry mechanisms, the S1 protein consists of RBD(receptor binding domain) that concedes explicitly (ACE-2) receptor. These coronavirus cell entry mechanisms depend upon cellular proteases, which include cell surface proteases TMPRSS2, lysosomal proteases cathepsins and human airway-trypsin like proteases (HAT). These are the features of SARS-CoV-2 entry which contribute to its severe symptoms and high pathogenicity.