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Papers by kenji momo

Research paper thumbnail of Association of the ward pharmacy service with active implementation of therapeutic drug monitoring for vancomycin and teicoplanin—an epidemiological surveillance study using Japanese large health insurance claims database

Journal of Pharmaceutical Health Care and Sciences, Aug 18, 2020

Research paper thumbnail of Preparation and Clinical Application of Indomethacin Gel for Medical Treatment of Stomatitis

Journal of the Pharmaceutical Society of Japan, May 1, 2005

Research paper thumbnail of Effects of Mexiletine, a CYP1A2 Inhibitor, on Tizanidine Pharmacokinetics and Pharmacodynamics

The Journal of Clinical Pharmacology, Mar 1, 2010

Research paper thumbnail of Development of evidences for proper use of medicines using medical big data

The Pharmaceutical Society of Japan, Feb 1, 2021

Research paper thumbnail of Survey on the Attitudes of Citizens toward Genetic Analysis Studies Associated with Clinical Trials Planned by the Pharmaceutical Industry

Research paper thumbnail of Simple determination of urine cefazolin concentration in pediatric patients with urinary tract infections using high‐performance liquid chromatography

Biomedical Chromatography, Sep 15, 2022

Recently, global health concerns regarding increasing multidrug resistance have arisen. This stud... more Recently, global health concerns regarding increasing multidrug resistance have arisen. This study aimed to develop a simple, inexpensive and rapid high‐performance liquid chromatography–ultraviolet (HPLC–UV) method for determining urinary concentrations of a first‐generation cephem antibiotic in pediatric patients with urinary tract infections (UTIs). HPLC–UV was used to analyze urinary cefazolin concentrations at a detection wavelength of 254 nm. The assay used contained 10‐fold diluted urine with an internal standard (cephapirin). The standard calibration curve for cefazolin was linear in the concentration range of 31.25–500 μg/ml (r2 > 0.999). The retention times of cefazolin and the internal standard were 4.2 and 4.9 min, respectively. The within‐ and between‐day coefficients of variation were in the concentration ranges 1.2–15.2 and 5.5–19.2%, respectively. The urinary cefazolin concentration of a pediatric patient with a UTI was 1,476.6 μg/ml, which was over 700‐fold higher than the minimum inhibitory concentration of cefazolin (≤2 μg/ml). The developed method is applicable to the confirmation of appropriate use for UTI treatment as therapeutic drug monitoring of cefazolin. Therefore, the findings of this study may contribute to the appropriate use of antibiotics to prevent antimicrobial resistance in pediatric patients with UTIs.

Research paper thumbnail of Identification of the Components of Proton Pump Inhibitors and Potassium-Competitive Acid Blocker That Lead to Cardiovascular Events in Working-Age Individuals: A 12-Month Retrospective Cohort Study Using a Large Claims Database

Biological & Pharmaceutical Bulletin, Sep 1, 2022

Research paper thumbnail of Acute kidney injury incidence in patients with hematological malignancy treated with meropenem and vancomycin for febrile neutropenia

Clinical Nephrology, Jun 1, 2019

Research paper thumbnail of Risk factors affecting the failed low‐density lipoprotein level achievement rate in working‐age male population at high cardiovascular risk

Journal of Clinical Pharmacy and Therapeutics, May 6, 2019

Research paper thumbnail of Clinical Survey of Tizanidine-induced Adverse Effects<br/>—Impact of Concomitant Drugs Providing Cytochrome P450 1A2 Modification—

Journal of the Pharmaceutical Society of Japan, 2013

Research paper thumbnail of Retrospective analysis of atlantoaxial rotatory fixation describing age distribution and gender ratio in children and adolescents: A preliminary report

Journal of Orthopaedic Science, Feb 1, 2023

Research paper thumbnail of A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition

Biomedical Chromatography, Mar 4, 2011

Research paper thumbnail of Failure of liposomal amphotericin B therapy in patients with severe pancreatitis complicated by Candida lusitaniae infection

Journal of Infection and Chemotherapy, Feb 1, 2023

Research paper thumbnail of A Survey of Near-Miss Dispensing Errors in Hospital Pharmacies in Japan: DEPP-J Study—Multi-Center Prospective Observational Study—

Biological & Pharmaceutical Bulletin, Oct 1, 2022

Research paper thumbnail of Current Status and the Future of Protection and Utilization of Personal Information at Medical Facilities Based on the Understanding of Related Regulations

Journal of the Pharmaceutical Society of Japan, Feb 1, 2021

Research paper thumbnail of How to Manage Drug Interactions in Clinical Settings (3)

Japanese Journal of Pharmaceutical Health Care and Sciences, Nov 10, 2018

Research paper thumbnail of How to Manage Drug Interactions in Clinical Settings (1)

Japanese Journal of Pharmaceutical Health Care and Sciences, Nov 10, 2018

Research paper thumbnail of Lower metabolic clearance of tizanidine in Japanese subjects

International Journal of Clinical Pharmacology and Therapeutics, Dec 1, 2013

Our aim was to determine whether metabolic clearance, renal clearance, or both elimination pathwa... more Our aim was to determine whether metabolic clearance, renal clearance, or both elimination pathways contribute to ethnic differences in tizanidine clearance, which is ~ 2-fold higher in Caucasians than in Asians. The pharmacokinetic parameters of tizanidine in 9 healthy male Japanese subjects were compared with those of Caucasians in previous studies. Metabolic clearance of tizanidine was lower in Japanese than in Caucasian subjects (5.9 vs. 8.1 - 10.9 l/h/kg), although renal clearances were similar (0.040 vs. 0.047 - 0.055 l/h/kg). The results suggest that ethnic differences in tizanidine clearance are due to differences in metabolic clearance.

Research paper thumbnail of Severe Drowsiness with Fever Induced by Transdermal Fentanyl Administration

Journal of Palliative Medicine, Aug 1, 2020

Research paper thumbnail of Indomethacin spray for radiation oral mucositis -A report of five cases

Palliative Care Research, 2007

Research paper thumbnail of Association of the ward pharmacy service with active implementation of therapeutic drug monitoring for vancomycin and teicoplanin—an epidemiological surveillance study using Japanese large health insurance claims database

Journal of Pharmaceutical Health Care and Sciences, Aug 18, 2020

Research paper thumbnail of Preparation and Clinical Application of Indomethacin Gel for Medical Treatment of Stomatitis

Journal of the Pharmaceutical Society of Japan, May 1, 2005

Research paper thumbnail of Effects of Mexiletine, a CYP1A2 Inhibitor, on Tizanidine Pharmacokinetics and Pharmacodynamics

The Journal of Clinical Pharmacology, Mar 1, 2010

Research paper thumbnail of Development of evidences for proper use of medicines using medical big data

The Pharmaceutical Society of Japan, Feb 1, 2021

Research paper thumbnail of Survey on the Attitudes of Citizens toward Genetic Analysis Studies Associated with Clinical Trials Planned by the Pharmaceutical Industry

Research paper thumbnail of Simple determination of urine cefazolin concentration in pediatric patients with urinary tract infections using high‐performance liquid chromatography

Biomedical Chromatography, Sep 15, 2022

Recently, global health concerns regarding increasing multidrug resistance have arisen. This stud... more Recently, global health concerns regarding increasing multidrug resistance have arisen. This study aimed to develop a simple, inexpensive and rapid high‐performance liquid chromatography–ultraviolet (HPLC–UV) method for determining urinary concentrations of a first‐generation cephem antibiotic in pediatric patients with urinary tract infections (UTIs). HPLC–UV was used to analyze urinary cefazolin concentrations at a detection wavelength of 254 nm. The assay used contained 10‐fold diluted urine with an internal standard (cephapirin). The standard calibration curve for cefazolin was linear in the concentration range of 31.25–500 μg/ml (r2 &gt; 0.999). The retention times of cefazolin and the internal standard were 4.2 and 4.9 min, respectively. The within‐ and between‐day coefficients of variation were in the concentration ranges 1.2–15.2 and 5.5–19.2%, respectively. The urinary cefazolin concentration of a pediatric patient with a UTI was 1,476.6 μg/ml, which was over 700‐fold higher than the minimum inhibitory concentration of cefazolin (≤2 μg/ml). The developed method is applicable to the confirmation of appropriate use for UTI treatment as therapeutic drug monitoring of cefazolin. Therefore, the findings of this study may contribute to the appropriate use of antibiotics to prevent antimicrobial resistance in pediatric patients with UTIs.

Research paper thumbnail of Identification of the Components of Proton Pump Inhibitors and Potassium-Competitive Acid Blocker That Lead to Cardiovascular Events in Working-Age Individuals: A 12-Month Retrospective Cohort Study Using a Large Claims Database

Biological & Pharmaceutical Bulletin, Sep 1, 2022

Research paper thumbnail of Acute kidney injury incidence in patients with hematological malignancy treated with meropenem and vancomycin for febrile neutropenia

Clinical Nephrology, Jun 1, 2019

Research paper thumbnail of Risk factors affecting the failed low‐density lipoprotein level achievement rate in working‐age male population at high cardiovascular risk

Journal of Clinical Pharmacy and Therapeutics, May 6, 2019

Research paper thumbnail of Clinical Survey of Tizanidine-induced Adverse Effects<br/>—Impact of Concomitant Drugs Providing Cytochrome P450 1A2 Modification—

Journal of the Pharmaceutical Society of Japan, 2013

Research paper thumbnail of Retrospective analysis of atlantoaxial rotatory fixation describing age distribution and gender ratio in children and adolescents: A preliminary report

Journal of Orthopaedic Science, Feb 1, 2023

Research paper thumbnail of A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition

Biomedical Chromatography, Mar 4, 2011

Research paper thumbnail of Failure of liposomal amphotericin B therapy in patients with severe pancreatitis complicated by Candida lusitaniae infection

Journal of Infection and Chemotherapy, Feb 1, 2023

Research paper thumbnail of A Survey of Near-Miss Dispensing Errors in Hospital Pharmacies in Japan: DEPP-J Study—Multi-Center Prospective Observational Study—

Biological & Pharmaceutical Bulletin, Oct 1, 2022

Research paper thumbnail of Current Status and the Future of Protection and Utilization of Personal Information at Medical Facilities Based on the Understanding of Related Regulations

Journal of the Pharmaceutical Society of Japan, Feb 1, 2021

Research paper thumbnail of How to Manage Drug Interactions in Clinical Settings (3)

Japanese Journal of Pharmaceutical Health Care and Sciences, Nov 10, 2018

Research paper thumbnail of How to Manage Drug Interactions in Clinical Settings (1)

Japanese Journal of Pharmaceutical Health Care and Sciences, Nov 10, 2018

Research paper thumbnail of Lower metabolic clearance of tizanidine in Japanese subjects

International Journal of Clinical Pharmacology and Therapeutics, Dec 1, 2013

Our aim was to determine whether metabolic clearance, renal clearance, or both elimination pathwa... more Our aim was to determine whether metabolic clearance, renal clearance, or both elimination pathways contribute to ethnic differences in tizanidine clearance, which is ~ 2-fold higher in Caucasians than in Asians. The pharmacokinetic parameters of tizanidine in 9 healthy male Japanese subjects were compared with those of Caucasians in previous studies. Metabolic clearance of tizanidine was lower in Japanese than in Caucasian subjects (5.9 vs. 8.1 - 10.9 l/h/kg), although renal clearances were similar (0.040 vs. 0.047 - 0.055 l/h/kg). The results suggest that ethnic differences in tizanidine clearance are due to differences in metabolic clearance.

Research paper thumbnail of Severe Drowsiness with Fever Induced by Transdermal Fentanyl Administration

Journal of Palliative Medicine, Aug 1, 2020

Research paper thumbnail of Indomethacin spray for radiation oral mucositis -A report of five cases

Palliative Care Research, 2007

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