srwa khalid - Academia.edu (original) (raw)

Uploads

Papers by srwa khalid

Research paper thumbnail of Is there an association between body mass index and pregnancy outcomes in frozen-thawed embryo transfer cycles?

Fertility and Sterility, 2013

Research paper thumbnail of The association of amniotic fluid index measurement and pregnancy outcome

Objective: identify the efficacy of AFI (amniotic fluid index) in pregnant women as a predictor o... more Objective: identify the efficacy of AFI (amniotic fluid index) in pregnant women as a predictor of pregnancy outcome including mode of delivery and neonatal outcome. Methods: a prospective cohort study done from September 2018 to February 2019, the study involved 300 women with a gestational age between (36 – 40 weeks). The AFI was measured by ultrasound (US), and accordingly, the women were divided into three groups: normal (AFI = 5 – 25cm), oligohydramnios (AFI <5cm), and polyhydramnios (AFI >25cm), each group consisting of 100 women. Results: The group of oligohydramnios has a significantly higher rate of C/S, induction of labor in comparison to normal and polyhydramnios (p-value <0.05). There’s a significant correlation between AFI and fetal weight, small for gestation is more in oligohydramnios and big baby in polyhydramnios. There’s a significant difference between AFI and ANALYSIS 24(105), September October, 2020 Medical Science ISSN 2321–7359 EISSN 2321–7367

Research paper thumbnail of Thyroid Dysfunction and Abnormal Uterine Bleeding

Indian Journal of Public Health Research & Development, 2019

Research paper thumbnail of The Clearance of Serum Human Epididymis Protein 4 Following Primary Cytoreductive Surgery for Ovarian Carcinoma

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2018

The aim of this study was to examine the clearance of serum human epididymis protein 4 (HE4) in t... more The aim of this study was to examine the clearance of serum human epididymis protein 4 (HE4) in the immediate postoperative period in patients undergoing maximal effort cytoreductive surgery for ovarian carcinoma. The study was performed at a tertiary gynecologic oncology center. The surgery was performed by accredited gynecological oncologists. Preoperative and serial postoperative venous blood samples at 4, 8, 24, 48, 72, 96, and 120 hours were taken from 10 sequential patients. Pretreatment HE4 is considered elevated at greater than 70 pmol/L. Human epididymis protein 4 was greater than 70 pmol/L in 7 patients, including all patients with high-grade serous carcinoma. Patients with preoperative elevation of serum HE4 and complete cytoreduction cleared more than 80% of serum HE4 in the first 4 hours and more than 88% within 5 days of surgery. One patient with incomplete cytoreduction of high-grade serous carcinoma had 66% clearance at 4 hours and a plateau thereafter. Human epididy...

Research paper thumbnail of Patients with cancer at the margins of reproductive age had reduced levels of anti‐Müllerian hormone compared with patients experiencing infertility

International Journal of Gynecology & Obstetrics, 2016

Objective: To compare the ovarian reserves between female patients with cancer and patients exper... more Objective: To compare the ovarian reserves between female patients with cancer and patients experiencing infertility. Method: A retrospective age-matched observational study was performed at Rotunda Hospital, Dublin. The study group included data from all female oncology patients attending for oocyte or embryo cryopreservation between January 1, 2009 and December 31, 2013. Anti-Müllerian hormone (AMH) levels were recorded at patients' initial visits before beginning chemotherapy or radiotherapy. The control group included patients without cancer who had their AMH levels recorded to investigate fertility or as a baseline level prior to beginning assisted reproductive treatment. Results: The records of 118 oncology and 5231 control patients from the study period were identified. There was no difference in AMH levels between patients in the oncology and control groups aged 30-38 years; however, significantly lower AMH levels were observed in patients in the oncology group aged 29 years and younger (17.89 pmol/L vs 23.35 pmol/L; P = 0.015), or at least 39 years (2.65 pmol/L vs 5.87 pmol/L; P = 0.028). Conclusion: Before commencing chemotherapy or radiotherapy, patients in the oncology group at the margins of reproductive age had a diminished ovarian reserve compared with the control group. This should be considered when planning optimal doses of follicular stimulating hormone as part of controlled ovarian-stimulation regimes performed for embryo or oocyte cryopreservation prior to chemotherapy or radiotherapy.

Research paper thumbnail of Is there an association between body mass index and pregnancy outcomes in frozen-thawed embryo transfer cycles?

Fertility and Sterility, 2013

Research paper thumbnail of The association of amniotic fluid index measurement and pregnancy outcome

Objective: identify the efficacy of AFI (amniotic fluid index) in pregnant women as a predictor o... more Objective: identify the efficacy of AFI (amniotic fluid index) in pregnant women as a predictor of pregnancy outcome including mode of delivery and neonatal outcome. Methods: a prospective cohort study done from September 2018 to February 2019, the study involved 300 women with a gestational age between (36 – 40 weeks). The AFI was measured by ultrasound (US), and accordingly, the women were divided into three groups: normal (AFI = 5 – 25cm), oligohydramnios (AFI <5cm), and polyhydramnios (AFI >25cm), each group consisting of 100 women. Results: The group of oligohydramnios has a significantly higher rate of C/S, induction of labor in comparison to normal and polyhydramnios (p-value <0.05). There’s a significant correlation between AFI and fetal weight, small for gestation is more in oligohydramnios and big baby in polyhydramnios. There’s a significant difference between AFI and ANALYSIS 24(105), September October, 2020 Medical Science ISSN 2321–7359 EISSN 2321–7367

Research paper thumbnail of Thyroid Dysfunction and Abnormal Uterine Bleeding

Indian Journal of Public Health Research & Development, 2019

Research paper thumbnail of The Clearance of Serum Human Epididymis Protein 4 Following Primary Cytoreductive Surgery for Ovarian Carcinoma

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2018

The aim of this study was to examine the clearance of serum human epididymis protein 4 (HE4) in t... more The aim of this study was to examine the clearance of serum human epididymis protein 4 (HE4) in the immediate postoperative period in patients undergoing maximal effort cytoreductive surgery for ovarian carcinoma. The study was performed at a tertiary gynecologic oncology center. The surgery was performed by accredited gynecological oncologists. Preoperative and serial postoperative venous blood samples at 4, 8, 24, 48, 72, 96, and 120 hours were taken from 10 sequential patients. Pretreatment HE4 is considered elevated at greater than 70 pmol/L. Human epididymis protein 4 was greater than 70 pmol/L in 7 patients, including all patients with high-grade serous carcinoma. Patients with preoperative elevation of serum HE4 and complete cytoreduction cleared more than 80% of serum HE4 in the first 4 hours and more than 88% within 5 days of surgery. One patient with incomplete cytoreduction of high-grade serous carcinoma had 66% clearance at 4 hours and a plateau thereafter. Human epididy...

Research paper thumbnail of Patients with cancer at the margins of reproductive age had reduced levels of anti‐Müllerian hormone compared with patients experiencing infertility

International Journal of Gynecology & Obstetrics, 2016

Objective: To compare the ovarian reserves between female patients with cancer and patients exper... more Objective: To compare the ovarian reserves between female patients with cancer and patients experiencing infertility. Method: A retrospective age-matched observational study was performed at Rotunda Hospital, Dublin. The study group included data from all female oncology patients attending for oocyte or embryo cryopreservation between January 1, 2009 and December 31, 2013. Anti-Müllerian hormone (AMH) levels were recorded at patients' initial visits before beginning chemotherapy or radiotherapy. The control group included patients without cancer who had their AMH levels recorded to investigate fertility or as a baseline level prior to beginning assisted reproductive treatment. Results: The records of 118 oncology and 5231 control patients from the study period were identified. There was no difference in AMH levels between patients in the oncology and control groups aged 30-38 years; however, significantly lower AMH levels were observed in patients in the oncology group aged 29 years and younger (17.89 pmol/L vs 23.35 pmol/L; P = 0.015), or at least 39 years (2.65 pmol/L vs 5.87 pmol/L; P = 0.028). Conclusion: Before commencing chemotherapy or radiotherapy, patients in the oncology group at the margins of reproductive age had a diminished ovarian reserve compared with the control group. This should be considered when planning optimal doses of follicular stimulating hormone as part of controlled ovarian-stimulation regimes performed for embryo or oocyte cryopreservation prior to chemotherapy or radiotherapy.

Log In