jawad ahmad khan - Academia.edu (original) (raw)
Papers by jawad ahmad khan
IWMI receives its principal funding from 58 governments, private foundations, and international a... more IWMI receives its principal funding from 58 governments, private foundations, and international and regional organizations known as the Consultative Group on International Agricultural Research (CGIAR). Support is also given by the Governments of Ghana,
Environmental Science and Pollution Research, 2021
Climate action got attention from the United Nation's Sustainable Development Goals (SDGs). Altho... more Climate action got attention from the United Nation's Sustainable Development Goals (SDGs). Although a large number of studies are investigating the said phenomenon, however, the literature on the top five responsible countries is unable to evaluate the role of environment-related technologies (ERTs) and institutional quality (IQ). The top five consumption-based carbon dioxide (CBCO 2) emitting economies, i.e., China, India, Japan, Russia, and the USA, are considerable stakeholders in this challenge. To fill this void, with the latest data available from 1992 to 2017, short-and long-run relationships are estimated with dynamic common correlated effects estimator and augmented mean group in the framework of EKC hypothesis. Reported results indicate the negative effect of ERTs and IQ towards CBCO 2 , which means that adoption of ERTs and better IQ is supportive in controlling environmental degradation. Findings are also robust to the policy implications for the UN's SDGs.
Journal of entomology and zoology studies, 2020
Hepatitis B is a chronic infection and is the main health concern especially in Asia, Africa, Sou... more Hepatitis B is a chronic infection and is the main health concern especially in Asia, Africa, Southern Europe and Latin America and around two billion individuals are infected with HBV on the globe, among them 400 million are suffering from chronic HBV infection. Current data was collected from the period for December 2017 to October 2019 from the pathology lab of Mardan Medical Complex, Mardan. The blood samples of 31,367 blood donors were screened with ELISA kit (ARCHITECT i1000SR automated immunoassay analyzer chemiluminescent micro particle immunoassay). The occurrence rate of HBV infection amongst the blood donors was studied using CMIA method at Mardan Medical Complex, Mardan. 6253 blood donors were detected as HBV positive in total 31,367 blood donors. Total number of male blood donors was 28531, in which 5769 were HBV positive and their ratio was 20.22%, while the total number of female blood donors was 2836 in which 484 were detected as HBV positive and their percentage was...
Journal of Public Affairs, 2020
Acta poloniae pharmaceutica, 2016
We aimed to assess guar and xantban gum based floating drug delivery system containing mefenamic ... more We aimed to assess guar and xantban gum based floating drug delivery system containing mefenamic acid. Floating tablets of nefenamic acid were formulated with different concentrations of guar and xanthan gum via wet granulation method. The flow properties of granules that is: bulk density, tapped density, flow rate, Carr index, Hausner's ratio, compressibility index and angle of repose as well as physical parameters of the compressed tablets including: hardness, friability, thickness and swelling indices were determined and found to be good. Xanthan gum was superior to guar gum in maintaining drug release, but a combination of polymers was found to be the best for achieving sustained release up to 12 h due to the synergistic effect of both gums. Drug release mechanism was best explained by Korsmeyer-Peppas model. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies showed absence of any visible interaction. Stability studies at 40⁰C ...
Acta poloniae pharmaceutica, 2017
Microemulsion was prepared using several concentrations of selected oil (pine oil), surfactant (c... more Microemulsion was prepared using several concentrations of selected oil (pine oil), surfactant (cre- mophor RH40), co-surfactant (isopropanol) and water to improve bioavailability by increasing solubility and permeability of lomoxicam, which was then incorporated to carbomer 940 gel base to fabricate microemulsion based gel (MEBG) to sustained permeability for transdermal delivery. Initially, the formulations were investi- gated for physicochemical characteristics, i.e., pH, conductivity, viscosity, refractive index, zeta size, poly-dis- persity index and Atomic Force Microscopy. Also, the significance of the components on in vitro permeability was observed to find out optimum microemulsion (ME,) using Box-Behnken-Design (BBD). MEBG was com- pared for in vitro permeation, stability, skin irritation and anti-inflammatory studies using control gel and in vivo bioavailability study with oral tablet. Microemulsions exhibited the physiological pH (5.35-5.99), oil in water nature (139-185...
Journal of Polymers and the Environment, 2016
In the present work covalently crosslinked smart polymeric system of hydrogel based on poly vinyl... more In the present work covalently crosslinked smart polymeric system of hydrogel based on poly vinyl alcohol (PVA) and methacrylic acid (MA) was designed by free radical polymerization with different compositions using glyoxal (40 % water solution) as crosslinker. It was observed that swelling of hydrogel had a pronounced enhancing effect on increasing the concentration of MA due to availability of more ionized carboxylic groups of MA but produced an opposite effect on increasing the concentration of glyoxal owing to less porous structure. As far as PVA is concerned, swelling did not show significant effect on increasing the concentration of PVA. Hydrophilic polymer PVA rich in hydroxyl group pertained to be highly interactive with water. It was examined that the release of metoprolol tartrate decreased with increased concentration of glyoxal, but increased with increase in concentration of MA. PVA/MA hydrogel was characterized by Fourier transform infrared spectroscopy and X-ray diffraction to study the structure and crystallinity of hydrogel respectively. Morphology was studied through scanning electron microscopy. Furthermore differential scanning calorimetry and thermogravimetric analysis were also performed to characterize thermal stability. It may be concluded that the mechanism of drug release was mainly non-Fickian diffusion.
LATIN AMERICAN JOURNAL OF PHARMACY
The purpose of present study is to optimize microemulsion of poorly water soluble NSAID, lornoxic... more The purpose of present study is to optimize microemulsion of poorly water soluble NSAID, lornoxicam. The microemulsion was optimized using three factor, three level Box Behnken statistical design. Independent variables were oil, surfactant and cosurfactant mixture (Smix) and water, while dependent variables were cumulative quantity permeated through rabbit skin, flux and lag time. Microemulsion was prepared using almond oil, Tween20 (surfactant) and dimethylsulfoxide (DMSO) (co-surfactant) and water. The ranges of pH, conductivity, droplet size, polydispersity index and viscosities was found to be 4-5, 102-205 μsiemens/cm, 50-90 nm, 0.120-0.350 and 50-430 cp, respectively, of all Box-Behnken derived formulations. In vitro release studies on Franz cell showed the optimized formulation consisted of 20% almond oil, 54% Smix (Tween20 and DMSO in 3:1) and 27% water. The cumulative quantity permeated, flux and lag time of the optimum formulation was found to be 8503 μg, 229 μg/cm2 h and 0.41 h. The results indicated that microemulsion containing DMSO as permeation enhancer is promising vehicle for enhanced transdermal delivery of Lornoxicam.
Frontiers in Human Neuroscience, 2014
The hybrid brain-computer interface (BCI)'s multimodal technology enables precision brain-signal ... more The hybrid brain-computer interface (BCI)'s multimodal technology enables precision brain-signal classification that can be used in the formulation of control commands. In the present study, an experimental hybrid near-infrared spectroscopy-electroencephalography (NIRS-EEG) technique was used to extract and decode four different types of brain signals. The NIRS setup was positioned over the prefrontal brain region, and the EEG over the left and right motor cortex regions. Twelve subjects participating in the experiment were shown four direction symbols, namely, "forward," "backward," "left," and "right." The control commands for forward and backward movement were estimated by performing arithmetic mental tasks related to oxy-hemoglobin (HbO) changes. The left and right directions commands were associated with right and left hand tapping, respectively. The high classification accuracies achieved showed that the four different control signals can be accurately estimated using the hybrid NIRS-EEG technology.
2014 Proceedings of the SICE Annual Conference (SICE), 2014
ABSTRACT In this paper, we have demonstrated the ability of a new multi-channel near-infrared spe... more ABSTRACT In this paper, we have demonstrated the ability of a new multi-channel near-infrared spectroscopy (NIRS) system to detect deception in a concealed information test (CIT) paradigm. Brain signals from prefrontal cortex area of four healthy male subjects are collected using two different machines for comparison. Oxy and deoxy-hemoglobin (HbO and HbR) signals are used to define the features and then data is classified using linear discriminant analysis (LDA). Results show that the difference in HbO and HbR signals during lie and truth can be detected by the new wireless NIRS system.
2014 International Conference on Robotics and Emerging Allied Technologies in Engineering (iCREATE), 2014
ABSTRACT One of the aims of brain-computer interface (BCI) is to restore the means of communicati... more ABSTRACT One of the aims of brain-computer interface (BCI) is to restore the means of communication for people suffering severe motor impairment, anarthria, or persisting in a vegetative state. Yes/no decoding with the help of an imaging technology such as functional near-infrared spectroscopy (fNIRS) can make this goal a reality. fNIRS is a relatively new non-invasive optical imaging modality offering the advantages of low cost, safety, portability and ease of use. Recently, an fNIRS based online covert yes/no decision decoding framework was presented [Naseer and Hong (2013) online binary decision decoding using functional near infrared spectroscopy for development of a braincomputer interface]. Herein we propose a method to improve support vector machine classification accuracies for decoding covert yes/no responses by using signal slope values of oxygenated and deoxygenated hemoglobin as features calculated for a confined temporal window within the total task period.
2014 International Conference on Robotics and Emerging Allied Technologies in Engineering (iCREATE), 2014
ABSTRACT It is known that approximately 80% of blood is composed of water (H2O); we developed an ... more ABSTRACT It is known that approximately 80% of blood is composed of water (H2O); we developed an algorithm which compensates the light absorbed by the water to improve the signal strength of oxy- and deoxy-hemoglobin (HbO and HbR) during mental activity. To practically implement the proposed algorithm, a new tri-wavelength LED based NIRS systems is used which is capable of detecting not only the concentration changes of HbO and HbR but also that of H2O. The proposed algorithm is tested using an arithmetic task experiment, performed with five healthy male subjects. By using the linear discriminant analysis (LDA) as classifier we were able to distinguish between the activity and rest periods. The results obtained in this study show that the classification accuracy to differentiate between task and rest period increases after we implied the water correction algorithm.
Journal of Ayub Medical College, Abbottabad : JAMC
Aortic valve disease is associated with eccentric or concentric left ventricular (LV) hypertrophy... more Aortic valve disease is associated with eccentric or concentric left ventricular (LV) hypertrophy and changes in the LV mass. The relationship between LV mass and function and the effect of LV remodeling after aortic valve replacement (AVR), in patients with aortic valve disease needs evaluation, that is largely unknown in our population. The aim of this study was to evaluate the effect of AVR on LV remodeling, in patients with aortic valve disease. Fifty patients with aortic valve disease were studied using transthoracic echocardiography to assess LV mass before AVR and compared with early postoperative changes in the LV dimensions and function. LV mass was studied preoperatively and before discharge in 50 consecutive patients undergoing isolated aortic valve replacement. Out of fifty patients, 47 (94%) were male and 03 (6%) were female. Mean age of the patients was 40.42 years. 22 (44%) had isolated aortic stenosis (AS), 16 (32%) patients had isolated aortic regurgitation (AR) and...
Asian Cardiovascular and Thoracic Annals, 2007
Anticoagulation in pregnancy was evaluated in 33 women with a mechanical heart valve prosthesis w... more Anticoagulation in pregnancy was evaluated in 33 women with a mechanical heart valve prosthesis who had 53 pregnancies between 1994 and 2006. Their mean age at valve operation was 24.4 +/- 5.4 years, and 22 (67%) had isolated mitral valve disease. Of these patients, 22 had a single pregnancy, 5 had 2 pregnancies, 3 had 3, and 3 had 4. In 43 pregnancies, the patients took warfarin throughout; in the other 10, heparin was used in the first trimester followed by warfarin until the last 15 days. Mean international normalized ratio and warfarin levels before, during, and after pregnancy were similar. Complications occurred in 3 (6%) women who had thrombosed valves: 2 (20%) in the heparin group and 1 (2%) who had warfarin only. Live births resulted from 37 (70%) pregnancies. There were significantly more abortions in the heparin group (6; 60%) than the warfarin group (8; 19%). Hemorrhage requiring transfusion occurred in 2 (5%) patients in the warfarin group. All live births resulted in healthy babies. It was concluded that anticoagulation with warfarin is safe during pregnancy in women with mechanical heart valves.
Asian Cardiovascular and Thoracic Annals, 2007
To assess long-term survival and anticoagulant-related complications after mechanical valve repla... more To assess long-term survival and anticoagulant-related complications after mechanical valve replacement in adolescents with rheumatic heart disease, 88 patients aged ≤ 18 years were prospectively followed up for 10 years (404.2 patient-years). There were 58 (65.9%) boys and 30 (34.1%) girls, with a mean age of 15.4 ± 2.1 years. Mitral regurgitation was detected in 39 (44.3%) patients, and both mitral and aortic regurgitation in 15 (17%). Ball valves were inserted in 52 (59.1%) patients, bileaflet valves in 31 (35.2%), and single-disc valves in 5 (5.7%). There were 4 (4.5%) hospital deaths and 11 late deaths. Patient survival at 30 days, 3 months, 1, 5, and 10 years was 95.5%, 93.2%, 87.5%, 82.9%, and 82.9%, respectively. Mechanical valve thrombosis occurred in 4 patients; it was fatal in 3 of them. Three patients died from stroke. Severe hemorrhage required hospital admission in 4 (4.5%) patients. Mechanical valve replacement in adolescents, with careful follow-up and anticoagulatio...
Asian Cardiovascular and Thoracic Annals, 2009
To compare hospital mortality and postoperative complications in patients with severe coronary ar... more To compare hospital mortality and postoperative complications in patients with severe coronary artery disease undergoing coronary artery bypass grafting with or without coronary endarterectomy, 100 consecutive patients were divided into 2 groups of 50 patients each. Group 1 had coronary endarterectomy, and group 2 had no coronary endarterectomy. There were 87 men and 13 women, with a mean age of 54.79 +/-7.8 years; 48% had stable angina. The right coronary artery was endarterectomized in 22 patients, the left anterior descending artery in 21, and the left circumflex in 7. There were no significant differences in outcomes. There was 1 hospital death in each group. Perioperative myocardial infarction occurred in 2 patients in group 1 and 1 in group 2. Endarterectomy is a suitable option to achieve complete revascularization in patients with refractory angina and severe diffuse disease.
Neuroscience Letters, 2015
h i g h l i g h t s • Feasibility of three-class fNIRS-BCI demonstrated. • Classification of fNIR... more h i g h l i g h t s • Feasibility of three-class fNIRS-BCI demonstrated. • Classification of fNIRS signals corresponding to three different brain activities. • Motor and prefrontal cortex activities used. • Intentionally-generated cognitive tasks as inputs.
IWMI receives its principal funding from 58 governments, private foundations, and international a... more IWMI receives its principal funding from 58 governments, private foundations, and international and regional organizations known as the Consultative Group on International Agricultural Research (CGIAR). Support is also given by the Governments of Ghana,
Environmental Science and Pollution Research, 2021
Climate action got attention from the United Nation's Sustainable Development Goals (SDGs). Altho... more Climate action got attention from the United Nation's Sustainable Development Goals (SDGs). Although a large number of studies are investigating the said phenomenon, however, the literature on the top five responsible countries is unable to evaluate the role of environment-related technologies (ERTs) and institutional quality (IQ). The top five consumption-based carbon dioxide (CBCO 2) emitting economies, i.e., China, India, Japan, Russia, and the USA, are considerable stakeholders in this challenge. To fill this void, with the latest data available from 1992 to 2017, short-and long-run relationships are estimated with dynamic common correlated effects estimator and augmented mean group in the framework of EKC hypothesis. Reported results indicate the negative effect of ERTs and IQ towards CBCO 2 , which means that adoption of ERTs and better IQ is supportive in controlling environmental degradation. Findings are also robust to the policy implications for the UN's SDGs.
Journal of entomology and zoology studies, 2020
Hepatitis B is a chronic infection and is the main health concern especially in Asia, Africa, Sou... more Hepatitis B is a chronic infection and is the main health concern especially in Asia, Africa, Southern Europe and Latin America and around two billion individuals are infected with HBV on the globe, among them 400 million are suffering from chronic HBV infection. Current data was collected from the period for December 2017 to October 2019 from the pathology lab of Mardan Medical Complex, Mardan. The blood samples of 31,367 blood donors were screened with ELISA kit (ARCHITECT i1000SR automated immunoassay analyzer chemiluminescent micro particle immunoassay). The occurrence rate of HBV infection amongst the blood donors was studied using CMIA method at Mardan Medical Complex, Mardan. 6253 blood donors were detected as HBV positive in total 31,367 blood donors. Total number of male blood donors was 28531, in which 5769 were HBV positive and their ratio was 20.22%, while the total number of female blood donors was 2836 in which 484 were detected as HBV positive and their percentage was...
Journal of Public Affairs, 2020
Acta poloniae pharmaceutica, 2016
We aimed to assess guar and xantban gum based floating drug delivery system containing mefenamic ... more We aimed to assess guar and xantban gum based floating drug delivery system containing mefenamic acid. Floating tablets of nefenamic acid were formulated with different concentrations of guar and xanthan gum via wet granulation method. The flow properties of granules that is: bulk density, tapped density, flow rate, Carr index, Hausner's ratio, compressibility index and angle of repose as well as physical parameters of the compressed tablets including: hardness, friability, thickness and swelling indices were determined and found to be good. Xanthan gum was superior to guar gum in maintaining drug release, but a combination of polymers was found to be the best for achieving sustained release up to 12 h due to the synergistic effect of both gums. Drug release mechanism was best explained by Korsmeyer-Peppas model. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies showed absence of any visible interaction. Stability studies at 40⁰C ...
Acta poloniae pharmaceutica, 2017
Microemulsion was prepared using several concentrations of selected oil (pine oil), surfactant (c... more Microemulsion was prepared using several concentrations of selected oil (pine oil), surfactant (cre- mophor RH40), co-surfactant (isopropanol) and water to improve bioavailability by increasing solubility and permeability of lomoxicam, which was then incorporated to carbomer 940 gel base to fabricate microemulsion based gel (MEBG) to sustained permeability for transdermal delivery. Initially, the formulations were investi- gated for physicochemical characteristics, i.e., pH, conductivity, viscosity, refractive index, zeta size, poly-dis- persity index and Atomic Force Microscopy. Also, the significance of the components on in vitro permeability was observed to find out optimum microemulsion (ME,) using Box-Behnken-Design (BBD). MEBG was com- pared for in vitro permeation, stability, skin irritation and anti-inflammatory studies using control gel and in vivo bioavailability study with oral tablet. Microemulsions exhibited the physiological pH (5.35-5.99), oil in water nature (139-185...
Journal of Polymers and the Environment, 2016
In the present work covalently crosslinked smart polymeric system of hydrogel based on poly vinyl... more In the present work covalently crosslinked smart polymeric system of hydrogel based on poly vinyl alcohol (PVA) and methacrylic acid (MA) was designed by free radical polymerization with different compositions using glyoxal (40 % water solution) as crosslinker. It was observed that swelling of hydrogel had a pronounced enhancing effect on increasing the concentration of MA due to availability of more ionized carboxylic groups of MA but produced an opposite effect on increasing the concentration of glyoxal owing to less porous structure. As far as PVA is concerned, swelling did not show significant effect on increasing the concentration of PVA. Hydrophilic polymer PVA rich in hydroxyl group pertained to be highly interactive with water. It was examined that the release of metoprolol tartrate decreased with increased concentration of glyoxal, but increased with increase in concentration of MA. PVA/MA hydrogel was characterized by Fourier transform infrared spectroscopy and X-ray diffraction to study the structure and crystallinity of hydrogel respectively. Morphology was studied through scanning electron microscopy. Furthermore differential scanning calorimetry and thermogravimetric analysis were also performed to characterize thermal stability. It may be concluded that the mechanism of drug release was mainly non-Fickian diffusion.
LATIN AMERICAN JOURNAL OF PHARMACY
The purpose of present study is to optimize microemulsion of poorly water soluble NSAID, lornoxic... more The purpose of present study is to optimize microemulsion of poorly water soluble NSAID, lornoxicam. The microemulsion was optimized using three factor, three level Box Behnken statistical design. Independent variables were oil, surfactant and cosurfactant mixture (Smix) and water, while dependent variables were cumulative quantity permeated through rabbit skin, flux and lag time. Microemulsion was prepared using almond oil, Tween20 (surfactant) and dimethylsulfoxide (DMSO) (co-surfactant) and water. The ranges of pH, conductivity, droplet size, polydispersity index and viscosities was found to be 4-5, 102-205 μsiemens/cm, 50-90 nm, 0.120-0.350 and 50-430 cp, respectively, of all Box-Behnken derived formulations. In vitro release studies on Franz cell showed the optimized formulation consisted of 20% almond oil, 54% Smix (Tween20 and DMSO in 3:1) and 27% water. The cumulative quantity permeated, flux and lag time of the optimum formulation was found to be 8503 μg, 229 μg/cm2 h and 0.41 h. The results indicated that microemulsion containing DMSO as permeation enhancer is promising vehicle for enhanced transdermal delivery of Lornoxicam.
Frontiers in Human Neuroscience, 2014
The hybrid brain-computer interface (BCI)'s multimodal technology enables precision brain-signal ... more The hybrid brain-computer interface (BCI)'s multimodal technology enables precision brain-signal classification that can be used in the formulation of control commands. In the present study, an experimental hybrid near-infrared spectroscopy-electroencephalography (NIRS-EEG) technique was used to extract and decode four different types of brain signals. The NIRS setup was positioned over the prefrontal brain region, and the EEG over the left and right motor cortex regions. Twelve subjects participating in the experiment were shown four direction symbols, namely, "forward," "backward," "left," and "right." The control commands for forward and backward movement were estimated by performing arithmetic mental tasks related to oxy-hemoglobin (HbO) changes. The left and right directions commands were associated with right and left hand tapping, respectively. The high classification accuracies achieved showed that the four different control signals can be accurately estimated using the hybrid NIRS-EEG technology.
2014 Proceedings of the SICE Annual Conference (SICE), 2014
ABSTRACT In this paper, we have demonstrated the ability of a new multi-channel near-infrared spe... more ABSTRACT In this paper, we have demonstrated the ability of a new multi-channel near-infrared spectroscopy (NIRS) system to detect deception in a concealed information test (CIT) paradigm. Brain signals from prefrontal cortex area of four healthy male subjects are collected using two different machines for comparison. Oxy and deoxy-hemoglobin (HbO and HbR) signals are used to define the features and then data is classified using linear discriminant analysis (LDA). Results show that the difference in HbO and HbR signals during lie and truth can be detected by the new wireless NIRS system.
2014 International Conference on Robotics and Emerging Allied Technologies in Engineering (iCREATE), 2014
ABSTRACT One of the aims of brain-computer interface (BCI) is to restore the means of communicati... more ABSTRACT One of the aims of brain-computer interface (BCI) is to restore the means of communication for people suffering severe motor impairment, anarthria, or persisting in a vegetative state. Yes/no decoding with the help of an imaging technology such as functional near-infrared spectroscopy (fNIRS) can make this goal a reality. fNIRS is a relatively new non-invasive optical imaging modality offering the advantages of low cost, safety, portability and ease of use. Recently, an fNIRS based online covert yes/no decision decoding framework was presented [Naseer and Hong (2013) online binary decision decoding using functional near infrared spectroscopy for development of a braincomputer interface]. Herein we propose a method to improve support vector machine classification accuracies for decoding covert yes/no responses by using signal slope values of oxygenated and deoxygenated hemoglobin as features calculated for a confined temporal window within the total task period.
2014 International Conference on Robotics and Emerging Allied Technologies in Engineering (iCREATE), 2014
ABSTRACT It is known that approximately 80% of blood is composed of water (H2O); we developed an ... more ABSTRACT It is known that approximately 80% of blood is composed of water (H2O); we developed an algorithm which compensates the light absorbed by the water to improve the signal strength of oxy- and deoxy-hemoglobin (HbO and HbR) during mental activity. To practically implement the proposed algorithm, a new tri-wavelength LED based NIRS systems is used which is capable of detecting not only the concentration changes of HbO and HbR but also that of H2O. The proposed algorithm is tested using an arithmetic task experiment, performed with five healthy male subjects. By using the linear discriminant analysis (LDA) as classifier we were able to distinguish between the activity and rest periods. The results obtained in this study show that the classification accuracy to differentiate between task and rest period increases after we implied the water correction algorithm.
Journal of Ayub Medical College, Abbottabad : JAMC
Aortic valve disease is associated with eccentric or concentric left ventricular (LV) hypertrophy... more Aortic valve disease is associated with eccentric or concentric left ventricular (LV) hypertrophy and changes in the LV mass. The relationship between LV mass and function and the effect of LV remodeling after aortic valve replacement (AVR), in patients with aortic valve disease needs evaluation, that is largely unknown in our population. The aim of this study was to evaluate the effect of AVR on LV remodeling, in patients with aortic valve disease. Fifty patients with aortic valve disease were studied using transthoracic echocardiography to assess LV mass before AVR and compared with early postoperative changes in the LV dimensions and function. LV mass was studied preoperatively and before discharge in 50 consecutive patients undergoing isolated aortic valve replacement. Out of fifty patients, 47 (94%) were male and 03 (6%) were female. Mean age of the patients was 40.42 years. 22 (44%) had isolated aortic stenosis (AS), 16 (32%) patients had isolated aortic regurgitation (AR) and...
Asian Cardiovascular and Thoracic Annals, 2007
Anticoagulation in pregnancy was evaluated in 33 women with a mechanical heart valve prosthesis w... more Anticoagulation in pregnancy was evaluated in 33 women with a mechanical heart valve prosthesis who had 53 pregnancies between 1994 and 2006. Their mean age at valve operation was 24.4 +/- 5.4 years, and 22 (67%) had isolated mitral valve disease. Of these patients, 22 had a single pregnancy, 5 had 2 pregnancies, 3 had 3, and 3 had 4. In 43 pregnancies, the patients took warfarin throughout; in the other 10, heparin was used in the first trimester followed by warfarin until the last 15 days. Mean international normalized ratio and warfarin levels before, during, and after pregnancy were similar. Complications occurred in 3 (6%) women who had thrombosed valves: 2 (20%) in the heparin group and 1 (2%) who had warfarin only. Live births resulted from 37 (70%) pregnancies. There were significantly more abortions in the heparin group (6; 60%) than the warfarin group (8; 19%). Hemorrhage requiring transfusion occurred in 2 (5%) patients in the warfarin group. All live births resulted in healthy babies. It was concluded that anticoagulation with warfarin is safe during pregnancy in women with mechanical heart valves.
Asian Cardiovascular and Thoracic Annals, 2007
To assess long-term survival and anticoagulant-related complications after mechanical valve repla... more To assess long-term survival and anticoagulant-related complications after mechanical valve replacement in adolescents with rheumatic heart disease, 88 patients aged ≤ 18 years were prospectively followed up for 10 years (404.2 patient-years). There were 58 (65.9%) boys and 30 (34.1%) girls, with a mean age of 15.4 ± 2.1 years. Mitral regurgitation was detected in 39 (44.3%) patients, and both mitral and aortic regurgitation in 15 (17%). Ball valves were inserted in 52 (59.1%) patients, bileaflet valves in 31 (35.2%), and single-disc valves in 5 (5.7%). There were 4 (4.5%) hospital deaths and 11 late deaths. Patient survival at 30 days, 3 months, 1, 5, and 10 years was 95.5%, 93.2%, 87.5%, 82.9%, and 82.9%, respectively. Mechanical valve thrombosis occurred in 4 patients; it was fatal in 3 of them. Three patients died from stroke. Severe hemorrhage required hospital admission in 4 (4.5%) patients. Mechanical valve replacement in adolescents, with careful follow-up and anticoagulatio...
Asian Cardiovascular and Thoracic Annals, 2009
To compare hospital mortality and postoperative complications in patients with severe coronary ar... more To compare hospital mortality and postoperative complications in patients with severe coronary artery disease undergoing coronary artery bypass grafting with or without coronary endarterectomy, 100 consecutive patients were divided into 2 groups of 50 patients each. Group 1 had coronary endarterectomy, and group 2 had no coronary endarterectomy. There were 87 men and 13 women, with a mean age of 54.79 +/-7.8 years; 48% had stable angina. The right coronary artery was endarterectomized in 22 patients, the left anterior descending artery in 21, and the left circumflex in 7. There were no significant differences in outcomes. There was 1 hospital death in each group. Perioperative myocardial infarction occurred in 2 patients in group 1 and 1 in group 2. Endarterectomy is a suitable option to achieve complete revascularization in patients with refractory angina and severe diffuse disease.
Neuroscience Letters, 2015
h i g h l i g h t s • Feasibility of three-class fNIRS-BCI demonstrated. • Classification of fNIR... more h i g h l i g h t s • Feasibility of three-class fNIRS-BCI demonstrated. • Classification of fNIRS signals corresponding to three different brain activities. • Motor and prefrontal cortex activities used. • Intentionally-generated cognitive tasks as inputs.