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Papers by khatuna dondoladze
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA
In the region of Bolnisi-Dmanisi, mineral extraction is carried out, where the certificate (ISO) ... more In the region of Bolnisi-Dmanisi, mineral extraction is carried out, where the certificate (ISO) is not maintained and the environment is polluted. Quantitative study of heavy metals, in particular cadmium, in this area shows that an increase in the concentration of cadmium is observed along the coastline of the Mashavera river, which poses a threat to human health. Aim of the study: monitoring of the content of cadmium in the water of the river Mashavera in the region of Bolnisi-Dmanisi. Monitoring in 2021-2022 revealed that the concentration of the heavy metal cadmium in the Mashavera river is increased, especially in the summer period in the settlements located near the quarry. The fact is very remarkable and requires the adoption of appropriate measures, as the population uses this water for irrigation, and the cadmium contained in the water accumulates in the vegetables, the population uses vegetables for food. The accumulation of cadmium in the human body is a risk factor for the development of acute or chronic diseases.
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA
Magnetite (Fe2+Fe3+2O4) is an iron-bearing mineral with magnetic properties. Mostly it is obtaine... more Magnetite (Fe2+Fe3+2O4) is an iron-bearing mineral with magnetic properties. Mostly it is obtained in its natural form. The purpose of our study is to study the effect of magnetite on health. At the first stage of research, we carried out X-ray fluorescence and X-ray phase analyzes of sand taken from beaches with magnetic and non-magnetic sand on the Black Sea coast, namely from the beaches of Ureki and Chakvi. It can be seen from the research results that the sands of Ureki and Chakvi differ in composition, this difference is not only in magnetite, but in the sand of Ureki (in the crystalline phase) there are two spar, and in the sand of Chakvi only one. However, there is more quartz in the sand taken from Chakvi than in the sand of Ureki.The rare composition of Ureki sand is likely to determine the health effects we plan to study in the next phase of our research.
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA
Open Access Macedonian Journal of Medical Sciences
Introduction: The elucidation of the mechanism of action of radon on antioxidant processes needs ... more Introduction: The elucidation of the mechanism of action of radon on antioxidant processes needs further research, however, based on the results of the experiment, it can be concluded that studies on experimental animals have shown that, while inhaling Tskhaltubo water, the phenomenon of hormesis develops. Methods: we placed 10 experimental animals (KM rats) in Radon contained mineral water spa`s sauna. Inhalation of radon-water was administered through the nose, for 10 minutes, once a day, in conditions of high humidity (about 90%) for 10 days. Results: Hormesis regulates oxidative processes in the brain due to the activation of antioxidants expressed in a decrease in existing epileptic seizures and is expressed in the activation of Na / K-ATPase and specific glutaminergic neurons of the "attack center" of the hypothalamus but also with the activation of the entire adaptive-compensatory system. Conclusion: Inhalation of radon contained water can be considered as a method...
Book Publisher International (a part of SCIENCEDOMAIN International), Nov 5, 2022
Journal of Biosciences and Medicines, 2022
International Journal of Radiation Biology, 2021
Abstract Purpose The aim of our research was to study the effect of radon hormesis balneotherapy ... more Abstract Purpose The aim of our research was to study the effect of radon hormesis balneotherapy using natural thermal waters of Tskaltubo spring, practically, its effect on oxidant and antioxidant systems and anxiety reactions in rats. Radon is a natural gas with radioactive properties, which can have a hermetic effect when used in small doses. Radon was used to activate antioxidant mechanisms in rats, which resulted an anxiolytic effect and positively enhanced the effect of balneotherapy. Materials and methods To study the effect of radon in balneotherapy, groups of experimental animals (rats) were exposed to three different treatments. The radon-containing waters of Tskaltubo spring were inhaled in one group and 5 after taking the water in another group. Saline was used for inhalation in animals of the saline group. In animals of the control and sham control groups, inhalation was not used. To assess the anxiolytic effect of radon inhalation, the anxiety was induced and behavioral tests were performed (the open field and the elevated plus-maze test) after 24 h and 5 days of inhalation procedures. Results The anxiety test results showed that exposure to low doses of radon led to a decrease in the level of anxiety in rats. The data show that the total distance traveled by rats in the open field test after inhalation of radon was significantly greater than that by animals in the sham control and control groups. During the open field and elevated plus-maze tests, rats that had inhaled radon spent more time in the central part of the open field and on the open arms of the maze than did the other groups of rats. In the group of rats that had not inhaled radon, an increase in anxiety was observed. The basis of this reaction was an increase in the glutathione concentration. Conclusion Based on our research, it can be concluded that the inhalation of small doses of radon, associated with treatments of waters from the Tskaltubo spring, activated the antioxidant systems of the body and enhanced the positive effect of balneotherapy. Clinically, this is expressed as a decrease in anxiety. Inhalation of small doses of radon activated antioxidant processes in the brain, causing an increase in glutathione/glutathione disulfide ratio in the brain.
The aim of this study is to investigate whether household frequency electromagnetic field affect ... more The aim of this study is to investigate whether household frequency electromagnetic field affect memory processes. Apparently in various studies researchers note that different frequencies electromagnetic field improve or impair memory. In memory process hormone ghrelin plays an important role, which participates in the neurogenesis processes of memory formation. We have studied effect of electromagnetic field (EMF) on ghrelin`s concentration and memory changes under EMF. We exposed male Wistar rats under EMF. The household frequency electromagnetic field was generated with a GSM mobile phone. For memory tests we used the two feeder and five choice serial reaction time tests (5-CSRTT). With this latter test we studied attention and concentration and in serum we measured the concentration of ghrelin by immunoferminal analysis. In serum ghrelin concentration increased in electromagnetic field exposure group, after 30th day of the exposure level of ghrelin is higher than after 10 day o...
European Scientific Journal, 2016
Ghrelin is one of the major ways of improving memory, which is approved by different amino acids ... more Ghrelin is one of the major ways of improving memory, which is approved by different amino acids ratio. However, reducing the concentration of Ghrelin helps to prevent the implementation of generated and stiffened nutritional act. The processes of stimulation cause various improvement of expressed behavior on positive stimulus. This is based on the type of overpass labyrinth for improving the reflexive behavior to two feeding test. These facts approve that the processes which was developed as a result of Ghrelin`s and EMF action and the central mechanisms of animals behavioral reaction on positive stimulus were connected to each other by morphofunctional and neurochemical organization.
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA
In the region of Bolnisi-Dmanisi, mineral extraction is carried out, where the certificate (ISO) ... more In the region of Bolnisi-Dmanisi, mineral extraction is carried out, where the certificate (ISO) is not maintained and the environment is polluted. Quantitative study of heavy metals, in particular cadmium, in this area shows that an increase in the concentration of cadmium is observed along the coastline of the Mashavera river, which poses a threat to human health. Aim of the study: monitoring of the content of cadmium in the water of the river Mashavera in the region of Bolnisi-Dmanisi. Monitoring in 2021-2022 revealed that the concentration of the heavy metal cadmium in the Mashavera river is increased, especially in the summer period in the settlements located near the quarry. The fact is very remarkable and requires the adoption of appropriate measures, as the population uses this water for irrigation, and the cadmium contained in the water accumulates in the vegetables, the population uses vegetables for food. The accumulation of cadmium in the human body is a risk factor for the development of acute or chronic diseases.
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA
Magnetite (Fe2+Fe3+2O4) is an iron-bearing mineral with magnetic properties. Mostly it is obtaine... more Magnetite (Fe2+Fe3+2O4) is an iron-bearing mineral with magnetic properties. Mostly it is obtained in its natural form. The purpose of our study is to study the effect of magnetite on health. At the first stage of research, we carried out X-ray fluorescence and X-ray phase analyzes of sand taken from beaches with magnetic and non-magnetic sand on the Black Sea coast, namely from the beaches of Ureki and Chakvi. It can be seen from the research results that the sands of Ureki and Chakvi differ in composition, this difference is not only in magnetite, but in the sand of Ureki (in the crystalline phase) there are two spar, and in the sand of Chakvi only one. However, there is more quartz in the sand taken from Chakvi than in the sand of Ureki.The rare composition of Ureki sand is likely to determine the health effects we plan to study in the next phase of our research.
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA
Open Access Macedonian Journal of Medical Sciences
Introduction: The elucidation of the mechanism of action of radon on antioxidant processes needs ... more Introduction: The elucidation of the mechanism of action of radon on antioxidant processes needs further research, however, based on the results of the experiment, it can be concluded that studies on experimental animals have shown that, while inhaling Tskhaltubo water, the phenomenon of hormesis develops. Methods: we placed 10 experimental animals (KM rats) in Radon contained mineral water spa`s sauna. Inhalation of radon-water was administered through the nose, for 10 minutes, once a day, in conditions of high humidity (about 90%) for 10 days. Results: Hormesis regulates oxidative processes in the brain due to the activation of antioxidants expressed in a decrease in existing epileptic seizures and is expressed in the activation of Na / K-ATPase and specific glutaminergic neurons of the "attack center" of the hypothalamus but also with the activation of the entire adaptive-compensatory system. Conclusion: Inhalation of radon contained water can be considered as a method...
Book Publisher International (a part of SCIENCEDOMAIN International), Nov 5, 2022
Journal of Biosciences and Medicines, 2022
International Journal of Radiation Biology, 2021
Abstract Purpose The aim of our research was to study the effect of radon hormesis balneotherapy ... more Abstract Purpose The aim of our research was to study the effect of radon hormesis balneotherapy using natural thermal waters of Tskaltubo spring, practically, its effect on oxidant and antioxidant systems and anxiety reactions in rats. Radon is a natural gas with radioactive properties, which can have a hermetic effect when used in small doses. Radon was used to activate antioxidant mechanisms in rats, which resulted an anxiolytic effect and positively enhanced the effect of balneotherapy. Materials and methods To study the effect of radon in balneotherapy, groups of experimental animals (rats) were exposed to three different treatments. The radon-containing waters of Tskaltubo spring were inhaled in one group and 5 after taking the water in another group. Saline was used for inhalation in animals of the saline group. In animals of the control and sham control groups, inhalation was not used. To assess the anxiolytic effect of radon inhalation, the anxiety was induced and behavioral tests were performed (the open field and the elevated plus-maze test) after 24 h and 5 days of inhalation procedures. Results The anxiety test results showed that exposure to low doses of radon led to a decrease in the level of anxiety in rats. The data show that the total distance traveled by rats in the open field test after inhalation of radon was significantly greater than that by animals in the sham control and control groups. During the open field and elevated plus-maze tests, rats that had inhaled radon spent more time in the central part of the open field and on the open arms of the maze than did the other groups of rats. In the group of rats that had not inhaled radon, an increase in anxiety was observed. The basis of this reaction was an increase in the glutathione concentration. Conclusion Based on our research, it can be concluded that the inhalation of small doses of radon, associated with treatments of waters from the Tskaltubo spring, activated the antioxidant systems of the body and enhanced the positive effect of balneotherapy. Clinically, this is expressed as a decrease in anxiety. Inhalation of small doses of radon activated antioxidant processes in the brain, causing an increase in glutathione/glutathione disulfide ratio in the brain.
The aim of this study is to investigate whether household frequency electromagnetic field affect ... more The aim of this study is to investigate whether household frequency electromagnetic field affect memory processes. Apparently in various studies researchers note that different frequencies electromagnetic field improve or impair memory. In memory process hormone ghrelin plays an important role, which participates in the neurogenesis processes of memory formation. We have studied effect of electromagnetic field (EMF) on ghrelin`s concentration and memory changes under EMF. We exposed male Wistar rats under EMF. The household frequency electromagnetic field was generated with a GSM mobile phone. For memory tests we used the two feeder and five choice serial reaction time tests (5-CSRTT). With this latter test we studied attention and concentration and in serum we measured the concentration of ghrelin by immunoferminal analysis. In serum ghrelin concentration increased in electromagnetic field exposure group, after 30th day of the exposure level of ghrelin is higher than after 10 day o...
European Scientific Journal, 2016
Ghrelin is one of the major ways of improving memory, which is approved by different amino acids ... more Ghrelin is one of the major ways of improving memory, which is approved by different amino acids ratio. However, reducing the concentration of Ghrelin helps to prevent the implementation of generated and stiffened nutritional act. The processes of stimulation cause various improvement of expressed behavior on positive stimulus. This is based on the type of overpass labyrinth for improving the reflexive behavior to two feeding test. These facts approve that the processes which was developed as a result of Ghrelin`s and EMF action and the central mechanisms of animals behavioral reaction on positive stimulus were connected to each other by morphofunctional and neurochemical organization.