kenneth A omoruyi - Academia.edu (original) (raw)

Papers by kenneth A omoruyi

Urachal abnormalities arerare and present more commonly in children. However when found in adults... more Urachal abnormalities arerare and present more commonly in children. However when found in adults, the commonest variety is infected urachal cysts compared with other urachal abnormalities (patent urachus, urachal sinus andvesicourachal diverticulum). Posterior urethral valves (PUV) have also been documented to coexist with urachal abnormalities. We report the case of an 8 year old male Nigerian who presented with a tender suprapubic mass, progressive weight loss and urinary incontinence. Diagnosis of infected urachal cyst was confirmed at surgery. He had complete excision of the mass and histology excluded malignant transformation. He subsequently had surgical site infection that was managed with antibiotics.

Background: Cancer of the cervix is caused by a virus called human papillomavirus (HPV) which inf... more Background: Cancer of the cervix is caused by a virus called human papillomavirus (HPV) which infects the uterine cervical epithelium. The Papanicolaou smear is a type of exfoliative cytology. Exfoliative cytology is the study of cells desquamated or shed from the body surfaces (e.g. cervix) or lesions for the purpose of diagnosis or cytological analysis. Aim: To do a cytological analysis of cervical Papanicolaou smears in a tertiary hospital in Calabar, Nigeria. Study Design: Retrospective prevalence study design. Original Research Article Irabor et al.; IRJO, 1(2): 1-9, 2018; Article no.IRJO.44418 2 Study Place and Duration: The study was done at the Department of Pathology, University of Calabar Teaching Hospital, Calabar on cervical smear analyzed between January, 2011 and December, 2013. Methodology: This is a retrospective prevalence study of the entire cervical smear (conventional smears) analyzed at the Department of Pathology, University of Calabar Teaching Hospital from Ja...

Journal of Cancer and Tumor International, 2018

Medico Research Chronicles, 2017

Cervical cancer represents a huge burden of non-infectious disease globally. It is the second com... more Cervical cancer represents a huge burden of non-infectious disease globally. It is the second commonest cancer in the female. There are over half a million deaths recorded every year as result of cervical cancer. The aetiological agent implicated in this disease is the human Papillomavirus. The high-risk human papillomavirus has been mostly implicated. The commonest high-risk human papillomavirus implicated in cervical cancer worldwide is type 16 and 18. The viral infection of the uterine cervical epithelium initially causes the development of precancerous lesions referred to as cervical intraepithelial lesions/squamous intraepithelial lesions which take many years to progress into cancer. The Papanicoulao smear test done for the screening of precancerous cervical lesions has been known to be effective in preventing the disease. The commonest types of cervical cancer are the cervical squamous cell carcinoma and adenocarcinoma.

The human papillomavirus (HPV) is an unenveloped double stranded deoxyribonucleic acid (dsDNA) vi... more The human papillomavirus (HPV) is an unenveloped double stranded deoxyribonucleic acid (dsDNA) virus capable of infecting humans and inducing cervical carcinoma in females. HPVs can also be grouped to high-risk and low-risk HPV types. Low-risk HPV types include types 6, 11, 42, 43, and 44. High-risk HPV types include types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70. HPV16 and 18 have been implicated as the commonest aetiologic agent in this disease. Various methods have been used in testing the presence of human papillomavirus including histology, pap smear, polymerase chain reaction and hybridization technique. Pap has been used for cervical carcinoma screening worldwide. Cervarix and Gardasil are effective vaccines against the human papillomavirus type 16 and 18.

Aim: To determine the relationship between age and histological types of cervical cancer in Calab... more Aim: To determine the relationship between age and histological types of cervical cancer in Calabar, Nigeria. Methodology: The study design is a prevalence study on archival specimens. The cervical cancer cases diagnosed between 2005 and 2013 were identified. Basic information (age at diagnosis, year of diagnosis and original histopathological diagnosis) was collected from medical records. The sample size for this study consists of all histological samples of cervical cancer seen in the Department of Pathology, University of Calabar Teaching Hospital, Calabar between 1 of January 2005 to 31 December 2013. The data obtained were analyzed. Results: A total of two hundred and forty-five (245) female subjects from 31 to 77 years were studied. The mean age of the subjects was 49 ± 5. Majority 160 (65.3%) of the subjects were aged below 51 years and those aged above 70 years has the highest prevalence 5 (2.5%). Subjects aged below 49 years are more likely to have keratinizing squamous cel...

International Journal of Contemporary Medical Research [IJCMR], Sep 1, 2019

Introduction: Pseudoepitheliomatous hyperplasia is a benign condition characterized by hyperplasi... more Introduction: Pseudoepitheliomatous hyperplasia is a benign condition characterized by hyperplasia of the epidermis and adnexal epithelium commonly occurring in reaction to several conditions including chronic burn wound. Case Report: An 18 month old male patient presented with scald burns to the scalp and face with chronicity and infection of the burn wound as consent for skin grafting was not given by the parents. Initial histology of incision biopsy specimen revealed a well-differentiated squamous cell carcinoma in a chronic burn wound on the scalp. This did not correlate with the clinical picture of the wound necessitating a second histologic review of the biopsy specimen, which this time was confirmed as pseudoepitheliomatous hyperplasia. Patient further declined excision and grafting with the wound eventually healing with scarring after 10 months. Conclusion: A very high index of suspicion is required in making the diagnosis of PEH. Public enlightenment is needed to educate people on wounds and their management if optimal results must be obtained.

Journal of Advances in Medicine and Medical Research

Leiomyomas are benign soft tissue neoplasms that arise from smooth muscles. Leiomyosarcoma is a m... more Leiomyomas are benign soft tissue neoplasms that arise from smooth muscles. Leiomyosarcoma is a malignant lesion of smooth muscle origin. This is a rare lesion in the uterus with 1-2 % of its benign counterpart, leiomyoma, transforming into the lesion. It is often aggressive and could develop at any site where the smooth muscle is found. We present a case of a 48-year-old farmer with pelvic mass with Ultra-sonography(USS) suggestive of leiomyoma. Hysterectomy was done and histologic diagnosis of leiomyosarcoma (LMS) was made. The patient was discharged 7 days post operation but was lost to follow up. Uterine LMS is an aggressive tumour, therefore, a high index of suspicion is needed especially for huge uterine nodules and such patients must be closely monitored for adequate management.

Journal of Advances in Medicine and Medical Research

Aim: To determine the prevalence of human papillomavirus (HPV) deoxyribonucleic acid in cervical ... more Aim: To determine the prevalence of human papillomavirus (HPV) deoxyribonucleic acid in cervical cancer specimens in Calabar, Nigeria. Study Design: This is a retrospective prevalence, a cross-sectional study on archival cervical cancer specimens.

Medico Research Chronicles

Background: Breast cancer is the commonest cancer in the female. Immunohistochemistry of breast c... more Background: Breast cancer is the commonest cancer in the female. Immunohistochemistry of breast cancer hormone receptor (ER and PR) and Her2 are very useful tools for assessing the tumor cells behavior and making choice of chemotherapy. Aims and Objective: The study aimed to describe the immunohistochemical profiles of breast carcinoma at University of Calabar Teaching Hospital (UCTH), Calabar. Method: This is a descriptive study of immunohistochemistry of breast carcinoma in UCTH using archival paraffin-embedded blocks of breast cancer tissue. The records of cases diagnosed as breast cancer in a five year period (2010-2014) in the department of Histopathology of UCTH are stained immunohistochemically for Oestrogen receptor(ER), Progesterone receptor(PR) and Human epidermal growth factor receptor 2(Her2). The demographic variables and receptor status were collated and analyzed. The status is related to the histopathologic characteristics of tumor size, histologic grade, and histologic subtypes. The findings were presented in tables and charts and statistical significance of variables tested. Result: One hundred and forty-seven (147) cases of breast cancer samples were analyzed. The mean age at diagnosis was 46.31+/-12.75 years old. The age ranged from 21-80 years old, the modal and median ages were 40 and 45 years respectively. Sixty-four percent (64%) were estrogen receptor positive. Progesterone receptor positive was 40.14% and Her2 positive was 21.09%. Conclusion: The majority of the breast cancer is estrogen receptor positive but progesterone receptor and Her2 receptor negative.

Considerable attention has been paid to infant vocalization. The aim of the current research is t... more Considerable attention has been paid to infant vocalization. The aim of the current research is to describe the prelinguistic vocal repertoire of seven young infants wearing cochlear implants and to argue for a strong relation between early developmental stages of speech, as cochlear implantation seems to trigger similar vocal performances to hearing peers. In contrast to previous studies based on typical development which argued for the existence of only one syllable type at each stage of prelinguistic speech, the present study recorded simultaneous coexistence of multi-syllable types of protophones in populations characterized as atypical. Results support a gradual transition from babbling stages into mature, more complex forms of vocalization that we meet on adult speech. Protophonic development is rapid during the first post-implant year. The findings are in agreement with other studies based on typically developing children. The difference is that current data broaden the results to disordered populations, like the infants with cochlear implants. The quantitative classification of protophones, through the combination of acoustic and auditory analyses provides a new reliable perspective for comparisons between populations with similar hearing experience. Speech pathology targets to explore the prelinguistic speech development and current methodology aims to contribute to this direction.

Background: Cancer of the cervix is caused by a virus called human papillomavirus (HPV) which inf... more Background: Cancer of the cervix is caused by a virus called human papillomavirus (HPV) which infects the uterine cervical epithelium. The Papanicolaou smear is a type of exfoliative cytology. Exfoliative cytology is the study of cells desquamated or shed from the body surfaces (e.g. cervix) or lesions for the purpose of diagnosis or cytological analysis. Aim: To do a cytological analysis of cervical Papanicolaou smears in a tertiary hospital in Calabar, Nigeria.. The relevant information including sociodemographic data, clinical information and diagnosis of the subjects were obtained from the medical records/cytology register and the information was analyzed. Results: A total of 525 Pap smear were analyzed during the study period. The age range of the patient is between 18 years and 90 years. The mean age of the subjects is 43 years ± 3 SD. The age group with the highest prevalence is the 41-50 years group making up 32% of the subjects followed by 31-40 years with a prevalence of 2...

Aim: To determine specific human papillomavirus genotypes isolated from cervical cancer specimens... more Aim: To determine specific human papillomavirus genotypes isolated from cervical cancer specimens in Calabar, Nigeria. Study Design: This is a cross-sectional study of archival paraffin-embedded tissue block of invasive cervical cancer specimen. Study Place and Period: This study was done at the department of pathology, University of Calabar Teaching Hospital, Calabar for cervical cancer specimen between January 2006 and December 2014. Methodology: Paraffin-embedded tissue block of invasive cervical cancer specimen from the study period (January 2006 to December 2014) were collected. Primary socio-demographic data were obtained from medical records in the department (such as surgical pathology register, 2 histopathology request forms). Sections of the tissue were obtained from the blocks. The deoxyribonucleic acid (DNA) was extracted and a polymerase chain reaction was done. Then DNA enzyme immunoassay and reverse hybridisation line probe assay were performed for human papillomaviru...

Background:Breast cancer is a heterogeneous disease that shows inter and intra-lesion variation. ... more Background:Breast cancer is a heterogeneous disease that shows inter and intra-lesion variation. The classification into molecular subtypes has made chemotherapeutic management of breast cancer easier and patient-specific with excellent outcomes. Immunohistochemistry are used as surrogates for intrinsic DNA gene in most resource poor countries. Aimsand objectives: This study aimed to describe prevalence of molecular subtypes of breast carcinoma using immunohistochemistry as surrogates for characteristics seen with intrinsic DNA gene. Methodology:The immunohistochemistry for oestrogen receptor, (ER), progesterone receptor (PR) and Human epidermal receptor2 (HER2) of the breast carcinoma diagnosed in the university of Calabar Teaching Hospital in a five year period from 1 st January 2010 to 31 December 2014 were collated. An algorithm is developed to determine the molecular subtypes. Luminal A (ER+/PR-, ER-/PR+. HER2-), Luminal B (ER+/PR-, ER-/PR+ and HER2+), Basal-like (ER-, PR-,HER2...

Journal of Cancer and Tumor International, 2018

Medico Research Chronicles, 2017

International Journal of Contemporary Medical Research [IJCMR], Sep 1, 2019

Journal of Advances in Medicine and Medical Research

Medico Research Chronicles

Background: Cancer of the cervix is caused by a virus called human papillomavirus (HPV) which inf... more Background: Cancer of the cervix is caused by a virus called human papillomavirus (HPV) which infects the uterine cervical epithelium. The Papanicolaou smear is a type of exfoliative cytology. Exfoliative cytology is the study of cells desquamated or shed from the body surfaces (e.g. cervix) or lesions for the purpose of diagnosis or cytological analysis. Aim: To do a cytological analysis of cervical Papanicolaou smears in a tertiary hospital in Calabar, Nigeria.. The relevant information including sociodemographic data, clinical information and diagnosis of the subjects were obtained from the medical records/cytology register and the information was analyzed. Results: A total of 525 Pap smear were analyzed during the study period. The age range of the patient is between 18 years and 90 years. The mean age of the subjects is 43 years ± 3 SD. The age group with the highest prevalence is the 41-50 years group making up 32% of the subjects followed by 31-40 years with a prevalence of 2...