larry clark - Academia.edu (original) (raw)

Papers by larry clark

Research paper thumbnail of Invasive Species Control and Resolution of Wildlife Damage Conflicts: A Framework for Chemical and Genetically Based Management Methods

Research paper thumbnail of Chemical irritation in birds: relationship between chemicalstructure of anthranilate and benzoic acid derivatives and repellency

Journal of Experimental Zoology

Research paper thumbnail of The Nest Protection Hypothesis: The Adaptive Use of Plant Secondary Compounds by the European Starling

Research paper thumbnail of Odor thresholds in passerines

Comparative Biochemistry and Physiology Part A: Physiology, 1993

Research paper thumbnail of Aerosolized essential oils and individual natural product compounds as brown treesnake repellents

Pest Management Science, 2002

Aerosolized essential oils and individual natural product Aerosolized essential oils and individu... more Aerosolized essential oils and individual natural product Aerosolized essential oils and individual natural product compounds as brown treesnake repellents compounds as brown treesnake repellents

Research paper thumbnail of Effect of Primary and Secondary Repellents on European Starlings: An Initial Assessment

The Journal of Wildlife Management, 2001

Research paper thumbnail of Ortho-Aminoacetophenone Repellency to Birds: Similarities to Methyl Anthranilate

The Journal of Wildlife Management, 1991

Research paper thumbnail of Effects of addition of a bird repellent to fish diets on their growth and bioaccumulation

Aquaculture Research, 2006

Research paper thumbnail of Covalent Modification of Schiff Base-Forming Proteins: In Vitro Evidence for Site Specificity and Behavioral Evidence for Production of Selective Hyposmia in Vivo

Annals of the New York Academy of Sciences, 1987

Chemical treatment of the olfactory epithelium can impair the sense of smell in two ways: product... more Chemical treatment of the olfactory epithelium can impair the sense of smell in two ways: production of a selective hyposmia or of general hyposmia. We have reported the former in tiger salamanders conditioned to respond to two odorants, cyclohexanone and dimethyldi~ulfide.'.~ An example of the latter can be seen in the results of ap

Research paper thumbnail of Calcium responses of chicken trigeminal ganglion neurons to methyl anthranilate and capsaicin

Journal of Experimental Biology, 2004

SUMMARY Using digital fluorescence imaging, we determined the effects of methyl anthranilate (MA)... more SUMMARY Using digital fluorescence imaging, we determined the effects of methyl anthranilate (MA), an avian irritant, and capsaicin (CAP), a mammalian irritant, on intracellular calcium ([Ca2+]i) in chicken trigeminal neurons. Concentration–response functions indicated that the threshold for inducing increases in [Ca2+]i was higher for CAP (30 μmol l–1) than for MA (10 μmol l–1). The maximum magnitudes of [Ca2+]iin response to MA and CAP were compared after normalization to 40 mmol l–1 KCl. At equal concentrations (300 μmol l–1), trigeminal neurons responded with a greater change in[Ca2+]i to MA (78% of KCl) than to CAP (43% of KCl). Furthermore, at 300 μmol l–1, 48% of neurons responded to MA whereas only 16% responded to CAP. The increases in[Ca2+]i induced by both MA and CAP were dependent upon extracellular calcium. While the calcium responses to MA were also dependent on extracellular sodium, responses to CAP were not. There were separate but overlapping populations of neurons ...

Research paper thumbnail of Pen Tests of Methyl Anthranilate as a Bird Repellent in Water

Research paper thumbnail of 1987 AnimBehav (Clark olfaction starling)

Research paper thumbnail of Nest desertion by the pinyon jay

Short Communications TABLE 2. Weight changes (g) of 11 Screech Owls between spring and fall-winte... more Short Communications TABLE 2. Weight changes (g) of 11 Screech Owls between spring and fall-winter. [Auk, Vol. 96 Spring Fall-winter Sex Date captured (weight) Date captured (weight) Wt. gain Male 05-14-75 (150) 10-29-75 (180) +30 Male 04-15-76 (145) 10-30-75 (180) +35 Male 05-18-78 (170) 12-28-77 (185) + 15 Male 04-24-75 (160) 02-22-77 (165) +5 Male 05-04-76 (185) 02-22-77 (150) a-35 Female 05-11-78 (205) 12-05-78 (225) + 20 Female 05-14-76 (160) 12-28-77 (200) +40 Female 05-22-75 (190) 02-21-77 (220) +30 Female 04-24-76 (180) 02-21-77 (190) + 10 Female 05-04-76 (180) 02-22-77 (185) +5 Unknown 05-06-76 (205) 01-01-75 (220) + 15 Mean males 156.2 177.5 +21.3 Mean females 183.0 204.0 + 21.0 a Banded as adult on i May 1967, was at least 103A yr old and in poor condition; excluded from mean for males. the extremely cold winter of 1977-78, which included deep snow, five dead Screech Owls were found. No dead owls were found in 1975-76 or 1976-77 when the boxes were checked in the spring. Eighteen and 15 pairs nested successfully in the 150 nest boxes in 1976 and 1977, respectively. The number declined to 6 in 1978 (6 in 150 boxes, or 4%) following the severe winter; this is the lowest percentage recorded since the study began in 1944 (VanCamp and Henny 1975). It appears that a fall weight gain is important to the Screech Owl, but in spite of the weight gain, extreme weather conditions, which tend to occur irregularly, can still pose a hardship for this species near the northern edge of its breeding range in Ohio. The manuscript was improved by the reviews of Vivian M. Mendenhall and Anne R. McLane. LITERATURE CITED EARHART, C. M., & N. K. JOHNSON. 1970. Size dimorphism and food habits of North American owls.

Research paper thumbnail of Chemoreception and the evolutionary and ecological significance of the use of green plants as nest fumigants by starlings

Research paper thumbnail of Reproductive strategy of the Norway rat, Rattus norvegicus in the presence of predator

Zoologicheskiĭ zhurnal

The reproductive success of laboratory rats (Rattus norvegicus) housed at different distances (2,... more The reproductive success of laboratory rats (Rattus norvegicus) housed at different distances (2, 20, and 80 m) from a predator (Lynx lynx) was investigated. Virgin female (n = 120) and male (n = 40) rats of an outbred laboratory population were used for the experiments. Groups of rats (I male and 3 females) were housed in standard cages in close proximity to the predator. Litter size, sex ratio. number of alive pups, number of placental scars and corpora lutea were counted; pre- and post-implantation losses were calculated for each female. The reproductive success of females calculated as a number of alive pups per female was much higher in both control groups (20 and 80 m) than in both test groups (2 and 2 m). Equal numbers of corpora lutea in all groups but different numbers of placental scars between the control and test groups indicated a higher pre-implantation loss in the experimental groups. The post-implantation loss was also higher in both test groups. The total loss (calc...

Research paper thumbnail of Bird Aversive Properties of Methyl Anthranilate, Yucca, Xanthoxylum, and Their Mixtures

We tested the bird aversive properties of methyl anthranilate, yucca extracts, and Xanthoxylum sp... more We tested the bird aversive properties of methyl anthranilate, yucca extracts, and Xanthoxylum spp. extracts in one-and two-bottle drinking assays that used European starlings (Sturnus vulgaris). In one-and two-bottle tests, methyl anthranilate proved to be the more potent stimulus in producing an avoidance response. Starlings avoided consuming Xanthoxylum and yucca only in the two-bottle tests. Previous studies showed that yucca was a good adjuvant in stabilizing lipophilic compounds in water. Starlings did not avoid binary mixtures of methyl anthranilate and yucca differently from what would be expected if they were only responding to the solution's methyl anthranilate content. However, yucca enhanced the aversive qualities of Xanthoxylum. The ability to identify mode of action for repellency and synergistic combinations of chemicals derived from natural products for use in repellent mixtures is an important aspect of the development of cost-effective, environmentally safe repellents for use in conflict resolution between humans and wildlife.

Research paper thumbnail of Selective deficits in the sense of smell caused by chemical modification of the olfactory epithelium

Research paper thumbnail of Human food flavor additives as bird repellents: I. Conjugated aromatic compounds

Pesticide Science, 1999

ABSTRACT Avian repellents derived from natural products and human food flavorants may be less exp... more ABSTRACT Avian repellents derived from natural products and human food flavorants may be less expensive to register under United States environmental pesticide registration requirements. However, one difficulty faced by workers attempting to target repellents for development is the need to screen large numbers of compounds for activity, as well as consideration of formulation and environmental constraints. In this study, we compare the bird repellent activity of aldehyde-based human food additives and compare the levels of activity with our previously elucidated model for structure–activity relationships (SAR) for bird repellents. We find that a previously elucidated SAR model for identifying acetophenone and anthranilate bird repellents is applicable to predicting the activity of aromatic aldehyde flavorants as well. In particular, of the nine flavorants tested, four, benzaldehyde, cinnamaldehyde, o-tolualdehyde, and o-anisaldehyde, warrant further consideration as bird repellents.L© 1999 Society of Chemical Industry

Research paper thumbnail of Potential for cell culture techniques as a wildlife management tool for screening primary repellents

International Biodeterioration & Biodegradation, 2000

The identi®cation of new chemical repellents for wildlife damage management is impeded by the nee... more The identi®cation of new chemical repellents for wildlife damage management is impeded by the need to perform cumbersome and expensive behavioral tests. Here, we report the development of in vitro cell culture methods to increase the speed and eciency of repellent screening while reducing costs, as well as the number of animals necessary for research. Our methods exploit the fact that eective primary repellents depend on the stimulation of pain receptors. We cultured trigeminal nociceptors (pain receptors) from Norway rat (Rattus norvegicus, laboratory strain), white leghorn chicken (Gallus gallus), coyote (Canis latrans), white-tailed deer (Odocoileus virginianus) and Canada goose (Branta canadensis), and then applied digital¯uorescence microscopy to measure changes in intracellular calcium (an index of cellular activation) in response to applications of known and eective repellents. Capsaicin, bradykinin and acetylcholine were more eective stimuli for rat, coyote, and deer neurons than cells from chicken.

Research paper thumbnail of A Review of Pathogens of Agricultural and Human Health Interest Found in Blackbirds

Because of their numbers and close association with humans and agriculture. the role of blackbird... more Because of their numbers and close association with humans and agriculture. the role of blackbirds in disease transmission has been of concern. Unfortunately fear systematic and quantit3tir.e studies have been carried out that bear on this issue. We review the extant literature on zoonases xnd oathoeens of aericultural concern where there is documented evidcnce for the . " involvement of blzckbirds and starlings. It is clear that blackbirds can exacerbate levels of risk for failures in agricultural biosecurity and human health. To what degree these levels of risk are raised is largelv unknown and should be the focus of future . studies because this information will prove vital in the assessment of management options.

Research paper thumbnail of Invasive Species Control and Resolution of Wildlife Damage Conflicts: A Framework for Chemical and Genetically Based Management Methods

Research paper thumbnail of Chemical irritation in birds: relationship between chemicalstructure of anthranilate and benzoic acid derivatives and repellency

Journal of Experimental Zoology

Research paper thumbnail of The Nest Protection Hypothesis: The Adaptive Use of Plant Secondary Compounds by the European Starling

Research paper thumbnail of Odor thresholds in passerines

Comparative Biochemistry and Physiology Part A: Physiology, 1993

Research paper thumbnail of Aerosolized essential oils and individual natural product compounds as brown treesnake repellents

Pest Management Science, 2002

Aerosolized essential oils and individual natural product Aerosolized essential oils and individu... more Aerosolized essential oils and individual natural product Aerosolized essential oils and individual natural product compounds as brown treesnake repellents compounds as brown treesnake repellents

Research paper thumbnail of Effect of Primary and Secondary Repellents on European Starlings: An Initial Assessment

The Journal of Wildlife Management, 2001

Research paper thumbnail of Ortho-Aminoacetophenone Repellency to Birds: Similarities to Methyl Anthranilate

The Journal of Wildlife Management, 1991

Research paper thumbnail of Effects of addition of a bird repellent to fish diets on their growth and bioaccumulation

Aquaculture Research, 2006

Research paper thumbnail of Covalent Modification of Schiff Base-Forming Proteins: In Vitro Evidence for Site Specificity and Behavioral Evidence for Production of Selective Hyposmia in Vivo

Annals of the New York Academy of Sciences, 1987

Chemical treatment of the olfactory epithelium can impair the sense of smell in two ways: product... more Chemical treatment of the olfactory epithelium can impair the sense of smell in two ways: production of a selective hyposmia or of general hyposmia. We have reported the former in tiger salamanders conditioned to respond to two odorants, cyclohexanone and dimethyldi~ulfide.'.~ An example of the latter can be seen in the results of ap

Research paper thumbnail of Calcium responses of chicken trigeminal ganglion neurons to methyl anthranilate and capsaicin

Journal of Experimental Biology, 2004

SUMMARY Using digital fluorescence imaging, we determined the effects of methyl anthranilate (MA)... more SUMMARY Using digital fluorescence imaging, we determined the effects of methyl anthranilate (MA), an avian irritant, and capsaicin (CAP), a mammalian irritant, on intracellular calcium ([Ca2+]i) in chicken trigeminal neurons. Concentration–response functions indicated that the threshold for inducing increases in [Ca2+]i was higher for CAP (30 μmol l–1) than for MA (10 μmol l–1). The maximum magnitudes of [Ca2+]iin response to MA and CAP were compared after normalization to 40 mmol l–1 KCl. At equal concentrations (300 μmol l–1), trigeminal neurons responded with a greater change in[Ca2+]i to MA (78% of KCl) than to CAP (43% of KCl). Furthermore, at 300 μmol l–1, 48% of neurons responded to MA whereas only 16% responded to CAP. The increases in[Ca2+]i induced by both MA and CAP were dependent upon extracellular calcium. While the calcium responses to MA were also dependent on extracellular sodium, responses to CAP were not. There were separate but overlapping populations of neurons ...

Research paper thumbnail of Pen Tests of Methyl Anthranilate as a Bird Repellent in Water

Research paper thumbnail of 1987 AnimBehav (Clark olfaction starling)

Research paper thumbnail of Nest desertion by the pinyon jay

Short Communications TABLE 2. Weight changes (g) of 11 Screech Owls between spring and fall-winte... more Short Communications TABLE 2. Weight changes (g) of 11 Screech Owls between spring and fall-winter. [Auk, Vol. 96 Spring Fall-winter Sex Date captured (weight) Date captured (weight) Wt. gain Male 05-14-75 (150) 10-29-75 (180) +30 Male 04-15-76 (145) 10-30-75 (180) +35 Male 05-18-78 (170) 12-28-77 (185) + 15 Male 04-24-75 (160) 02-22-77 (165) +5 Male 05-04-76 (185) 02-22-77 (150) a-35 Female 05-11-78 (205) 12-05-78 (225) + 20 Female 05-14-76 (160) 12-28-77 (200) +40 Female 05-22-75 (190) 02-21-77 (220) +30 Female 04-24-76 (180) 02-21-77 (190) + 10 Female 05-04-76 (180) 02-22-77 (185) +5 Unknown 05-06-76 (205) 01-01-75 (220) + 15 Mean males 156.2 177.5 +21.3 Mean females 183.0 204.0 + 21.0 a Banded as adult on i May 1967, was at least 103A yr old and in poor condition; excluded from mean for males. the extremely cold winter of 1977-78, which included deep snow, five dead Screech Owls were found. No dead owls were found in 1975-76 or 1976-77 when the boxes were checked in the spring. Eighteen and 15 pairs nested successfully in the 150 nest boxes in 1976 and 1977, respectively. The number declined to 6 in 1978 (6 in 150 boxes, or 4%) following the severe winter; this is the lowest percentage recorded since the study began in 1944 (VanCamp and Henny 1975). It appears that a fall weight gain is important to the Screech Owl, but in spite of the weight gain, extreme weather conditions, which tend to occur irregularly, can still pose a hardship for this species near the northern edge of its breeding range in Ohio. The manuscript was improved by the reviews of Vivian M. Mendenhall and Anne R. McLane. LITERATURE CITED EARHART, C. M., & N. K. JOHNSON. 1970. Size dimorphism and food habits of North American owls.

Research paper thumbnail of Chemoreception and the evolutionary and ecological significance of the use of green plants as nest fumigants by starlings

Research paper thumbnail of Reproductive strategy of the Norway rat, Rattus norvegicus in the presence of predator

Zoologicheskiĭ zhurnal

The reproductive success of laboratory rats (Rattus norvegicus) housed at different distances (2,... more The reproductive success of laboratory rats (Rattus norvegicus) housed at different distances (2, 20, and 80 m) from a predator (Lynx lynx) was investigated. Virgin female (n = 120) and male (n = 40) rats of an outbred laboratory population were used for the experiments. Groups of rats (I male and 3 females) were housed in standard cages in close proximity to the predator. Litter size, sex ratio. number of alive pups, number of placental scars and corpora lutea were counted; pre- and post-implantation losses were calculated for each female. The reproductive success of females calculated as a number of alive pups per female was much higher in both control groups (20 and 80 m) than in both test groups (2 and 2 m). Equal numbers of corpora lutea in all groups but different numbers of placental scars between the control and test groups indicated a higher pre-implantation loss in the experimental groups. The post-implantation loss was also higher in both test groups. The total loss (calc...

Research paper thumbnail of Bird Aversive Properties of Methyl Anthranilate, Yucca, Xanthoxylum, and Their Mixtures

We tested the bird aversive properties of methyl anthranilate, yucca extracts, and Xanthoxylum sp... more We tested the bird aversive properties of methyl anthranilate, yucca extracts, and Xanthoxylum spp. extracts in one-and two-bottle drinking assays that used European starlings (Sturnus vulgaris). In one-and two-bottle tests, methyl anthranilate proved to be the more potent stimulus in producing an avoidance response. Starlings avoided consuming Xanthoxylum and yucca only in the two-bottle tests. Previous studies showed that yucca was a good adjuvant in stabilizing lipophilic compounds in water. Starlings did not avoid binary mixtures of methyl anthranilate and yucca differently from what would be expected if they were only responding to the solution's methyl anthranilate content. However, yucca enhanced the aversive qualities of Xanthoxylum. The ability to identify mode of action for repellency and synergistic combinations of chemicals derived from natural products for use in repellent mixtures is an important aspect of the development of cost-effective, environmentally safe repellents for use in conflict resolution between humans and wildlife.

Research paper thumbnail of Selective deficits in the sense of smell caused by chemical modification of the olfactory epithelium

Research paper thumbnail of Human food flavor additives as bird repellents: I. Conjugated aromatic compounds

Pesticide Science, 1999

ABSTRACT Avian repellents derived from natural products and human food flavorants may be less exp... more ABSTRACT Avian repellents derived from natural products and human food flavorants may be less expensive to register under United States environmental pesticide registration requirements. However, one difficulty faced by workers attempting to target repellents for development is the need to screen large numbers of compounds for activity, as well as consideration of formulation and environmental constraints. In this study, we compare the bird repellent activity of aldehyde-based human food additives and compare the levels of activity with our previously elucidated model for structure–activity relationships (SAR) for bird repellents. We find that a previously elucidated SAR model for identifying acetophenone and anthranilate bird repellents is applicable to predicting the activity of aromatic aldehyde flavorants as well. In particular, of the nine flavorants tested, four, benzaldehyde, cinnamaldehyde, o-tolualdehyde, and o-anisaldehyde, warrant further consideration as bird repellents.L© 1999 Society of Chemical Industry

Research paper thumbnail of Potential for cell culture techniques as a wildlife management tool for screening primary repellents

International Biodeterioration & Biodegradation, 2000

The identi®cation of new chemical repellents for wildlife damage management is impeded by the nee... more The identi®cation of new chemical repellents for wildlife damage management is impeded by the need to perform cumbersome and expensive behavioral tests. Here, we report the development of in vitro cell culture methods to increase the speed and eciency of repellent screening while reducing costs, as well as the number of animals necessary for research. Our methods exploit the fact that eective primary repellents depend on the stimulation of pain receptors. We cultured trigeminal nociceptors (pain receptors) from Norway rat (Rattus norvegicus, laboratory strain), white leghorn chicken (Gallus gallus), coyote (Canis latrans), white-tailed deer (Odocoileus virginianus) and Canada goose (Branta canadensis), and then applied digital¯uorescence microscopy to measure changes in intracellular calcium (an index of cellular activation) in response to applications of known and eective repellents. Capsaicin, bradykinin and acetylcholine were more eective stimuli for rat, coyote, and deer neurons than cells from chicken.

Research paper thumbnail of A Review of Pathogens of Agricultural and Human Health Interest Found in Blackbirds

Because of their numbers and close association with humans and agriculture. the role of blackbird... more Because of their numbers and close association with humans and agriculture. the role of blackbirds in disease transmission has been of concern. Unfortunately fear systematic and quantit3tir.e studies have been carried out that bear on this issue. We review the extant literature on zoonases xnd oathoeens of aericultural concern where there is documented evidcnce for the . " involvement of blzckbirds and starlings. It is clear that blackbirds can exacerbate levels of risk for failures in agricultural biosecurity and human health. To what degree these levels of risk are raised is largelv unknown and should be the focus of future . studies because this information will prove vital in the assessment of management options.