luisa simonsen - Academia.edu (original) (raw)
Papers by luisa simonsen
Journal of human and clinical genetics, Oct 1, 2020
Peroxisomal disorders are a group of expanding genetic diseases divided into two major categories... more Peroxisomal disorders are a group of expanding genetic diseases divided into two major categories: peroxisome biogenesis defects (Zellweger spectrum disorder), and single enzymatic defects. Disorders of Peroxisome Biogenesis occur when there are biallelic pathogenic variants in any of the 13 PEX genes, which code for the peroxins, proteins required for peroxisome biogenesis. This group of disorders includes two distinct phenotypes: Rhizomelic Chondrodysplasia Punctata Type-1 and Zellweger Spectrum Disorders (ZSD), of which Zellweger syndrome is the most severe, neonatal adrenoleukodystrophy is intermediate, and infantile Refsum is the mildest. The spectrum's most frequent defects are observed in the proteins PEX1 and PEX6, and the most common clinical presentation is Zellweger spectrum, which is often associated with craniofacial dysmorphism with neurologic abnormalities. Typically, the neuroimaging pattern shows several malformative features, including a range of cortical gyral abnormalities such as microgyria and pachygyria, and impairment of the myelination. Nevertheless, we report two siblings with peroxisomal disorder, with unexpected leukodystrophy pattern of the brain mimicking lysosomal storage disease, with classical imaging features of Krabbe disease on brain magnetic resonance image. By whole exome sequencing, we identified two pathogenic variants in compound heterozygosity in PEX6: Chr6:42.933.455 C>T (c.2435G>A), and Chr6:42.935.188 C>T (c.1802G>A). Thus, a final diagnosis of peroxisome disorder was confirmed. The index cases highlight the importance of considering peroxisome disorders as a differential diagnosis for patients with imaging features that resemble Krabbe disease.
PEX6: An Imaging Overlap Between Peroxisomal and Lysosomal Storage Diseases César Augusto Pinheir... more PEX6: An Imaging Overlap Between Peroxisomal and Lysosomal Storage Diseases César Augusto Pinheiro Ferreira Alves1,3*, Luisa Norbert Simonsen2, Jonathan Rodrigues1, Isabella Peixoto de Barcelos2, Clarissa Bueno2, Ramon Moura Dos Santos1, Fernando Kok2,4, Leandro Tavares Lucato1 1Neuroradiology Section, Hospital das Clínicas da Universidade de São Paulo, Brazil 2Neurogenetics Unit Neurology Department, Hospital das Clínicas da Universidade de São Paulo, Brazil 3Division of Neuroradiology, Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA 4Mendelics Genomic Analysis, São Paulo, SP, Brazil
Journal of human and clinical genetics, Oct 1, 2020
Peroxisomal disorders are a group of expanding genetic diseases divided into two major categories... more Peroxisomal disorders are a group of expanding genetic diseases divided into two major categories: peroxisome biogenesis defects (Zellweger spectrum disorder), and single enzymatic defects. Disorders of Peroxisome Biogenesis occur when there are biallelic pathogenic variants in any of the 13 PEX genes, which code for the peroxins, proteins required for peroxisome biogenesis. This group of disorders includes two distinct phenotypes: Rhizomelic Chondrodysplasia Punctata Type-1 and Zellweger Spectrum Disorders (ZSD), of which Zellweger syndrome is the most severe, neonatal adrenoleukodystrophy is intermediate, and infantile Refsum is the mildest. The spectrum's most frequent defects are observed in the proteins PEX1 and PEX6, and the most common clinical presentation is Zellweger spectrum, which is often associated with craniofacial dysmorphism with neurologic abnormalities. Typically, the neuroimaging pattern shows several malformative features, including a range of cortical gyral abnormalities such as microgyria and pachygyria, and impairment of the myelination. Nevertheless, we report two siblings with peroxisomal disorder, with unexpected leukodystrophy pattern of the brain mimicking lysosomal storage disease, with classical imaging features of Krabbe disease on brain magnetic resonance image. By whole exome sequencing, we identified two pathogenic variants in compound heterozygosity in PEX6: Chr6:42.933.455 C>T (c.2435G>A), and Chr6:42.935.188 C>T (c.1802G>A). Thus, a final diagnosis of peroxisome disorder was confirmed. The index cases highlight the importance of considering peroxisome disorders as a differential diagnosis for patients with imaging features that resemble Krabbe disease.
PEX6: An Imaging Overlap Between Peroxisomal and Lysosomal Storage Diseases César Augusto Pinheir... more PEX6: An Imaging Overlap Between Peroxisomal and Lysosomal Storage Diseases César Augusto Pinheiro Ferreira Alves1,3*, Luisa Norbert Simonsen2, Jonathan Rodrigues1, Isabella Peixoto de Barcelos2, Clarissa Bueno2, Ramon Moura Dos Santos1, Fernando Kok2,4, Leandro Tavares Lucato1 1Neuroradiology Section, Hospital das Clínicas da Universidade de São Paulo, Brazil 2Neurogenetics Unit Neurology Department, Hospital das Clínicas da Universidade de São Paulo, Brazil 3Division of Neuroradiology, Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA 4Mendelics Genomic Analysis, São Paulo, SP, Brazil