mahmoud said - Academia.edu (original) (raw)
Papers by mahmoud said
Egyptian Journal of Chemistry
Knowledge integration within the organization translates the raw knowledge into actionable knowle... more Knowledge integration within the organization translates the raw knowledge into actionable knowledge to solve organization problems.Knowledge used in this process can have different formalism that fall in two categories, logical based approach like first order logic, descriptive logic and, the other is non-logical based approach like natural language, ontology, semantic network etc.Many knowledge integration frameworks have been proposed to ease this complex process to ensure the result knowledge meet some quality attributes i.e. soundness, completeness etc. The aim of this study is to explore and analyse existing research in knowledge integration framework focusing on the formalism of raw knowledge and actionable knowledge as well as techniques used by knowledge integration framework and the limitations of those knowledge integration frameworks. This paper presents a systematic review of several researches which propose knowledge integration framework in last five years.We found mo...
Journal of Biosciences and Medicines, 2021
Medical imaging procedures such as computed tomography (CT) and cone-beam computed tomography (CB... more Medical imaging procedures such as computed tomography (CT) and cone-beam computed tomography (CBCT) have been widely used in the diagnosis, detection and treatments of cancers worldwide. The achieved efficiency in the clinical workflow and improved patient care come at a price of radiation doses that pose potential cancer risks to the patients, especially the children who are more susceptible to the radiation damage than the adults. To address this concern, we have newly developed an iPhone app termed CT Gently that can be used to estimate the organ doses and associated cancer risk from CT and CBCT scans based on individual anatomy and scan mode. Furthermore, the CT Gently app can generate optimized mAs and kVp settings for personalized low-dose CT and CBCT scans, essential to the children undergoing these imaging procedures. The increasing radiation exposure to the large population including millions of children necessitates the applications of personalized CT and CBCT imaging for the children as well as the adults.
Frontiers in Plant Science
Breeding of agricultural crops adapted to climate change and resistant to diseases and pests is h... more Breeding of agricultural crops adapted to climate change and resistant to diseases and pests is hindered by a limited gene pool because of domestication and thousands of years of human selection. One way to increase genetic variation is chromosome-mediated gene transfer from wild relatives by cross hybridization. In the case of wheat (Triticum aestivum), the species of genus Aegilops are a particularly attractive source of new genes and alleles. However, during the evolution of the Aegilops and Triticum genera, diversification of the D-genome lineage resulted in the formation of diploid C, M, and U genomes of Aegilops. The extent of structural genome alterations, which accompanied their evolution and speciation, and the shortage of molecular tools to detect Aegilops chromatin hamper gene transfer into wheat. To investigate the chromosome structure and help develop molecular markers with a known physical position that could improve the efficiency of the selection of desired introgres...
Journal of Performance of Constructed Facilities
The following corrections should be made to the original paper: • Fig. 4 should be corrected. The... more The following corrections should be made to the original paper: • Fig. 4 should be corrected. The labels in the figure were incorrect and could mislead the reader. The correct Fig. 4 is provided herein. • The authors regret that the "Acknowledgments" section was dropped from the paper. It is provided herein. Fig. 4. Constant voltage accelerated corrosion setup.
Engineering Structures
Abstract The experimental work presented in this paper investigated the effect of large corroded ... more Abstract The experimental work presented in this paper investigated the effect of large corroded area of the flexural reinforcement on the structural response of two-way reinforced concrete slabs. Four typical full-size two-way reinforced concrete slabs were fabricated and tested for this study. The slab dimensions were 1900 mm × 1900 mm × 150 mm. The reinforcement of the slabs were totally corroded except for one-half of the development length at the end of the reinforcement. The corroded area was 1480 mm × 1480 mm. A uniform level of corrosion was induced by using an accelerated corrosion technique through applying constant current density of 200 μ A / cm 2 through the reinforcement. Four different levels of corrosion were reached 0%, 15%, 25%, and 50% of the mass loss. The results are obtained in terms of load versus deflection curves, load versus crack width curves, crack patterns, deflection profiles, slab rotations, energy absorption, and ductility index. The results showed that the increase in mass loss, led to a reduction in the slab capacity and stiffness. Whereas the deflection capacities, slab rotations, and crack widths increased with increased mass loss. The experimental failure loads were compared with the predictions of four different codes. None of codes gave safe predictions for the slabs with 25% and 50% mass loss.
Construction and Building Materials
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017
Considerable attention has been paid to the introduction of novel naturally occurring plant-deriv... more Considerable attention has been paid to the introduction of novel naturally occurring plant-derived radiosensitizer compounds in order to augment the radiation efficacy and improve the treatment outcome of different tumors. This study was therefore undertaken to evaluate the antitumor, antiangiogeneic, and synergistic radiosensitizing effects of apigenin, a dietary flavonoid, and/or cryptotanshinone, a terpenoid isolated from the roots of Salvia miltiorrhiza, against the growth of solid Ehrlich carcinoma in female mice. Apigenin (50 mg/kg body weight) and/or cryptotanshinone (40 mg/kg body weight) was intraperitoneally (i.p.) injected into non-irradiated or γ-irradiated (6.5 Gy whole-body γ-irradiation) solid Ehrlich carcinoma-bearing mice for 30 consecutive days. Investigations included molecular targets involved in proliferation, inflammation, angiogenesis, and tumor invasiveness. Treatment with apigenin and/or cryptotanshinone significantly suppressed the growth of solid Ehrlich ...
Naunyn-Schmiedeberg's archives of pharmacology, 2017
There is no standard treatment of chronic nonbacterial prostatitis in humans. The current study w... more There is no standard treatment of chronic nonbacterial prostatitis in humans. The current study was aimed to investigate the effect of montelukast, an antagonist of cysteinyl leukotriene receptor-1, against estrogen-induced, nonbacterial lateral lobe-specific prostate inflammation in rats. Male Wistar rats were randomized into five groups of six rats, including sham controls (group 1) and castrated rats (group 2), whereas nonbacterial prostatitis (NBP) was induced in groups 3-5 by castration followed by a daily subcutaneous injection of estradiol (0.25 mg/kg body weight) for 30 days. The rats were left otherwise untreated (group 3) or received a daily oral administration of montelukast (1 and 10 mg/kg body weight for groups 4 and 5, respectively) from the 17th day after castration for two consecutive weeks. Compared with sham controls, induction of NBP led to a significant increase in serum leukotriene B4 (LTB4), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) levels, ...
The treatment and disposal of petroleum oily sludges represent major challenges for petroleum ind... more The treatment and disposal of petroleum oily sludges represent major challenges for petroleum industries. The oily sludges consume a high portion of a refiner's budget and pose a serious threat to the environment. Montreal and Kyoto protocols introduced significant restrictions on the disposal of petroleum wastes and reduced the options available for treating this type of hazardous wastes. This research considered the application of bioremediation principles to petroleum oily sludge using a new testing technique. Approximately, 35% of the total petroleum hydrocarbons, and 81% of the aliphatic hydrocarbons in the sludge were degraded using a fungal-bacterial co-culture. To my knowledge, this was the first time fungal-bacterial co-cultures have been used in the treatment of petroleum oily sludge. Prior to treatment with the co-cultures, the sludge was subjected to a special electrokinetic separation technology that reduced its oil and water contents. The cultures were isolated from petroleum oily sludge taken from the bottom of crude oil storage tanks. The fungal and bacterial strains, used in the co-culture, were identified as Paecilomyces variotii and Bacillus cereus , respectively. The cultures were inoculated on 0.22 om filters laid over the sludge. Reduction in aliphatic hydrocarbons was estimated using Fourier transform infrared spectrometry (FTIR). Total Petroleum Hydrocarbons (TPH) were estimated using solvent extraction. An amphoteric surfactant was used in the studies but it did not improve biodegradation rates. The testing technique gave a comprehensive indication of the efficiency of the process and the toxicity of the sludge for defined cultures of the microorganisms.
Chromosome Research
Terminal deletions in Hordeum chilense chromosomes were induced genetically by the gametocidal ac... more Terminal deletions in Hordeum chilense chromosomes were induced genetically by the gametocidal activity of an alien chromosome 2C derived from Aegilops cylindrica. Diploid organisms such as H.chilense do not tolerate deletions, so them strategy that we followed allowed their obtention in both wheat and tritordeum genetic background. Terminal deletions were observed in all seven H.chilense chromosomes, except in chromosome 7Hch. Unfortunately, we failed to establish many of deletions because of sterility. Fertile homozygous plants with deficiencies in the short arm of chromosomes 1Hch and 3Hch and in the long arm of chromosomes 4Hch and 6Hch were obtained. Deletions in the long arm of chromosome 4Hch were obtained in tritordeum background. Deficiencies in the short arms of both chromosomes 1Hch and 3Hch and in the long arm of chromosome 6Hch were established, both as addition or substitution lines, in wheat background. All these plants showed variations in morphological traits and al...
The Journal of Pathology
Several mediators of systemic vasodilatation in liver cirrhosis have been reported. Among these i... more Several mediators of systemic vasodilatation in liver cirrhosis have been reported. Among these is nitric oxide (NO), which has been proposed as one of the main mediators. In this study, sera and liver biopsies were analysed from 15 patients with clinically and pathologically diagnosed liver cirrhosis. In addition, sera from seven and liver biopsies from three healthy controls were used. Serum levels of nitrite (the end product of NO) were measured using the Griess reaction and the expression of the inducible nitric oxide synthase (iNOS) and constitutive nitric oxide synthase (ecNOS) proteins was investigated using immunohistochemistry. This study shows that serum nitrite levels (94 ± 9.8 µmol/l) in cirrhotic patients were significantly (p Keywords: cytokines; ecNOS; hepatitis; iNOS; inflammation; liver cirrhosis; nitric oxide; portal hypertension Document Type: Research Article DOI: http://dx.doi.org/10.1002/path.1377 Affiliations: 1: Departments of Tropical Medicine and General Me...
Journal of toxicology and environmental health. Part A, 2015
Benign prostatic hyperplasia (BPH), a disease occurring frequently among elderly males, is a slow... more Benign prostatic hyperplasia (BPH), a disease occurring frequently among elderly males, is a slow progressive enlargement of the fibromuscular and epithelial structures of the prostate gland. Dietary factors may influence the prostate and exert an influence on prostatic growth and disease. The current study was undertaken to investigate the protective effect of dietary flaxseed supplementation against testosterone-induced prostatic hyperplasia in male rats. Forty male Wistar rats were divided into 5 groups: (1) untreated control; (2) treatment with testosterone propionate (TP) to induce prostate enlargement; (3) TP-treated group fed a diet containing 5% milled flaxseed; (4) TP-treated group fed a diet containing 10% milled flaxseed; and (5) TP-treated group fed a diet containing 20 ppm finasteride. Treatment with TP significantly increased the absolute and relative weights of different prostatic lobes, serum testosterone (T), and testosterone/estradiol ratio, as well as prostatic va...
Economic Quality Control, 2010
ABSTRACT The method to measure the market risk (which stocks are exposed) by the slope coefficien... more ABSTRACT The method to measure the market risk (which stocks are exposed) by the slope coefficient of a linear regression model (that relates the returns of the asset and the returns of a market index) is known as market model. When applying this method it is extremely important to check the stability of the parameters (the slope, the intercept and the variance) over the time to neutralize the market risk. Procedures known in statistical quality control as analysis of linear profiles are presented for such purpose. By statistical tests based on the F-statistics, it is possible to identify the sources of variation and also out-of-control samples. Numerical examples illustrate the proposed procedures.
Egyptian Journal of Biochemistry and Molecular Biology, 2011
ABSTRACT
Journal of toxicologic pathology, 2009
The present study was undertaken to investigate the effect of dietary supplementation with nimesu... more The present study was undertaken to investigate the effect of dietary supplementation with nimesulide or eugenol on N-nitrosodiethylamine (DEN)-initiated early hepatocarcinogenesis in F344 male rats. Both compounds did not alter the expression of cytochrome P450 (CYP) 2E1, the enzyme that plays a major role in the activation of DEN to genotoxic products; however, nimesulide induced the expression of CYP1A1. Western blot analysis revealed that COX-1 and COX-2 protein expressions were not modulated by DEN compared with normal controls. Furthermore, post-initiation feeding with nimesulide or eugenol did not modulate COX-2 protein expression in normal or DEN-treated rats, whereas eugenol significantly increased the liver prostaglandin E(2) (PGE(2)) levels of DEN-injected animals compared with the DEN controls. Ultimately, nimesulide or eugenol did not modify DEN-induced hepatocarcinogenesis as evidenced by insignificant changes in the number and size of preneoplastic placental glutathio...
Pharmaceutical biology, 2015
Context: The antitumor activity of aloin, the active anthraquinone of Aloe juice, against differe... more Context: The antitumor activity of aloin, the active anthraquinone of Aloe juice, against different murine and human tumors has been reported. In the present study, the impact of repeated aloin treatment at its maximum tolerated dose on serum levels of lipid profile, some elements, iron status and kidney function, compared with doxorubicin (a cardiotoxic anthracycline and inhibitor of erythropoiesis), was assessed. Rats were treated with a single dose of doxorubicin (30 mg/kg body weight, intraperitoneal) or aloin (50 mg/kg body weight, intramuscular) twice weekly over 2 weeks. Acute doxorubicin treatment elevated serum levels of triacylglycerols (59.90%), total cholesterol (42.29%), cholesteryl esters (54.75%), low density lipoprotein-cholesterol (230.16%), very low density lipoprotein-cholesterol (56.42%), urea (287.53%), and creatinine (85.38%), whereas serum high density lipoprotein-cholesterol, sodium, and calcium levels were reduced (44.61, 9.61, and 9.76%, respectively), as c...
Egyptian Journal of Chemistry
Knowledge integration within the organization translates the raw knowledge into actionable knowle... more Knowledge integration within the organization translates the raw knowledge into actionable knowledge to solve organization problems.Knowledge used in this process can have different formalism that fall in two categories, logical based approach like first order logic, descriptive logic and, the other is non-logical based approach like natural language, ontology, semantic network etc.Many knowledge integration frameworks have been proposed to ease this complex process to ensure the result knowledge meet some quality attributes i.e. soundness, completeness etc. The aim of this study is to explore and analyse existing research in knowledge integration framework focusing on the formalism of raw knowledge and actionable knowledge as well as techniques used by knowledge integration framework and the limitations of those knowledge integration frameworks. This paper presents a systematic review of several researches which propose knowledge integration framework in last five years.We found mo...
Journal of Biosciences and Medicines, 2021
Medical imaging procedures such as computed tomography (CT) and cone-beam computed tomography (CB... more Medical imaging procedures such as computed tomography (CT) and cone-beam computed tomography (CBCT) have been widely used in the diagnosis, detection and treatments of cancers worldwide. The achieved efficiency in the clinical workflow and improved patient care come at a price of radiation doses that pose potential cancer risks to the patients, especially the children who are more susceptible to the radiation damage than the adults. To address this concern, we have newly developed an iPhone app termed CT Gently that can be used to estimate the organ doses and associated cancer risk from CT and CBCT scans based on individual anatomy and scan mode. Furthermore, the CT Gently app can generate optimized mAs and kVp settings for personalized low-dose CT and CBCT scans, essential to the children undergoing these imaging procedures. The increasing radiation exposure to the large population including millions of children necessitates the applications of personalized CT and CBCT imaging for the children as well as the adults.
Frontiers in Plant Science
Breeding of agricultural crops adapted to climate change and resistant to diseases and pests is h... more Breeding of agricultural crops adapted to climate change and resistant to diseases and pests is hindered by a limited gene pool because of domestication and thousands of years of human selection. One way to increase genetic variation is chromosome-mediated gene transfer from wild relatives by cross hybridization. In the case of wheat (Triticum aestivum), the species of genus Aegilops are a particularly attractive source of new genes and alleles. However, during the evolution of the Aegilops and Triticum genera, diversification of the D-genome lineage resulted in the formation of diploid C, M, and U genomes of Aegilops. The extent of structural genome alterations, which accompanied their evolution and speciation, and the shortage of molecular tools to detect Aegilops chromatin hamper gene transfer into wheat. To investigate the chromosome structure and help develop molecular markers with a known physical position that could improve the efficiency of the selection of desired introgres...
Journal of Performance of Constructed Facilities
The following corrections should be made to the original paper: • Fig. 4 should be corrected. The... more The following corrections should be made to the original paper: • Fig. 4 should be corrected. The labels in the figure were incorrect and could mislead the reader. The correct Fig. 4 is provided herein. • The authors regret that the "Acknowledgments" section was dropped from the paper. It is provided herein. Fig. 4. Constant voltage accelerated corrosion setup.
Engineering Structures
Abstract The experimental work presented in this paper investigated the effect of large corroded ... more Abstract The experimental work presented in this paper investigated the effect of large corroded area of the flexural reinforcement on the structural response of two-way reinforced concrete slabs. Four typical full-size two-way reinforced concrete slabs were fabricated and tested for this study. The slab dimensions were 1900 mm × 1900 mm × 150 mm. The reinforcement of the slabs were totally corroded except for one-half of the development length at the end of the reinforcement. The corroded area was 1480 mm × 1480 mm. A uniform level of corrosion was induced by using an accelerated corrosion technique through applying constant current density of 200 μ A / cm 2 through the reinforcement. Four different levels of corrosion were reached 0%, 15%, 25%, and 50% of the mass loss. The results are obtained in terms of load versus deflection curves, load versus crack width curves, crack patterns, deflection profiles, slab rotations, energy absorption, and ductility index. The results showed that the increase in mass loss, led to a reduction in the slab capacity and stiffness. Whereas the deflection capacities, slab rotations, and crack widths increased with increased mass loss. The experimental failure loads were compared with the predictions of four different codes. None of codes gave safe predictions for the slabs with 25% and 50% mass loss.
Construction and Building Materials
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017
Considerable attention has been paid to the introduction of novel naturally occurring plant-deriv... more Considerable attention has been paid to the introduction of novel naturally occurring plant-derived radiosensitizer compounds in order to augment the radiation efficacy and improve the treatment outcome of different tumors. This study was therefore undertaken to evaluate the antitumor, antiangiogeneic, and synergistic radiosensitizing effects of apigenin, a dietary flavonoid, and/or cryptotanshinone, a terpenoid isolated from the roots of Salvia miltiorrhiza, against the growth of solid Ehrlich carcinoma in female mice. Apigenin (50 mg/kg body weight) and/or cryptotanshinone (40 mg/kg body weight) was intraperitoneally (i.p.) injected into non-irradiated or γ-irradiated (6.5 Gy whole-body γ-irradiation) solid Ehrlich carcinoma-bearing mice for 30 consecutive days. Investigations included molecular targets involved in proliferation, inflammation, angiogenesis, and tumor invasiveness. Treatment with apigenin and/or cryptotanshinone significantly suppressed the growth of solid Ehrlich ...
Naunyn-Schmiedeberg's archives of pharmacology, 2017
There is no standard treatment of chronic nonbacterial prostatitis in humans. The current study w... more There is no standard treatment of chronic nonbacterial prostatitis in humans. The current study was aimed to investigate the effect of montelukast, an antagonist of cysteinyl leukotriene receptor-1, against estrogen-induced, nonbacterial lateral lobe-specific prostate inflammation in rats. Male Wistar rats were randomized into five groups of six rats, including sham controls (group 1) and castrated rats (group 2), whereas nonbacterial prostatitis (NBP) was induced in groups 3-5 by castration followed by a daily subcutaneous injection of estradiol (0.25 mg/kg body weight) for 30 days. The rats were left otherwise untreated (group 3) or received a daily oral administration of montelukast (1 and 10 mg/kg body weight for groups 4 and 5, respectively) from the 17th day after castration for two consecutive weeks. Compared with sham controls, induction of NBP led to a significant increase in serum leukotriene B4 (LTB4), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) levels, ...
The treatment and disposal of petroleum oily sludges represent major challenges for petroleum ind... more The treatment and disposal of petroleum oily sludges represent major challenges for petroleum industries. The oily sludges consume a high portion of a refiner's budget and pose a serious threat to the environment. Montreal and Kyoto protocols introduced significant restrictions on the disposal of petroleum wastes and reduced the options available for treating this type of hazardous wastes. This research considered the application of bioremediation principles to petroleum oily sludge using a new testing technique. Approximately, 35% of the total petroleum hydrocarbons, and 81% of the aliphatic hydrocarbons in the sludge were degraded using a fungal-bacterial co-culture. To my knowledge, this was the first time fungal-bacterial co-cultures have been used in the treatment of petroleum oily sludge. Prior to treatment with the co-cultures, the sludge was subjected to a special electrokinetic separation technology that reduced its oil and water contents. The cultures were isolated from petroleum oily sludge taken from the bottom of crude oil storage tanks. The fungal and bacterial strains, used in the co-culture, were identified as Paecilomyces variotii and Bacillus cereus , respectively. The cultures were inoculated on 0.22 om filters laid over the sludge. Reduction in aliphatic hydrocarbons was estimated using Fourier transform infrared spectrometry (FTIR). Total Petroleum Hydrocarbons (TPH) were estimated using solvent extraction. An amphoteric surfactant was used in the studies but it did not improve biodegradation rates. The testing technique gave a comprehensive indication of the efficiency of the process and the toxicity of the sludge for defined cultures of the microorganisms.
Chromosome Research
Terminal deletions in Hordeum chilense chromosomes were induced genetically by the gametocidal ac... more Terminal deletions in Hordeum chilense chromosomes were induced genetically by the gametocidal activity of an alien chromosome 2C derived from Aegilops cylindrica. Diploid organisms such as H.chilense do not tolerate deletions, so them strategy that we followed allowed their obtention in both wheat and tritordeum genetic background. Terminal deletions were observed in all seven H.chilense chromosomes, except in chromosome 7Hch. Unfortunately, we failed to establish many of deletions because of sterility. Fertile homozygous plants with deficiencies in the short arm of chromosomes 1Hch and 3Hch and in the long arm of chromosomes 4Hch and 6Hch were obtained. Deletions in the long arm of chromosome 4Hch were obtained in tritordeum background. Deficiencies in the short arms of both chromosomes 1Hch and 3Hch and in the long arm of chromosome 6Hch were established, both as addition or substitution lines, in wheat background. All these plants showed variations in morphological traits and al...
The Journal of Pathology
Several mediators of systemic vasodilatation in liver cirrhosis have been reported. Among these i... more Several mediators of systemic vasodilatation in liver cirrhosis have been reported. Among these is nitric oxide (NO), which has been proposed as one of the main mediators. In this study, sera and liver biopsies were analysed from 15 patients with clinically and pathologically diagnosed liver cirrhosis. In addition, sera from seven and liver biopsies from three healthy controls were used. Serum levels of nitrite (the end product of NO) were measured using the Griess reaction and the expression of the inducible nitric oxide synthase (iNOS) and constitutive nitric oxide synthase (ecNOS) proteins was investigated using immunohistochemistry. This study shows that serum nitrite levels (94 ± 9.8 µmol/l) in cirrhotic patients were significantly (p Keywords: cytokines; ecNOS; hepatitis; iNOS; inflammation; liver cirrhosis; nitric oxide; portal hypertension Document Type: Research Article DOI: http://dx.doi.org/10.1002/path.1377 Affiliations: 1: Departments of Tropical Medicine and General Me...
Journal of toxicology and environmental health. Part A, 2015
Benign prostatic hyperplasia (BPH), a disease occurring frequently among elderly males, is a slow... more Benign prostatic hyperplasia (BPH), a disease occurring frequently among elderly males, is a slow progressive enlargement of the fibromuscular and epithelial structures of the prostate gland. Dietary factors may influence the prostate and exert an influence on prostatic growth and disease. The current study was undertaken to investigate the protective effect of dietary flaxseed supplementation against testosterone-induced prostatic hyperplasia in male rats. Forty male Wistar rats were divided into 5 groups: (1) untreated control; (2) treatment with testosterone propionate (TP) to induce prostate enlargement; (3) TP-treated group fed a diet containing 5% milled flaxseed; (4) TP-treated group fed a diet containing 10% milled flaxseed; and (5) TP-treated group fed a diet containing 20 ppm finasteride. Treatment with TP significantly increased the absolute and relative weights of different prostatic lobes, serum testosterone (T), and testosterone/estradiol ratio, as well as prostatic va...
Economic Quality Control, 2010
ABSTRACT The method to measure the market risk (which stocks are exposed) by the slope coefficien... more ABSTRACT The method to measure the market risk (which stocks are exposed) by the slope coefficient of a linear regression model (that relates the returns of the asset and the returns of a market index) is known as market model. When applying this method it is extremely important to check the stability of the parameters (the slope, the intercept and the variance) over the time to neutralize the market risk. Procedures known in statistical quality control as analysis of linear profiles are presented for such purpose. By statistical tests based on the F-statistics, it is possible to identify the sources of variation and also out-of-control samples. Numerical examples illustrate the proposed procedures.
Egyptian Journal of Biochemistry and Molecular Biology, 2011
ABSTRACT
Journal of toxicologic pathology, 2009
The present study was undertaken to investigate the effect of dietary supplementation with nimesu... more The present study was undertaken to investigate the effect of dietary supplementation with nimesulide or eugenol on N-nitrosodiethylamine (DEN)-initiated early hepatocarcinogenesis in F344 male rats. Both compounds did not alter the expression of cytochrome P450 (CYP) 2E1, the enzyme that plays a major role in the activation of DEN to genotoxic products; however, nimesulide induced the expression of CYP1A1. Western blot analysis revealed that COX-1 and COX-2 protein expressions were not modulated by DEN compared with normal controls. Furthermore, post-initiation feeding with nimesulide or eugenol did not modulate COX-2 protein expression in normal or DEN-treated rats, whereas eugenol significantly increased the liver prostaglandin E(2) (PGE(2)) levels of DEN-injected animals compared with the DEN controls. Ultimately, nimesulide or eugenol did not modify DEN-induced hepatocarcinogenesis as evidenced by insignificant changes in the number and size of preneoplastic placental glutathio...
Pharmaceutical biology, 2015
Context: The antitumor activity of aloin, the active anthraquinone of Aloe juice, against differe... more Context: The antitumor activity of aloin, the active anthraquinone of Aloe juice, against different murine and human tumors has been reported. In the present study, the impact of repeated aloin treatment at its maximum tolerated dose on serum levels of lipid profile, some elements, iron status and kidney function, compared with doxorubicin (a cardiotoxic anthracycline and inhibitor of erythropoiesis), was assessed. Rats were treated with a single dose of doxorubicin (30 mg/kg body weight, intraperitoneal) or aloin (50 mg/kg body weight, intramuscular) twice weekly over 2 weeks. Acute doxorubicin treatment elevated serum levels of triacylglycerols (59.90%), total cholesterol (42.29%), cholesteryl esters (54.75%), low density lipoprotein-cholesterol (230.16%), very low density lipoprotein-cholesterol (56.42%), urea (287.53%), and creatinine (85.38%), whereas serum high density lipoprotein-cholesterol, sodium, and calcium levels were reduced (44.61, 9.61, and 9.76%, respectively), as c...