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Research paper thumbnail of One-pot synthesis of tri- and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions

Chinese Chemical Letters, 2010

An efficient, rapid, simple and scalable synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubst... more An efficient, rapid, simple and scalable synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles is shown by condensation reaction of benzil, aldehydes and ammonium acetate/aniline in the presence of deep eutectic solvents as eco-friendly ionic liquid catalysts under solvent-free conditions at 100°C. This approach offers many advantages such as good yield, reduction of waste, short reaction time, easy isolation of products, facile purification and environmentally benign reaction conditions.

Research paper thumbnail of One-pot synthesis of tri- and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions

Chinese Chemical Letters, 2010

An efficient, rapid, simple and scalable synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubst... more An efficient, rapid, simple and scalable synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles is shown by condensation reaction of benzil, aldehydes and ammonium acetate/aniline in the presence of deep eutectic solvents as eco-friendly ionic liquid catalysts under solvent-free conditions at 100°C. This approach offers many advantages such as good yield, reduction of waste, short reaction time, easy isolation of products, facile purification and environmentally benign reaction conditions.

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