mamdouh mohamed - Academia.edu (original) (raw)
Papers by mamdouh mohamed
Bioorganic chemistry, Jan 5, 2018
A novel quinolinyl pyrrolone and quinolinyl pyridazinone derivatives has been synthesized and cha... more A novel quinolinyl pyrrolone and quinolinyl pyridazinone derivatives has been synthesized and characterized using different spectroscopic and elemental analysis techniques. Most of the target compounds displayed promising antiproliferative activity; In general, the pyrrolone derivatives 4a-f exhibited higher antiproliferative activity than their corresponding pyridazinone. The pyrrolone 4f showed outstanding antiproliferative activity with moderate selectivity against CNS and renal cancer with selectivity ratio of 3.49 and 3.56, respectively. Compound 4e and 5d experienced tubulin polymerization inhibitory activity comparable to that of vincristine while 4c, 4e and 4d showed good BRAF kinase inhibition compared to Erlotinib. Docking of compound 4e into colchicine binding site and biological assay results revealed that these compounds act mainly through tubulin polymerization inhibitory mechanism and can exhibit pre G1 apoptosis and cell cycle arrest at G2/M phase.
![Research paper thumbnail of Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production](https://attachments.academia-assets.com/100393670/thumbnails/1.jpg)
](European journal of medicinal chemistry, Jan 25, 2018
A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their rea... more A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were synthesized and evaluated for their ability to inhibit reactive oxygen species (ROS) generation, antioxidant activity and anticancer activity against a panel of cancer cell lines using MTT assay. The results showed that these compounds can inhibit ROS generation during the metabolic phase of phagocytosis in a dose-dependent manner where compounds 5d and 5e were the most potent samples with higher inhibitory activities (ICvalues 3.3 and 1.4 μM, respectively) than that of the reference acetylsalicylic acid (IC = 9.7 μM). Results for the determination of potential antioxidant properties of the synthesized compounds showed that compounds 5d and 5e containing pyrazino[1,2-a]indol-1-one backbone were the most acive and even comparable to Trolox. Compounds 3d-f and 5d-f with the least ICvalues in MTT assay were tested against three known a...
Journal of Medical Sciences(Faisalabad), 2007
Petroleum Science and Technology, 2001
Poly(2,5-benzimidazole) membrane (ABPBI) was investigated for the removal of phosphate species fr... more Poly(2,5-benzimidazole) membrane (ABPBI) was investigated for the removal of phosphate species from aqueous solution. This work was conducted to provide fundamental information from the study of equilibrium adsorption isotherms, and to investigate the adsorption mechanisms in the removal of phosphate species using ABPBI. Batch experiments were performed under various conditions of initial phosphate concentration, pH, and contact time. The Langmuir monolayer adsorption capacity of ABPBI was calculated as 87.90 mg/g. The pseudo-firstorder kinetic, pseudo-second-order kinetic, and the intraparticle diffusion models were used to describe the kinetic data and rate constants were evaluated. The activation energy for degradation estimated by Kissinger method for ABPBI was found to be 62.6 kJ/mol in air atmosphere. The physicochemical properties of ABPBI were investigated by FT-IR, TGA, and SEM techniques.
Physics of Fluids, 2021
This paper was selected as an Editor's Pick ARTICLES YOU MAY BE INTERESTED IN Collisional ferrohy... more This paper was selected as an Editor's Pick ARTICLES YOU MAY BE INTERESTED IN Collisional ferrohydrodynamics of magnetic fluid droplets on superhydrophobic surfaces
Bioorganic chemistry, Jan 5, 2018
A novel quinolinyl pyrrolone and quinolinyl pyridazinone derivatives has been synthesized and cha... more A novel quinolinyl pyrrolone and quinolinyl pyridazinone derivatives has been synthesized and characterized using different spectroscopic and elemental analysis techniques. Most of the target compounds displayed promising antiproliferative activity; In general, the pyrrolone derivatives 4a-f exhibited higher antiproliferative activity than their corresponding pyridazinone. The pyrrolone 4f showed outstanding antiproliferative activity with moderate selectivity against CNS and renal cancer with selectivity ratio of 3.49 and 3.56, respectively. Compound 4e and 5d experienced tubulin polymerization inhibitory activity comparable to that of vincristine while 4c, 4e and 4d showed good BRAF kinase inhibition compared to Erlotinib. Docking of compound 4e into colchicine binding site and biological assay results revealed that these compounds act mainly through tubulin polymerization inhibitory mechanism and can exhibit pre G1 apoptosis and cell cycle arrest at G2/M phase.
European journal of medicinal chemistry, Jan 25, 2018
A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their rea... more A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were synthesized and evaluated for their ability to inhibit reactive oxygen species (ROS) generation, antioxidant activity and anticancer activity against a panel of cancer cell lines using MTT assay. The results showed that these compounds can inhibit ROS generation during the metabolic phase of phagocytosis in a dose-dependent manner where compounds 5d and 5e were the most potent samples with higher inhibitory activities (ICvalues 3.3 and 1.4 μM, respectively) than that of the reference acetylsalicylic acid (IC = 9.7 μM). Results for the determination of potential antioxidant properties of the synthesized compounds showed that compounds 5d and 5e containing pyrazino[1,2-a]indol-1-one backbone were the most acive and even comparable to Trolox. Compounds 3d-f and 5d-f with the least ICvalues in MTT assay were tested against three known a...
Journal of Medical Sciences(Faisalabad), 2007
Petroleum Science and Technology, 2001
Poly(2,5-benzimidazole) membrane (ABPBI) was investigated for the removal of phosphate species fr... more Poly(2,5-benzimidazole) membrane (ABPBI) was investigated for the removal of phosphate species from aqueous solution. This work was conducted to provide fundamental information from the study of equilibrium adsorption isotherms, and to investigate the adsorption mechanisms in the removal of phosphate species using ABPBI. Batch experiments were performed under various conditions of initial phosphate concentration, pH, and contact time. The Langmuir monolayer adsorption capacity of ABPBI was calculated as 87.90 mg/g. The pseudo-firstorder kinetic, pseudo-second-order kinetic, and the intraparticle diffusion models were used to describe the kinetic data and rate constants were evaluated. The activation energy for degradation estimated by Kissinger method for ABPBI was found to be 62.6 kJ/mol in air atmosphere. The physicochemical properties of ABPBI were investigated by FT-IR, TGA, and SEM techniques.
Physics of Fluids, 2021
This paper was selected as an Editor's Pick ARTICLES YOU MAY BE INTERESTED IN Collisional ferrohy... more This paper was selected as an Editor's Pick ARTICLES YOU MAY BE INTERESTED IN Collisional ferrohydrodynamics of magnetic fluid droplets on superhydrophobic surfaces