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Papers by manas ranjan mishra

International Journal of Pharmaceutical Sciences and Drug Research, 2019

Capecitabine is a 'pro-drug' to the cytotoxic agent 5-fluorouracil (5-FU) intended to adm... more Capecitabine is a 'pro-drug' to the cytotoxic agent 5-fluorouracil (5-FU) intended to administered orally. Capecitabine is generally used as first line monotherapy for advanced colon cancer. Simple, rapid, accurate UV spectrophotometric methods were developed in the present study and validated for the estimation of Capecitabine in bulk and its formulations as per ICH guidelines. Three solvent systems viz., 0.1N NaOH, 0.1N HCl and Methanol: Water (1:3) was tried. The results suggest that the developed method shows linearity over the range of concentration 2-24μg/ml and a correlation coefficient of 0.9999. Accuracy, precision, linearity, robustness, and ruggedness were statistically validated as per ICH guidelines for all the developed methods. The % RSD values for validated methods were found to be less than 1.5 and methods will find application in routine analysis of drug formulations containing Capecitabine.

Current Drug Therapy

Background: Herbal medications have been used for centuries in traditional Indian medicine to red... more Background: Herbal medications have been used for centuries in traditional Indian medicine to reduce fertility in several regions. Among them, Sida acuta (S. acuta) is a traditional herb having antifertility effects with other broad medicinal properties. In this work, it was studied for its effect on fertility in female rats. Objective: The purpose of this research was to conduct effectiveness and safety investigations on S. acuta root, an antifertility plant widely used in Asian countries. Methods: Fertile albino Wistar female rats (200-250 gm) were used for antifertility investigations. The animals were separated into four groups, each with six members, and treated with 200 and 400 mg/kg of the methanolic extract in combination with Ethinyl Estradiol (0.3mg/kg body weight) as per schedule. They all took place for seven days. On the 8th day, every positive rat was decapitated under ether anesthesia, and the uterus and surrounding tissues were taken from it for fast weight measureme...

Journal of Pharmaceutical Research, 2021

known as Guava, is a well-known traditional medicinal plant used in treatment of vomiting, diarrh... more known as Guava, is a well-known traditional medicinal plant used in treatment of vomiting, diarrhea, dysentery, flatulence, gastroenteritis, abdominal distention and hyperglycemia. The present study was carried out to evaluate Phytochemical and Comparative in vitro anthelmintic activity of P. guajava leave extracts against Indian adult earthworm Pheretima posthuma. Methods: The traditional medicinal plant is used to control gastrointestinal infections. The phytochemical analysis and anthelmintic effects of extracts (Chloform, aqueous & methanol) and the standard drug (Piperazine citrate) were tested against Indian adult earthworm. The time taken to paralyze and death time of earthworm was considered for anthelmintic effects. Results: The phytochemical analysis revealed the presence of flavanoids, glycosides, alkaloids, steroids, and tannins. Methanolic extract of P. guajava leave extract was showed significant anthelmintic activity among all extracts. Methanolic extract have been found the highest rate of paralysis (1.820±0.242 min) and death (5.573±0.315 min) of earthworm against the standard drug Piperazine citrate. Conclusion: The wormicidal activity of P. guajava leaves extract suggests that it could be effective against parasitic infections of humans and validate the traditional use of P. guajava as a natural therapy for treatment of anthelmintic infection.

Andrographis peniculata (Acanthaeceae) is a traditional Indian herb used historically as support ... more Andrographis peniculata (Acanthaeceae) is a traditional Indian herb used historically as support for a healthy immune system. The following study was carried out using excision wound model in order to establish the wound healing activity of the drug on Swiss Wistar strain rats of either sex. The treatment was continued till the complete healing of the wound. For topical application, 2%w/w ointment of ethanolic extract and petroleum ether extract was prepared in 2% w/w PEG-4000; the control group of animals was left untreated. It was observed that there was complete healing on 12 th post wounding day by applying both the extract. The wound contractions on 12th day in petroleum ether extract, ethanolic extract were shown to be 10.17±0.60 and 16.33±0.67 respectively. The healing was assessed by the rate of wound contraction. Andrographis peniculata ethanolic extract possesses better wound healing property in comparison to control and also with petroleum ether extract.

Research Journal of Pharmacy and Technology, 2011

Musa sapientum commonly known as banana is widely used in Indian folk medicine for the treatment ... more Musa sapientum commonly known as banana is widely used in Indian folk medicine for the treatment of so many diseases. Anthelmintic activity of M. sapientum was performed on its ethanolic extract because it rendered positive to tannin and phenolic compounds in comparison of other solvent extract qualitative phytochemical tests. Anthelmintic activity was performed on adult Indian earthworm, Pheretima posthuma. The results were showed ethanolic extract dose 50 to 250 mg/ml dose significant paralyzed and dead of earthworm in comparison of standard Piperazine citrate 10 to 50 mg/ml. Anthelmintic activity, paralysis and death of warm in ethanolic extract 50mg/ml 15±0.1 and 28±0.3, 250mg/ml, 01±0.8 and 7±0.1, however, Piperazine citrate 10 mg/ml 40±1 and 68±0.3, 50mg/ml 02±0.3 and 7±0.7.

Scoparia dulcis Linn.(S. dulcis)or sweet broom weed commonly known as Mithipatti and Bana Dhania ... more Scoparia dulcis Linn.(S. dulcis)or sweet broom weed commonly known as Mithipatti and Bana Dhania in Western Orissa, it is also known as 'GhodaTulsi'in Hindi. The present review attempts to narrate the chemical constituents of S.dulcis and their uses. S.dulcis is rich in flavones, terpenes and steroids. Main chemical constituents such as scoparic acid A-C, scopadulcic acid A and B, scopadulciol, scopadulin and ammelin have been shown to contribute to the observed medicinal effect of the plant. In this review we have composed the structure and functions of those active ingredients with their melting point and other physical properties individually.Some aspects of the several speculated pharmacological properties of S. dulcis have been validated by scientific research, which includes the presence of hypoglycaemic and anti-tumour promoting compound. It also has antimicrobial and antifungal effects as well as antihyperlipidemic action.

Ancient Science of Life, 2012

This manuscript covers a detailed pharmacognostic evaluation of Scoparia dulcis Linn. whole plant... more This manuscript covers a detailed pharmacognostic evaluation of Scoparia dulcis Linn. whole plant (Scrophulariaceae), including morphology, microscopy, physicochemical, and phytochemical screening. Microscopy of different plant part was done by performing transverse sections and longitudinal sections, which were identified by the different staining reagents and dyes. Physicochemical constants were done for whole plant; it includes ash value, extractive value and moisture content. Phytochemical screening was done for aqueous and methanolic extract in maceration and soxhletion, results revealed the presence of alkaloids, glycosides, carbohydrates, phenolic compound, flavonoids, saponins, proteins, and amino acids. These study includes parameters to establish the authenticity of S. dulcis and can possibly help to differentiate the drug from its other species.

irjps.info

... MR Mishra1*, A. Mishra1, DK Pradhan1, RK Behera2, S. Jha3, AK Panda4 1Gayatri College of Phar... more ... MR Mishra1*, A. Mishra1, DK Pradhan1, RK Behera2, S. Jha3, AK Panda4 1Gayatri College of Pharmacy, Sambalpur-Odisha 2School of Chemistry, Sambalpur University, Burla, Sambalpur, Odisha, India. ... 6. Prajapati ND, Purohit, SS, Sharma AK, Kumar T. “A hand ...

Pharmacognosy Journal, 2011

irjps.info

Page 1. Pradhan et al.: IntRJPharmSci.2012; 03(01); 0029 Research article Phytochemical screening... more Page 1. Pradhan et al.: IntRJPharmSci.2012; 03(01); 0029 Research article Phytochemical screening of the root of Sida acuta Burm. F. DK Pradhan1*, MR Mishra1*, A. Mishra1, AK Panda2, RK Behera3, S. Jha4. 1Gayatri College of Pharmacy, Sambalpur-Odisha, India. ...

Journal of chemical health risks, 2024

Sarcostemma acidum Voigt, commonly known as Somlata, is a leafless plant from the Apocynaceae fam... more Sarcostemma acidum Voigt, commonly known as Somlata, is a leafless plant from the Apocynaceae family, mainly found in Bihar, West Bengal, Odisha, and South India. Sarcostemma acidum Voigt, a medicinal plant traditionally employed in various folk medicine systems, has garnered significant attention due to its rich phytochemical composition and diverse pharmacological activities. This study aimed to comprehensively investigate the phytochemical constituents of Sarcostemma acidum Voigt and evaluate its pharmacological properties. It has traditional medicinal uses for conditions like otitis, dog bites, snake bites, rabies, emesis, arthritis, and leprosy. The plant extract exhibited significant antioxidant activity, as evidenced by its ability to scavenge free radicals. Furthermore, Sarcostemma acidum Voigt demonstrated anti-inflammatory properties by inhibiting key inflammatory mediators. The plant's juice is valued for its health-restorative properties. The stem extract inhibits spermatogenesis and reduces sperm count, showing an antipsychotic effect. Microscopic examination reveals its stem structure, and phytochemical analysis indicates various compounds present. Pharmacological studies on the aqueous stem extract show analgesic, antipyretic, and antidiabetic effects. The extract is found safe in acute toxicity studies, and the analgesic effect is confirmed by Eddy's hot plate method. Antipyretic effects are demonstrated in a Brewer's yeast-induced pyrexia rat model, while antidiabetic effects are shown in an adrenaline-induced diabetic rat model. Overall, the pharmacological study affirms the beneficial effects of Sarcostemma acidum.

International Journal of Pharmaceutical Sciences and Drug Research, 2019

Capecitabine is a 'pro-drug' to the cytotoxic agent 5-fluorouracil (5-FU) intended to adm... more Capecitabine is a 'pro-drug' to the cytotoxic agent 5-fluorouracil (5-FU) intended to administered orally. Capecitabine is generally used as first line monotherapy for advanced colon cancer. Simple, rapid, accurate UV spectrophotometric methods were developed in the present study and validated for the estimation of Capecitabine in bulk and its formulations as per ICH guidelines. Three solvent systems viz., 0.1N NaOH, 0.1N HCl and Methanol: Water (1:3) was tried. The results suggest that the developed method shows linearity over the range of concentration 2-24μg/ml and a correlation coefficient of 0.9999. Accuracy, precision, linearity, robustness, and ruggedness were statistically validated as per ICH guidelines for all the developed methods. The % RSD values for validated methods were found to be less than 1.5 and methods will find application in routine analysis of drug formulations containing Capecitabine.

Current Drug Therapy

Background: Herbal medications have been used for centuries in traditional Indian medicine to red... more Background: Herbal medications have been used for centuries in traditional Indian medicine to reduce fertility in several regions. Among them, Sida acuta (S. acuta) is a traditional herb having antifertility effects with other broad medicinal properties. In this work, it was studied for its effect on fertility in female rats. Objective: The purpose of this research was to conduct effectiveness and safety investigations on S. acuta root, an antifertility plant widely used in Asian countries. Methods: Fertile albino Wistar female rats (200-250 gm) were used for antifertility investigations. The animals were separated into four groups, each with six members, and treated with 200 and 400 mg/kg of the methanolic extract in combination with Ethinyl Estradiol (0.3mg/kg body weight) as per schedule. They all took place for seven days. On the 8th day, every positive rat was decapitated under ether anesthesia, and the uterus and surrounding tissues were taken from it for fast weight measureme...

Journal of Pharmaceutical Research, 2021

known as Guava, is a well-known traditional medicinal plant used in treatment of vomiting, diarrh... more known as Guava, is a well-known traditional medicinal plant used in treatment of vomiting, diarrhea, dysentery, flatulence, gastroenteritis, abdominal distention and hyperglycemia. The present study was carried out to evaluate Phytochemical and Comparative in vitro anthelmintic activity of P. guajava leave extracts against Indian adult earthworm Pheretima posthuma. Methods: The traditional medicinal plant is used to control gastrointestinal infections. The phytochemical analysis and anthelmintic effects of extracts (Chloform, aqueous & methanol) and the standard drug (Piperazine citrate) were tested against Indian adult earthworm. The time taken to paralyze and death time of earthworm was considered for anthelmintic effects. Results: The phytochemical analysis revealed the presence of flavanoids, glycosides, alkaloids, steroids, and tannins. Methanolic extract of P. guajava leave extract was showed significant anthelmintic activity among all extracts. Methanolic extract have been found the highest rate of paralysis (1.820±0.242 min) and death (5.573±0.315 min) of earthworm against the standard drug Piperazine citrate. Conclusion: The wormicidal activity of P. guajava leaves extract suggests that it could be effective against parasitic infections of humans and validate the traditional use of P. guajava as a natural therapy for treatment of anthelmintic infection.

Andrographis peniculata (Acanthaeceae) is a traditional Indian herb used historically as support ... more Andrographis peniculata (Acanthaeceae) is a traditional Indian herb used historically as support for a healthy immune system. The following study was carried out using excision wound model in order to establish the wound healing activity of the drug on Swiss Wistar strain rats of either sex. The treatment was continued till the complete healing of the wound. For topical application, 2%w/w ointment of ethanolic extract and petroleum ether extract was prepared in 2% w/w PEG-4000; the control group of animals was left untreated. It was observed that there was complete healing on 12 th post wounding day by applying both the extract. The wound contractions on 12th day in petroleum ether extract, ethanolic extract were shown to be 10.17±0.60 and 16.33±0.67 respectively. The healing was assessed by the rate of wound contraction. Andrographis peniculata ethanolic extract possesses better wound healing property in comparison to control and also with petroleum ether extract.

Research Journal of Pharmacy and Technology, 2011

Musa sapientum commonly known as banana is widely used in Indian folk medicine for the treatment ... more Musa sapientum commonly known as banana is widely used in Indian folk medicine for the treatment of so many diseases. Anthelmintic activity of M. sapientum was performed on its ethanolic extract because it rendered positive to tannin and phenolic compounds in comparison of other solvent extract qualitative phytochemical tests. Anthelmintic activity was performed on adult Indian earthworm, Pheretima posthuma. The results were showed ethanolic extract dose 50 to 250 mg/ml dose significant paralyzed and dead of earthworm in comparison of standard Piperazine citrate 10 to 50 mg/ml. Anthelmintic activity, paralysis and death of warm in ethanolic extract 50mg/ml 15±0.1 and 28±0.3, 250mg/ml, 01±0.8 and 7±0.1, however, Piperazine citrate 10 mg/ml 40±1 and 68±0.3, 50mg/ml 02±0.3 and 7±0.7.

Scoparia dulcis Linn.(S. dulcis)or sweet broom weed commonly known as Mithipatti and Bana Dhania ... more Scoparia dulcis Linn.(S. dulcis)or sweet broom weed commonly known as Mithipatti and Bana Dhania in Western Orissa, it is also known as 'GhodaTulsi'in Hindi. The present review attempts to narrate the chemical constituents of S.dulcis and their uses. S.dulcis is rich in flavones, terpenes and steroids. Main chemical constituents such as scoparic acid A-C, scopadulcic acid A and B, scopadulciol, scopadulin and ammelin have been shown to contribute to the observed medicinal effect of the plant. In this review we have composed the structure and functions of those active ingredients with their melting point and other physical properties individually.Some aspects of the several speculated pharmacological properties of S. dulcis have been validated by scientific research, which includes the presence of hypoglycaemic and anti-tumour promoting compound. It also has antimicrobial and antifungal effects as well as antihyperlipidemic action.

Ancient Science of Life, 2012

This manuscript covers a detailed pharmacognostic evaluation of Scoparia dulcis Linn. whole plant... more This manuscript covers a detailed pharmacognostic evaluation of Scoparia dulcis Linn. whole plant (Scrophulariaceae), including morphology, microscopy, physicochemical, and phytochemical screening. Microscopy of different plant part was done by performing transverse sections and longitudinal sections, which were identified by the different staining reagents and dyes. Physicochemical constants were done for whole plant; it includes ash value, extractive value and moisture content. Phytochemical screening was done for aqueous and methanolic extract in maceration and soxhletion, results revealed the presence of alkaloids, glycosides, carbohydrates, phenolic compound, flavonoids, saponins, proteins, and amino acids. These study includes parameters to establish the authenticity of S. dulcis and can possibly help to differentiate the drug from its other species.

irjps.info

... MR Mishra1*, A. Mishra1, DK Pradhan1, RK Behera2, S. Jha3, AK Panda4 1Gayatri College of Phar... more ... MR Mishra1*, A. Mishra1, DK Pradhan1, RK Behera2, S. Jha3, AK Panda4 1Gayatri College of Pharmacy, Sambalpur-Odisha 2School of Chemistry, Sambalpur University, Burla, Sambalpur, Odisha, India. ... 6. Prajapati ND, Purohit, SS, Sharma AK, Kumar T. “A hand ...

Pharmacognosy Journal, 2011

irjps.info

Page 1. Pradhan et al.: IntRJPharmSci.2012; 03(01); 0029 Research article Phytochemical screening... more Page 1. Pradhan et al.: IntRJPharmSci.2012; 03(01); 0029 Research article Phytochemical screening of the root of Sida acuta Burm. F. DK Pradhan1*, MR Mishra1*, A. Mishra1, AK Panda2, RK Behera3, S. Jha4. 1Gayatri College of Pharmacy, Sambalpur-Odisha, India. ...

Journal of chemical health risks, 2024

Sarcostemma acidum Voigt, commonly known as Somlata, is a leafless plant from the Apocynaceae fam... more Sarcostemma acidum Voigt, commonly known as Somlata, is a leafless plant from the Apocynaceae family, mainly found in Bihar, West Bengal, Odisha, and South India. Sarcostemma acidum Voigt, a medicinal plant traditionally employed in various folk medicine systems, has garnered significant attention due to its rich phytochemical composition and diverse pharmacological activities. This study aimed to comprehensively investigate the phytochemical constituents of Sarcostemma acidum Voigt and evaluate its pharmacological properties. It has traditional medicinal uses for conditions like otitis, dog bites, snake bites, rabies, emesis, arthritis, and leprosy. The plant extract exhibited significant antioxidant activity, as evidenced by its ability to scavenge free radicals. Furthermore, Sarcostemma acidum Voigt demonstrated anti-inflammatory properties by inhibiting key inflammatory mediators. The plant's juice is valued for its health-restorative properties. The stem extract inhibits spermatogenesis and reduces sperm count, showing an antipsychotic effect. Microscopic examination reveals its stem structure, and phytochemical analysis indicates various compounds present. Pharmacological studies on the aqueous stem extract show analgesic, antipyretic, and antidiabetic effects. The extract is found safe in acute toxicity studies, and the analgesic effect is confirmed by Eddy's hot plate method. Antipyretic effects are demonstrated in a Brewer's yeast-induced pyrexia rat model, while antidiabetic effects are shown in an adrenaline-induced diabetic rat model. Overall, the pharmacological study affirms the beneficial effects of Sarcostemma acidum.