manuel Sanchez - Academia.edu (original) (raw)
Papers by manuel Sanchez
Journal of The American Academy of Dermatology, 1992
IEEE Transactions on Vehicular Technology, 2001
Wide-band indoor radio channel characterization for broadband radio access networks and unlicense... more Wide-band indoor radio channel characterization for broadband radio access networks and unlicensed national information infrastructure has been performed at 5.8 GHz, and results are given in this paper. Delay spreads of 8.8 and 17.2 ns and coherence bandwidths of 9.6 and 4 MHz have been found for line-of-sight (LoS) and obstructed line-of-sight (OLoS) situations, respectively. Results have been compared with predictions made using a ray-tracing tool. To get accurate predictions, a good description of the electromagnetic properties of the obstacles present in the environment is needed. Several experiments were made in order to characterize the electromagnetic parameters of six typical building materials. Transmission and reflection coefficients were measured using the free-space technique. A multiple successive internal reflection model was used to estimate the permittivity and conductivity by comparing the measured and predicted values of the coefficients. Several samples of each material were measured, and the results vary from sample to sample. This variation has been characterized by the calculation of confidence bands for the parameters. The influence of both the dielectric parameters and the order of reflections considered in the ray-tracing tool has been analyzed. The effect is reduced on narrow-band predictions but is more important on wide-band parameters as the delay spread. It is shown that the measured delay spread cumulative distribution function falls within the band predicted using the measured maximum and minimum values of permittivity
New England Journal of Medicine, 1984
Molecular and Biochemical Parasitology, 1992
Phytomonas sp. isolated from Euphorbia characias was adapted to SDM-79 medium. Cells isolated in ... more Phytomonas sp. isolated from Euphorbia characias was adapted to SDM-79 medium. Cells isolated in the early stationary phase of growth were analyzed for their capacity to utilize plant carbohydrates for their energy requirements. The cellulose-degrading enzymes amylase, amylomaltase, invertase, carboxymethylcellulase, and the pectin-degrading enzymes polygalacturonase and oligo-D-galactosiduronate lyase were present in Phytomonas sp. and were all, except for amylomaltase, excreted into the external medium. Glucose, fructose and mannose served as the major energy substrates. Catabolism of carbohydrates occurred mainly via aerobic glycolysis according to the Embden-Meyerhof pathway, of which all the enzymes were detected. Likewise, the end-products of glycolysis, acetate and pyruvate, glycerol, succinate and ethanol were detected in the culture medium, as were the enzymes responsible for their production. Mitochondria were incapable of oxidizing succinate, 2-oxoglutarate, pyruvate, malate and proline, but had a high capacity to oxidize glycerol 3-phosphate. This oxidation was completely inhibited by salicylhydroxamic acid. No cytochromes could be detected either in intact mitochondria or in sub-mitochondrial particles. Mitochondrial respiration was not inhibited by antimycin, azide or cyanide. The glycolytic enzymes, from hexokinase to phosphoglycerate kinase, and the enzymes glycerol kinase, glycerol-3-phosphate dehydrogenase, phosphoenolpyruvate carboxykinase, malate dehydrogenase and adenylate kinase, were all associated with glycosomes that had a buoyant density of about 1.24 g cm-1 in sucrose. Cytochemical staining revealed the presence of catalase in these organelles. The cytosolic enzyme pyruvate kinase was activated by fructose 2,6-bisphosphate, typical of all other pyruvate kinases from Kinetoplastida. The energy metabolism of the plant parasite Phytomonas sp. isolated from E. characias resembled that of the bloodstream form of the mammalian parasite Trypanosoma brucei.
Journal of Vegetation Science, 1996
Abstract. Vegetation zonation in salt marshes has traditionally been attributed largely to altitu... more Abstract. Vegetation zonation in salt marshes has traditionally been attributed largely to altitudinal differences, since altitude determines the temporal pattern of tidal flooding and is thus closely related to proximate determinants of the distribution of species and plant communities. We investigated the distribution of vascular plants and plant communities along a series of altitudinal transects in two salt marshes in the northwestern Iberian Peninsula. Our results indicate that altitudinal range varies significantly both among species and among communities, and confirm that salt-marsh vegetation characteristics (species cover and composition) can be predicted on the basis of altitude, particularly at the lower levels of the profile.
Remote Sensing of Environment, 2005
IEEE Transactions on Microwave Theory and Techniques, 2005
Biochemistry, 1994
Tremorgenic indole alkaloids produce neurological disorders (e.g., staggers syndromes) in ruminan... more Tremorgenic indole alkaloids produce neurological disorders (e.g., staggers syndromes) in ruminants. The mode of action of these fungal mycotoxins is not understood but may be related to their known effects on neurotransmitter release. To determine whether these effects could be due to inhibition of K+ channels, the interaction of various indole diterpenes with high-conductance Ca(2+)-activated K+ (maxi-K) channels was examined. Paspalitrem A, paspalitrem C, aflatrem, penitrem A, and paspalinine inhibit binding of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. In contrast, three structurally related compounds, paxilline, verruculogen, and paspalicine, enhanced toxin binding. As predicted from the binding studies, covalent incorporation of [125I]ChTX into the 31-kDa subunit of the maxi-K channel was blocked by compounds that inhibit [125I]ChTX binding and enhanced by compounds that stimulate [125I]ChTX binding. Modulation of [125I]ChTX binding was due to allosteric mechanisms. Despite their different effects on binding of [125I]ChTX to maxi-K channels, all compounds potently inhibited maxi-K channels in electrophysiological experiments. Other types of voltage-dependent or Ca(2+)-activated K+ channels examined were not affected. Chemical modifications of paxilline indicate a defined structure-activity relationship for channel inhibition. Paspalicine, a deshydroxy analog of paspalinine lacking tremorgenic activity, also potently blocked maxi-K channels. Taken together, these data suggest that indole diterpenes are the most potent nonpeptidyl inhibitors of maxi-K channels identified to date. Some of their pharmacological properties could be explained by inhibition of maxi-K channels, although tremorgenicity may be unrelated to channel block.
Journal of The American Academy of Dermatology, 1992
IEEE Transactions on Vehicular Technology, 2001
Wide-band indoor radio channel characterization for broadband radio access networks and unlicense... more Wide-band indoor radio channel characterization for broadband radio access networks and unlicensed national information infrastructure has been performed at 5.8 GHz, and results are given in this paper. Delay spreads of 8.8 and 17.2 ns and coherence bandwidths of 9.6 and 4 MHz have been found for line-of-sight (LoS) and obstructed line-of-sight (OLoS) situations, respectively. Results have been compared with predictions made using a ray-tracing tool. To get accurate predictions, a good description of the electromagnetic properties of the obstacles present in the environment is needed. Several experiments were made in order to characterize the electromagnetic parameters of six typical building materials. Transmission and reflection coefficients were measured using the free-space technique. A multiple successive internal reflection model was used to estimate the permittivity and conductivity by comparing the measured and predicted values of the coefficients. Several samples of each material were measured, and the results vary from sample to sample. This variation has been characterized by the calculation of confidence bands for the parameters. The influence of both the dielectric parameters and the order of reflections considered in the ray-tracing tool has been analyzed. The effect is reduced on narrow-band predictions but is more important on wide-band parameters as the delay spread. It is shown that the measured delay spread cumulative distribution function falls within the band predicted using the measured maximum and minimum values of permittivity
New England Journal of Medicine, 1984
Molecular and Biochemical Parasitology, 1992
Phytomonas sp. isolated from Euphorbia characias was adapted to SDM-79 medium. Cells isolated in ... more Phytomonas sp. isolated from Euphorbia characias was adapted to SDM-79 medium. Cells isolated in the early stationary phase of growth were analyzed for their capacity to utilize plant carbohydrates for their energy requirements. The cellulose-degrading enzymes amylase, amylomaltase, invertase, carboxymethylcellulase, and the pectin-degrading enzymes polygalacturonase and oligo-D-galactosiduronate lyase were present in Phytomonas sp. and were all, except for amylomaltase, excreted into the external medium. Glucose, fructose and mannose served as the major energy substrates. Catabolism of carbohydrates occurred mainly via aerobic glycolysis according to the Embden-Meyerhof pathway, of which all the enzymes were detected. Likewise, the end-products of glycolysis, acetate and pyruvate, glycerol, succinate and ethanol were detected in the culture medium, as were the enzymes responsible for their production. Mitochondria were incapable of oxidizing succinate, 2-oxoglutarate, pyruvate, malate and proline, but had a high capacity to oxidize glycerol 3-phosphate. This oxidation was completely inhibited by salicylhydroxamic acid. No cytochromes could be detected either in intact mitochondria or in sub-mitochondrial particles. Mitochondrial respiration was not inhibited by antimycin, azide or cyanide. The glycolytic enzymes, from hexokinase to phosphoglycerate kinase, and the enzymes glycerol kinase, glycerol-3-phosphate dehydrogenase, phosphoenolpyruvate carboxykinase, malate dehydrogenase and adenylate kinase, were all associated with glycosomes that had a buoyant density of about 1.24 g cm-1 in sucrose. Cytochemical staining revealed the presence of catalase in these organelles. The cytosolic enzyme pyruvate kinase was activated by fructose 2,6-bisphosphate, typical of all other pyruvate kinases from Kinetoplastida. The energy metabolism of the plant parasite Phytomonas sp. isolated from E. characias resembled that of the bloodstream form of the mammalian parasite Trypanosoma brucei.
Journal of Vegetation Science, 1996
Abstract. Vegetation zonation in salt marshes has traditionally been attributed largely to altitu... more Abstract. Vegetation zonation in salt marshes has traditionally been attributed largely to altitudinal differences, since altitude determines the temporal pattern of tidal flooding and is thus closely related to proximate determinants of the distribution of species and plant communities. We investigated the distribution of vascular plants and plant communities along a series of altitudinal transects in two salt marshes in the northwestern Iberian Peninsula. Our results indicate that altitudinal range varies significantly both among species and among communities, and confirm that salt-marsh vegetation characteristics (species cover and composition) can be predicted on the basis of altitude, particularly at the lower levels of the profile.
Remote Sensing of Environment, 2005
IEEE Transactions on Microwave Theory and Techniques, 2005
Biochemistry, 1994
Tremorgenic indole alkaloids produce neurological disorders (e.g., staggers syndromes) in ruminan... more Tremorgenic indole alkaloids produce neurological disorders (e.g., staggers syndromes) in ruminants. The mode of action of these fungal mycotoxins is not understood but may be related to their known effects on neurotransmitter release. To determine whether these effects could be due to inhibition of K+ channels, the interaction of various indole diterpenes with high-conductance Ca(2+)-activated K+ (maxi-K) channels was examined. Paspalitrem A, paspalitrem C, aflatrem, penitrem A, and paspalinine inhibit binding of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. In contrast, three structurally related compounds, paxilline, verruculogen, and paspalicine, enhanced toxin binding. As predicted from the binding studies, covalent incorporation of [125I]ChTX into the 31-kDa subunit of the maxi-K channel was blocked by compounds that inhibit [125I]ChTX binding and enhanced by compounds that stimulate [125I]ChTX binding. Modulation of [125I]ChTX binding was due to allosteric mechanisms. Despite their different effects on binding of [125I]ChTX to maxi-K channels, all compounds potently inhibited maxi-K channels in electrophysiological experiments. Other types of voltage-dependent or Ca(2+)-activated K+ channels examined were not affected. Chemical modifications of paxilline indicate a defined structure-activity relationship for channel inhibition. Paspalicine, a deshydroxy analog of paspalinine lacking tremorgenic activity, also potently blocked maxi-K channels. Taken together, these data suggest that indole diterpenes are the most potent nonpeptidyl inhibitors of maxi-K channels identified to date. Some of their pharmacological properties could be explained by inhibition of maxi-K channels, although tremorgenicity may be unrelated to channel block.