marie poot - Academia.edu (original) (raw)

Papers by marie poot

Physica Status Solidi B-basic Solid State Physics, 2007

We study the bending mode vibration in suspended carbon nanotubes. Based on the theory of continu... more We study the bending mode vibration in suspended carbon nanotubes. Based on the theory of continuum mechanics, we have developed a model for flexural oscillations of suspended nanotubes. A detailed analysis of the electrostatic force, the scaling behavior of the model and the gate tuning is given. The model is used to fit experimental data and to reconstruct the gate dependence of the tension and strain in the nanotube.

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1984

Applied Physics Letters, 2008

Applied Physics Letters, 2014

Science, 2009

Nanoscale resonators that oscillate at high frequencies are useful in many measurement applicatio... more Nanoscale resonators that oscillate at high frequencies are useful in many measurement applications. We studied a high-quality mechanical resonator made from a suspended carbon nanotube driven into motion by applying a periodic radio frequency potential using a ...

Physical review letters, 2010

Mutation Research/DNA Repair, 1992

In order to assess spontaneous mutability and accuracy of DNA joining in ataxia telangiectasia, a... more In order to assess spontaneous mutability and accuracy of DNA joining in ataxia telangiectasia, a disorder with spontaneous chromosome breakage, the replicating shuttle vector plasmid, pZ189, was transfected into SV40 virus-transformed fibroblasts from ataxia telangiectasia patients. The ataxia telangiectasia fibroblasts showed elevated frequency of micronuclei, a measure of chromosome breakage. The spontaneous mutation frequency was normal with circular plasmids passed through the ataxia telangiectasia line. These results were compared to those with transformed fibroblasts from a patient with xeroderma pigmentosum, and from a normal donor. Mutation analysis revealed spontaneous point mutations and deletions in the plasmids with all 3 cell lines, however, insertions or complex mutations were only detectable with the ataxia telangiectasia line. To assess DNA-joining ability, linear plasmids which require joining of the DNA ends by host cell enzymes for survival, were transfected into the cells. We found a 2.4-fold less efficient DNA joining in ataxia telangiectasia fibroblasts (p = 0.04) and a 2.0-fold higher mutation frequency (p less than 0.01) in the recircularized plasmids than with the normal line. Plasmid DNA joining and mutation frequency were normal with the xeroderma pigmentosum fibroblasts. These findings with the ataxia telangiectasia fibroblasts of abnormal types of spontaneous mutations in the transfected plasmid and inefficient, error-prone DNA joining may be related to the increased chromosome breakage in these cells. In contrast, an EB virus-transformed ataxia telangiectasia lymphoblast line with normal frequency of micronuclei showed normal types of spontaneous mutations in the transfected plasmid and normal frequency of DNA joining which was error-prone. These data indicate that mechanisms that produce chromosome breakage in ataxia telangiectasia cells can be reflected in processing of plasmid vectors.

Faraday Discussions, 2006

… of Histochemistry & …, 1996

0022-1514/96/$3.30 The J owd of Histochemistry and Cytochemistry Copyright 0 1996 by The Histoche... more 0022-1514/96/$3.30 The J owd of Histochemistry and Cytochemistry Copyright 0 1996 by The Histochemical Society, Inc. ... Vol. 44. No. 12, pp. 1363-1372, 1996 Printed in US.A. ... Analysis of Mitochondrial Morphology and Function with ... MARTIN POOT, 'YU-ZHONG ZHANG, ...

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2011

The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association ... more The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. In the present study we attempted to replicate this finding using an independent case-control design of 1,170 cases with autism spectrum disorder (ASD) (874 of which fulfilled narrow criteria for Autism (A)) from five centers within Europe (UK, Germany, the Netherlands, Italy, and Iceland), and 35,307 controls. The combined sample size gave us a non-centrality parameter (NCP) of 11.9, with 93% power to detect allelic association of rs4141463 at an alpha of 0.05 with odds ratio of 0.84 (the best odds ratio estimate of the AGP Consortium data), and for the narrow diagnosis of autism, an NCP of 8.9 and power of 85%. Our case-control data were analyzed for association, stratified by each center, and the summary statistics were combined using the meta-analysis program, GWAMA. This resulted in an odds ratio (OR) of 1.03 (95% CI 0.944-1.133), with a P-value of 0.5 for ASD and OR of 0.99 (95% CI 0.88-1.11) with P-value = 0.85 for the Autism (A) sub-group. Therefore, this study does not provide support for the reported association between rs4141463 and autism.

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2009

American Journal of Medical Genetics Part A, 2005

Cytogenetic and Genome Research, 2002

Highly differentiated, heteromorphic ZZ female symbol/ZW male symbol sex chromosomes were found i... more Highly differentiated, heteromorphic ZZ female symbol/ZW male symbol sex chromosomes were found in the karyotypes of the neotropical leptodactylid frogs Eleutherodactylus euphronides and E. shrevei. The W chromosomes are the largest heterochromatic, female-specific chromosomes so far discovered in the class Amphibia. The analyses of the banding patterns with AT-and GC base-pair specific fluorochromes show that the constitutive heterochromatin in the giant W chromosomes consists of various categories of repetitive ...

American Journal of Medical Genetics Part A, 2007