maryam asgari - Academia.edu (original) (raw)

Papers by maryam asgari

Journal of the American Academy of Dermatology, 2011

Archives of Dermatology, 2009

To examine whether antioxidant supplement use is associated with melanoma risk in light of recent... more To examine whether antioxidant supplement use is associated with melanoma risk in light of recently published data from the Supplementation in Vitamins and Mineral Antioxidants (SUVIMAX) study, which reported a 4-fold higher melanoma risk in women randomized to receive a supplement with nutritionally appropriate doses of antioxidants.

Journal of Investigative Dermatology, 2012

Laboratory data suggest that intake of vitamin A and carotenoids may have chemopreventive benefit... more Laboratory data suggest that intake of vitamin A and carotenoids may have chemopreventive benefits against melanoma, but epidemiological studies examining the association have yielded conflicting results. We examined whether dietary and supplemental vitamin A and carotenoid intake was associated with melanoma risk among 69,635 men and women who were participants of the VITamins And Lifestyle (VITAL) cohort study in western Washington. After an average of 5.84 years of follow-up, 566 incident melanomas were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of melanoma associated with dietary, supplemental, and total vitamin A and carotenoid intake after adjusting for melanoma risk factors. Baseline use of individual retinol supplements was associated with a significant reduction in melanoma risk (HR: 0.60; 95% CI: 0.41-0.89). High-dose (41,200 mg per day) supplemental retinol was also associated with reduced melanoma risk (HR: 0.74; 95% CI: 0.55-1.00), as compared with non-users. The reduction in melanoma risk was stronger in sun-exposed anatomic sites. There was no association of melanoma risk with dietary or total intake of vitamin A or carotenoids. Retinol supplementation may have a preventative role in melanoma among women.

Dermatologic Surgery, 2001

Background. The term evidence-based medicine (EBM) is increasingly being used. Physicians, journa... more Background. The term evidence-based medicine (EBM) is increasingly being used. Physicians, journal editors, insurance companies, and patients are applying its tenets to clinical decision making. Although there are concerns about the overly zealous application of EBM to clinical situations, many of the basic concepts are important in improving decision making.Objective. To define evidence-based medicine and to review potential problems in basing decision making entirely on less-than-ideal evidence.Methods. We reviewed the EBM literature and looked for examples in dermatology of pitfalls in decision making based on poor evidence.Results. Following a definition of EBM, we review problems inherent in anecdotes and uncontrolled trials, including the placebo effect. Examples of medical practice that have been alteredby doing more rigorous studies are provided.Conclusions. Concepts of EBM as currently defined should be considered by dermatologic surgeons in assessing the available information for clinical decision making.

Chinese Chemical Letters, 2009

Under microwave irradiation, the corresponding hydroxycyclopentenones were prepared in high yield... more Under microwave irradiation, the corresponding hydroxycyclopentenones were prepared in high yields by the cross-aldol reactions of benzil with various ketones. When the reactions were performed in various solvents under classical heating for a long time, they produced the products in relatively low yields.