mehmet cengiz üstüner - Academia.edu (original) (raw)
Papers by mehmet cengiz üstüner
International Journal of Research in Education and Science, 2018
The aim of the present study was to examine the relationships between perceptions of teacher'... more The aim of the present study was to examine the relationships between perceptions of teacher's transformational leadership, organizational support, organizational justice and quality of work life. A model suggesting that teacher perceptions of the transformational leadership behavior of school administrators directly affected their perceptions about quality of work life, as well as, indirectly through their perceptions of organizational justice and organizational support is proposed. In order to test this model, a path analysis was conducted within the framework of Structural Equation Modeling (SEM). Participants of the study included 658 teachers employed in state pre-schools, primary schools, junior high schools and high schools affiliated to the Ministry of National Education in Kilis province, Turkey, during the 2015-2016 academic years. "Transformational Leadership Scale", "Organizational Justice Scale", "Perceived Organizational Support Scale"...
JOURNAL OF EDUCATION AND FUTURE, 2017
Bu arastirmanin amaci, ogretmen adaylarinin duygusal zekâ duzeyi ile sosyal girisimcilik ozellikl... more Bu arastirmanin amaci, ogretmen adaylarinin duygusal zekâ duzeyi ile sosyal girisimcilik ozellikleri arasindaki iliskide oz yeterlik algilarinin aracilik rolunu incelemektir. Arastirmada iliskisel tarama modeli kullanilmistir. Arastirmanin katilimcilarini Kilis 7 Aralik Universitesi Muallim Rifat Egitim Fakultesi’ndeki farkli programlarda ogrenim goren 360 ogretmen adayi olusturmaktadir. Arastirma verilerinin toplanmasinda “Ogretmen adaylarinin sosyal girisimcilik olcegi”, “Oz yeterlik olcegi” ve “Duygusal zekâ olcegi” kullanilmistir. Arastirma verilerinin analizinde betimsel istatistikler, korelasyon analizi ve aracilik etkisini belirmek amaciyla bootstrap yontemi kullanilmistir. Arastirma verilerinin analizi sonucunda; ogretmen adaylarinin duygusal zekâ duzeyi, oz yeterlik algisi ve sosyal girisimcilik ozellikleri arasinda pozitif yonde anlamli iliskiler oldugu gorulmustur. Ayrica ogretmen adaylarinin duygusal zekâ duzeyi ile sosyal girisimcilik ozellikleri arasindaki iliskide oz ...
International Journal of Evaluation and Research in Education (IJERE), 2019
The aim of this research was to analyze the measurement invariance of the "Teachers' Sen... more The aim of this research was to analyze the measurement invariance of the "Teachers' Sense of Self-Efficacy Scale," developed by Tschannen-Moran and Hoy, and adapted into Turkish and Turkish culture by Çapa, Çakıroğlu and Sarıkaya, with respect to gender. Turkish version of the scale consists of 24 items and 3 subscales. The scale measures pre-service teachers' and teachers' sense of and belief in self-efficacy for student engagement, classroom management and instructional strategies. Research revealed that the scale is being used by a myriad of researchers. The sample of this study consists of 267 female, 163 male pre-service teachers who participated in the Pedagogical Formation Certificate Traning at Inönü University in the 2017-2018 academic years. First of all, CFA was executed in order to confirm the validity of the scale's current structure for both genders which was confirmed based on the analysis results. Then, MGCFA was executed to analyze the sca...
İnönü Üniversitesi Eğitim Fakültesi Dergisi, 2017
The objective of the present is to adapt the work-related quality of life scale developed by Van ... more The objective of the present is to adapt the work-related quality of life scale developed by Van Laar, Edwards and Easton (2007) to Turkish and educational organizations. The study was conducted with four different study groups. The first study group included 31 English teachers (language validity), the second study group included 50 teachers (item total correlation and internal consistency coefficient analysis), the third group of the study included 324 teachers (construct validity), and the fourth study group included 118 teachers (test-retest reliability). In the linguistic equivalence study, the correlation coefficient between English and Turkish forms of scale is .77. In the pilot scheme conducted for the Turkish form of the scale, it was observed that the scale item total correlation values varied between 0.32 and 0.84, and the Cronbach alpha internal consistency coefficient for the scale was .95. Confirmatory factor analysis, performed to confirm the construct of the 23 item and 6 factor scale (χ² / Sd = 402.6657 / 224 = 1.79; RMSEA = .05; SRMR = .05; CFI = .96; NNFI = .95), and the results demonstrated that the scale had model goodness of fit and sub-dimension factor loads varied between .33 and .97. In reliability studies, it was determined that the test-retest and Cronbach Alpha internal consistency coefficients for the whole scale and its sub-dimensions were found as follows; job and career satisfaction (0.78; 0.73), general well-being (.79; .81), control at work (.89; .71), stress at work (.70; .77), working conditions (.80; .80), homework interface (.91; .75), work-related quality of life general (.93; .88). Based on these findings, it could be argued that the Turkish form of the work-related quality of life is valid and reliable.
African Journal of Microbiology Research, 2011
The Korean Journal of Physiology & Pharmacology, 2014
Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolid... more Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B (NF-κ B) activation. In this study, we aimed to investigate the effects of PDTC to testicular torsion-detorsion (T/D) injury. Forty adult male Sprague-Dawley rats were separated into four groups. A sham operation was performed in group I. In group II, torsion is performed 2 hours by 720 degree extravaginally testis. In group III, 4 h reperfusion of the testis was performed after 2 h of testicular torsion. In group IV, after performing the same surgical procedures as in group III, PDTC (100 mg/kg, intravenous's) was administered before 30 min of detorsion. The testes tissue malondialdehyde (MDA), superoxide dismutase (SOD) catalase (CAT) level was evaluated. Histological evaluations were performed after hematoxylin and eosin staining. Testicular tissue MDA levels were the highest in the T/D groups compared with treatment group. Administration of PDTC prevented a further increase in MDA levels. Significant decrease occurred in CAT and SOD levels in treatment group compared with the control group. The rats in the treatment group had normal testicular architecture. The results suggest that PDTC can be a potential protective agent for preventing the biochemical and histological changes related to oxidative stress in testicular injury caused by testis torsion.
Seizure, 2010
We aimed to investigate the effects of levetiracetam on oxidative stress which is one of the new ... more We aimed to investigate the effects of levetiracetam on oxidative stress which is one of the new antiepileptic drugs in epileptic patients. Methods: The study consisted of 21 patients with cryptogenic partial epilepsy. We determined the urinary 15F-2t-isoprostane levels of the 30 patients which is a marker of oxidative stress. Morning urine samples were collected from the patients before beginning LEV and after 3 months treatment. Of these patients 9 were excluded from the study that had seizure history in the last 1 month. Urinary levels of 15-F2t-isoprostane determined by ELISA initially and after 3 months treatment for each patient. Results: Mean age of the 21 patients was 29.6, of these 11 were females and 10 males. Mean urinary 15F-2t-isoprostane level of the patients was 876 AE 447 ng/mg Cr before the treatment of LEV. After 3 months treatment the mean 15F-2t-isoprostane level of the patients was 1560 AE 630. The patients had significantly higher levels of urinary 15F-2t-isoprostane when compared with initial levels (p = 0.025). Conclusion: Our results showed the increase of urinary 15F-2t-isoprostane levels in epileptic patients whom were treated with LEV which may indicate that LEV induces the oxidative stress in epileptic patients.
Clinical & Investigative Medicine, 2009
Objective: To evaluate the histopathological and antioxidant effects of vitamin E (VE) treatment ... more Objective: To evaluate the histopathological and antioxidant effects of vitamin E (VE) treatment on brain tissue in streptozotocin (STZ)-induced diabetic rats. Methods: Thirty two male Wistar albino rats were used. The study comprised four groups of 8 rats: Group A - untreated group, group B - diabetic group, group C - VE and group D - diabetic plus VE. In the diabetic groups, diabetes was induced by a single intraperitoneal injection of 65 mg/kg STZ. Vitamin E was given 50 mg/kg/day i.p. for three weeks. Concentrations of glucose, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were detected in the haemolysate. Results: Glucose concentrations were increased in the blood of the STZ-treated rats compared with those in the diabetic groups (group B and D). The MDA concentrations in the brain from diabetic rats increased, whereas the GPx, SOD, CAT concentrations decreased. Treatment with VE returned concentrations of MDA, GPx, SOD and ...
Amac: Son yillarda kimyasal ilaclarin yan etkilerine karsi bitkisel urunlere olan ilgi hizla artm... more Amac: Son yillarda kimyasal ilaclarin yan etkilerine karsi bitkisel urunlere olan ilgi hizla artmaktadir. Indol turevi bir non steroidal anti-inflamatuar ilac olan indometazin ile deneysel ulser modeli olusturmak yaygin bir yontemdir. Antioksidanlar, mukozal hasari onlenmesinde onemli bir rol oynayabilir. Anti-inflamatuar, antimikrobiyal, yara iyilesmesi, antioksidan, antineoplastik, antianksiyete, antidepresan ve anti ulseratif etkileri olan Sari Kantaron olarak bilinen Hypericum perforatum L., halk arasinda bircok hastaligin tedavisinde kullanilan geleneksel bir bitkidir. Bizde calismamiz da Sari Kantaron yaginin gastrik mukozal iyilesme ve hasar onleyici etkisini arastirmayi planladik. Gerec ve yontemler: Calismada, Sprague-Dawley erkek sicanlar kullanildi. Mukozal hasar induklenmeden 1 saat once Hypericum perforatum yagi (HPY) (2 ml/kg) olacak sekilde verildi. Mukozal hasar intragastrik olarak 30 mg/kg indometazin uygulamasi ile olusturuldu. Calismanin sonunda mide dokularinda u...
Lipopolysaccharide (LPS) is a main constituent of Gram-negative bacterial cell walls and is consi... more Lipopolysaccharide (LPS) is a main constituent of Gram-negative bacterial cell walls and is considered a leading cause of sepsis. S-allyl cysteine (SAC) is a water-soluble organosulfur component present in garlic which has a potent antioxidant and free radical scavenger activity. The purpose of this study is to examine the antioxidant and anti-inflammatory potential of SAC on endotoxin LPS-induced sepsis. Female Wistar albino rats were divided into 6 groups. LPS (5 mg/kg) was applied to rats in sepsis and treatment groups intraperitoneally. After 24 hours from LPS injection 50 mg/kg and 100 mg/kg SAC was orally administrated to treatment groups. Lung and liver 18F-fluoro-deoxy-D-glucose (18F-FDG) uptake was measured by 18FDG-PET scan. Serum levels of nuclear factor-kappa B (NF-κβ), tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase-9 (MMP-9), plasma levels of interleukin-1β (IL-1β), IL-6 and tissue levels of oxidative stress markers catalase (CAT), superoxide dismutase (S...
African Journal of Pharmacy and Pharmacology, 2011
To investigate the effect of gallic acid (GA) on kidney and liver against oxidative stress during... more To investigate the effect of gallic acid (GA) on kidney and liver against oxidative stress during renal ischemia-reperfusion (I/R) injury, by determining biochemical parameters and evaluating histological examinations.
OSMANGAZİ JOURNAL OF MEDICINE, 2015
Our aim is to investigate the detection of fractal dimension (Box-counting dimensions) with prote... more Our aim is to investigate the detection of fractal dimension (Box-counting dimensions) with protective effects of lycopene and catechin in carbon tetrachloride-treated rat's liver. Fractal dimension measure intensity and complexity of subject. The rats were divided into six groups as liquid oil, lycopene, catechin, carbon tetrachloride plus lycopene, carbon tetrachloride plus catechin and carbon tetrachloride. The tissue samples were obtained at end of 2İst day. The liver tissue distortions were evaluated using hematoxylin and eosin staining. The regions of hepatocyte were separated into Small Square under light microscopy. Then, counted at least one nucleus with intersection of one square. Fractal dimension were determined by using this formula; ln(N(n))/ln(2 n). Notably, there was no difference between control and catechin-treated rats on fractal dimension values. But, a lycopene value was bigger than control and catechin administrated rats. In carbon tetrachloride-treated rat, fractal dimension is less. It was increased in lycopene plus carbon tetrachloride and catechin plus carbon tetrachloride with compare to carbon tetrachloride group. The findings confirmed, if hepatocyte is less, fractal dimension will decrease On other hand, carbon tetrachloride decreased fractal dimension due to less hepatocyte. It was increased in fractal dimension due to high hepatocyte in catechin and lycopene treated rats, because of their protective effects. This study is combination of medicine and mathematics, as fractal dimension. It was calculated, toxicity and protective effects of antioxidant materials could be determined in this way.
International Journal of Research in Education and Science, 2018
The aim of the present study was to examine the relationships between perceptions of teacher'... more The aim of the present study was to examine the relationships between perceptions of teacher's transformational leadership, organizational support, organizational justice and quality of work life. A model suggesting that teacher perceptions of the transformational leadership behavior of school administrators directly affected their perceptions about quality of work life, as well as, indirectly through their perceptions of organizational justice and organizational support is proposed. In order to test this model, a path analysis was conducted within the framework of Structural Equation Modeling (SEM). Participants of the study included 658 teachers employed in state pre-schools, primary schools, junior high schools and high schools affiliated to the Ministry of National Education in Kilis province, Turkey, during the 2015-2016 academic years. "Transformational Leadership Scale", "Organizational Justice Scale", "Perceived Organizational Support Scale"...
JOURNAL OF EDUCATION AND FUTURE, 2017
Bu arastirmanin amaci, ogretmen adaylarinin duygusal zekâ duzeyi ile sosyal girisimcilik ozellikl... more Bu arastirmanin amaci, ogretmen adaylarinin duygusal zekâ duzeyi ile sosyal girisimcilik ozellikleri arasindaki iliskide oz yeterlik algilarinin aracilik rolunu incelemektir. Arastirmada iliskisel tarama modeli kullanilmistir. Arastirmanin katilimcilarini Kilis 7 Aralik Universitesi Muallim Rifat Egitim Fakultesi’ndeki farkli programlarda ogrenim goren 360 ogretmen adayi olusturmaktadir. Arastirma verilerinin toplanmasinda “Ogretmen adaylarinin sosyal girisimcilik olcegi”, “Oz yeterlik olcegi” ve “Duygusal zekâ olcegi” kullanilmistir. Arastirma verilerinin analizinde betimsel istatistikler, korelasyon analizi ve aracilik etkisini belirmek amaciyla bootstrap yontemi kullanilmistir. Arastirma verilerinin analizi sonucunda; ogretmen adaylarinin duygusal zekâ duzeyi, oz yeterlik algisi ve sosyal girisimcilik ozellikleri arasinda pozitif yonde anlamli iliskiler oldugu gorulmustur. Ayrica ogretmen adaylarinin duygusal zekâ duzeyi ile sosyal girisimcilik ozellikleri arasindaki iliskide oz ...
International Journal of Evaluation and Research in Education (IJERE), 2019
The aim of this research was to analyze the measurement invariance of the "Teachers' Sen... more The aim of this research was to analyze the measurement invariance of the "Teachers' Sense of Self-Efficacy Scale," developed by Tschannen-Moran and Hoy, and adapted into Turkish and Turkish culture by Çapa, Çakıroğlu and Sarıkaya, with respect to gender. Turkish version of the scale consists of 24 items and 3 subscales. The scale measures pre-service teachers' and teachers' sense of and belief in self-efficacy for student engagement, classroom management and instructional strategies. Research revealed that the scale is being used by a myriad of researchers. The sample of this study consists of 267 female, 163 male pre-service teachers who participated in the Pedagogical Formation Certificate Traning at Inönü University in the 2017-2018 academic years. First of all, CFA was executed in order to confirm the validity of the scale's current structure for both genders which was confirmed based on the analysis results. Then, MGCFA was executed to analyze the sca...
İnönü Üniversitesi Eğitim Fakültesi Dergisi, 2017
The objective of the present is to adapt the work-related quality of life scale developed by Van ... more The objective of the present is to adapt the work-related quality of life scale developed by Van Laar, Edwards and Easton (2007) to Turkish and educational organizations. The study was conducted with four different study groups. The first study group included 31 English teachers (language validity), the second study group included 50 teachers (item total correlation and internal consistency coefficient analysis), the third group of the study included 324 teachers (construct validity), and the fourth study group included 118 teachers (test-retest reliability). In the linguistic equivalence study, the correlation coefficient between English and Turkish forms of scale is .77. In the pilot scheme conducted for the Turkish form of the scale, it was observed that the scale item total correlation values varied between 0.32 and 0.84, and the Cronbach alpha internal consistency coefficient for the scale was .95. Confirmatory factor analysis, performed to confirm the construct of the 23 item and 6 factor scale (χ² / Sd = 402.6657 / 224 = 1.79; RMSEA = .05; SRMR = .05; CFI = .96; NNFI = .95), and the results demonstrated that the scale had model goodness of fit and sub-dimension factor loads varied between .33 and .97. In reliability studies, it was determined that the test-retest and Cronbach Alpha internal consistency coefficients for the whole scale and its sub-dimensions were found as follows; job and career satisfaction (0.78; 0.73), general well-being (.79; .81), control at work (.89; .71), stress at work (.70; .77), working conditions (.80; .80), homework interface (.91; .75), work-related quality of life general (.93; .88). Based on these findings, it could be argued that the Turkish form of the work-related quality of life is valid and reliable.
African Journal of Microbiology Research, 2011
The Korean Journal of Physiology & Pharmacology, 2014
Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolid... more Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B (NF-κ B) activation. In this study, we aimed to investigate the effects of PDTC to testicular torsion-detorsion (T/D) injury. Forty adult male Sprague-Dawley rats were separated into four groups. A sham operation was performed in group I. In group II, torsion is performed 2 hours by 720 degree extravaginally testis. In group III, 4 h reperfusion of the testis was performed after 2 h of testicular torsion. In group IV, after performing the same surgical procedures as in group III, PDTC (100 mg/kg, intravenous's) was administered before 30 min of detorsion. The testes tissue malondialdehyde (MDA), superoxide dismutase (SOD) catalase (CAT) level was evaluated. Histological evaluations were performed after hematoxylin and eosin staining. Testicular tissue MDA levels were the highest in the T/D groups compared with treatment group. Administration of PDTC prevented a further increase in MDA levels. Significant decrease occurred in CAT and SOD levels in treatment group compared with the control group. The rats in the treatment group had normal testicular architecture. The results suggest that PDTC can be a potential protective agent for preventing the biochemical and histological changes related to oxidative stress in testicular injury caused by testis torsion.
Seizure, 2010
We aimed to investigate the effects of levetiracetam on oxidative stress which is one of the new ... more We aimed to investigate the effects of levetiracetam on oxidative stress which is one of the new antiepileptic drugs in epileptic patients. Methods: The study consisted of 21 patients with cryptogenic partial epilepsy. We determined the urinary 15F-2t-isoprostane levels of the 30 patients which is a marker of oxidative stress. Morning urine samples were collected from the patients before beginning LEV and after 3 months treatment. Of these patients 9 were excluded from the study that had seizure history in the last 1 month. Urinary levels of 15-F2t-isoprostane determined by ELISA initially and after 3 months treatment for each patient. Results: Mean age of the 21 patients was 29.6, of these 11 were females and 10 males. Mean urinary 15F-2t-isoprostane level of the patients was 876 AE 447 ng/mg Cr before the treatment of LEV. After 3 months treatment the mean 15F-2t-isoprostane level of the patients was 1560 AE 630. The patients had significantly higher levels of urinary 15F-2t-isoprostane when compared with initial levels (p = 0.025). Conclusion: Our results showed the increase of urinary 15F-2t-isoprostane levels in epileptic patients whom were treated with LEV which may indicate that LEV induces the oxidative stress in epileptic patients.
Clinical & Investigative Medicine, 2009
Objective: To evaluate the histopathological and antioxidant effects of vitamin E (VE) treatment ... more Objective: To evaluate the histopathological and antioxidant effects of vitamin E (VE) treatment on brain tissue in streptozotocin (STZ)-induced diabetic rats. Methods: Thirty two male Wistar albino rats were used. The study comprised four groups of 8 rats: Group A - untreated group, group B - diabetic group, group C - VE and group D - diabetic plus VE. In the diabetic groups, diabetes was induced by a single intraperitoneal injection of 65 mg/kg STZ. Vitamin E was given 50 mg/kg/day i.p. for three weeks. Concentrations of glucose, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were detected in the haemolysate. Results: Glucose concentrations were increased in the blood of the STZ-treated rats compared with those in the diabetic groups (group B and D). The MDA concentrations in the brain from diabetic rats increased, whereas the GPx, SOD, CAT concentrations decreased. Treatment with VE returned concentrations of MDA, GPx, SOD and ...
Amac: Son yillarda kimyasal ilaclarin yan etkilerine karsi bitkisel urunlere olan ilgi hizla artm... more Amac: Son yillarda kimyasal ilaclarin yan etkilerine karsi bitkisel urunlere olan ilgi hizla artmaktadir. Indol turevi bir non steroidal anti-inflamatuar ilac olan indometazin ile deneysel ulser modeli olusturmak yaygin bir yontemdir. Antioksidanlar, mukozal hasari onlenmesinde onemli bir rol oynayabilir. Anti-inflamatuar, antimikrobiyal, yara iyilesmesi, antioksidan, antineoplastik, antianksiyete, antidepresan ve anti ulseratif etkileri olan Sari Kantaron olarak bilinen Hypericum perforatum L., halk arasinda bircok hastaligin tedavisinde kullanilan geleneksel bir bitkidir. Bizde calismamiz da Sari Kantaron yaginin gastrik mukozal iyilesme ve hasar onleyici etkisini arastirmayi planladik. Gerec ve yontemler: Calismada, Sprague-Dawley erkek sicanlar kullanildi. Mukozal hasar induklenmeden 1 saat once Hypericum perforatum yagi (HPY) (2 ml/kg) olacak sekilde verildi. Mukozal hasar intragastrik olarak 30 mg/kg indometazin uygulamasi ile olusturuldu. Calismanin sonunda mide dokularinda u...
Lipopolysaccharide (LPS) is a main constituent of Gram-negative bacterial cell walls and is consi... more Lipopolysaccharide (LPS) is a main constituent of Gram-negative bacterial cell walls and is considered a leading cause of sepsis. S-allyl cysteine (SAC) is a water-soluble organosulfur component present in garlic which has a potent antioxidant and free radical scavenger activity. The purpose of this study is to examine the antioxidant and anti-inflammatory potential of SAC on endotoxin LPS-induced sepsis. Female Wistar albino rats were divided into 6 groups. LPS (5 mg/kg) was applied to rats in sepsis and treatment groups intraperitoneally. After 24 hours from LPS injection 50 mg/kg and 100 mg/kg SAC was orally administrated to treatment groups. Lung and liver 18F-fluoro-deoxy-D-glucose (18F-FDG) uptake was measured by 18FDG-PET scan. Serum levels of nuclear factor-kappa B (NF-κβ), tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase-9 (MMP-9), plasma levels of interleukin-1β (IL-1β), IL-6 and tissue levels of oxidative stress markers catalase (CAT), superoxide dismutase (S...
African Journal of Pharmacy and Pharmacology, 2011
To investigate the effect of gallic acid (GA) on kidney and liver against oxidative stress during... more To investigate the effect of gallic acid (GA) on kidney and liver against oxidative stress during renal ischemia-reperfusion (I/R) injury, by determining biochemical parameters and evaluating histological examinations.
OSMANGAZİ JOURNAL OF MEDICINE, 2015
Our aim is to investigate the detection of fractal dimension (Box-counting dimensions) with prote... more Our aim is to investigate the detection of fractal dimension (Box-counting dimensions) with protective effects of lycopene and catechin in carbon tetrachloride-treated rat's liver. Fractal dimension measure intensity and complexity of subject. The rats were divided into six groups as liquid oil, lycopene, catechin, carbon tetrachloride plus lycopene, carbon tetrachloride plus catechin and carbon tetrachloride. The tissue samples were obtained at end of 2İst day. The liver tissue distortions were evaluated using hematoxylin and eosin staining. The regions of hepatocyte were separated into Small Square under light microscopy. Then, counted at least one nucleus with intersection of one square. Fractal dimension were determined by using this formula; ln(N(n))/ln(2 n). Notably, there was no difference between control and catechin-treated rats on fractal dimension values. But, a lycopene value was bigger than control and catechin administrated rats. In carbon tetrachloride-treated rat, fractal dimension is less. It was increased in lycopene plus carbon tetrachloride and catechin plus carbon tetrachloride with compare to carbon tetrachloride group. The findings confirmed, if hepatocyte is less, fractal dimension will decrease On other hand, carbon tetrachloride decreased fractal dimension due to less hepatocyte. It was increased in fractal dimension due to high hepatocyte in catechin and lycopene treated rats, because of their protective effects. This study is combination of medicine and mathematics, as fractal dimension. It was calculated, toxicity and protective effects of antioxidant materials could be determined in this way.