mehrzad jafarzadeh - Academia.edu (original) (raw)

Uploads

Papers by mehrzad jafarzadeh

International Immunology, 2010

Journal of biostatistics and epidemiology, Dec 1, 2021

BMC Nutrition

BackgroundSome evidence shows that meal timing is associated with diet quality. We aimed to inves... more BackgroundSome evidence shows that meal timing is associated with diet quality. We aimed to investigate the relationship between meal timing and breakfast quality in a sample of Iranian adults.MethodsThis cross-sectional study was conducted on 850 men and women living in Tehran, Iran. Dietary data was recorded by three non-consecutive 24-h dietary recalls. The Breakfast Quality Index (BQI) was calculated. Time-related meal patterns included the interval between the first and last meal (eating and fasting window), frequency of meals, length of sleep, and time of first and last eating occasion. The multiple linear regression analysis was used to identify the relationships between time-related meal patterns and BQI.ResultsThe mean (95% CI) of BQI was 4.52 (4.45–4.65) and the maximum was 8. Bread, cheese, vegetables, fruits, energy, and carbohydrate intake showed positive associations with BQI scores. Longer fasting time showed a positive association with fruits (β (CI 95%)) (0.11 (0.00...

Journal of Diabetes Research, 2021

Objectives. Although the risk factors for diabetic neuropathy and diabetic foot ulcer have been d... more Objectives. Although the risk factors for diabetic neuropathy and diabetic foot ulcer have been detected, there was no practical modeling for their prediction. We aimed to design a logistic regression model on an Iranian dataset to predict the probability of experiencing diabetic foot ulcers up to a considered age in diabetic patients. Methods. The present study was a statistical modeling on a previously published dataset. The covariates were sex, age, body mass index (BMI), fasting blood sugar (FBS), hemoglobin A1C (HbA1C), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), insulin dependency, and statin use. The final model of logistic regression was designed through a manual stepwise method. To study the performance of the model, an area under receiver operating characteristic (AUC) curve was reported. A scoring system was defined according to the beta coefficients to be used in logistic function for calculation of the probability. Results. The pret...

s Background: We studied the impact of SUMO4 M55V polymorphism on susceptibility to diabetic neph... more s Background: We studied the impact of SUMO4 M55V polymorphism on susceptibility to diabetic nephropathy in Iranian type 2 diabetes patients. Materials and methods: The patient group consisted of 50 Iranian type 2 diabetes patients with nephropathy, and the control group consisted of 50 Iranian type 2 diabetes patients without nephropathy. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method for the M55V. Results: The frequency of SUMO4 AA, AG, and GG genotypes were 48%, 36%, and 16% in the patient group and 20%, 52%, and 28% in the control group. There was a significant increase in frequency of SUMO4 AA genotype in type 2 diabetes patients with nephropathy compared to type 2 diabetes patients without nephropathy (48% vs 20%, P=0.003). Discussion: These findings indicate that SUMO4 M55V Polymorphism is associated with diabetic nephropathy in Iranian type 2 diabetes patients. [Farhad Shahsavar, Abdolreza Kheirollahi, Mehr...

Background In the majority of cancers, metastasis of tumor cells is main cause of treatment failu... more Background In the majority of cancers, metastasis of tumor cells is main cause of treatment failure. The current research investigated the effectiveness basic fibroblast growth factor (bFGF) peptide developed to inhibit tumor growth in 4T1 metastatic breast cancer through the PI3K/AKT and ERK/MAPK signal transduction pathways. In BALB/c mice, the tumor was induced through 4T1 tumor graft. Administration of the peptide was done one time a day at various doses of 1, 2.5, or 10 mg/kg over 14 days. After two weeks, the designed peptide injected .After the treatment period, the mice underwent surgery, and tumors were used for the Immunohistochemistry, Apoptosis, and western blot examinations.Results Based on one-way ANOVA and p ≤0.05, findings showed that the P-AKT and p-ERK contents in tumors treated with peptide reduced in two mentioned signaling pathways and the peptide injection were effective in reducing or inhibiting tumor growth.Conclusion Our findings showed that in the two signa...

Reviews in Medical Virology

Reviews in Medical Microbiology

Journal of Burn Care & Research

Background There are few studies on the inflammatory processes and role of cytokines involved in ... more Background There are few studies on the inflammatory processes and role of cytokines involved in pediatric burn injuries. The present study aims to measure the serum levels of cytokines and their relationship with the degree of burn injury in children. Methods Within the 48 hours of hospitalization, the serum samples were obtained to measure inflammatory cytokines (Interleukins 6,8,10 and TNF-alpha). The level of all of these cytokine factors was assessed by Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results The mean levels of IL-6, IL-8, IL-10 and TNF-α was 18.15 ± 4.77 pg/ml, 59.54 ± 4.59 pg/ml, 8.41 ± 2.09 pg/ml and 1.48 ± 0.15 pg/ml, respectively, which were higher than the normal range designated for healthy pediatrics age group. The levels of TNF-α were higher in patients with sepsis (P=0.03), and deceased patients (P=0.001). There was a statistically significance difference in the levels of IL-8 in patients with second (0.001) and third degree (0.001) burn injuries ...

Diabetes Research and Clinical Practice, 2010

Open Life Sciences

Objective Given the role of basic fibroblastic growth factor (bFGF) in tumor growth, it has been ... more Objective Given the role of basic fibroblastic growth factor (bFGF) in tumor growth, it has been considered as a potential target for tumor therapy. In this study, we investigate the effect of bFGF antagonistic peptide on the growth and angiogenesis of 4T1 mammary carcinoma tumor (MCT) in BALB/c mice. Methods An engineered peptide was injected into BALB/c mice in doses of 1, 2.5, 5 and 10 mg/kg daily for 14 days. Immunohistochemical analysis using anti-CD31 and anti-CD34 were conducted as indices of angiogenesis. In addition, blood samples were taken from the eyes of treated and control mice and the levels of Interleukin-8 (IL-8) and Tumor Necrosis Factor-α (TNF-α) were measured by ELISA. Data was analyzed by ANOVA using SPSS. Results The antagonistic peptide inhibited growth and angiogenesis of MCT (P ≤0.05), and decreased the serum level of IL-8 and TNF-α in treated groups compared to the control groups. Conclusion The inhibition of tumor angiogenesis has been considered as an imp...