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Tunisie Medicale, 2001

Entre 1969 et 1999, 149 patients porteurs de communication interauriculaire type ostium secundum,... more Entre 1969 et 1999, 149 patients porteurs de communication interauriculaire type ostium secundum, ont ete catheterises. L'âge moyen des patients etait de 21.5 ± 16 ans (2-67). La pression arterielle pulmonaire systolique est en moyenne de 35 ± 15.6 mm Hg (15-140). La fermeture du defect septal a ete realisee chez 108 patients (107 fois par chirurgie, et une fois par catheterisme interventionnel). Le suivi moyen des 117 patients etait de 8 ± 7 ans (1-20). La mortalite globale etait de 2.7% L'hypertension arterielle pulmonaire severe (pression systolique superieure ≥ a 50 mm Hg) observee dans 13.4% des cas, etait constatee a tous les âges, mais surtout au-dela de l'âge de 20 ans. L'obstruction vasculaire pulmonaire etait notee dans 2% des cas. L'analyse des donnees cliniques et hemodynamiques a permis de deduire que l'hypertension arterielle pulmonaire severe complique frequemment l'evolution des communications interauriculaires type ostium secundum Elle s'installe de maniere imprevisible a tous les âges, et aggrave considerablement le pronostic de la cardiopathie. Le profil hemodynamique des CIA, ainsi que l'essor actuel des techniques de fermeture par catheterisme interventionnel, incitent a realiser l'exploration invasive de maniere plus routiniere, pour un choix approprie et precoce de l'option therapeutique.

A pressão arterial vem recebendo destaque na clínica veterinária atual, podendo ser mensurada de ... more A pressão arterial vem recebendo destaque na clínica veterinária atual, podendo ser mensurada de forma não-invasiva, pelo método oscilométrico, entre outros. Fatores como a idade já foram relacionados com distúrbios na pressão arterial. O sódio, elemento vital na fisiologia celular de animais, já foi relacionado com o aumento da pressão arterial. Desta forma, este trabalho correlaciona a idade, os valores da pressão arterial sistêmica, sistólica e diastólica, com os níveis séricos de sódio em cães adultos hígidos. Foram estudados 23 cães adultos, hígidos, de ambos os sexos e idade variável, alimentados com ração comercial (standard). As pressões arteriais, sistólica (PAS) e diastólica (PAD), e pulso foram aferidas por esfigmomanômetro digital humano. O nível sérico de sódio foi obtido pelo método de reagente enzimático em modo cinético, utilizando kit comercial. Foi realizada a Correlação de Pearson entre as variáveis. Os valores da PAS, PAD, pulso e sódio sérico, variaram respectivamente de 96-184mmHg, 53-137mmHg, 64-135bpm e 120-157mEq/L. Foi observada uma correlação positiva entre as variáveis idade e PAS, idade e PAD, sódio e PAS, e sódio e PAD, enquanto os valores de idade e sódio sérico, demonstraram uma correlação negativa. Nas condições deste estudo conclui-se que há pouca interferência nos valores de pressão arterial, sistólica e diastólica, pela idade e o nível sérico de sódio, em cães adultos hígidos.

Archives of Dermatological Research, 2009

The Journal of Heart and Lung Transplantation, 2006

Background: After undergoing heart transplantation and the subsequent compulsive immunosuppressiv... more Background: After undergoing heart transplantation and the subsequent compulsive immunosuppressive treatments, patients are at risk of rejection episodes, infectious complications or cancer development. Thus, it is probable that the various subsets of peripheral cytotoxic lymphocytes are modulated in such patients. This area of study can now be investigated by examining the numerous recently described natural killer (NK)-cell-related surface receptors. Methods: A prospective cohort of 60 heart transplant recipients and 60 controls was studied. The partitioning of lymphocyte subsets, especially NK (CD3 Ϫ /CD56 ϩ), T (CD3 ϩ /CD56 Ϫ) and NKT-like (CD3 ϩ / CD56 ϩ) cells, was compared in both groups using multi-parametric flow cytometry. Moreover, expression of a series of seven NK-related receptors was compared on the three subsets defined by CD56 expression. Results: A significant increase in NK-cell levels was observed in transplanted patients, as compared with controls, whereas T and NKT-like cells were in similar proportions in both groups. Two NK-related receptors showed significantly different levels of expression in heart transplant recipients: the cytotoxic effector, CD244, which was in a significantly increased proportion on T and NKT-like cells; and the activating receptor, CD161, which was expressed significantly less on NK and NKT-like cells, but more on T cells. Conclusions: These findings indicate that cytotoxic NK-related cells, increased in proportion, also display increased levels of activity-associated markers in heart transplant recipients. Viral infection or the immunosuppressive regimen could be responsible for the modulation of regulatory receptors on NK and NKT-like cells in heart transplant recipients.

Annales de Cardiologie et d'Angéiologie, 2005

Objective. – To determine the in-hospital prognosis and late outcome of cardiogenic shock complic... more Objective. – To determine the in-hospital prognosis and late outcome of cardiogenic shock complicating acute myocardial infarction treated by early (<24 hours) percutaneous coronary intervention (PCI).Methods. – Retrospective monocentric study of a consecutive cohort of patients undergoing early PCI (< 24 heures) for cardiogenic shock complicating acute myocardial infarction from 1994 to 2004.Results. – The cohort included 175 patients (mean age =65 ±14 years, 68% male). A successful PCI was obtained in 69% of patients. The in-hospital mortality was 43%. Independent risk factors associated with an increased mortality were: absence of TIMI three flow (P <0.0001), absence of smoking (P <0.009) and the need for mechanical ventilation (P <0.002). Nor stent use or anti GP IIb/IIIa infusions were predictors of a better outcome. At hospital discharge, mean left ventricular ejection fraction (LVEF) was 38 ±12%. Kaplan-Meier estimate of survival was 63% for in-hospital survivors (maximum follow-up =9 years). Independent predictors of an impaired long-term outcome were: a LVEF <0.3 (P <0,028) and 3-vessel disease on coronary angiography (P <0,004).Conclusion. – In-hospital mortality of patients suffering cardiogenic shock complicating acute myocardial infarction and treated by PCI remains high despite PCI improvement. The long-term survival appears, however, to be better than that of patients with coronary artery disease and low LVEF.

Tunisie Medicale, 2001

Entre 1969 et 1999, 149 patients porteurs de communication interauriculaire type ostium secundum,... more Entre 1969 et 1999, 149 patients porteurs de communication interauriculaire type ostium secundum, ont ete catheterises. L'âge moyen des patients etait de 21.5 ± 16 ans (2-67). La pression arterielle pulmonaire systolique est en moyenne de 35 ± 15.6 mm Hg (15-140). La fermeture du defect septal a ete realisee chez 108 patients (107 fois par chirurgie, et une fois par catheterisme interventionnel). Le suivi moyen des 117 patients etait de 8 ± 7 ans (1-20). La mortalite globale etait de 2.7% L'hypertension arterielle pulmonaire severe (pression systolique superieure ≥ a 50 mm Hg) observee dans 13.4% des cas, etait constatee a tous les âges, mais surtout au-dela de l'âge de 20 ans. L'obstruction vasculaire pulmonaire etait notee dans 2% des cas. L'analyse des donnees cliniques et hemodynamiques a permis de deduire que l'hypertension arterielle pulmonaire severe complique frequemment l'evolution des communications interauriculaires type ostium secundum Elle s'installe de maniere imprevisible a tous les âges, et aggrave considerablement le pronostic de la cardiopathie. Le profil hemodynamique des CIA, ainsi que l'essor actuel des techniques de fermeture par catheterisme interventionnel, incitent a realiser l'exploration invasive de maniere plus routiniere, pour un choix approprie et precoce de l'option therapeutique.

A pressão arterial vem recebendo destaque na clínica veterinária atual, podendo ser mensurada de ... more A pressão arterial vem recebendo destaque na clínica veterinária atual, podendo ser mensurada de forma não-invasiva, pelo método oscilométrico, entre outros. Fatores como a idade já foram relacionados com distúrbios na pressão arterial. O sódio, elemento vital na fisiologia celular de animais, já foi relacionado com o aumento da pressão arterial. Desta forma, este trabalho correlaciona a idade, os valores da pressão arterial sistêmica, sistólica e diastólica, com os níveis séricos de sódio em cães adultos hígidos. Foram estudados 23 cães adultos, hígidos, de ambos os sexos e idade variável, alimentados com ração comercial (standard). As pressões arteriais, sistólica (PAS) e diastólica (PAD), e pulso foram aferidas por esfigmomanômetro digital humano. O nível sérico de sódio foi obtido pelo método de reagente enzimático em modo cinético, utilizando kit comercial. Foi realizada a Correlação de Pearson entre as variáveis. Os valores da PAS, PAD, pulso e sódio sérico, variaram respectivamente de 96-184mmHg, 53-137mmHg, 64-135bpm e 120-157mEq/L. Foi observada uma correlação positiva entre as variáveis idade e PAS, idade e PAD, sódio e PAS, e sódio e PAD, enquanto os valores de idade e sódio sérico, demonstraram uma correlação negativa. Nas condições deste estudo conclui-se que há pouca interferência nos valores de pressão arterial, sistólica e diastólica, pela idade e o nível sérico de sódio, em cães adultos hígidos.

Archives of Dermatological Research, 2009

The Journal of Heart and Lung Transplantation, 2006

Background: After undergoing heart transplantation and the subsequent compulsive immunosuppressiv... more Background: After undergoing heart transplantation and the subsequent compulsive immunosuppressive treatments, patients are at risk of rejection episodes, infectious complications or cancer development. Thus, it is probable that the various subsets of peripheral cytotoxic lymphocytes are modulated in such patients. This area of study can now be investigated by examining the numerous recently described natural killer (NK)-cell-related surface receptors. Methods: A prospective cohort of 60 heart transplant recipients and 60 controls was studied. The partitioning of lymphocyte subsets, especially NK (CD3 Ϫ /CD56 ϩ), T (CD3 ϩ /CD56 Ϫ) and NKT-like (CD3 ϩ / CD56 ϩ) cells, was compared in both groups using multi-parametric flow cytometry. Moreover, expression of a series of seven NK-related receptors was compared on the three subsets defined by CD56 expression. Results: A significant increase in NK-cell levels was observed in transplanted patients, as compared with controls, whereas T and NKT-like cells were in similar proportions in both groups. Two NK-related receptors showed significantly different levels of expression in heart transplant recipients: the cytotoxic effector, CD244, which was in a significantly increased proportion on T and NKT-like cells; and the activating receptor, CD161, which was expressed significantly less on NK and NKT-like cells, but more on T cells. Conclusions: These findings indicate that cytotoxic NK-related cells, increased in proportion, also display increased levels of activity-associated markers in heart transplant recipients. Viral infection or the immunosuppressive regimen could be responsible for the modulation of regulatory receptors on NK and NKT-like cells in heart transplant recipients.

Annales de Cardiologie et d'Angéiologie, 2005

Objective. – To determine the in-hospital prognosis and late outcome of cardiogenic shock complic... more Objective. – To determine the in-hospital prognosis and late outcome of cardiogenic shock complicating acute myocardial infarction treated by early (<24 hours) percutaneous coronary intervention (PCI).Methods. – Retrospective monocentric study of a consecutive cohort of patients undergoing early PCI (< 24 heures) for cardiogenic shock complicating acute myocardial infarction from 1994 to 2004.Results. – The cohort included 175 patients (mean age =65 ±14 years, 68% male). A successful PCI was obtained in 69% of patients. The in-hospital mortality was 43%. Independent risk factors associated with an increased mortality were: absence of TIMI three flow (P <0.0001), absence of smoking (P <0.009) and the need for mechanical ventilation (P <0.002). Nor stent use or anti GP IIb/IIIa infusions were predictors of a better outcome. At hospital discharge, mean left ventricular ejection fraction (LVEF) was 38 ±12%. Kaplan-Meier estimate of survival was 63% for in-hospital survivors (maximum follow-up =9 years). Independent predictors of an impaired long-term outcome were: a LVEF <0.3 (P <0,028) and 3-vessel disease on coronary angiography (P <0,004).Conclusion. – In-hospital mortality of patients suffering cardiogenic shock complicating acute myocardial infarction and treated by PCI remains high despite PCI improvement. The long-term survival appears, however, to be better than that of patients with coronary artery disease and low LVEF.