mohammad fallah - Academia.edu (original) (raw)
Papers by mohammad fallah
Journal of Mathematics, 2021
One of the new concepts that have found a considerable position in many countries of the world is... more One of the new concepts that have found a considerable position in many countries of the world is organizing EFQM organizational excellence models. Different organizations and institutions have been evaluated and compared on its basis, and the move towards improvement and promotion is strengthened in them due to creation of competitive space. The EFQM organizational excellence model cannot remove the managers’ and users’ need for the levels of quantitative goals’ operation solely. Thus, requirement for a tool which considers quantitative goals and present environment was felt, and in this manner, various assessment processes were created to be used in different organizations; one of the most important ones is the technique for Data Envelopment Analysis. Evaluating organization efficiency based on the EFQM model is one of the strategic managerial tools in many organizations. The classic DEA models were designed to work with deterministic data and cannot deal with uncertainties in the...
Avicenna Journal of Clinical Medicine
journal of ilam university of medical sciences
Symmetry
There are numerous models for solving the efficiency evaluation in data envelopment analysis (DEA... more There are numerous models for solving the efficiency evaluation in data envelopment analysis (DEA) with fuzzy input and output data. However, because of the limitation of those strategies, they cannot be implemented for solving fully fuzzy DEA (FFDEA). Furthermore, in real-world problems with imprecise data, fuzziness is not sufficient to consider, and the reliability of the information is also very vital. To overcome these flaws, this paper presented a new method for solving the fully fuzzy DEA model where all parameters are Z-numbers. The new approach is primarily based on crisp linear programming and has a simple structure. Moreover, it is proved that the only existing method to solve FFDEA with Z-numbers is not valid. An example is also presented to illustrate the efficiency of our proposed method and provide an explanation for the content of the paper.
Tropical animal health and production, Jan 15, 2018
Bovine viral diarrhea virus (BVDV) and bovine herpes virus-1 (BHV-1) remain as the major pathogen... more Bovine viral diarrhea virus (BVDV) and bovine herpes virus-1 (BHV-1) remain as the major pathogens with heavy economic consequences in Iran. The prevalence of antibodies against BVDV and BHV-1, the rate of BVDV persistently infected (PI) animals, and associated risk factors were evaluated in a cross-sectional study carried out in Zanjan Province, Northwest Iran, in December 2011. A total number of 562 cattle in 10 herds and five cities were randomly selected, and their serum samples were tested to detect antibodies to these viruses and also BVDV antigen-positive (PI) animals. The data were analyzed with Pearson's correlation coefficient, chi-square, and logistic regression test. In total, nine and eight of the selected herds were seropositive to BVDV and BHV-1, respectively. The overall seroprevalence of these infections were estimated at 28.6 and 10.7% for BVDV and BHV-1, respectively, and 0.53% of the samples were detected as persistently infected. Statistical analysis reveale...
Avicenna Journal of Clinical Microbiology and Infection
IEEE Transactions on Acoustics, Speech, and Signal Processing
The constant false alarm rate (CFAR) detection algorithm considered by Chen and Reed is generaliz... more The constant false alarm rate (CFAR) detection algorithm considered by Chen and Reed is generalized to a test which is able to detect the presence of a known optical signal pattern which has nonnegligible unknown relative intensities in several signal-plus-noise hands or channels. This new test and its statistics are analytically evaluated and the signal-to-noise ratio (SNR) performance improvement is analyzed. Both theoretical and computer simulation results show that is of importance to generalize the previous CFAR detection algorithm [ 11 to a test which is able to detect the presence of an optical signal pattern with nonzero intensity in signal-plus-noise bands Or channels. An effort was made in [6] to find and compute the statistics of this generalized CFAR test, but the results were incomplete. the SNR improvement factor of this new algorithm using multiple hand scenes over the single scene of maximum SNR can be substantial. The SNR gain of this new detection algorithm and the one given by Chen and Reed are compared. It illustrates that the GSNR of the test using the full data array is always greater than that of using a partial data array. The data base used to simulate this new adaptive CFAR test is obtained from actual LANDSAT image scenes. The present results for optical detection are extendable to radar target detection and to other related detection problems.
Turkish journal of urology, 2017
Regarding technical difficulties that obese body habitus might impose to percutaneous nephrolitho... more Regarding technical difficulties that obese body habitus might impose to percutaneous nephrolithotomy (PNL) success and higher risk of peri-operative complications in this group of patients, we decided to retrospectively gather data from our patients during past 8 years to determine the stone free and complication rates. Between January 2007-December 2015, seventy-eight obese patients with body mass index over 35 who had indication for PNL including stones larger than 2 cm in pelvi-calyceal system or smaller extracorporeal shock wave lithotripsy (ESWL) resistant stones or who were not a fit candidate for ESWL due to increased skin to target distance, with no contraindication of PNL (including bleeding diathesis, inability to be positioned in prone) were enrolled. They were randomly assigned to group 1 (standard PNL with nephrostomy and ureteral stent) or group 2 (totally tubeless PNL with no ureteral stent and no nephrostomy). The outcomes were compared. The transfusion rate, operat...
International Journal of Preventive Medicine, 2016
Background: This study was performed to evaluate changes in tear indices and confocal microscopic... more Background: This study was performed to evaluate changes in tear indices and confocal microscopic findings after corneal collagen cross-linking (CXL) in patients with progressive keratoconus in Farabi Hospital in Tehran, Iran, during 2012-2013. Materials and Methods: In this analytical study, 32 consecutive eyes of 23 patients (mean age of 20.91 years) with progressive keratoconus were enrolled. The standard cross-linking surgery was performed for all patients. Visual, refractive and topographic evaluations were done before and 6 months after the surgery. Tear function tests and confocal microscopic examination were performed before and 1 month and 6 months after the procedure using the paired t-test with SPSS software. Results: Using the confocal microscopy, all eyes showed reduced or absent subepithelial nerve plexus. Differences in basal epithelial cell density, epithelial mean cell area and keratocyte density in anterior and middle stroma and endothelial cell pleomorphism were all statistically significant between 1 month and 6 months after CXL (P<0.05). No statistically significant change was noted in the number of the endothelial cells and polymegathismt after 6 months follow-up. Significant improvement was noted in uncorrected visual acuity, best corrected visual acuity, flattest corneal meridian and maximum keratometry in pentacam after 6 months of the procedure. Conclusion: Corneal collagen cross-linking can cause a significant reduction in subepithelial nerve plexus and significant alterations in keratocyte density in anterior and middle stroma.
Medical Science Monitor International Medical Journal of Experimental and Clinical Research, Apr 1, 2002
Background: The object of the study was to study the efficacy and safety of furazolidone and tetr... more Background: The object of the study was to study the efficacy and safety of furazolidone and tetracycline compared to metronidazole and amoxicillin in an omeprazole based triple therapy in a prospective randomized-blind-clinical trial. Material/Methods: Patients with endoscopically verified active duodenal ulcer disease in the presence of Helicobacter pylori infection were eligible to enter the study. Endoscopy was performed a day before and 6-8 weeks after the cessation of treatment. H. pylori status was assessed by histologic examination (Giemsa stain) of biopsy specimens were taken from the antrum and corpus. H. pylori eradication was defined as absence in histology of the biopsy specimens at the second endoscopy. Ulcer healing was considered as decrease in ulcer size to less than 20% of its primary size. Patients were randomly assigned to receive omeprazole 20 mg, amoxicillin 1000 mg and metronidazole 500 mg (OAM group) or omeprazole 20 mg, tetracycline 500 mg and furazolidone 200 mg (OTF group). All medications were taken twice daily, for 2 weeks. Results: Out of 111 patients enrolled in the study, 108 completed a course of treatment and underwent a follow-up endoscopy, with 54 patients in each group. H. pylori eradication was achieved in 52 patients (96.3%-95% CI: 91.27-100) in OTF group and 45 patients (83.3%-95% CI: 73.35-93.25) in OAM group (P=0.015). Our study showed the superiority of OTF vs. OAM regimen with a 13% increment in eradication rate, with only occasional severe side effect. Conclusions: In conclusion OTF regimen is a safe, cheaper and effective alternative for OTF regimen and we recommend it to be used especially in developing countries.
Journal of Oceanography, Jan 15, 2014
Journal of Kermanshah University of Medical Sciences, Jul 6, 2003
Medical Science Monitor International Medical Journal of Experimental and Clinical Research, Dec 1, 2002
The aim of this study was to determine the seroprevalence of hepatitis B and C viruses and abnorm... more The aim of this study was to determine the seroprevalence of hepatitis B and C viruses and abnormal liver function tests among hemophiliacs in Guilan province, Iran. Patients registered with Guilan Hemophilia Society (GHS) were enrolled in this study, and evaluated for the presence of hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV-Ab) and liver function tests. One hundred and one patients (100 males, 1 female, mean age 19.7 years, range 3-71 years) from 110 registered hemophiliacs were enrolled in this study. 29 patients (28.7%) had elevated Alanine aminotransferase (ALT), 27 (26.7%) and 72 (71.3%) were positive for HBsAg and HCV-Ab, respectively. Seropositivity for HCV-Ab correlated with the duration of treatment with clotting factor until 1997 (P=0.01). There was also an inverse correlation between factor VIII &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; IX activity and seropositivity for HCV-Ab (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) and HBsAg (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.04). HCV-Ab was more likely to be positive among those received lyophilized factor VIII and cryoprecipitate than lyophilized factor VIII alone (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01). In addition HCV-Ab seropositivity was more common among those received factor IX concentrate and fresh frozen plasma (FFP) than those received only FFP (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01). Based upon our finding, prevalence of HBsAg positive cases in Guilan province was higher than other studies. Although frequency of HCV-Ab was similar to other studies, frequency of increased ALT was less. Upon the results emerged from this study, we recommend that all hemophiliacs should be vaccinated against HBV and should have regular program for checking HCV.
Medical Science Monitor International Medical Journal of Experimental and Clinical Research, Oct 1, 2003
Background: The aim of this study was to determine the effect of metronidazole in patients who di... more Background: The aim of this study was to determine the effect of metronidazole in patients who did not cure after treatment with triclabendazole, in Guilan (Northern Province of Iran). Material/methods: Patients, who passed fasciola egg in stool and had positive serum anti fasciola antibody (ELISA), at least three months after treatment with triclabendazole, were enrolled and received 1.5 g/day metronidazole orally for three weeks. Two months and 12 months after end of therapy, stool examination in 3 consecutive days and serum anti fasciola antibody were performed. Frequency of patients with negative serology for fasciola and/or absence of fasciola egg in stool were determined. Chi-square test was used and P value <0.05 was considered significant. Results: Forty-six patients, 26 females and 20 males, were enrolled with mean (+/-SD) age of 34.6(+/-9.8) years. Three patients excluded because of drug side effect and poor compliance. Two months after end of therapy, stool exam became negative in 35 patients and in 31 patients became negative both in serology and stool examination. (Difference in response to treat between age groups and genders was not significant). All patients with abdominal pain became pain free after therapy. Most frequent side effects were metallic taste in 14 (30.4%), headache in 8 (17.4%) and nausea in 6 (13%). 12 months after end of therapy, 28 out of 35 patients were examined again and all were negative both in serology and egg in stool examination. Conclusions: Metronidazole, 1.5 g/day for 3 weeks, seems to be an effective, available, well-tolerated alternative for treatment of human fascioliasis.
Jurnal Agritech Fakultas Teknologi Pertanian Ugm, Jun 28, 2013
Medical Science Monitor International Medical Journal of Experimental and Clinical Research, 2003
Background: We studied the incidence of Helicobacter pylori infection in patients with hyperemesi... more Background: We studied the incidence of Helicobacter pylori infection in patients with hyperemesis gravidarum (HG) in comparison with non-HG pregnant women, and investigated whether there was a correlation between positive serology for H. pylori IgG, the time of onset, and the duration of HG symptoms. Material/Methods: 54 pregnant women with HG were enrolled in a matched case-control study. For each case in the group, a pregnant woman without HG matched for age, parity and gestational age was selected as a control. The patients in the experimental group were asked the exact time of symptom onset, and both groups were monitored during pregnancy for symptoms and outcome. Serum H. pylori IgG antibody was measured by enzyme-linked immunosorbant assay (ELISA). Results: Positive serum H. pylori IgG antibody was detected in 88.9% of the patients in the experimental group vs. 40.7% of the controls (P<0.001). Three of the four patients with abortions in each group were seropositive. Age, parity, level of education, symptom onset, and duration and outcome of pregnancy were comparable in both seropositive and seronegative patients with HG. Conclusion: Although more patients with HG were seropositive for H. pylori infection than controls, we were not able to demonstrate correlation between seropositivity for H. pylori and the time of onset or duration of HG symptoms. Although H. pylori infection may be an important factor in exacerbating HG, it may not represent the sole cause of the disease.
Iranian journal of parasitology
Metronidazole, a 5-nitroimidazole derivative, is the main antitrichomonal agent of choice for tre... more Metronidazole, a 5-nitroimidazole derivative, is the main antitrichomonal agent of choice for treatment of trichomoniasis. Since 1962, some cases of treatment failure with metronidazole have been reported and recently drug resistance is now on the rise in the world. This study was aimed to determine current susceptibility of Iranian isolates of Trichomonas vaginalis to metronidazole. This study was performed on 50 T. vaginalis isolates collected from west and central areas of Iran. After axenisation of the parasites, susceptibility testing was carried out by using serial twofold dilutions of metronidazole (400 to 0.1 μg/ml). The minimum inhibitory concentration (MIC) and the minimum lethal concentration (MLC) of the trichomonads were determined after 48 h incubation at 35.5 °C. Drug susceptibility assays of the all isolates were carried out two times in triplicate under aerobic and anaerobic conditions. Ninety-eight percent of the T. vaginalis isolates (49/50) were sensitive to metr...
Journal of Research in Health Sciences, 2010
Trichomoniasis is recognized as a major sexually transmitted dis-ease (STD) in the world and has ... more Trichomoniasis is recognized as a major sexually transmitted dis-ease (STD) in the world and has the highest prevalence and incidence of STD. the prevalence strongly is related to cultural and social norms in different socie-ties, in relation to sexual partnership, monogamy, or polygamy. Our objective was to describe the frequency and natural history of infection and correlation of clini-cal signs with parasite detection. From February 2006 to March 2007, in a cross sectional study, clinical and wet mount examination of vaginal smear along with culture were performed on 683 women attending to private outpatient clinics in Hamadan, western Iran. Trichomoniasis was diagnosed based on major clinical symptoms. Diagnosis was con-firmed using wet mount microscopically and culture in Diamond medium. Only 2.2% of patients with clinically diagnosed trichomonal vaginitis were positive for Trichomonas vaginalis by wet smear and culture. The mean age of patients was 33.6±9.7 yr, and majority of them were married and non-pregnant. Some (5 patients) infected cases were divorced and others (7 patients) hus-band were car driver. There was not statistically significant relationship be-tween clinical diagnosis and laboratory findings (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.5), because the most of pa-tients diagnosed trichomoniasis, were infected by Candida or other vaginal infec-tions. Because of special cultural background, the vaginal trichomoniasis has minor importance problem in this population and clinical diagnosis is not effi-cient for treatment decision.
Journal of Mathematics, 2021
One of the new concepts that have found a considerable position in many countries of the world is... more One of the new concepts that have found a considerable position in many countries of the world is organizing EFQM organizational excellence models. Different organizations and institutions have been evaluated and compared on its basis, and the move towards improvement and promotion is strengthened in them due to creation of competitive space. The EFQM organizational excellence model cannot remove the managers’ and users’ need for the levels of quantitative goals’ operation solely. Thus, requirement for a tool which considers quantitative goals and present environment was felt, and in this manner, various assessment processes were created to be used in different organizations; one of the most important ones is the technique for Data Envelopment Analysis. Evaluating organization efficiency based on the EFQM model is one of the strategic managerial tools in many organizations. The classic DEA models were designed to work with deterministic data and cannot deal with uncertainties in the...
Avicenna Journal of Clinical Medicine
journal of ilam university of medical sciences
Symmetry
There are numerous models for solving the efficiency evaluation in data envelopment analysis (DEA... more There are numerous models for solving the efficiency evaluation in data envelopment analysis (DEA) with fuzzy input and output data. However, because of the limitation of those strategies, they cannot be implemented for solving fully fuzzy DEA (FFDEA). Furthermore, in real-world problems with imprecise data, fuzziness is not sufficient to consider, and the reliability of the information is also very vital. To overcome these flaws, this paper presented a new method for solving the fully fuzzy DEA model where all parameters are Z-numbers. The new approach is primarily based on crisp linear programming and has a simple structure. Moreover, it is proved that the only existing method to solve FFDEA with Z-numbers is not valid. An example is also presented to illustrate the efficiency of our proposed method and provide an explanation for the content of the paper.
Tropical animal health and production, Jan 15, 2018
Bovine viral diarrhea virus (BVDV) and bovine herpes virus-1 (BHV-1) remain as the major pathogen... more Bovine viral diarrhea virus (BVDV) and bovine herpes virus-1 (BHV-1) remain as the major pathogens with heavy economic consequences in Iran. The prevalence of antibodies against BVDV and BHV-1, the rate of BVDV persistently infected (PI) animals, and associated risk factors were evaluated in a cross-sectional study carried out in Zanjan Province, Northwest Iran, in December 2011. A total number of 562 cattle in 10 herds and five cities were randomly selected, and their serum samples were tested to detect antibodies to these viruses and also BVDV antigen-positive (PI) animals. The data were analyzed with Pearson's correlation coefficient, chi-square, and logistic regression test. In total, nine and eight of the selected herds were seropositive to BVDV and BHV-1, respectively. The overall seroprevalence of these infections were estimated at 28.6 and 10.7% for BVDV and BHV-1, respectively, and 0.53% of the samples were detected as persistently infected. Statistical analysis reveale...
Avicenna Journal of Clinical Microbiology and Infection
IEEE Transactions on Acoustics, Speech, and Signal Processing
The constant false alarm rate (CFAR) detection algorithm considered by Chen and Reed is generaliz... more The constant false alarm rate (CFAR) detection algorithm considered by Chen and Reed is generalized to a test which is able to detect the presence of a known optical signal pattern which has nonnegligible unknown relative intensities in several signal-plus-noise hands or channels. This new test and its statistics are analytically evaluated and the signal-to-noise ratio (SNR) performance improvement is analyzed. Both theoretical and computer simulation results show that is of importance to generalize the previous CFAR detection algorithm [ 11 to a test which is able to detect the presence of an optical signal pattern with nonzero intensity in signal-plus-noise bands Or channels. An effort was made in [6] to find and compute the statistics of this generalized CFAR test, but the results were incomplete. the SNR improvement factor of this new algorithm using multiple hand scenes over the single scene of maximum SNR can be substantial. The SNR gain of this new detection algorithm and the one given by Chen and Reed are compared. It illustrates that the GSNR of the test using the full data array is always greater than that of using a partial data array. The data base used to simulate this new adaptive CFAR test is obtained from actual LANDSAT image scenes. The present results for optical detection are extendable to radar target detection and to other related detection problems.
Turkish journal of urology, 2017
Regarding technical difficulties that obese body habitus might impose to percutaneous nephrolitho... more Regarding technical difficulties that obese body habitus might impose to percutaneous nephrolithotomy (PNL) success and higher risk of peri-operative complications in this group of patients, we decided to retrospectively gather data from our patients during past 8 years to determine the stone free and complication rates. Between January 2007-December 2015, seventy-eight obese patients with body mass index over 35 who had indication for PNL including stones larger than 2 cm in pelvi-calyceal system or smaller extracorporeal shock wave lithotripsy (ESWL) resistant stones or who were not a fit candidate for ESWL due to increased skin to target distance, with no contraindication of PNL (including bleeding diathesis, inability to be positioned in prone) were enrolled. They were randomly assigned to group 1 (standard PNL with nephrostomy and ureteral stent) or group 2 (totally tubeless PNL with no ureteral stent and no nephrostomy). The outcomes were compared. The transfusion rate, operat...
International Journal of Preventive Medicine, 2016
Background: This study was performed to evaluate changes in tear indices and confocal microscopic... more Background: This study was performed to evaluate changes in tear indices and confocal microscopic findings after corneal collagen cross-linking (CXL) in patients with progressive keratoconus in Farabi Hospital in Tehran, Iran, during 2012-2013. Materials and Methods: In this analytical study, 32 consecutive eyes of 23 patients (mean age of 20.91 years) with progressive keratoconus were enrolled. The standard cross-linking surgery was performed for all patients. Visual, refractive and topographic evaluations were done before and 6 months after the surgery. Tear function tests and confocal microscopic examination were performed before and 1 month and 6 months after the procedure using the paired t-test with SPSS software. Results: Using the confocal microscopy, all eyes showed reduced or absent subepithelial nerve plexus. Differences in basal epithelial cell density, epithelial mean cell area and keratocyte density in anterior and middle stroma and endothelial cell pleomorphism were all statistically significant between 1 month and 6 months after CXL (P<0.05). No statistically significant change was noted in the number of the endothelial cells and polymegathismt after 6 months follow-up. Significant improvement was noted in uncorrected visual acuity, best corrected visual acuity, flattest corneal meridian and maximum keratometry in pentacam after 6 months of the procedure. Conclusion: Corneal collagen cross-linking can cause a significant reduction in subepithelial nerve plexus and significant alterations in keratocyte density in anterior and middle stroma.
Medical Science Monitor International Medical Journal of Experimental and Clinical Research, Apr 1, 2002
Background: The object of the study was to study the efficacy and safety of furazolidone and tetr... more Background: The object of the study was to study the efficacy and safety of furazolidone and tetracycline compared to metronidazole and amoxicillin in an omeprazole based triple therapy in a prospective randomized-blind-clinical trial. Material/Methods: Patients with endoscopically verified active duodenal ulcer disease in the presence of Helicobacter pylori infection were eligible to enter the study. Endoscopy was performed a day before and 6-8 weeks after the cessation of treatment. H. pylori status was assessed by histologic examination (Giemsa stain) of biopsy specimens were taken from the antrum and corpus. H. pylori eradication was defined as absence in histology of the biopsy specimens at the second endoscopy. Ulcer healing was considered as decrease in ulcer size to less than 20% of its primary size. Patients were randomly assigned to receive omeprazole 20 mg, amoxicillin 1000 mg and metronidazole 500 mg (OAM group) or omeprazole 20 mg, tetracycline 500 mg and furazolidone 200 mg (OTF group). All medications were taken twice daily, for 2 weeks. Results: Out of 111 patients enrolled in the study, 108 completed a course of treatment and underwent a follow-up endoscopy, with 54 patients in each group. H. pylori eradication was achieved in 52 patients (96.3%-95% CI: 91.27-100) in OTF group and 45 patients (83.3%-95% CI: 73.35-93.25) in OAM group (P=0.015). Our study showed the superiority of OTF vs. OAM regimen with a 13% increment in eradication rate, with only occasional severe side effect. Conclusions: In conclusion OTF regimen is a safe, cheaper and effective alternative for OTF regimen and we recommend it to be used especially in developing countries.
Journal of Oceanography, Jan 15, 2014
Journal of Kermanshah University of Medical Sciences, Jul 6, 2003
Medical Science Monitor International Medical Journal of Experimental and Clinical Research, Dec 1, 2002
The aim of this study was to determine the seroprevalence of hepatitis B and C viruses and abnorm... more The aim of this study was to determine the seroprevalence of hepatitis B and C viruses and abnormal liver function tests among hemophiliacs in Guilan province, Iran. Patients registered with Guilan Hemophilia Society (GHS) were enrolled in this study, and evaluated for the presence of hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV-Ab) and liver function tests. One hundred and one patients (100 males, 1 female, mean age 19.7 years, range 3-71 years) from 110 registered hemophiliacs were enrolled in this study. 29 patients (28.7%) had elevated Alanine aminotransferase (ALT), 27 (26.7%) and 72 (71.3%) were positive for HBsAg and HCV-Ab, respectively. Seropositivity for HCV-Ab correlated with the duration of treatment with clotting factor until 1997 (P=0.01). There was also an inverse correlation between factor VIII &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp; IX activity and seropositivity for HCV-Ab (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) and HBsAg (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.04). HCV-Ab was more likely to be positive among those received lyophilized factor VIII and cryoprecipitate than lyophilized factor VIII alone (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01). In addition HCV-Ab seropositivity was more common among those received factor IX concentrate and fresh frozen plasma (FFP) than those received only FFP (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01). Based upon our finding, prevalence of HBsAg positive cases in Guilan province was higher than other studies. Although frequency of HCV-Ab was similar to other studies, frequency of increased ALT was less. Upon the results emerged from this study, we recommend that all hemophiliacs should be vaccinated against HBV and should have regular program for checking HCV.
Medical Science Monitor International Medical Journal of Experimental and Clinical Research, Oct 1, 2003
Background: The aim of this study was to determine the effect of metronidazole in patients who di... more Background: The aim of this study was to determine the effect of metronidazole in patients who did not cure after treatment with triclabendazole, in Guilan (Northern Province of Iran). Material/methods: Patients, who passed fasciola egg in stool and had positive serum anti fasciola antibody (ELISA), at least three months after treatment with triclabendazole, were enrolled and received 1.5 g/day metronidazole orally for three weeks. Two months and 12 months after end of therapy, stool examination in 3 consecutive days and serum anti fasciola antibody were performed. Frequency of patients with negative serology for fasciola and/or absence of fasciola egg in stool were determined. Chi-square test was used and P value <0.05 was considered significant. Results: Forty-six patients, 26 females and 20 males, were enrolled with mean (+/-SD) age of 34.6(+/-9.8) years. Three patients excluded because of drug side effect and poor compliance. Two months after end of therapy, stool exam became negative in 35 patients and in 31 patients became negative both in serology and stool examination. (Difference in response to treat between age groups and genders was not significant). All patients with abdominal pain became pain free after therapy. Most frequent side effects were metallic taste in 14 (30.4%), headache in 8 (17.4%) and nausea in 6 (13%). 12 months after end of therapy, 28 out of 35 patients were examined again and all were negative both in serology and egg in stool examination. Conclusions: Metronidazole, 1.5 g/day for 3 weeks, seems to be an effective, available, well-tolerated alternative for treatment of human fascioliasis.
Jurnal Agritech Fakultas Teknologi Pertanian Ugm, Jun 28, 2013
Medical Science Monitor International Medical Journal of Experimental and Clinical Research, 2003
Background: We studied the incidence of Helicobacter pylori infection in patients with hyperemesi... more Background: We studied the incidence of Helicobacter pylori infection in patients with hyperemesis gravidarum (HG) in comparison with non-HG pregnant women, and investigated whether there was a correlation between positive serology for H. pylori IgG, the time of onset, and the duration of HG symptoms. Material/Methods: 54 pregnant women with HG were enrolled in a matched case-control study. For each case in the group, a pregnant woman without HG matched for age, parity and gestational age was selected as a control. The patients in the experimental group were asked the exact time of symptom onset, and both groups were monitored during pregnancy for symptoms and outcome. Serum H. pylori IgG antibody was measured by enzyme-linked immunosorbant assay (ELISA). Results: Positive serum H. pylori IgG antibody was detected in 88.9% of the patients in the experimental group vs. 40.7% of the controls (P<0.001). Three of the four patients with abortions in each group were seropositive. Age, parity, level of education, symptom onset, and duration and outcome of pregnancy were comparable in both seropositive and seronegative patients with HG. Conclusion: Although more patients with HG were seropositive for H. pylori infection than controls, we were not able to demonstrate correlation between seropositivity for H. pylori and the time of onset or duration of HG symptoms. Although H. pylori infection may be an important factor in exacerbating HG, it may not represent the sole cause of the disease.
Iranian journal of parasitology
Metronidazole, a 5-nitroimidazole derivative, is the main antitrichomonal agent of choice for tre... more Metronidazole, a 5-nitroimidazole derivative, is the main antitrichomonal agent of choice for treatment of trichomoniasis. Since 1962, some cases of treatment failure with metronidazole have been reported and recently drug resistance is now on the rise in the world. This study was aimed to determine current susceptibility of Iranian isolates of Trichomonas vaginalis to metronidazole. This study was performed on 50 T. vaginalis isolates collected from west and central areas of Iran. After axenisation of the parasites, susceptibility testing was carried out by using serial twofold dilutions of metronidazole (400 to 0.1 μg/ml). The minimum inhibitory concentration (MIC) and the minimum lethal concentration (MLC) of the trichomonads were determined after 48 h incubation at 35.5 °C. Drug susceptibility assays of the all isolates were carried out two times in triplicate under aerobic and anaerobic conditions. Ninety-eight percent of the T. vaginalis isolates (49/50) were sensitive to metr...
Journal of Research in Health Sciences, 2010
Trichomoniasis is recognized as a major sexually transmitted dis-ease (STD) in the world and has ... more Trichomoniasis is recognized as a major sexually transmitted dis-ease (STD) in the world and has the highest prevalence and incidence of STD. the prevalence strongly is related to cultural and social norms in different socie-ties, in relation to sexual partnership, monogamy, or polygamy. Our objective was to describe the frequency and natural history of infection and correlation of clini-cal signs with parasite detection. From February 2006 to March 2007, in a cross sectional study, clinical and wet mount examination of vaginal smear along with culture were performed on 683 women attending to private outpatient clinics in Hamadan, western Iran. Trichomoniasis was diagnosed based on major clinical symptoms. Diagnosis was con-firmed using wet mount microscopically and culture in Diamond medium. Only 2.2% of patients with clinically diagnosed trichomonal vaginitis were positive for Trichomonas vaginalis by wet smear and culture. The mean age of patients was 33.6±9.7 yr, and majority of them were married and non-pregnant. Some (5 patients) infected cases were divorced and others (7 patients) hus-band were car driver. There was not statistically significant relationship be-tween clinical diagnosis and laboratory findings (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.5), because the most of pa-tients diagnosed trichomoniasis, were infected by Candida or other vaginal infec-tions. Because of special cultural background, the vaginal trichomoniasis has minor importance problem in this population and clinical diagnosis is not effi-cient for treatment decision.