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Research paper thumbnail of “Association of Low HDL of NAFLD Patients with or without Metabolic Syndrome: A Study in Rajshahi Medical College Hospital, Rajshahi, Bangladesh”

Background: Metabolic syndrome describes the co-occurrence of central adiposity, hyperglycemia, h... more Background: Metabolic syndrome describes the co-occurrence of central adiposity, hyperglycemia, hypertension, lipid abnormalities and other metabolic changes that increase risk of cardiovascular, cerebrovascular, renal diseases. Nonalcoholic fatty liver disease (NAFLD) is associated with a substantial increased risk of cardiovascular disease (CVD), which is partly related to low HDL-C level. This multi-system condition has adverse effects on many organs, the liver being one of them. Non-alcoholic fatty liver disease appears to be the hepatic manifestation of metabolic syndrome, and is increasingly recognized as a major contributor to the burden of chronic liver disease world-wide. Objective: To find out the Association of Low HDL of NAFLD Patients With or Without Metabolic Syndrome. Materials and Methods: This is a cross sectional descriptive study which was conducted in the Department of Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh. 250 patients age above 20 ye...

Research paper thumbnail of “Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome In Type 2 Diabetes Mellitus Patients in Rajshahi Medical College Hospital, Rajshahi, Bangladesh”

Saudi Journal of Medical and Pharmaceutical Sciences, 2020

Research paper thumbnail of Thyroid Function in Children with Nephrotic Syndrome and Normal Renal Function in a Tertiary Level Hospital, Rajshahi

TAJ: Journal of Teachers Association, 2019

Background: Nephrotic syndrome (NS) is a one of most common renal disease in children causing mas... more Background: Nephrotic syndrome (NS) is a one of most common renal disease in children causing massive proteinuria. In patients with NS, other proteins like thyroid hormones and hormone binding protein are also lost in urine in addition to albuminuria. So, this study was done to find out the thyroid function status of nephrotic syndrome children and to compare the thyroid function of healthy control children. Method: This cross sectional comparative study was carried out in the Department of Paediatrics, Rajshahi Medical College and Nuclear Medicine Centre, Rajshahi. Total 30 patients of both sex and age between 2-12 years diagnosed as nephrotic syndrome were included in this study and another 30 non-nephrotic syndrome apparently healthy children were taken as control. History, clinical examinations and laboratory investigations were recorded in preformed questionnaire. Thyroid function statuses also were evaluated in both patient and healthy control. After data collection, statistic...

Research paper thumbnail of Bacterial Contamination of Stethoscope in a Tertiary Care Hospital

TAJ: Journal of Teachers Association, 2018

Research paper thumbnail of Cutaneous Anthrax Outbreak in Rajshahi District

TAJ: Journal of Teachers Association, 2018

Research paper thumbnail of Epidemiological and molecular analyses of a non-seasonal outbreak of acute icteric hepatitis E in Bangladesh

Journal of Medical Virology, 2013

Acute hepatitis due to hepatitis E virus (HEV) is endemic in Bangladesh, but its epidemiological ... more Acute hepatitis due to hepatitis E virus (HEV) is endemic in Bangladesh, but its epidemiological characteristics and virological features remain obscure. An outbreak of acute icteric hepatitis E occurred in Rajshahi, Bangladesh during 2010 when 200 patients with visible jaundice visited physicians within a period of 1 month (January-February). Clinical and epidemiological data were collected from these patients using questionnaires. Nucleic acids were isolated from 15 patients who were selected at random to ascertain their HEV genotypes. Near-complete nucleotide sequences of the HEV genome were detected in two patients and partial ORF2 regions in the other 13 patients. All patients tested positive for IgM antibodies to HEV but negative for other hepatitis viruses. Most patients were icteric and complained of vomiting, fever, itching, and abdominal pain. All 15 HEV sequences formed a single cluster within genotype 1a. Two of the 7,186-nt HEV sequences were 99.8% identical. This is the first study to report the clinical, epidemiological, and molecular characterization of an outbreak of acute hepatitis E in Bangladesh.

Research paper thumbnail of Study on Liver Dysfunction in Type 2 Diabetic Patients in Bangladesh

Euroasian journal of hepato-gastroenterology

Diabetes mellitus (DM) represents one of the major lifestyle-related pathological conditions; the... more Diabetes mellitus (DM) represents one of the major lifestyle-related pathological conditions; the incidence and prevalence of DM have reached an epidemic level around the world. Diabetes mellitus is usually associated with obesity, coronary diseases, and cerebral pathologies. However, more insights are required to evaluate a temporal relation between DM and hepatic functions. This study assesses whether and to what extent liver functions are modified in DM patients. A total of 100 patients with type 2 DM and 100 normal healthy controls were enrolled in this study following proper scrutiny of inclusion and exclusion criteria. Different parameters of liver function tests were measured in patients in the two groups. Data were analyzed to assess the extent and magnitude of abnormal liver functions in DM. The levels of bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, and prothrombin time were 0.737 ± 0.311 mg/dL, 39.00 ± 24.21 IU/L, 26.42 ± 10.40 IU/L...

Research paper thumbnail of “Association of Low HDL of NAFLD Patients with or without Metabolic Syndrome: A Study in Rajshahi Medical College Hospital, Rajshahi, Bangladesh”

Background: Metabolic syndrome describes the co-occurrence of central adiposity, hyperglycemia, h... more Background: Metabolic syndrome describes the co-occurrence of central adiposity, hyperglycemia, hypertension, lipid abnormalities and other metabolic changes that increase risk of cardiovascular, cerebrovascular, renal diseases. Nonalcoholic fatty liver disease (NAFLD) is associated with a substantial increased risk of cardiovascular disease (CVD), which is partly related to low HDL-C level. This multi-system condition has adverse effects on many organs, the liver being one of them. Non-alcoholic fatty liver disease appears to be the hepatic manifestation of metabolic syndrome, and is increasingly recognized as a major contributor to the burden of chronic liver disease world-wide. Objective: To find out the Association of Low HDL of NAFLD Patients With or Without Metabolic Syndrome. Materials and Methods: This is a cross sectional descriptive study which was conducted in the Department of Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh. 250 patients age above 20 ye...

Research paper thumbnail of “Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome In Type 2 Diabetes Mellitus Patients in Rajshahi Medical College Hospital, Rajshahi, Bangladesh”

Saudi Journal of Medical and Pharmaceutical Sciences, 2020

Research paper thumbnail of Thyroid Function in Children with Nephrotic Syndrome and Normal Renal Function in a Tertiary Level Hospital, Rajshahi

TAJ: Journal of Teachers Association, 2019

Background: Nephrotic syndrome (NS) is a one of most common renal disease in children causing mas... more Background: Nephrotic syndrome (NS) is a one of most common renal disease in children causing massive proteinuria. In patients with NS, other proteins like thyroid hormones and hormone binding protein are also lost in urine in addition to albuminuria. So, this study was done to find out the thyroid function status of nephrotic syndrome children and to compare the thyroid function of healthy control children. Method: This cross sectional comparative study was carried out in the Department of Paediatrics, Rajshahi Medical College and Nuclear Medicine Centre, Rajshahi. Total 30 patients of both sex and age between 2-12 years diagnosed as nephrotic syndrome were included in this study and another 30 non-nephrotic syndrome apparently healthy children were taken as control. History, clinical examinations and laboratory investigations were recorded in preformed questionnaire. Thyroid function statuses also were evaluated in both patient and healthy control. After data collection, statistic...

Research paper thumbnail of Bacterial Contamination of Stethoscope in a Tertiary Care Hospital

TAJ: Journal of Teachers Association, 2018

Research paper thumbnail of Cutaneous Anthrax Outbreak in Rajshahi District

TAJ: Journal of Teachers Association, 2018

Research paper thumbnail of Epidemiological and molecular analyses of a non-seasonal outbreak of acute icteric hepatitis E in Bangladesh

Journal of Medical Virology, 2013

Acute hepatitis due to hepatitis E virus (HEV) is endemic in Bangladesh, but its epidemiological ... more Acute hepatitis due to hepatitis E virus (HEV) is endemic in Bangladesh, but its epidemiological characteristics and virological features remain obscure. An outbreak of acute icteric hepatitis E occurred in Rajshahi, Bangladesh during 2010 when 200 patients with visible jaundice visited physicians within a period of 1 month (January-February). Clinical and epidemiological data were collected from these patients using questionnaires. Nucleic acids were isolated from 15 patients who were selected at random to ascertain their HEV genotypes. Near-complete nucleotide sequences of the HEV genome were detected in two patients and partial ORF2 regions in the other 13 patients. All patients tested positive for IgM antibodies to HEV but negative for other hepatitis viruses. Most patients were icteric and complained of vomiting, fever, itching, and abdominal pain. All 15 HEV sequences formed a single cluster within genotype 1a. Two of the 7,186-nt HEV sequences were 99.8% identical. This is the first study to report the clinical, epidemiological, and molecular characterization of an outbreak of acute hepatitis E in Bangladesh.

Research paper thumbnail of Study on Liver Dysfunction in Type 2 Diabetic Patients in Bangladesh

Euroasian journal of hepato-gastroenterology

Diabetes mellitus (DM) represents one of the major lifestyle-related pathological conditions; the... more Diabetes mellitus (DM) represents one of the major lifestyle-related pathological conditions; the incidence and prevalence of DM have reached an epidemic level around the world. Diabetes mellitus is usually associated with obesity, coronary diseases, and cerebral pathologies. However, more insights are required to evaluate a temporal relation between DM and hepatic functions. This study assesses whether and to what extent liver functions are modified in DM patients. A total of 100 patients with type 2 DM and 100 normal healthy controls were enrolled in this study following proper scrutiny of inclusion and exclusion criteria. Different parameters of liver function tests were measured in patients in the two groups. Data were analyzed to assess the extent and magnitude of abnormal liver functions in DM. The levels of bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, and prothrombin time were 0.737 ± 0.311 mg/dL, 39.00 ± 24.21 IU/L, 26.42 ± 10.40 IU/L...