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Benha Medical Journal
Background: Chronic pancreatitis (CP) is a disease characterized by permanent damage of the pancr... more Background: Chronic pancreatitis (CP) is a disease characterized by permanent damage of the pancreas. Objective: evaluate the possible therapeutic effect of ghrelin and exosomes derived from mesenchymal stem cells in the treatment of chronic pancreatitis. Materials and Methods: Sixty-two adult male albino rats were randomly divided into six groups. Group I (control group). Group II (affected group): Rats were injected intraperitoneally by larginine at a dose of 500 mg/100g body weight that is 2.5 ml of larginine solution/100g body weight five times at three days intervals, dissolved in citrate buffer. Group III (recovery group). Group IV: CP treated with ghrelin. Group V: CP treated with MSCs derived exosomes. Group VI: CP treated with ghrelin and MSCs derived exosomes. Pancreatic specimens were taken and prepared for histological and immunohistochemical examination. Results: Group II and III showed signs of degeneration. There were distorted acini with cytoplasmic vacuolation, decrease number of cells of islets, empty spaces between islets, dilated congested blood vessels and cellular infiltration. Furthermore, there was intense positive collagen fibers deposition, iNOS and CD8 immunostaining. Groups IV and V showed improvement of some histological microscopic changes in group II, significant decrease (P <0.01) of group IV, V, VI compared with group II. While group VI showed histological architecture near to control group. Conclusion: ghrelin and exosomes can treat chronic pancreatitis. However, better results can be obtained when exosomes were given with ghrelin.
Journal of Engineering Materials and …, 2012
In this work, new proposed damage tensors are studied in order to investigate the damage effect v... more In this work, new proposed damage tensors are studied in order to investigate the damage effect variables in the mechanical behavior of materials. All cases studied in this work are defined in terms of the elasticity of the material and based on the hypotheses of both elastic strain equivalence and elastic energy equivalence. Moreover, the new proposed damage tensors are anisotropically expressed in terms of the well-known damage effect tensor M. The principal-valued damage effect tensor is used to obtain the first scalar invariant of that tensor and its inverse, which are employed in expressing and verifying the new proposed damage tensors. The study demonstrates that most of the new proposed damage tensors are verified within the framework of continuum damage mechanics. In addition, new hybrid damage tensors are proposed which are defined in terms of the damage effect tensor and the new proposed damage tensors. The new hybrid damage tensors are eventually expressed in terms of the damage effect tensor.
Benha Medical Journal
Background: Chronic pancreatitis (CP) is a disease characterized by permanent damage of the pancr... more Background: Chronic pancreatitis (CP) is a disease characterized by permanent damage of the pancreas. Objective: evaluate the possible therapeutic effect of ghrelin and exosomes derived from mesenchymal stem cells in the treatment of chronic pancreatitis. Materials and Methods: Sixty-two adult male albino rats were randomly divided into six groups. Group I (control group). Group II (affected group): Rats were injected intraperitoneally by larginine at a dose of 500 mg/100g body weight that is 2.5 ml of larginine solution/100g body weight five times at three days intervals, dissolved in citrate buffer. Group III (recovery group). Group IV: CP treated with ghrelin. Group V: CP treated with MSCs derived exosomes. Group VI: CP treated with ghrelin and MSCs derived exosomes. Pancreatic specimens were taken and prepared for histological and immunohistochemical examination. Results: Group II and III showed signs of degeneration. There were distorted acini with cytoplasmic vacuolation, decrease number of cells of islets, empty spaces between islets, dilated congested blood vessels and cellular infiltration. Furthermore, there was intense positive collagen fibers deposition, iNOS and CD8 immunostaining. Groups IV and V showed improvement of some histological microscopic changes in group II, significant decrease (P <0.01) of group IV, V, VI compared with group II. While group VI showed histological architecture near to control group. Conclusion: ghrelin and exosomes can treat chronic pancreatitis. However, better results can be obtained when exosomes were given with ghrelin.
Journal of Engineering Materials and …, 2012
In this work, new proposed damage tensors are studied in order to investigate the damage effect v... more In this work, new proposed damage tensors are studied in order to investigate the damage effect variables in the mechanical behavior of materials. All cases studied in this work are defined in terms of the elasticity of the material and based on the hypotheses of both elastic strain equivalence and elastic energy equivalence. Moreover, the new proposed damage tensors are anisotropically expressed in terms of the well-known damage effect tensor M. The principal-valued damage effect tensor is used to obtain the first scalar invariant of that tensor and its inverse, which are employed in expressing and verifying the new proposed damage tensors. The study demonstrates that most of the new proposed damage tensors are verified within the framework of continuum damage mechanics. In addition, new hybrid damage tensors are proposed which are defined in terms of the damage effect tensor and the new proposed damage tensors. The new hybrid damage tensors are eventually expressed in terms of the damage effect tensor.