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Papers by m q
Journal of Clinical Investigation, 1991
Stratum corneum lipids comprise an approximately equimolar mixture of sphingolipids, cholesterol,... more Stratum corneum lipids comprise an approximately equimolar mixture of sphingolipids, cholesterol, and free fatty acids, arranged as intercellular membrane bilayers that are presumed to mediate the epidermal permeability barrier. Prior studies have shown that alterations in epidermal barrier function lead to a rapid increase in cholesterol and fatty acid synthesis which parallels the early stages of the repair process. Despite an abundance of indirect evidence for their role in the barrier, the importance of sphingolipids has yet to be demonstrated directly. Whereas sphingolipid synthesis also increases during barrier repair, this response is delayed in comparison to cholesterol and fatty acid synthesis . J. Lipid Res. 32:1151-1158. To further delineate the role of sphingolipids in barrier homeostasis, we assessed the impact of inhibition of sphingolipid synthesis on epidermal barrier recovery. A single topical application of 0-chloro-L-alanine (f-CA), an irreversible inhibitor of serine-palmitoyl transferase (SPT), applied to acetone-treated skin of hairless mice resulted in: (a) > 75% inhibition of SP1 activity at 30 min (P < 0.001); (b) a global decrease in sphingolipid synthesis between 1 and 3 h (P < 0.02); (c) reduction of epidermal sphingolipid content at 18 h (P < 0.01); (d) delayed reaccumulation of histochemical staining for sphingolipids in the stratum corneum; and (e) reduced numbers and contents of lamellar bodies in the stratum granulosum. Finally, despite its immediate, marked diminution of sphingolipid synthesis, #-CA slowed barrier recovery only at late time points (> 6 h) after acetone treatment. This inhibition was overridden by coapplications of ceramides (the distal SPT product), indicating that the delay in repair was not due to nonspecific toxicity. These studies demonstrate a distinctive role for epidermal sphingolipids in permeability barrier homeostasis. (J. Clin. Invest. 1991. 88:1338-1345
Copyright © 1987 by The Regents of the University of California All rights reserved. No part of t... more Copyright © 1987 by The Regents of the University of California All rights reserved. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and ...
Geological Society of America Bulletin, 1987
The closing of Tethys and the tectonics of the Himalaya DC „,,x,r,i cv i Department ofGeology, Th... more The closing of Tethys and the tectonics of the Himalaya DC „,,x,r,i cv i Department ofGeology, The University, Leicester LEI 7RH, United Kingdom В. r. WINDLEY ) MP COWARD Department of Geology, Imperial College, Prince Consort ...
Journal of Fluid Mechanics, 1980
Hot-wire and flow-visualization studies have been carried out in three air jets subjected to pure... more Hot-wire and flow-visualization studies have been carried out in three air jets subjected to pure-tone acoustic excitation, and the instability, vortex roll-up and transition as well as jet response to the controlled excitation have been investigated. The centreline fluctuation intensity can be enhanced by inducing stable vortex pairing to a level much higher than even that a t the 'preferred mode', but can also be suppressed below the unexcited level under certain conditions of excitation. The conditions most favourable to vortex pairing were determined as a function of the excitation Strouhal number, the Reynolds number (Re,), and the initial shear-layer state, i.e. laminar or turbulent. It is shown that the rolled-up vortex rings undergo pairing under two distinct conditions of excitation: 'the shear layer mode' when the Strouhal number based on the initial shear-layer momentum thickness (Xt,) is about 0.012, and 'the jet column mode' when the Strouhal number based on the jet diameter (Xt,) is about 0.85. The former involves pairing of the near-exit thin vortex rings when the initial boundary layer is laminar, irrespective of the value of St,. The latter involves pairing of the thick vortex rings a t x / D r 1.75, irrespective of St, or whether the initial boundary layer is laminar or turbulent. For laminar exit boundary layer, pairing is found to be stable, i.e., occurring regularly in space and time, for R e , < 5 x lo4, but becomes intermittent with increasing Re, or fluctuation intensity in the initial boundary layer.
Journal of Fluid Mechanics, 1981
... 133 Turbulence suppression in free shear flows by controlled excitation By KBMQ ZAMAN AND AKM... more ... 133 Turbulence suppression in free shear flows by controlled excitation By KBMQ ZAMAN AND AKMF HUSSAIN Department of Mechanicrtl Engineering, University of Houston, Texas 77004 (Reoeived 20 November 1979) ... Page 2. 134 KB M. Q. Zaman and A. KM F. Hussain ...
Analytical Chemistry, 1956
Page 1. VOLUME 28, NO. 11, NOVEMBER 1956 for magnesium after magnesium had been added. In other w... more Page 1. VOLUME 28, NO. 11, NOVEMBER 1956 for magnesium after magnesium had been added. In other words, all analyses were made but once, but in effect each mixture was analyzed in triplicate. These iesults are shown in Table IV. 1655 Diehl, H., Goeta. ...
Proceedings of The National Academy of Sciences, 1997
A new method for predicting internal coding exons in genomic DNA sequences has been developed. Th... more A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons.
Journal of Clinical Investigation, 1991
Stratum corneum lipids comprise an approximately equimolar mixture of sphingolipids, cholesterol,... more Stratum corneum lipids comprise an approximately equimolar mixture of sphingolipids, cholesterol, and free fatty acids, arranged as intercellular membrane bilayers that are presumed to mediate the epidermal permeability barrier. Prior studies have shown that alterations in epidermal barrier function lead to a rapid increase in cholesterol and fatty acid synthesis which parallels the early stages of the repair process. Despite an abundance of indirect evidence for their role in the barrier, the importance of sphingolipids has yet to be demonstrated directly. Whereas sphingolipid synthesis also increases during barrier repair, this response is delayed in comparison to cholesterol and fatty acid synthesis . J. Lipid Res. 32:1151-1158. To further delineate the role of sphingolipids in barrier homeostasis, we assessed the impact of inhibition of sphingolipid synthesis on epidermal barrier recovery. A single topical application of 0-chloro-L-alanine (f-CA), an irreversible inhibitor of serine-palmitoyl transferase (SPT), applied to acetone-treated skin of hairless mice resulted in: (a) > 75% inhibition of SP1 activity at 30 min (P < 0.001); (b) a global decrease in sphingolipid synthesis between 1 and 3 h (P < 0.02); (c) reduction of epidermal sphingolipid content at 18 h (P < 0.01); (d) delayed reaccumulation of histochemical staining for sphingolipids in the stratum corneum; and (e) reduced numbers and contents of lamellar bodies in the stratum granulosum. Finally, despite its immediate, marked diminution of sphingolipid synthesis, #-CA slowed barrier recovery only at late time points (> 6 h) after acetone treatment. This inhibition was overridden by coapplications of ceramides (the distal SPT product), indicating that the delay in repair was not due to nonspecific toxicity. These studies demonstrate a distinctive role for epidermal sphingolipids in permeability barrier homeostasis. (J. Clin. Invest. 1991. 88:1338-1345
Copyright © 1987 by The Regents of the University of California All rights reserved. No part of t... more Copyright © 1987 by The Regents of the University of California All rights reserved. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and ...
Geological Society of America Bulletin, 1987
The closing of Tethys and the tectonics of the Himalaya DC „,,x,r,i cv i Department ofGeology, Th... more The closing of Tethys and the tectonics of the Himalaya DC „,,x,r,i cv i Department ofGeology, The University, Leicester LEI 7RH, United Kingdom В. r. WINDLEY ) MP COWARD Department of Geology, Imperial College, Prince Consort ...
Journal of Fluid Mechanics, 1980
Hot-wire and flow-visualization studies have been carried out in three air jets subjected to pure... more Hot-wire and flow-visualization studies have been carried out in three air jets subjected to pure-tone acoustic excitation, and the instability, vortex roll-up and transition as well as jet response to the controlled excitation have been investigated. The centreline fluctuation intensity can be enhanced by inducing stable vortex pairing to a level much higher than even that a t the 'preferred mode', but can also be suppressed below the unexcited level under certain conditions of excitation. The conditions most favourable to vortex pairing were determined as a function of the excitation Strouhal number, the Reynolds number (Re,), and the initial shear-layer state, i.e. laminar or turbulent. It is shown that the rolled-up vortex rings undergo pairing under two distinct conditions of excitation: 'the shear layer mode' when the Strouhal number based on the initial shear-layer momentum thickness (Xt,) is about 0.012, and 'the jet column mode' when the Strouhal number based on the jet diameter (Xt,) is about 0.85. The former involves pairing of the near-exit thin vortex rings when the initial boundary layer is laminar, irrespective of the value of St,. The latter involves pairing of the thick vortex rings a t x / D r 1.75, irrespective of St, or whether the initial boundary layer is laminar or turbulent. For laminar exit boundary layer, pairing is found to be stable, i.e., occurring regularly in space and time, for R e , < 5 x lo4, but becomes intermittent with increasing Re, or fluctuation intensity in the initial boundary layer.
Journal of Fluid Mechanics, 1981
... 133 Turbulence suppression in free shear flows by controlled excitation By KBMQ ZAMAN AND AKM... more ... 133 Turbulence suppression in free shear flows by controlled excitation By KBMQ ZAMAN AND AKMF HUSSAIN Department of Mechanicrtl Engineering, University of Houston, Texas 77004 (Reoeived 20 November 1979) ... Page 2. 134 KB M. Q. Zaman and A. KM F. Hussain ...
Analytical Chemistry, 1956
Page 1. VOLUME 28, NO. 11, NOVEMBER 1956 for magnesium after magnesium had been added. In other w... more Page 1. VOLUME 28, NO. 11, NOVEMBER 1956 for magnesium after magnesium had been added. In other words, all analyses were made but once, but in effect each mixture was analyzed in triplicate. These iesults are shown in Table IV. 1655 Diehl, H., Goeta. ...
Proceedings of The National Academy of Sciences, 1997
A new method for predicting internal coding exons in genomic DNA sequences has been developed. Th... more A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons.