muayad sraibet - Academia.edu (original) (raw)
Papers by muayad sraibet
Journal of Pharmaceutical Negative Results, Oct 10, 2022
Background: Methylenetetrahydrofolate reductase (MTHFR) C677T is a single nucleotide polymorphism... more Background: Methylenetetrahydrofolate reductase (MTHFR) C677T is a single nucleotide polymorphism (SNP) that affects the production of 5-methyltetrahydrofolate (5-MTHF), the active folate that enables the recycling of homocysteine (Hcy) to methionine. Objective: to investigate the association between the MTHFR (C677T) polymorphism and the outcomes of intracytoplasmic sperm injection (ICSI). Methods: A prospective cohort study included 85 infertile women undergoing ICSI treatment at the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies in Baghdad, Iraq. The study period extended from January 2022 to September 2023. The MTHFR C677T polymorphism genotyping was evaluated in these patients, and they were classified into three groups according to genotyping results: normal (CC), heterozygote mutated (CT), and mutated homozygote (TT). In addition, we conducted a comparative analysis of oocyte, embryo and pregnancy rates among these three groups. Results: In comparison to the CT and TT genotypes, the total number of oocytes, total embryos, mature oocytes, good-quality embryos, and pregnancy rate were all found to be significantly higher (p<0.05) in the CC genotype. Compared to the CC group, the proportion of immature oocytes and poor-quality embryos was significantly higher in the TT and CT groups (p<0.05). The rate of fertilization was comparable among the study groups. Conclusions: The maternal MTHFR C677T polymorphism is linked to oocyte number, maturity, total embryo, embryo quality, and pregnancy in ICSI. In light of this, MTHFR polymorphism in our community offers useful data regarding the success of ICSI.
Iraqi journal of embryos and infertility researches, Nov 7, 2023
Iraqi journal of embryos and infertility researches, Nov 7, 2023
Iraqi journal of embryos and infertility researches, Nov 7, 2023
Iraqi journal of embryos and infertility researches, May 7, 2023
Iraqi journal of embryos and infertility researches, May 7, 2023
Iraqi journal of embryos and infertility researches, Jun 5, 2021
IraQi Journal of Embryos and Infertility Researches
For successful implantation, a high-quality embryo, receptive endometrium, and tight communicatio... more For successful implantation, a high-quality embryo, receptive endometrium, and tight communication between the two are required. The lack of uterine contractions during embryo transfer is one of the characteristics that greatly affects endometrial receptivity. This is because it has been observed that ET may cause uterine contractions, which may be harmful to embryonic apposition and endometrial blood flow .The aim of this study was to assess how magnesium sulfate administration on the day of embryo transfer improve sub endometrial blood flow, endometrial receptivity, and increase implantation rate and clinical pregnancy rate . Eighty infertile women undergoing ART cycles participated in this prospective. Recombinant FSH (Gonal-F) was used in a controlled ovarian hyperstimulation technique. The first group A (n=40) got a 4gm infusion of magnesium sulfate, while the second placebo control group B (n=40) received 200ml of 5% glucose water as a placebo, respectively. While there were n...
IraQi Journal of Embryos and Infertility Researches
Successful implantation needs a receptive endometrium, a functional and normal embryo at the stag... more Successful implantation needs a receptive endometrium, a functional and normal embryo at the stage of blastocyst developmental and a synchronized dialogue between embryonic tissues and maternal tissues. Local angiogenesis is an essential pre-requisite for implantation and pregnancy. This study included 63 infertile women (32 women as study group receiving hyaluronic acid and 31 control group) who were subjected to ovulation induction programs with GnRH antagonist protocols for IVF/ICSI procedures. Blood samples were taken by Vacutainer tubes and centrifuged according to the manufacturer’s instructions for the preparation of serum samples. Serum samples for LYVE1 were obtained from each patient when the basal hormonal status was determined. The second time point when the samples were obtained on the day of ova pickup, after that the G1 embryos will be transferred inside uterine cavity. Then performance of endometrial receptivity parameters or patterns evaluation and patients were fol...
IraQi Journal of Embryos and Infertility Researches
Due to malfunction of the hypothalamus-pituitary-ovary axis and probable dysregulation of ovarian... more Due to malfunction of the hypothalamus-pituitary-ovary axis and probable dysregulation of ovarian activities such as follicle selection or follicular atresia, PCOS patients' ovary has a large amount of small follicles but no developed follicles. L-carnitine is a tiny, water-soluble chemical that plays a critical role in fat metabolism. It is required for appropriate mitochondrial fatty acid oxidation and acyl-CoA ester excretion, as well as affecting ATP levels. The study was conducted in High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University and Al-Farah private I.V.F center, 60 infertile women diagnosed with polycystic ovarian syndrome have been enrolled in this study and enter their IVF/ICSI cycle; they were informed about the study and signed a written informed consent. They were grouped into treatment group (n=30) who were treated with L-Carnitine® tablet for two months (VERO UNIVERSAL and NOW) and placebo group (n=30). All enr...
Indian Journal of Public Health Research and Development, 2019
International Journal of Research in Pharmaceutical Sciences, Jul 6, 2020
A prospective randomised (comparative) study was conducted in the High Institute for Infertility ... more A prospective randomised (comparative) study was conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies in AL-Nahrain University, Baghdad-Iraq, from the 1 st of October 2018 till 1 st of September 2019 involving seventy women of infertile couples with the same inclusion and exclusion criteria. They were randomly allocated into two groupsreceiving minimal ovarian stimulation protocol (Clomiphene Citrate and Human Menopausal Gonadotropin) with IUI adding lexible GnRH antagonist protocol (Cetrorelix) to the study group. IUI was done 40-44 hours after ovulation trigger. There were no signi icant statistical variances among control and study groups in demographic characteristics concerning: age, BMI, type, duration and cause of infertility. There was no important variance in a mean day of trigger among control and study groups, 12.43 ±1.56 versus 13.11 ±1.49, at the same order (p = 0.064). The Mean number of dominant follicles was considerably greater in study groups than that of the group control, 2.40 ±1.03 versus 1.89 ±0.83, respectively (p = 0.025).Mean serum Estradiol of the study group was signi icantly higher than that of the control group, 478.68 ±423.61 versus 273.12 ±254.57, respectively (p = 0.016). The proportion of women with LH> 10 were signi icantly less frequent in the study group in comparison with the control group, 22.9 % versus 68.6 %, at the same order (p < 0.001). There was no important variance in mean serum Progesterone among control and study groups. There was no signi icant difference in the characteristic of the dominant follicle, ruptured versus not ruptured, (p = 0.124) on the day of IUI. The pregnancy rate was higher in the study group when compared with the control group; however, the difference in pregnancy rate doesn't reach statistical import (p = 0.145
Iraqi journal of embryos and infertility researches, Aug 17, 2022
Reactive oxygen species (ROS) are active chemical compounds created by the body's metabolic proce... more Reactive oxygen species (ROS) are active chemical compounds created by the body's metabolic process and are crucial in human reproduction. Excessive ROS can contribute to oxidative stress, which has been linked to poor fertility. Embryo culture medium plays an essential role in IVF/ICSI cycles. Eighty participants underwent ovarian stimulation and ICSI cycles; ROS levels were measured in blood samples on the ovum pickup (OPU) day and in each embryo culture dish on ET day using enzyme-linked immunosorbent assay (ELISA). These values were associated with the quality of generated embryos. Women were divided into two groups, the first had day 3 embryo transfers, whereas the second received blastocyst transfers on day 5. Grades I embryos count was shown to be inversely related to the serum and culture medium ROS levels. Pregnant women had significantly greater levels of GI embryos (p=0.011) and lower levels of GIII embryos (p=0.024). Pregnancy rates for the third-and fifth-days of the embryo transfers were 24% and 50%, respectively, with (p=0.045). Pregnancy success rates were increased after ET day 5, and were strongly influenced by transfer day. Blastocyststage embryos with high serum ROS levels were found to be underdeveloped. Culture medium ROS levels can be used as an adjuvant criterion for embryo selection and metabolic marker for developing embryos.
International journal of health sciences
Back ground: Serum chemerin levels are associated with both body fat percentage and BMI, and elev... more Back ground: Serum chemerin levels are associated with both body fat percentage and BMI, and elevated chemerin levels are associated with metabolic problems and inflammatory shifts. Aim: The aim of this study was to evaluate the effect of BMI in serum and follicular fluid chemerin and Leptin level on patients undergoing ICSI. Patients and methods: This study was performed by participating 44 women undergo ICSI procedure devided in to two groups based on BMI in to non-obese group, theirBMI<30 and obese group there BMI>30 . Both groups are infertile women who attend high institute of infertility diagnosis and assisted reproductive technologies at Al-NAHRAIN university In AL-KADHIMIA city in BAGHDAD. From NOVEMBER 2021 to the end of MAY 2022. Blood sample was drown from each patient at day of oocyte pick up for serum chemerin measurements Also follicular fluid is collected for chemerin and Leptin level. Results: The result in non obese group showed a significant positive corre...
International journal of health sciences
Background: Pregnancy has been one of life’s great mysteries. The endometrium is where life begin... more Background: Pregnancy has been one of life’s great mysteries. The endometrium is where life begins, and a receptive endometrium lies at the crossroads of menstruation and pregnancy. Aim of the study: To evaluate the effects of different medical drugs used routinely to improve endometrial thickness, vascularity, and pregnancy rates and to find out the best medical protocol could be used to improve endometrial thickness, vasculature, and pregnancy rate for patient with thin and poorly vascularized endometrium regardless the cause. Materials and methods: The study was carried out on 200 infertile women who have thin , poorly vascularized endometrium, after they matched the inclusion and exclusion criteria , those patients were divided randomly into five groups ; 40 patient in each group, group A received esterofem oral 2mg tablet every 12 hours from day 2 of menstrual cycle till the day of ovulation trigger , group B received vagifem vaginal tablets 25 microgram from the fourth day of ...
NVEO - NATURAL VOLATILES & ESSENTIAL OILS Journal | NVEO, Nov 11, 2021
The Wild cherry, Sweet cherry (botanic name, Prunus avium) is a species of cherry fruits which ha... more The Wild cherry, Sweet cherry (botanic name, Prunus avium) is a species of cherry fruits which has wide distribution in the world. To evaluate the efficacy of using global medium alone versus global medium plus alcohol extract of Prunus avium for in vitro sperm activation (ISA) to asthenozoospermic human semen samples to improve sperm parameters. The study was done on thirty five asthenozoospermic human semen samples. The semen parameters were recorded according to WHO criteria (1999). All semen samples were undergone activation, by using Global medium alone as control group, and by using a mixture of global medium with ethanol extract of Prunus avium to be considered as an experimental group. The results were recorded 30 minutes and 60 minutes after incubation. The results of this study showed significant difference (P˂0.05) in percentage of sperm moƟlity, grade A, grade B and percentage of normal sperm morphology of post activation with Global medium compared with pre-activation r...
Inflammatory bowel disease of unknown etiology and remain chronic progressive inflammation with n... more Inflammatory bowel disease of unknown etiology and remain chronic progressive inflammation with no effective line of treatment .It is mandatory to investigate new drugs with more therapeutic efficacy. The aim of the current study is to investigate the effect of Captopril on inflammatory biomarkers , oxidative stress parameters and histological outcome in experimentally induced colitis. Experimental colitis was induced in rats by rectal administration of 4% acetic acid (vol/vol) .Rats with colitis were received either captopril 30mg/kg or sulfasalazine 100mg/kg orally for 7days.Macroscopical and microscopical assessment and the measurement of the colonic cytokines (IL-6 and TNF-α) , oxidative stress markers ; myeloperoxidase (MPO) and malondialdehyde (MDA) , and adhesion molecules (E-Selectin and ICAM-1) .Our results had shown that both macroscopical lesion area and histological colonic injury induced by acetic acid were significantly reduced by both captopril and sulfasalazine .Thes...
International Journal of Research in Pharmaceutical Sciences, 2020
A prospective randomised (comparative) study was conducted in the High Institute for Infertility ... more A prospective randomised (comparative) study was conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies in AL-Nahrain University, Baghdad – Iraq, from the 1st of October 2018 till 1st of September 2019 involving seventy women of infertile couples with the same inclusion and exclusion criteria. They were randomly allocated into two groupsreceiving minimal ovarian stimulation protocol (Clomiphene Citrate and Human Menopausal Gonadotropin) with IUI adding flexible GnRH antagonist protocol (Cetrorelix) to the study group. IUI was done 40-44 hours after ovulation trigger. There were no significant statistical variances among control and study groups in demographic characteristics concerning: age, BMI, type, duration and cause of infertility. There was no important variance in a mean day of trigger among control and study groups, 12.43 ±1.56 versus 13.11 ±1.49, at the same order (p = 0.064). The Mean number of dominant follicles was considerably g...
Journal of Pharmaceutical Negative Results, Oct 10, 2022
Background: Methylenetetrahydrofolate reductase (MTHFR) C677T is a single nucleotide polymorphism... more Background: Methylenetetrahydrofolate reductase (MTHFR) C677T is a single nucleotide polymorphism (SNP) that affects the production of 5-methyltetrahydrofolate (5-MTHF), the active folate that enables the recycling of homocysteine (Hcy) to methionine. Objective: to investigate the association between the MTHFR (C677T) polymorphism and the outcomes of intracytoplasmic sperm injection (ICSI). Methods: A prospective cohort study included 85 infertile women undergoing ICSI treatment at the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies in Baghdad, Iraq. The study period extended from January 2022 to September 2023. The MTHFR C677T polymorphism genotyping was evaluated in these patients, and they were classified into three groups according to genotyping results: normal (CC), heterozygote mutated (CT), and mutated homozygote (TT). In addition, we conducted a comparative analysis of oocyte, embryo and pregnancy rates among these three groups. Results: In comparison to the CT and TT genotypes, the total number of oocytes, total embryos, mature oocytes, good-quality embryos, and pregnancy rate were all found to be significantly higher (p<0.05) in the CC genotype. Compared to the CC group, the proportion of immature oocytes and poor-quality embryos was significantly higher in the TT and CT groups (p<0.05). The rate of fertilization was comparable among the study groups. Conclusions: The maternal MTHFR C677T polymorphism is linked to oocyte number, maturity, total embryo, embryo quality, and pregnancy in ICSI. In light of this, MTHFR polymorphism in our community offers useful data regarding the success of ICSI.
Iraqi journal of embryos and infertility researches, Nov 7, 2023
Iraqi journal of embryos and infertility researches, Nov 7, 2023
Iraqi journal of embryos and infertility researches, Nov 7, 2023
Iraqi journal of embryos and infertility researches, May 7, 2023
Iraqi journal of embryos and infertility researches, May 7, 2023
Iraqi journal of embryos and infertility researches, Jun 5, 2021
IraQi Journal of Embryos and Infertility Researches
For successful implantation, a high-quality embryo, receptive endometrium, and tight communicatio... more For successful implantation, a high-quality embryo, receptive endometrium, and tight communication between the two are required. The lack of uterine contractions during embryo transfer is one of the characteristics that greatly affects endometrial receptivity. This is because it has been observed that ET may cause uterine contractions, which may be harmful to embryonic apposition and endometrial blood flow .The aim of this study was to assess how magnesium sulfate administration on the day of embryo transfer improve sub endometrial blood flow, endometrial receptivity, and increase implantation rate and clinical pregnancy rate . Eighty infertile women undergoing ART cycles participated in this prospective. Recombinant FSH (Gonal-F) was used in a controlled ovarian hyperstimulation technique. The first group A (n=40) got a 4gm infusion of magnesium sulfate, while the second placebo control group B (n=40) received 200ml of 5% glucose water as a placebo, respectively. While there were n...
IraQi Journal of Embryos and Infertility Researches
Successful implantation needs a receptive endometrium, a functional and normal embryo at the stag... more Successful implantation needs a receptive endometrium, a functional and normal embryo at the stage of blastocyst developmental and a synchronized dialogue between embryonic tissues and maternal tissues. Local angiogenesis is an essential pre-requisite for implantation and pregnancy. This study included 63 infertile women (32 women as study group receiving hyaluronic acid and 31 control group) who were subjected to ovulation induction programs with GnRH antagonist protocols for IVF/ICSI procedures. Blood samples were taken by Vacutainer tubes and centrifuged according to the manufacturer’s instructions for the preparation of serum samples. Serum samples for LYVE1 were obtained from each patient when the basal hormonal status was determined. The second time point when the samples were obtained on the day of ova pickup, after that the G1 embryos will be transferred inside uterine cavity. Then performance of endometrial receptivity parameters or patterns evaluation and patients were fol...
IraQi Journal of Embryos and Infertility Researches
Due to malfunction of the hypothalamus-pituitary-ovary axis and probable dysregulation of ovarian... more Due to malfunction of the hypothalamus-pituitary-ovary axis and probable dysregulation of ovarian activities such as follicle selection or follicular atresia, PCOS patients' ovary has a large amount of small follicles but no developed follicles. L-carnitine is a tiny, water-soluble chemical that plays a critical role in fat metabolism. It is required for appropriate mitochondrial fatty acid oxidation and acyl-CoA ester excretion, as well as affecting ATP levels. The study was conducted in High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University and Al-Farah private I.V.F center, 60 infertile women diagnosed with polycystic ovarian syndrome have been enrolled in this study and enter their IVF/ICSI cycle; they were informed about the study and signed a written informed consent. They were grouped into treatment group (n=30) who were treated with L-Carnitine® tablet for two months (VERO UNIVERSAL and NOW) and placebo group (n=30). All enr...
Indian Journal of Public Health Research and Development, 2019
International Journal of Research in Pharmaceutical Sciences, Jul 6, 2020
A prospective randomised (comparative) study was conducted in the High Institute for Infertility ... more A prospective randomised (comparative) study was conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies in AL-Nahrain University, Baghdad-Iraq, from the 1 st of October 2018 till 1 st of September 2019 involving seventy women of infertile couples with the same inclusion and exclusion criteria. They were randomly allocated into two groupsreceiving minimal ovarian stimulation protocol (Clomiphene Citrate and Human Menopausal Gonadotropin) with IUI adding lexible GnRH antagonist protocol (Cetrorelix) to the study group. IUI was done 40-44 hours after ovulation trigger. There were no signi icant statistical variances among control and study groups in demographic characteristics concerning: age, BMI, type, duration and cause of infertility. There was no important variance in a mean day of trigger among control and study groups, 12.43 ±1.56 versus 13.11 ±1.49, at the same order (p = 0.064). The Mean number of dominant follicles was considerably greater in study groups than that of the group control, 2.40 ±1.03 versus 1.89 ±0.83, respectively (p = 0.025).Mean serum Estradiol of the study group was signi icantly higher than that of the control group, 478.68 ±423.61 versus 273.12 ±254.57, respectively (p = 0.016). The proportion of women with LH> 10 were signi icantly less frequent in the study group in comparison with the control group, 22.9 % versus 68.6 %, at the same order (p < 0.001). There was no important variance in mean serum Progesterone among control and study groups. There was no signi icant difference in the characteristic of the dominant follicle, ruptured versus not ruptured, (p = 0.124) on the day of IUI. The pregnancy rate was higher in the study group when compared with the control group; however, the difference in pregnancy rate doesn't reach statistical import (p = 0.145
Iraqi journal of embryos and infertility researches, Aug 17, 2022
Reactive oxygen species (ROS) are active chemical compounds created by the body's metabolic proce... more Reactive oxygen species (ROS) are active chemical compounds created by the body's metabolic process and are crucial in human reproduction. Excessive ROS can contribute to oxidative stress, which has been linked to poor fertility. Embryo culture medium plays an essential role in IVF/ICSI cycles. Eighty participants underwent ovarian stimulation and ICSI cycles; ROS levels were measured in blood samples on the ovum pickup (OPU) day and in each embryo culture dish on ET day using enzyme-linked immunosorbent assay (ELISA). These values were associated with the quality of generated embryos. Women were divided into two groups, the first had day 3 embryo transfers, whereas the second received blastocyst transfers on day 5. Grades I embryos count was shown to be inversely related to the serum and culture medium ROS levels. Pregnant women had significantly greater levels of GI embryos (p=0.011) and lower levels of GIII embryos (p=0.024). Pregnancy rates for the third-and fifth-days of the embryo transfers were 24% and 50%, respectively, with (p=0.045). Pregnancy success rates were increased after ET day 5, and were strongly influenced by transfer day. Blastocyststage embryos with high serum ROS levels were found to be underdeveloped. Culture medium ROS levels can be used as an adjuvant criterion for embryo selection and metabolic marker for developing embryos.
International journal of health sciences
Back ground: Serum chemerin levels are associated with both body fat percentage and BMI, and elev... more Back ground: Serum chemerin levels are associated with both body fat percentage and BMI, and elevated chemerin levels are associated with metabolic problems and inflammatory shifts. Aim: The aim of this study was to evaluate the effect of BMI in serum and follicular fluid chemerin and Leptin level on patients undergoing ICSI. Patients and methods: This study was performed by participating 44 women undergo ICSI procedure devided in to two groups based on BMI in to non-obese group, theirBMI<30 and obese group there BMI>30 . Both groups are infertile women who attend high institute of infertility diagnosis and assisted reproductive technologies at Al-NAHRAIN university In AL-KADHIMIA city in BAGHDAD. From NOVEMBER 2021 to the end of MAY 2022. Blood sample was drown from each patient at day of oocyte pick up for serum chemerin measurements Also follicular fluid is collected for chemerin and Leptin level. Results: The result in non obese group showed a significant positive corre...
International journal of health sciences
Background: Pregnancy has been one of life’s great mysteries. The endometrium is where life begin... more Background: Pregnancy has been one of life’s great mysteries. The endometrium is where life begins, and a receptive endometrium lies at the crossroads of menstruation and pregnancy. Aim of the study: To evaluate the effects of different medical drugs used routinely to improve endometrial thickness, vascularity, and pregnancy rates and to find out the best medical protocol could be used to improve endometrial thickness, vasculature, and pregnancy rate for patient with thin and poorly vascularized endometrium regardless the cause. Materials and methods: The study was carried out on 200 infertile women who have thin , poorly vascularized endometrium, after they matched the inclusion and exclusion criteria , those patients were divided randomly into five groups ; 40 patient in each group, group A received esterofem oral 2mg tablet every 12 hours from day 2 of menstrual cycle till the day of ovulation trigger , group B received vagifem vaginal tablets 25 microgram from the fourth day of ...
NVEO - NATURAL VOLATILES & ESSENTIAL OILS Journal | NVEO, Nov 11, 2021
The Wild cherry, Sweet cherry (botanic name, Prunus avium) is a species of cherry fruits which ha... more The Wild cherry, Sweet cherry (botanic name, Prunus avium) is a species of cherry fruits which has wide distribution in the world. To evaluate the efficacy of using global medium alone versus global medium plus alcohol extract of Prunus avium for in vitro sperm activation (ISA) to asthenozoospermic human semen samples to improve sperm parameters. The study was done on thirty five asthenozoospermic human semen samples. The semen parameters were recorded according to WHO criteria (1999). All semen samples were undergone activation, by using Global medium alone as control group, and by using a mixture of global medium with ethanol extract of Prunus avium to be considered as an experimental group. The results were recorded 30 minutes and 60 minutes after incubation. The results of this study showed significant difference (P˂0.05) in percentage of sperm moƟlity, grade A, grade B and percentage of normal sperm morphology of post activation with Global medium compared with pre-activation r...
Inflammatory bowel disease of unknown etiology and remain chronic progressive inflammation with n... more Inflammatory bowel disease of unknown etiology and remain chronic progressive inflammation with no effective line of treatment .It is mandatory to investigate new drugs with more therapeutic efficacy. The aim of the current study is to investigate the effect of Captopril on inflammatory biomarkers , oxidative stress parameters and histological outcome in experimentally induced colitis. Experimental colitis was induced in rats by rectal administration of 4% acetic acid (vol/vol) .Rats with colitis were received either captopril 30mg/kg or sulfasalazine 100mg/kg orally for 7days.Macroscopical and microscopical assessment and the measurement of the colonic cytokines (IL-6 and TNF-α) , oxidative stress markers ; myeloperoxidase (MPO) and malondialdehyde (MDA) , and adhesion molecules (E-Selectin and ICAM-1) .Our results had shown that both macroscopical lesion area and histological colonic injury induced by acetic acid were significantly reduced by both captopril and sulfasalazine .Thes...
International Journal of Research in Pharmaceutical Sciences, 2020
A prospective randomised (comparative) study was conducted in the High Institute for Infertility ... more A prospective randomised (comparative) study was conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies in AL-Nahrain University, Baghdad – Iraq, from the 1st of October 2018 till 1st of September 2019 involving seventy women of infertile couples with the same inclusion and exclusion criteria. They were randomly allocated into two groupsreceiving minimal ovarian stimulation protocol (Clomiphene Citrate and Human Menopausal Gonadotropin) with IUI adding flexible GnRH antagonist protocol (Cetrorelix) to the study group. IUI was done 40-44 hours after ovulation trigger. There were no significant statistical variances among control and study groups in demographic characteristics concerning: age, BMI, type, duration and cause of infertility. There was no important variance in a mean day of trigger among control and study groups, 12.43 ±1.56 versus 13.11 ±1.49, at the same order (p = 0.064). The Mean number of dominant follicles was considerably g...