muhammad Ali - Academia.edu (original) (raw)

Papers by muhammad Ali

Pakistan Journal of Agricultural Sciences, 2016

This paper describes a tool for managing architectural knowledge and rationale. The tool has been... more This paper describes a tool for managing architectural knowledge and rationale. The tool has been developed to support a framework for capturing and using architectural knowledge to improve the architecture process. This paper describes the main architectural components and features of the tool. The paper also provides examples of using the tool for supporting wellknown architecture design and analysis methods.

A subset of CD161 (NK1) T cells express an invariant V␣14J␣281 TCR-␣ chain (V␣ invt T cells) and ... more A subset of CD161 (NK1) T cells express an invariant V␣14J␣281 TCR-␣ chain (V␣ invt T cells) and produce Th2 and Th1 cytokines rapidly in response to CD1d, but their physiological function(s) remain unclear. We have found that CD1d-reactive T cells mediate to resistance against the acute, cytopathic virus diabetogenic encephalomyocarditis virus (EMCV-D) in relatively Th1-biased, C57BL/6-based backgrounds. We show now that these results generalize to Th2biased, hypersensitive BALB/c mice. CD1d-KO BALB/c mice were more susceptible to EMCV-D.

Journal of Molecular Biology, 1996

supercoiling. In the absence of HU, Escherichia coli formed tiny colonies on agar, rapidly accumu... more supercoiling. In the absence of HU, Escherichia coli formed tiny colonies on agar, rapidly accumulated suppressor mutations, and was hypersensitive to 2 Institut de Biologie novobiocin. Three types of evidence implicated gyrase in the suppression Physico-Chimique, 13 rue of an HU deficiency. First, spontaneous suppressors that restored normal Pierre et Marie Curie growth and reduced sensitivity to novobiocin mapped in gyrB, one of the 75005, Paris, France genes encoding DNA gyrase. Second, a pair of known gyrB mutations (gyrB-203 Ts gyrB-221 Nov R ) allowed normal growth at permissive (30°C) but not at intermediate (37°C) conditions. Third, introduction of a gyrB-expressing plasmid restored normal colony size. DNA supercoiling comparisons showed that chromosomal supercoiling decreased in the absence of HU and increased toward wild-type levels in the presence of a spontaneous gyrB suppressor. Taken together, these data establish that HU has a physiological role in chromosomal DNA topology, probably by facilitating the action of gyrase.

Natural Product Reports, 2005

Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phen... more Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C 6 -C 3 ) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities, and comprises the data reported in more than 100 peer-reviewed articles, so as to highlight the recently reported bioactive lignans that could be a first step towards the development of potential new therapeutic agents.

Cancer, 1985

Fine-needle aspiration biopsy specimens from 15 histologically proven cases of Ewing's sarcoma of... more Fine-needle aspiration biopsy specimens from 15 histologically proven cases of Ewing's sarcoma of the bone were studied by both light and electron microscopy. Large glycogen deposits in the Ewing's sarcoma cells could be easily recognized in smears stained routinely with Diff-Quik (American Scientific Product, McCraw Park, IL). These deposits appeared as punched-out clear spaces in the cytoplasm. Ultrastructurally the tumor cells could be divided into chief cells and dark cells. The chief cells were further categorized based on their nuclear morphologic features into cleaved, noncleaved, and intermediate cells. The dominant cell was noncleaved in eight, cleaved in three, and intermediate in four cases. All five tumors with abundant glycogen were composed predominantly of noncleaved cells. The tumor cells in aspiration material appeared to be irregular in shape, and some had cytoplasmic processes. In one tumor these processes were quite prominent; this caused some difficulty in differentiation from neuroblastoma.

With an increase in the number of transistors on-chip, the complexity of the system also increase... more With an increase in the number of transistors on-chip, the complexity of the system also increases. In order to cope with the growing interconnect infrastructure, the "Network on chip (NoC)" concept was introduced. With network methodologies coming on-chip, various characteristics of traditional networks come into play. So far, failures that are common in regular networks were hardly considered onchip; this paper introduces ideas of dynamic routing in the context of NoCs and explains how they could be applied to cope with adverse physical effects of deep sub-micron technology.

IEEE Transactions on Circuits and Systems Ii: Analog and Digital Signal Processing, 1998

Abstract A multiphase sinusoidal oscillator circuit is presented. The oscillator can produce N ou... more Abstract A multiphase sinusoidal oscillator circuit is presented. The oscillator can produce N output-currents (N being even or odd) equally spaced in phase. The circuit uses translinear bipolar second-generation current-controlled conveyors, grounded capacitors and enjoys ...

Journal of Systems and Software, 2006

Many claims have been made about the consequences of not documenting design rationale. The genera... more Many claims have been made about the consequences of not documenting design rationale. The general perception is that designers and architects usually do not fully understand the critical role of systematic use and capture of design rationale. However, there is to date little empirical evidence available on what design rationale mean to practitioners, how valuable they consider it, and how they use and document it during the design process. This paper reports a survey of practitioners to probe their perception of the value of design rationale and how they use and document the background knowledge related to their design decisions. Based on 81 valid responses, this study has discovered that practitioners recognize the importance of documenting design rationale and frequently use them to reason about their design choices. However, they have indicated barriers to the use and documentation of design rationale. Based on the findings, we conclude that further research is needed to develop methodology and tool support for design rationale capture and usage. Furthermore, we put forward some specific research questions about design rationale that could be further investigated to benefit industry practice.

Geochimica Et Cosmochimica Acta, 1996