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Research paper thumbnail of Encapsulation of proteins into tunable and giant mesocage alumina

Chemical Communications, 2012

Protein bioadsorption has rapidly attracted attention partially because of the promising advances... more Protein bioadsorption has rapidly attracted attention partially because of the promising advances in diagnostic assays, sensors, separations, and gene technology. Tunable and giant mesocage alumina cavities (5 nm to 20 nm) show capability in size-selective encapsulation and diffusivity of large proteins into interior pores.

Research paper thumbnail of Mesoporous nanomagnet supercaptors for selective heme-proteins from human cells

Chemical Communications, 2012

All materials were used without further purification. Nickel chloride, anhydrous sodium acetate (... more All materials were used without further purification. Nickel chloride, anhydrous sodium acetate (NaAc), ferric chloride, ferrous chloride, ammonia solution, Ethylene glycol (EG), and oleic acid were obtained from Wako Company Ltd. Osaka, Japan.

Research paper thumbnail of Molecular modeling and 3D-QSAR studies of benzothiazol-2-ylacetonitrile derivatives as c-Jun N-terminal kinase 3 inhibitors

… Chem-Bio Informatics …, 2006

Author;SHAIKH ABDUL RAJJAK(Tohoku Univ.) ISMAEL MOHAMED(Tohoku Univ.) TSUBOI HIDEYUKI(Tohoku Univ... more Author;SHAIKH ABDUL RAJJAK(Tohoku Univ.) ISMAEL MOHAMED(Tohoku Univ.) TSUBOI HIDEYUKI(Tohoku Univ.) KOYAMA MICHIHISA(Tohoku Univ.) ENDOU AKIRA(Tohoku Univ.) TAKABA HIROMITSU(Tohoku Univ.) KUBO MOMOJI(Tohoku Univ.) KUBO ...

Research paper thumbnail of Theoretical study of the hydroxylation of KCNQ2 potassium channel opener by Cytochrome P450 3A4

Nano Gakkai Taikai …, 2005

Research paper thumbnail of Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children

Resuscitation, 2009

114 children experienced at least one episode of respiratory arrest (RA) or cardiopulmonary arres... more 114 children experienced at least one episode of respiratory arrest (RA) or cardiopulmonary arrest (CPA). Cardiopulmonary resuscitation (CPR) was performed on all children. “Do not resuscitate order” (DNR) was given in 15 patients after initial resuscitation. Eighty two patients (72%) ...

Research paper thumbnail of An Evolving Automaton for RNA Secondary Structure Prediction

Conventional methods for RNA 2D structure prediction search for minimal free energy structures. R... more Conventional methods for RNA 2D structure prediction search for minimal free energy structures. RNA's, however, RNA's do not always adopt global minimum structures. Rather, their structure is the result of the folding pathway followed by the structure in nature, which adopts sub-optimal folds occurring along the pathway. Our algorithm consists of an automaton that generates RNA structures by searching for optimal folding pathways. The automaton is endowed of operations to travel throughout the hyperspace of conformers embedded in a base pairing matrix. Using genetic programming it evolves optimizing its ability to find optimal pathways and finally 2D structures. Comparing the evolving automaton with conventional methods shows its potential.

Research paper thumbnail of Mesocylindrical Aluminosilica Monolith Biocaptors for Size-Selective Macromolecule Cargos

Advanced Functional Materials, 2012

ABSTRACT Immobilization of biological macromolecules, such as protein, onto solid supports is an ... more ABSTRACT Immobilization of biological macromolecules, such as protein, onto solid supports is an important method for diagnostic assays andgenetechnology. This present study reports the size-selective adsorption/removal of virtual proteins that have different shapes, sizes, functions, and properties, such as insulin, cytochrome c, lysozyme, myoglobin, β-lactoglobin, α-amylase, hemoglobin, and myosin in aqueous water using mesobiocaptor monoliths. To prevent large proteins from adsorbing and remaining attached to adsorbent surfaces, large, open, cylindrical-pored, three-dimensional cubic aluminosilica mesostructures with large aluminum contents and micrometer-sized monolith particles were fabricated. The unique physical properties and the surface functionality of the mesobiocaptors enhance protein adsorption characteristics in terms of loading capacity and quantity of the sample, ensuring a higher concentration of adsorbed proteins, interior pore diffusivity, and encapsulation in a short period. Thermodynamic studies indicate that protein adsorption into the mesobiocaptor pores is favorable and spontaneous. Theoretical models were used to investigate the major driving forces for the most optimal performance of the protein adsorption. The geometrical findings point to key factors, such as surface energy, intermolecular forces, charge distribution, hydrophobicity, and electrostatic interaction, which might control the adsorption into the interior large, open cylindrical mesobiocaptor cavities (sized 3–16 nm) without aggregation of these proteins on the exterior surfaces of monoliths. Indeed, the availability of adsorption of single proteins from mixtures based on size- and shape-selective separation opens new avenues of research in encapsulation of proteins and bioanalysis.

Research paper thumbnail of SAPS 3 scores at the start of renal replacement therapy predict mortality in critically ill patients with acute kidney injury

Research paper thumbnail of Encapsulation of proteins into tunable and giant mesocage alumina

Chemical Communications, 2012

Protein bioadsorption has rapidly attracted attention partially because of the promising advances... more Protein bioadsorption has rapidly attracted attention partially because of the promising advances in diagnostic assays, sensors, separations, and gene technology. Tunable and giant mesocage alumina cavities (5 nm to 20 nm) show capability in size-selective encapsulation and diffusivity of large proteins into interior pores.

Research paper thumbnail of Mesoporous nanomagnet supercaptors for selective heme-proteins from human cells

Chemical Communications, 2012

All materials were used without further purification. Nickel chloride, anhydrous sodium acetate (... more All materials were used without further purification. Nickel chloride, anhydrous sodium acetate (NaAc), ferric chloride, ferrous chloride, ammonia solution, Ethylene glycol (EG), and oleic acid were obtained from Wako Company Ltd. Osaka, Japan.

Research paper thumbnail of Molecular modeling and 3D-QSAR studies of benzothiazol-2-ylacetonitrile derivatives as c-Jun N-terminal kinase 3 inhibitors

… Chem-Bio Informatics …, 2006

Author;SHAIKH ABDUL RAJJAK(Tohoku Univ.) ISMAEL MOHAMED(Tohoku Univ.) TSUBOI HIDEYUKI(Tohoku Univ... more Author;SHAIKH ABDUL RAJJAK(Tohoku Univ.) ISMAEL MOHAMED(Tohoku Univ.) TSUBOI HIDEYUKI(Tohoku Univ.) KOYAMA MICHIHISA(Tohoku Univ.) ENDOU AKIRA(Tohoku Univ.) TAKABA HIROMITSU(Tohoku Univ.) KUBO MOMOJI(Tohoku Univ.) KUBO ...

Research paper thumbnail of Theoretical study of the hydroxylation of KCNQ2 potassium channel opener by Cytochrome P450 3A4

Nano Gakkai Taikai …, 2005

Research paper thumbnail of Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children

Resuscitation, 2009

114 children experienced at least one episode of respiratory arrest (RA) or cardiopulmonary arres... more 114 children experienced at least one episode of respiratory arrest (RA) or cardiopulmonary arrest (CPA). Cardiopulmonary resuscitation (CPR) was performed on all children. “Do not resuscitate order” (DNR) was given in 15 patients after initial resuscitation. Eighty two patients (72%) ...

Research paper thumbnail of An Evolving Automaton for RNA Secondary Structure Prediction

Conventional methods for RNA 2D structure prediction search for minimal free energy structures. R... more Conventional methods for RNA 2D structure prediction search for minimal free energy structures. RNA's, however, RNA's do not always adopt global minimum structures. Rather, their structure is the result of the folding pathway followed by the structure in nature, which adopts sub-optimal folds occurring along the pathway. Our algorithm consists of an automaton that generates RNA structures by searching for optimal folding pathways. The automaton is endowed of operations to travel throughout the hyperspace of conformers embedded in a base pairing matrix. Using genetic programming it evolves optimizing its ability to find optimal pathways and finally 2D structures. Comparing the evolving automaton with conventional methods shows its potential.

Research paper thumbnail of Mesocylindrical Aluminosilica Monolith Biocaptors for Size-Selective Macromolecule Cargos

Advanced Functional Materials, 2012

ABSTRACT Immobilization of biological macromolecules, such as protein, onto solid supports is an ... more ABSTRACT Immobilization of biological macromolecules, such as protein, onto solid supports is an important method for diagnostic assays andgenetechnology. This present study reports the size-selective adsorption/removal of virtual proteins that have different shapes, sizes, functions, and properties, such as insulin, cytochrome c, lysozyme, myoglobin, β-lactoglobin, α-amylase, hemoglobin, and myosin in aqueous water using mesobiocaptor monoliths. To prevent large proteins from adsorbing and remaining attached to adsorbent surfaces, large, open, cylindrical-pored, three-dimensional cubic aluminosilica mesostructures with large aluminum contents and micrometer-sized monolith particles were fabricated. The unique physical properties and the surface functionality of the mesobiocaptors enhance protein adsorption characteristics in terms of loading capacity and quantity of the sample, ensuring a higher concentration of adsorbed proteins, interior pore diffusivity, and encapsulation in a short period. Thermodynamic studies indicate that protein adsorption into the mesobiocaptor pores is favorable and spontaneous. Theoretical models were used to investigate the major driving forces for the most optimal performance of the protein adsorption. The geometrical findings point to key factors, such as surface energy, intermolecular forces, charge distribution, hydrophobicity, and electrostatic interaction, which might control the adsorption into the interior large, open cylindrical mesobiocaptor cavities (sized 3–16 nm) without aggregation of these proteins on the exterior surfaces of monoliths. Indeed, the availability of adsorption of single proteins from mixtures based on size- and shape-selective separation opens new avenues of research in encapsulation of proteins and bioanalysis.

Research paper thumbnail of SAPS 3 scores at the start of renal replacement therapy predict mortality in critically ill patients with acute kidney injury