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Papers by mustafa oran

Moleküler Biyoloji ve Genetik, Apr 6, 2023

protective effects of o-3 fatty acids on doxorubicin-induced hepato-toxicity and nephrotoxicity i... more protective effects of o-3 fatty acids on doxorubicin-induced hepato-toxicity and nephrotoxicity in rats

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, 2020

Hipokalemik periyodik paralizi (HPP), ağır egzersiz, diyet yapma veya yüksek karbonhidratlı yemek... more Hipokalemik periyodik paralizi (HPP), ağır egzersiz, diyet yapma veya yüksek karbonhidratlı yemekler ile tetiklenen ve ağrısız kas güçsüzlüğü ataklarıyla karakterize kaslarda iyon kanallarındaki bir defekt ile ilgili olan nadir görülen bir nöromüsküler bozukluktur. Biz bu olguda ani başlangıçlı güç kaybı şikayetiyle Acil Servis (AS)’e başvuran ve daha öncede benzer şikayetleri olan 37 yaşındaki bir erkek hastayı sunuyoruz. AS’te çalışılan rutin kan testlerinde serum potasyum seviyesi belirgin olarak düşük saptandı. Hipokaleminin diğer nedenleri dışlandı. Hastanın semptomları potasyum yerine koyma tedavisi ile 4 saat gibi kısa bir sürede tamamen düzeldi. Bu olgu, ani flask paralizisi ile başvuran genç hastalarda ayırıcı tanıda nadir olmasına rağmen HPP’nin düşünülmesi gerektiğini ve serum potasyum seviyelerine bakılarak kolayca belirlenebileceğini göstermektedir.

European review for medical and pharmacological sciences, 2021

OBJECTIVE There is more pronounced hypercoagulation in COVID-19 infection than in other viral lun... more OBJECTIVE There is more pronounced hypercoagulation in COVID-19 infection than in other viral lung infections. Oxidized phospholipids (OxPLs) appear in COVID-19-infected lungs due to oxidative stress, after which they promote the induction of tissue factor (TF) expression and inflammatory programmers in monocytes, as well as activate endothelial cells to recruit and bind to monocytes. Therefore, we aimed to demonstrate the role of OxPLs in inflammatory and procoagulant responses in COVID-19 infection. PATIENTS AND METHODS Patients with a positive SARS-CoV-2 polymerase chain reaction test and ten healthy donors were included in the study. Peripheral blood was drawn at inclusion for OxPAPC, IFN-γ, and CCL2 serum level measurements. Clinical data were collected from electronic patient medical files. The serum levels of OxPAPC, IFNγ, and CCL2 were measured by immune assays. RESULTS Seventy-two patients were included in the study. OxPAPC and CCL2 were higher in the patients than in the c...

International Journal of Basic and Clinical Medicine, 2013

Aim Irritable gastrointestinal system disease which reduces the quality of life due to abdominal ... more Aim Irritable gastrointestinal system disease which reduces the quality of life due to abdominal pain secondary to defecation change and it has a high prevalence in society. It is known that inflammation and changes in immune system have a role in the pathogenesis of IBS. Materials and Methods In this study, we aimed to investigate retrospectively the erythrocyte and platelet counts of patients with IBS and compare them to those of healthy controls. Files of 30 patients with IBS and 30 healthy people , who consulted to gastroenterology clinic in Namik Kemal University Faculty of Medicine, were scanned. The erythrocyte and platelet counts of these people as well as their demographics were recorded. Results It was seen that RBC, HGB, HCT, MCV, MCH, MCHC, RDWCV and RDWSD levels did not differ in patients with IBS compared with the control group. Similarly, we found that PLT, MPV, PDW, PCT and PLCR did not differ in patients with IBS compared with the control group. Conclusion We are of...

International Journal of Basic and Clinical Medicine, 2013

Heterotopic Gastric Mucosa (inlet patch) is a clinical entity, described firstly by Schmit as a c... more Heterotopic Gastric Mucosa (inlet patch) is a clinical entity, described firstly by Schmit as a congenital anomaly, characterized by settling of gastric mucosa in any part of the gastrointestinal mucosa. It causes various clinical symptoms due to acid secretion. Our case is oberved rarelly in case of inlet patch

Objectives: Increased carotid intima-media thickness (IMT) reflects subclinical vascular damage a... more Objectives: Increased carotid intima-media thickness (IMT) reflects subclinical vascular damage and is related to obstructive sleep apnea (OSA) syndrome and hypertension. Osteoprotegerin OPG is a member of the tumor necrosis factor superfamily and increases leukocyte adhesion. The relationship between increased OPG and atherosclerosis is well known, but there is still no eviden- ce whether there is an association between OPG and resistant hypertension. This study investigated the association between OPG and drug resistant hypertension in patients with OSA and non-OSA. Patients and methods: We investigated the association between serum OPG levels and carotid IMT in patients with drug resi- stant hypertensive OSA (ODR) patients (n= 39) and drug resistant hypertensive non-OSA(NODR) patients (n=34) and drug-respon- sive hypertensive non-OSA controls (n=36). Results: OPG levels and carotid IMT were found to be higher in the ODR (12.4(5.9-19.5) and 0.89 ±0.5) and in the NODR group (11.9(5...

Acta Medica Mediterranea, 2021

Introduction: Obesity, by causing hypofibrinolysis and thrombotic complications, ought to be a ri... more Introduction: Obesity, by causing hypofibrinolysis and thrombotic complications, ought to be a risk factor in terms of disease severity and mortality in COVID-19 infection.We aim to investigate the effects of obesity on fibrinolytic system in coronavirus patients while studying the changes of major fibrinolytic inhibitors plasminogen activator inhibitor (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI). Material and methods: Sixty-six patients and 21 healthy donors were investigated and observed until either their recovery or death. Body mass index (BMI) was calculated for each person and peripheral blood used for PAI-1 and TAFI measurements. PAI-1 antigen and TAFI activated/inactivated (TAFIa/i) were measured using ELISA kits. Results: PAI-1 antigen and TAFIa/i plasma levels are higher in patients than in control group (P<00001 for both).Patients needing ICU had higher TAFIa/i values than non-ICU patients. The 15 patients who died had higher TAFIa/i levels than thos...

European Journal of General Medicine, 2016

Objective: Recently neutrophil-to-lymphocyte ratio (NLR)-the level of neutrophil reflecting the s... more Objective: Recently neutrophil-to-lymphocyte ratio (NLR)-the level of neutrophil reflecting the severity of inflammation and lymphocyte occurring after physiological stress has been gaining popularity, which was, along with other inflammatory markers, commonly accepted as an accurate marker of the inflammatory status.In this multi-centered study, an early, rapid, and low-cost diagnosis method was investigated. To this end, the correlation between chronic obstructive pulmonary disease and inflammation was planned to be utilized and whether neutrophil-to-lymphocyte ratio can be used as a valid tool in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease was investigated. Method: We retrospectively enrolled the 467 patients. Control group included sex and age-matched healthy people.C-Reactive protein, forced expiratory volume-1, forced vital capacity, complete blood count and clinical data A receiver-operating characteristic curve analysis was performed to determine the best cutoff value of N/L ratio and C-Reaktif protein to predict the exacerbation. Two-sided p values <0.05 were considered statistically significant. Results: By spearman analysis, there was a strong correlation between.C-Reactive protein and N/L ratio in both stable group (r=0.436, p<0.001) and exacerbation group (r=0.534, p=0.001). Conclusion: Neutrophil/lymphocyte ratio may bea useful predictor of inflammation in chronic obstructive pulmonary disease and acute exacarbation of chronic obstructive pulmonary disease patients.

Annals of the Rheumatic Diseases, 2015

levels: Cluster 1 (n°117 patients) reflects the lowest average levels across all symptoms; Cluste... more levels: Cluster 1 (n°117 patients) reflects the lowest average levels across all symptoms; Cluster 3 (n°116 patients) reflects the highest average levels. Clusters 2 (n°120 patients) capture moderate symptoms levels with lower levels of depression and anxiety than Cluster 3 (Figure). Conclusions: The results of this pilot study suggest that using the Web/Internetbased diary as patient terminal seems to provide a ubiquitous, easy-to-use, and cost efficient solution for patient-centered data acquisition in the management of FM. The data provides a snapshot of FM and help support the clinical impression that there are distinct subsets of patients with FM. Furthermore, the definition of clinically homogeneous subgroups need to be in different countries, contexts and patient samples. References: [1] Salaffi F, Franchignoni F, Giordano A, et al. Psychometric characteristics of the Italian version of the revised Fibromyalgia Impact Questionnaire using classical test theory and Rasch analysis. Clinical and Experimental Rheumatology 2013. [2] Salaffi F, Sarzi-Puttini P, Girolimetti R, et al. Development and validation of the self-administered Fibromyalgia Assessment Status: a disease-specific composite measure for evaluating treatment effect. Arthritis Research & Therapy; 11:R125 2009.

European Journal of General Medicine, 2015

Many bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. H... more Many bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. However, the pathophysiological mechanisms whereby this anaemia promotes deterioration in immunity remain largely unexplained. In order to enlighten this pathophysiological link , serum levels of macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1), which play an important roles in a healthy functioning immune system, were examined in patients with IDA and healthy volunteers. A total of 30 patients with IDA (mean age 33.6±7.8 years, 30% male) and 30 healthy individuals (mean age 30.1 ± 8.8 years, 27 % male) were included. Serum MIF and MCP-1 levels were measured in a sandwich-assay format, using commercial enzyme-linked immunosorbent assay kits. There was no statistically significant difference in age and gender distribution between participants with IDA and controls (p>0.05). Serum MIF and MCP-1 concentrations were lower in the IDA group than in the control group (p < 0.005, and p < 0.01, respectively). When considering the role of MIF and MCP-1 in maintaining the normal immune response of the organism, a decrease in production in patients with IDA may contribute to immune dysfunction in these individuals.

Angiology, 2015

Statins have multiple effects (also known as pleiotropic effects) on inflammation, plaque stabili... more Statins have multiple effects (also known as pleiotropic effects) on inflammation, plaque stabilization, endothelial function, and hemostasis. We evaluated the effects of rosuvastatin on mean platelet volume (MPV)—a marker for platelet activity—in patients with diabetes mellitus (DM) on rosuvastatin medication. Patients (n = 178) who were to be prescribed high-intensity rosuvastatin were retrospectively enrolled according to their medical records. Baseline and 6-month biochemical tests, automated blood count, cell-volume analysis, and their cardiovascular risk factors were recorded. Rosuvastatin significantly reduced the MPV and the lipid parameters including total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C). However, there was no correlation between MPV and LDL-C before ( r = −.66; P = .383) and after ( r = −.112; P = .135) rosuvastatin treatment or between ΔMPV and ΔLDL-C after 40 mg rosuvastatin daily therapy ( r = −.155; P = .073). Rosuvastatin sig...

Toxicology and industrial health, Jan 19, 2013

This study aims to evaluate the protective effects of ω-3 fatty acids (FAs) on doxorubicin (DOX)-... more This study aims to evaluate the protective effects of ω-3 fatty acids (FAs) on doxorubicin (DOX)-induced hepatotoxicity and nephrotoxicity in rats. A total of 24 adult male Sprague Dawley rats were divided into three groups. Control group was given only saline by intragastric gavage. DOX group received DOX at the dose of 30 mg/kg intraperitoneally on day 28. DOX-ω-3 FA group was given as ω-3 FAs at the dose of 400 mg/kg daily by intragastric gavage for 30 days and received DOX at the dose of 30 mg/kg intraperitoneally on day 28. At the end of the 30-day experimental period, the serum, liver and kidney tissue specimens were taken from the animals by giving a general anesthesia. Glutathione (GSH) and malondialdehyde (MDA) levels in serum and GSH and MDA levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in liver and kidney tissues were measured spectrophotometrically. In our study, a significant increase in MDA levels was observed in rats when given a...

Cardiology Journal, 2014

Background: There are contradictory reports about the relationship between fetuin-A and atheroscl... more Background: There are contradictory reports about the relationship between fetuin-A and atherosclerotic process. Coronary artery disease is the most important cause of mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to investigate the association of serum fetuin-A level with mean carotid intima-media thickness (cIMT) and ankle-brachial index (ABI) in COPD. Methods: We evaluated the association of serum fetuin-A level, mean cIMT and ABI in normotensive subjects with COPD (n = 65) and with non-COPD (n = 50). Results: Fetuin-A level was significantly lower (63.5 ± 19.8 ng/mL, 72.9 ± 16.2 ng/mL, p = 0.035) and C-reactive protein level higher (4 [1-10] vs. 3 [1-12] mg/dL, p = 0.034) in COPD patients than the control group. Compared to controls, fetuin-A level was significantly lower (63.5 ± 19.8 ng/mL, 72.9 ± 16.2 ng/mL, p = 0.035) and mean cIMT higher (0.69 [0.50-0.98] vs. 0.62 [0.44-0.98] mm, p = 0.034, respectively) in the COPD group. There was a significant negative correlation between mean cIMT and fetuin-A levels

Toxicology and Industrial Health, 2013

The goal of this study was to examine the neuroprotective effect of ebselen against intracerebrov... more The goal of this study was to examine the neuroprotective effect of ebselen against intracerebroventricular streptozotocin (ICV-STZ)-induced oxidative stress and neuronal apoptosis in rat brain. A total of 30 adult male Sprague-Dawley rats were randomly divided into 3 groups of 10 animals each: control, ICV-STZ, and ICV-STZ treated with ebselen. The ICV-STZ group rats were injected bilaterally with ICV-STZ (3 mg/kg) on days 1 and 3, and ebselen (10 mg/kg/day) was administered for 14 days starting from 1st day of ICV-STZ injection to day 14. Rats were killed at the end of the study and brain tissues were removed for biochemical and histopathological investigation. Our results demonstrated, for the first time, the neuroprotective effect of ebselen on Alzheimer’s disease (AD) model in rats. Our present study, in ICV-STZ group, showed significant increase in tissue malondialdehyde levels and significant decrease in enzymatic antioxidants superoxide dismutase and glutathione peroxidase i...

TURKISH JOURNAL OF MEDICAL SCIENCES, 2014

Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result fr... more Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.

Dicle Medical Journal/Dicle Tıp Dergisi, 2014

Neuropsychiatric Disease and Treatment, 2013

Background: Patients with schizophrenia have a higher risk for cardiovascular diseases, which is ... more Background: Patients with schizophrenia have a higher risk for cardiovascular diseases, which is associated with early mortality compared with the nonschizophrenic population. Early diagnosis of cardiovascular diseases in asymptomatic periods in patients with schizophrenia would enhance their quality of life and reduce mortality. Echocardiography, carotid ultrasonography, and ankle brachial index (ABI) measurement are known to be beneficial methods of detecting subclinical cardiovascular diseases and of risk stratification. The present study investigated carotid intima media thickness (CIMT) and ABI and echocardiographic parameters measured via conventional and tissue Doppler echocardiography in patients with schizophrenia in comparison with a control group. Methods: The present case-control study included 116 patients with schizophrenia and 88 healthy patients. Participants with any current comorbid psychiatric disorder, current or lifetime neurological and medical problems, current coronary artery disease, diabetes, hypertension, hypothyroidism, or hyperthyroidism or who were using antihypertensives, antidiabetic agents, or antiobesity drugs were excluded. High-resolution B-mode ultrasound images were used to measure CIMT. Conventional and tissue Doppler measurements were performed according to the recommendations of the American Society of Echocardiography. Results: Low ABI, mitral ratio of the early (E) to late (A) ventricular filling velocities, septal E′, septal S′, lateral E′, lateral S′, septal E′/septal A′, lateral E′/lateral A′, and high septal A′, mitral E/septal E′, mitral E/lateral E′, and CIMT values were observed in the schizophrenia group compared with the control group. Conclusion: Doppler parameters supported the hypothesis that patients with schizophrenia are at high risk for cardiovascular diseases.

Dicle Medical …, 2010

Objectives: The aim of this study was to investigate the relationship between subclinical hypothy... more Objectives: The aim of this study was to investigate the relationship between subclinical hypothyroid and QTc dispersionindicating local heterogeneity in repolarization of myocardium, which is well known as independent cardiac risk factor for sudden death and ...

Moleküler Biyoloji ve Genetik, Apr 6, 2023

protective effects of o-3 fatty acids on doxorubicin-induced hepato-toxicity and nephrotoxicity i... more protective effects of o-3 fatty acids on doxorubicin-induced hepato-toxicity and nephrotoxicity in rats

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, 2020

Hipokalemik periyodik paralizi (HPP), ağır egzersiz, diyet yapma veya yüksek karbonhidratlı yemek... more Hipokalemik periyodik paralizi (HPP), ağır egzersiz, diyet yapma veya yüksek karbonhidratlı yemekler ile tetiklenen ve ağrısız kas güçsüzlüğü ataklarıyla karakterize kaslarda iyon kanallarındaki bir defekt ile ilgili olan nadir görülen bir nöromüsküler bozukluktur. Biz bu olguda ani başlangıçlı güç kaybı şikayetiyle Acil Servis (AS)’e başvuran ve daha öncede benzer şikayetleri olan 37 yaşındaki bir erkek hastayı sunuyoruz. AS’te çalışılan rutin kan testlerinde serum potasyum seviyesi belirgin olarak düşük saptandı. Hipokaleminin diğer nedenleri dışlandı. Hastanın semptomları potasyum yerine koyma tedavisi ile 4 saat gibi kısa bir sürede tamamen düzeldi. Bu olgu, ani flask paralizisi ile başvuran genç hastalarda ayırıcı tanıda nadir olmasına rağmen HPP’nin düşünülmesi gerektiğini ve serum potasyum seviyelerine bakılarak kolayca belirlenebileceğini göstermektedir.

European review for medical and pharmacological sciences, 2021

OBJECTIVE There is more pronounced hypercoagulation in COVID-19 infection than in other viral lun... more OBJECTIVE There is more pronounced hypercoagulation in COVID-19 infection than in other viral lung infections. Oxidized phospholipids (OxPLs) appear in COVID-19-infected lungs due to oxidative stress, after which they promote the induction of tissue factor (TF) expression and inflammatory programmers in monocytes, as well as activate endothelial cells to recruit and bind to monocytes. Therefore, we aimed to demonstrate the role of OxPLs in inflammatory and procoagulant responses in COVID-19 infection. PATIENTS AND METHODS Patients with a positive SARS-CoV-2 polymerase chain reaction test and ten healthy donors were included in the study. Peripheral blood was drawn at inclusion for OxPAPC, IFN-γ, and CCL2 serum level measurements. Clinical data were collected from electronic patient medical files. The serum levels of OxPAPC, IFNγ, and CCL2 were measured by immune assays. RESULTS Seventy-two patients were included in the study. OxPAPC and CCL2 were higher in the patients than in the c...

International Journal of Basic and Clinical Medicine, 2013

Aim Irritable gastrointestinal system disease which reduces the quality of life due to abdominal ... more Aim Irritable gastrointestinal system disease which reduces the quality of life due to abdominal pain secondary to defecation change and it has a high prevalence in society. It is known that inflammation and changes in immune system have a role in the pathogenesis of IBS. Materials and Methods In this study, we aimed to investigate retrospectively the erythrocyte and platelet counts of patients with IBS and compare them to those of healthy controls. Files of 30 patients with IBS and 30 healthy people , who consulted to gastroenterology clinic in Namik Kemal University Faculty of Medicine, were scanned. The erythrocyte and platelet counts of these people as well as their demographics were recorded. Results It was seen that RBC, HGB, HCT, MCV, MCH, MCHC, RDWCV and RDWSD levels did not differ in patients with IBS compared with the control group. Similarly, we found that PLT, MPV, PDW, PCT and PLCR did not differ in patients with IBS compared with the control group. Conclusion We are of...

International Journal of Basic and Clinical Medicine, 2013

Heterotopic Gastric Mucosa (inlet patch) is a clinical entity, described firstly by Schmit as a c... more Heterotopic Gastric Mucosa (inlet patch) is a clinical entity, described firstly by Schmit as a congenital anomaly, characterized by settling of gastric mucosa in any part of the gastrointestinal mucosa. It causes various clinical symptoms due to acid secretion. Our case is oberved rarelly in case of inlet patch

Objectives: Increased carotid intima-media thickness (IMT) reflects subclinical vascular damage a... more Objectives: Increased carotid intima-media thickness (IMT) reflects subclinical vascular damage and is related to obstructive sleep apnea (OSA) syndrome and hypertension. Osteoprotegerin OPG is a member of the tumor necrosis factor superfamily and increases leukocyte adhesion. The relationship between increased OPG and atherosclerosis is well known, but there is still no eviden- ce whether there is an association between OPG and resistant hypertension. This study investigated the association between OPG and drug resistant hypertension in patients with OSA and non-OSA. Patients and methods: We investigated the association between serum OPG levels and carotid IMT in patients with drug resi- stant hypertensive OSA (ODR) patients (n= 39) and drug resistant hypertensive non-OSA(NODR) patients (n=34) and drug-respon- sive hypertensive non-OSA controls (n=36). Results: OPG levels and carotid IMT were found to be higher in the ODR (12.4(5.9-19.5) and 0.89 ±0.5) and in the NODR group (11.9(5...

Acta Medica Mediterranea, 2021

Introduction: Obesity, by causing hypofibrinolysis and thrombotic complications, ought to be a ri... more Introduction: Obesity, by causing hypofibrinolysis and thrombotic complications, ought to be a risk factor in terms of disease severity and mortality in COVID-19 infection.We aim to investigate the effects of obesity on fibrinolytic system in coronavirus patients while studying the changes of major fibrinolytic inhibitors plasminogen activator inhibitor (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI). Material and methods: Sixty-six patients and 21 healthy donors were investigated and observed until either their recovery or death. Body mass index (BMI) was calculated for each person and peripheral blood used for PAI-1 and TAFI measurements. PAI-1 antigen and TAFI activated/inactivated (TAFIa/i) were measured using ELISA kits. Results: PAI-1 antigen and TAFIa/i plasma levels are higher in patients than in control group (P<00001 for both).Patients needing ICU had higher TAFIa/i values than non-ICU patients. The 15 patients who died had higher TAFIa/i levels than thos...

European Journal of General Medicine, 2016

Objective: Recently neutrophil-to-lymphocyte ratio (NLR)-the level of neutrophil reflecting the s... more Objective: Recently neutrophil-to-lymphocyte ratio (NLR)-the level of neutrophil reflecting the severity of inflammation and lymphocyte occurring after physiological stress has been gaining popularity, which was, along with other inflammatory markers, commonly accepted as an accurate marker of the inflammatory status.In this multi-centered study, an early, rapid, and low-cost diagnosis method was investigated. To this end, the correlation between chronic obstructive pulmonary disease and inflammation was planned to be utilized and whether neutrophil-to-lymphocyte ratio can be used as a valid tool in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease was investigated. Method: We retrospectively enrolled the 467 patients. Control group included sex and age-matched healthy people.C-Reactive protein, forced expiratory volume-1, forced vital capacity, complete blood count and clinical data A receiver-operating characteristic curve analysis was performed to determine the best cutoff value of N/L ratio and C-Reaktif protein to predict the exacerbation. Two-sided p values <0.05 were considered statistically significant. Results: By spearman analysis, there was a strong correlation between.C-Reactive protein and N/L ratio in both stable group (r=0.436, p<0.001) and exacerbation group (r=0.534, p=0.001). Conclusion: Neutrophil/lymphocyte ratio may bea useful predictor of inflammation in chronic obstructive pulmonary disease and acute exacarbation of chronic obstructive pulmonary disease patients.

Annals of the Rheumatic Diseases, 2015

levels: Cluster 1 (n°117 patients) reflects the lowest average levels across all symptoms; Cluste... more levels: Cluster 1 (n°117 patients) reflects the lowest average levels across all symptoms; Cluster 3 (n°116 patients) reflects the highest average levels. Clusters 2 (n°120 patients) capture moderate symptoms levels with lower levels of depression and anxiety than Cluster 3 (Figure). Conclusions: The results of this pilot study suggest that using the Web/Internetbased diary as patient terminal seems to provide a ubiquitous, easy-to-use, and cost efficient solution for patient-centered data acquisition in the management of FM. The data provides a snapshot of FM and help support the clinical impression that there are distinct subsets of patients with FM. Furthermore, the definition of clinically homogeneous subgroups need to be in different countries, contexts and patient samples. References: [1] Salaffi F, Franchignoni F, Giordano A, et al. Psychometric characteristics of the Italian version of the revised Fibromyalgia Impact Questionnaire using classical test theory and Rasch analysis. Clinical and Experimental Rheumatology 2013. [2] Salaffi F, Sarzi-Puttini P, Girolimetti R, et al. Development and validation of the self-administered Fibromyalgia Assessment Status: a disease-specific composite measure for evaluating treatment effect. Arthritis Research & Therapy; 11:R125 2009.

European Journal of General Medicine, 2015

Many bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. H... more Many bodily systems are affected by iron deficiency anaemia (IDA), including the immune system. However, the pathophysiological mechanisms whereby this anaemia promotes deterioration in immunity remain largely unexplained. In order to enlighten this pathophysiological link , serum levels of macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1), which play an important roles in a healthy functioning immune system, were examined in patients with IDA and healthy volunteers. A total of 30 patients with IDA (mean age 33.6±7.8 years, 30% male) and 30 healthy individuals (mean age 30.1 ± 8.8 years, 27 % male) were included. Serum MIF and MCP-1 levels were measured in a sandwich-assay format, using commercial enzyme-linked immunosorbent assay kits. There was no statistically significant difference in age and gender distribution between participants with IDA and controls (p>0.05). Serum MIF and MCP-1 concentrations were lower in the IDA group than in the control group (p < 0.005, and p < 0.01, respectively). When considering the role of MIF and MCP-1 in maintaining the normal immune response of the organism, a decrease in production in patients with IDA may contribute to immune dysfunction in these individuals.

Angiology, 2015

Statins have multiple effects (also known as pleiotropic effects) on inflammation, plaque stabili... more Statins have multiple effects (also known as pleiotropic effects) on inflammation, plaque stabilization, endothelial function, and hemostasis. We evaluated the effects of rosuvastatin on mean platelet volume (MPV)—a marker for platelet activity—in patients with diabetes mellitus (DM) on rosuvastatin medication. Patients (n = 178) who were to be prescribed high-intensity rosuvastatin were retrospectively enrolled according to their medical records. Baseline and 6-month biochemical tests, automated blood count, cell-volume analysis, and their cardiovascular risk factors were recorded. Rosuvastatin significantly reduced the MPV and the lipid parameters including total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C). However, there was no correlation between MPV and LDL-C before ( r = −.66; P = .383) and after ( r = −.112; P = .135) rosuvastatin treatment or between ΔMPV and ΔLDL-C after 40 mg rosuvastatin daily therapy ( r = −.155; P = .073). Rosuvastatin sig...

Toxicology and industrial health, Jan 19, 2013

This study aims to evaluate the protective effects of ω-3 fatty acids (FAs) on doxorubicin (DOX)-... more This study aims to evaluate the protective effects of ω-3 fatty acids (FAs) on doxorubicin (DOX)-induced hepatotoxicity and nephrotoxicity in rats. A total of 24 adult male Sprague Dawley rats were divided into three groups. Control group was given only saline by intragastric gavage. DOX group received DOX at the dose of 30 mg/kg intraperitoneally on day 28. DOX-ω-3 FA group was given as ω-3 FAs at the dose of 400 mg/kg daily by intragastric gavage for 30 days and received DOX at the dose of 30 mg/kg intraperitoneally on day 28. At the end of the 30-day experimental period, the serum, liver and kidney tissue specimens were taken from the animals by giving a general anesthesia. Glutathione (GSH) and malondialdehyde (MDA) levels in serum and GSH and MDA levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in liver and kidney tissues were measured spectrophotometrically. In our study, a significant increase in MDA levels was observed in rats when given a...

Cardiology Journal, 2014

Background: There are contradictory reports about the relationship between fetuin-A and atheroscl... more Background: There are contradictory reports about the relationship between fetuin-A and atherosclerotic process. Coronary artery disease is the most important cause of mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to investigate the association of serum fetuin-A level with mean carotid intima-media thickness (cIMT) and ankle-brachial index (ABI) in COPD. Methods: We evaluated the association of serum fetuin-A level, mean cIMT and ABI in normotensive subjects with COPD (n = 65) and with non-COPD (n = 50). Results: Fetuin-A level was significantly lower (63.5 ± 19.8 ng/mL, 72.9 ± 16.2 ng/mL, p = 0.035) and C-reactive protein level higher (4 [1-10] vs. 3 [1-12] mg/dL, p = 0.034) in COPD patients than the control group. Compared to controls, fetuin-A level was significantly lower (63.5 ± 19.8 ng/mL, 72.9 ± 16.2 ng/mL, p = 0.035) and mean cIMT higher (0.69 [0.50-0.98] vs. 0.62 [0.44-0.98] mm, p = 0.034, respectively) in the COPD group. There was a significant negative correlation between mean cIMT and fetuin-A levels

Toxicology and Industrial Health, 2013

The goal of this study was to examine the neuroprotective effect of ebselen against intracerebrov... more The goal of this study was to examine the neuroprotective effect of ebselen against intracerebroventricular streptozotocin (ICV-STZ)-induced oxidative stress and neuronal apoptosis in rat brain. A total of 30 adult male Sprague-Dawley rats were randomly divided into 3 groups of 10 animals each: control, ICV-STZ, and ICV-STZ treated with ebselen. The ICV-STZ group rats were injected bilaterally with ICV-STZ (3 mg/kg) on days 1 and 3, and ebselen (10 mg/kg/day) was administered for 14 days starting from 1st day of ICV-STZ injection to day 14. Rats were killed at the end of the study and brain tissues were removed for biochemical and histopathological investigation. Our results demonstrated, for the first time, the neuroprotective effect of ebselen on Alzheimer’s disease (AD) model in rats. Our present study, in ICV-STZ group, showed significant increase in tissue malondialdehyde levels and significant decrease in enzymatic antioxidants superoxide dismutase and glutathione peroxidase i...

TURKISH JOURNAL OF MEDICAL SCIENCES, 2014

Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result fr... more Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.

Dicle Medical Journal/Dicle Tıp Dergisi, 2014

Neuropsychiatric Disease and Treatment, 2013

Background: Patients with schizophrenia have a higher risk for cardiovascular diseases, which is ... more Background: Patients with schizophrenia have a higher risk for cardiovascular diseases, which is associated with early mortality compared with the nonschizophrenic population. Early diagnosis of cardiovascular diseases in asymptomatic periods in patients with schizophrenia would enhance their quality of life and reduce mortality. Echocardiography, carotid ultrasonography, and ankle brachial index (ABI) measurement are known to be beneficial methods of detecting subclinical cardiovascular diseases and of risk stratification. The present study investigated carotid intima media thickness (CIMT) and ABI and echocardiographic parameters measured via conventional and tissue Doppler echocardiography in patients with schizophrenia in comparison with a control group. Methods: The present case-control study included 116 patients with schizophrenia and 88 healthy patients. Participants with any current comorbid psychiatric disorder, current or lifetime neurological and medical problems, current coronary artery disease, diabetes, hypertension, hypothyroidism, or hyperthyroidism or who were using antihypertensives, antidiabetic agents, or antiobesity drugs were excluded. High-resolution B-mode ultrasound images were used to measure CIMT. Conventional and tissue Doppler measurements were performed according to the recommendations of the American Society of Echocardiography. Results: Low ABI, mitral ratio of the early (E) to late (A) ventricular filling velocities, septal E′, septal S′, lateral E′, lateral S′, septal E′/septal A′, lateral E′/lateral A′, and high septal A′, mitral E/septal E′, mitral E/lateral E′, and CIMT values were observed in the schizophrenia group compared with the control group. Conclusion: Doppler parameters supported the hypothesis that patients with schizophrenia are at high risk for cardiovascular diseases.

Dicle Medical …, 2010

Objectives: The aim of this study was to investigate the relationship between subclinical hypothy... more Objectives: The aim of this study was to investigate the relationship between subclinical hypothyroid and QTc dispersionindicating local heterogeneity in repolarization of myocardium, which is well known as independent cardiac risk factor for sudden death and ...