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American Heart Journal, 2001
are elevated during inflammatory conditions. 8,10-12 The current study tested the hypothesis that... more are elevated during inflammatory conditions. 8,10-12 The current study tested the hypothesis that chronic inflammation and endothelial activation may be present in patients with heart failure and may contribute to the pathogenesis of this syndrome. We compared the plasma levels of circulating VCAM-1 and ICAM-1 in patients with heart failure with and without underlying coronary artery disease with those of healthy control subjects. Methods Patients Three groups were studied: (1) 23 male patients aged 48 to 74 years (mean 65 ± 9 years) with chronic heart failure and coronary artery disease (ischemic cardiomyopathy), (2) 12 patients (9 male, 3 female), aged 51 to 78 years (mean 64 ± 8 years) with chronic heart failure without coronary artery disease (dilated cardiomyopathy), and (3) 11 healthy volunteers (8 male, 3 female, mean age 49 ± 14 years) with normal exercise capacity, no clinical history of chest pain, and without risk factors for coronary artery disease. Medical history and information about risk factors for coronary artery disease were obtained from standardized and validated interviewer-administered questionnaires. All patients underwent coronary angiography, and coronary artery disease was diagnosed as >20%
American Heart Journal, 2001
are elevated during inflammatory conditions. 8,10-12 The current study tested the hypothesis that... more are elevated during inflammatory conditions. 8,10-12 The current study tested the hypothesis that chronic inflammation and endothelial activation may be present in patients with heart failure and may contribute to the pathogenesis of this syndrome. We compared the plasma levels of circulating VCAM-1 and ICAM-1 in patients with heart failure with and without underlying coronary artery disease with those of healthy control subjects. Methods Patients Three groups were studied: (1) 23 male patients aged 48 to 74 years (mean 65 ± 9 years) with chronic heart failure and coronary artery disease (ischemic cardiomyopathy), (2) 12 patients (9 male, 3 female), aged 51 to 78 years (mean 64 ± 8 years) with chronic heart failure without coronary artery disease (dilated cardiomyopathy), and (3) 11 healthy volunteers (8 male, 3 female, mean age 49 ± 14 years) with normal exercise capacity, no clinical history of chest pain, and without risk factors for coronary artery disease. Medical history and information about risk factors for coronary artery disease were obtained from standardized and validated interviewer-administered questionnaires. All patients underwent coronary angiography, and coronary artery disease was diagnosed as >20%