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Papers by nadica kovacevic
Vojnosanitetski Pregled, 2023
Background/Aim. Quantitative hepatitis B virus (HBV) surface antigen (qHBsAg) has become increasi... more Background/Aim. Quantitative hepatitis B virus (HBV) surface antigen (qHBsAg) has become increasingly widespread in the last few years in both diagnostic and therapeutic protocols for HBV infection. Numerous studies have proposed it as a surrogate marker for covalently closed circular DNA (cccDNA). The aim of the study was to determine the correlation between qHBsAg and HBV DNA viremia in untreated patients. Methods. The study included 112 untreated patients diagnosed with chronic HBV infection. Demographic and other data from medical records and laboratory analyses, taken as part of routine chronic HBV infection diagnosis with the determination of qHBsAg and HBV DNA viremia, were recorded for all patients. Results. The average age of the patients included in the study was 48.27 ± 15.14 years; males (58%) were more represented. qHBsAg levels had a high-intensity positive correlation with HBV DNA viremia. The concentration of qHBsAg, HBV DNA viremia, and the concentrations of alanine aminotransferase and aspartate aminotransferase showed statistically significantly higher values in HBV e antigen (HBeAg)-positive than in HBeAg-negative patients. Conclusion. Our study showed that qHBsAg has a highintensity positive correlation with HBV DNA viremia. The use of qHBsAg is essential for determining the phase of chronic HBV infection, assessment of the success and length of treatment, as well as for safe discontinuation of antiviral therapy with a lower risk of relapse.
Medicinski Pregled, 2014
Sažetak Uvod. Hronična hepatitis C virusna infekcija u starijem životnom dobu nije mnogo proučava... more Sažetak Uvod. Hronična hepatitis C virusna infekcija u starijem životnom dobu nije mnogo proučavana iako se očekuje porast prevalencije ove bolesti u starijoj populaciji. Materijal i metode. U radu su prikazane kliničko-epidemiološke karakteristike hroničnog hepatitisa kod 153 bolesnika starosti 65 i više godina, lečenih na Klinici za infektivne bolesti Kliničkog centra Vojvodine u Novom Sadu. Rezultati. Nešto zastupljenije su bile osobe ženskog pola − 55,55%; hepatitis C virusna infekcija je najčešće otkrivena slučajno, prilikom drugih pregleda, i najčešće je stečena postransfuziono-u 42,48% slučajeva. Prosečna dužina trajanja infekcije bila je 28,48 godina; ubedljivo najčešće je bila izazvana genotipom 1 hepatitis C virusa i patohistološkim pregledom biopsije jetre se najčešće radilo o teškoj fibrozi i cirozi − 72,22% slučajeva. Uspeh antivirusne terapije primenjene kod 16 bolesnika iznosio je 62,5%. Zaključak. Antivirusna terapija se kod osoba starijeg životnog doba retko primenjuje, ali uspeh od 62,5% u našem uzorku ukazuje na opravdanu primenu terapije uprkos starosti i komorbiditetima.
Medicina
Background: This study aimed to investigate the clinical form, risk factors, and outcomes of pati... more Background: This study aimed to investigate the clinical form, risk factors, and outcomes of patients with COVID-19 and Clostridioides difficile co-infections. Methods: This retrospective study (2 September 2021–1 April 2022) included all patients with Clostridioides difficile infection (CDI) and COVID-19 infection who were admitted to the Covid Hospital of the University Clinical Center of Vojvodina. Results: A total of 5124 COVID-19 patients were admitted to the Covid Hospital, and 326 of them (6.36%) developed hospital-onset CDI. Of those, 326 of the CDI patients (88.65%) were older than 65 years. The median time of CDI onset was 12.88 days. Previous hospitalizations showed 69.93% of CDI patients compared to 38.81% in the non-CDI group (p = 0.029). The concomitant antibiotics exposure was higher among the CDI group versus the non-CDI group (88.65% vs. 68.42%, p = 0.037). Albumin levels were ≤ 25 g/L among 39.57% of the CDI patients and 21.71% in the non-CDI patients (p = 0.021). ...
Microorganisms
The aim of this study was to investigate the differences of Clostridioides difficile infection (C... more The aim of this study was to investigate the differences of Clostridioides difficile infection (CDI) during the COVID-19 pandemic compared to the pre-COVID-19 era. CDI patients treated at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Serbia during 2017–2019 (n = 304) were compared with COVID-19/CDI patients treated in period September 2021–September 2022 (n = 387). Groups were compared by age, gender, comorbidities, previous medications, laboratory findings, and outcome within 30 days. In the CDI/COVID-19 group, we found: greater percentage of males 59.8% vs. 42.6% (p ≤ 0.001), older age 72.8 ± 9.4 vs. 65.6 ± 11.7 (p ≤ 0.001), higher Charlson comorbidity score (CCS) (3.06 ± 1.54 vs. 2.33 ± 1.34 (p ≤ 0.001), greater percentage of chronic renal failure (33.9% vs. 23.4% (p = 0.003), malignances (24.3% vs. 13.5% (p ≤ 0.001), chronic obstructive pulmonary disease (22.7% vs. 15.5% (p = 0.017), higher usage of macrolide (38.5% vs. 8.6% (p ≤ 0.001), greater percentage of...
Journal of Clinical and Experimental Hepatology, 2014
levels in HBeAg positive chronic HBV infected were 5410.17 IU/ml and 1.86x10 9 IU/ml with a corre... more levels in HBeAg positive chronic HBV infected were 5410.17 IU/ml and 1.86x10 9 IU/ml with a correlation coefficient of À0.184 (P = 0.256). The mean qHBsAg and HBV-DNA levels in HBeAg negative chronic HBV infected were 5229.24 IU/ml and 1.8x10 7 IU/ml with a correlation coefficient of 0.044 (P = 0.583). The HBV-DNA levels were significantly higher in HBeAg positive patients (1.86Â10 9 vs 1.8x10 7 ; P = 0.003). Conclusion: There is no significant correlation between quantitative HBsAg levels and HBV-DNA levels irrespective of the HBeAg status. HBV-DNA levels are significantly higher in HBeAg positive patients.
Medicinski pregled
Infectious diseases are a part of the history of this region. Devastating epidemics of plague, sm... more Infectious diseases are a part of the history of this region. Devastating epidemics of plague, smallpox, and cholera were frequent during the 18th and the 19th centuries. Other infectious diseases were a serious problem as well: alimentary tract infections, scarlet fever, diphtheria, whooping cough. Geographic position, climate, migrations, as well as the tradition and lack of medical staff and medications, affected the frequency and outcome of infections. Patients with infectious diseases were first treated at home. Later, a hospital in Visarion street was opened as an isolation facility and a hospital for homeless patients. The development of science and the education of medical personnel exerted the greatest influence on the control and later treatment of infectious diseases. These measures resulted in the establishment of the first specialized medical institutions in Novi Sad during the cholera outbreak in 1884. After that, temporary pediatric units were organized for the treatm...
Medicinski pregled, 2014
Introduction. Clostridium difficile is the most common infectious cause of nosocomial diarrhea. R... more Introduction. Clostridium difficile is the most common infectious cause of nosocomial diarrhea. Recommended treatments for Clostridium difficile infection include metronidazole and vancomycin. Recent investigation has shown an increasing rate of metronidazole treatment failure, particularly among the elderly. The authors studied the outcome of metronidazole therapy for Clostridium difficile infection in patients over 65 years of age and risk factors associated with metronidazole treatment failure. Material and Methods. This retrospective study was performed at the Department of Infectious Diseases, Clinical Center of Vojvodina from January 2011 to January 2014. The study sample included 112 patients, over 65 years of age, diagnosed with Clostridium difficile infection, who were treated with oral metronidazole 400 mg 3 times per day for 10 days. The efficacy of treatment regimen was assessed by resolution of diarrhea and rates of recurrence within 60 days after completion of therapy ...
Medicinski pregled, 2013
Introduction. Clostridium difficile enterocolitis is a potentially fatal disease showing increasi... more Introduction. Clostridium difficile enterocolitis is a potentially fatal disease showing increasing incidence in hospital environment. Therapeutic approach in the management of Clostridium difficile enterocolitis is highly complex, particularly because of its tendency to relapse and reinfection. The study was aimed at investigating the factors influencing the development of Clostridium difficile enterocolitis and outcomes of enterocolitis after administration of standard antimicrobial therapy combined with probiotic supplement. Material and Methods. A non-comparative prospective observational study encompassed 42 patients (22 males and 20 females) diagnosed with Clostridium difficile enterocolitis and treated at the Department of Infectious Diseases in Novi Sad in the period October 2011 - April 2012. Results. Higher incidence of the disease was found in elderly patients (78.6% of them were over 60 years of age), after antimicrobial therapy (83.8%), after hospitalization (83.3%) and...
Biology of Blood and Marrow Transplantation, 2014
serotherapy exposure good OS (low NRM) was noted in a high-risk group of HCT patients.
Minerva Gastroenterology, 2022
Medical review
Introduction. The end of 20th and beginning of 21st century is marked by the discovery of new, su... more Introduction. The end of 20th and beginning of 21st century is marked by the discovery of new, supercontagious and fast spreading viral diseases. Since 1967, more than 40 new agents have been identified, including human immunodeficiency virus, Ebola, Marburg fever, severe acute respiratory syndrome, hepatitis C, hepatitis E viruses and Zika virus. Modern lifestyle, availability and speed of air traffic, migrations, as well as climate changes, enable faster spreading of infectious diseases from the regions that were hardly reachable. We selected a few diseases that raised the greatest attention among experts and public in general. Ebola. Ebola virus raises anxiety due to high mortality and fast spreading by using inter-human contact. Zika virus. Zika virus, that most often causes mild symptoms, is potentially responsible for microcephaly in neonates. Dengue. Dengue virus is an ?old story?, but in last decades incidence has multiplied by 30. West Nile virus. Although discovered in 193...
Vojnosanitetski pregled
Background/Aim. Hepatic steatosis in patients with chronic hepatitis C occurs in about half of th... more Background/Aim. Hepatic steatosis in patients with chronic hepatitis C occurs in about half of the cases. Its occurrence is influenced by factors of the host and viral factors and its importance lies in the fact that it reduces the success of antiviral therapy based on interferon in the treatment of chronic hepatitis C and that, associated with other factors, exacerbates liver disease. The aim of this study was to determine the prevalence and severity of steatosis in patients with chronic hepatitis C and to determine the factors that affect its occurrence. Methods. The study included 123 patients with chronic hepatitis C with diagnosis of liver steatosis made by liver biopsy and histopathological examination according to which ? 5% of hepatocytes was affected by fatty change. Based on the presence of steatosis, the patients were divided into two groups: 43 patients with steatosis and 80 patients without steatosis. The influence of certain factors on the occurrence of steatosis was e...
Srpski arhiv za celokupno lekarstvo, 2017
Introduction/Objective. Viral gastroenteritides (VGEs) have great infectious potential and may oc... more Introduction/Objective. Viral gastroenteritides (VGEs) have great infectious potential and may occur in all age groups. Loss of fluid due to vomiting and diarrhea represent a special risk, and may result in a more severe clinical presentation in children, the elderly, and people with chronic diseases. The aim of the study was to explore the causes of VGEs among hospitalized patients, as well as to evaluate the severity of clinical symptoms in rotavirus and norovirus infections. Methods. The observational prospective study included 191 patients aged 2?88 years who were treated at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Novi Sad, over a two-year period. Testing of stool samples for viral agents was done by the reverse-transcription polymerase chain reaction method. Positive findings were found in 59 patients. Results. Of 59 patients with confirmed viral gastroenteritis, in 31 (52.5%) it was caused by rotavirus, in 17 (28.8%) by norovirus, three patients (5.1%...
Vojnosanitetski pregled, 2013
Background/Aim. Most infections caused by influenza A (H1N1) 2009 virus are presented by mild res... more Background/Aim. Most infections caused by influenza A (H1N1) 2009 virus are presented by mild respiratory symptoms. However, some patients required admission to the intensive care unit (ICU). In this article we aimed to describe the clinical and laboratory characteristics of the patients with influenza A (H1N1) 2009, antiviral therapy use, the disease outcome and risk factors associated with the severe disease. Methods. The patients with the signs and symptoms of novel influenza A (H1N1) 2009, admitted to the Clinic for Infectious Disease in Novi Sad, were evaluated. The study included 293 patients hospitalized between October 2009 and February 2010. Basic demographic data, underlying medical conditions, clinical signs and symptoms, duration of the disease before the admission, laboratory tests, radiographic findings, treatment, and the final outcome (survived, died) were all noted. Factors associated with severe disease requiring ICU admission were determined by comparing the ICU c...
Medicinski pregled, 2014
Introduction. The aim of the retrospective part of this research was to present the risk factors,... more Introduction. The aim of the retrospective part of this research was to present the risk factors, etiology, clinical picture, therapy and outcome of urinary infections in elderly patients treated at the Department of Infectious Diseases in Novi Sad. The prospective part was aimed at establishing the most common risk factors for urinary infections among users in the Gerontology Center "Novi Sad? and determining the appropriate preventive measures by using an assessment questionnaire. Material and Methods. The retrospective research included 81 patients diagnosed with urinary infection. The patients were over 65 years of age and were treated at the Department of Infectious Diseases in the period from 2010 to September 2012. Within the prospective part of research, a poll was conducted among users of Gerontology Center ?Novi Sad? by applying an "Urination Disorder Test? questionnaire. Results. The average age of participants was 75.47 years (min 65, max 96, SD 6.86), and the ...
Medicinski pregled
The aim of this article was to point to ubiquitous adenoviral infections and to give a literature... more The aim of this article was to point to ubiquitous adenoviral infections and to give a literature overview. Adenoviral infections present with a variety of clinical manifestations, causing many differential diagnosis problems. In our country diagnosis is made using the complement fixation test (CFT), which detects antibodies due to soluble group specific antigen. In acute infections, we need two sera samples given in 2 weeks period with 4-fold rise or fall in titers. Due to many asymptomatic infections which can given increased titer by CFT, many physicians think that patients have a persistent infection. Persistent adenoviral infections need not be accompanied by any special clinical symptomatology. However, adenoviral infections still play an important role in acute respiratory infections. The most severe respiratory infection is pneumonia which can be associated with acute respiratory distress syndrome and death. Disseminated adenoviral diseases appear in 2.5% of all adenoviral i...
Medicinski pregled, 2014
Introduction. Osteoporosis is a chronic, progressive bone disease which leads to a reduction in b... more Introduction. Osteoporosis is a chronic, progressive bone disease which leads to a reduction in bone mineral density and disruption of bone micro-architecture. Patients with osteoporosis have an increased risk of fractures caused by ?small trauma? - stresses which would not normally cause fracture in a non-osteoporotic individual. This study was aimed at determining the incidence of osteoporosis in geriatric population, crucial demographic parameters (gender and age structure) in patients, presence of comorbidities, and the most common drug choice in treatment of osteoporosis. Material and Methods. A retrospective study was conducted in the period from August 1st, 2012 to May 12th, 2014 and it included 526 patients over 65 years of age who were diagnosed to have osteoporosis based on clinical findings (presence/absence of pathological fractures), laboratory tests and osteodensitometry. Data were analyzed by using standard statistical methods and statistical significance was assessed...
Medicinski glasnik
Sažetak Cilj retrospektivnog dela istraživanja bio je da se prikažu faktori rizika, etiologija, k... more Sažetak Cilj retrospektivnog dela istraživanja bio je da se prikažu faktori rizika, etiologija, klinička slika, primenjena terapija i ishod urinarnih infekcija kod starijih osoba koje su lečene na Klinici za infektivne bolesti u Novom Sadu. Cilj prospektivnog dela studije bio je da se primenom upitnika utvrde najčešći faktori rizika za urinarne infekcije među korisnicima Gerontološkog centra "Novi Sad". Materijal i metode. Retrospektivni deo istraživanja obuhvatio je 81 bolesnika sa dijagnozom urinarne infekcije koji su bili stariji od 65 godina i koji su lečeni na Klinici za infektivne bolesti u periodu od 2010. do septembra 2012. Prospektivni deo istraživanja obavljen je anketiranjem korisnika Gerontološkog centra "Novi Sad" pomoću upitnika "Test poremećaja mokrenja". Rezultati. Prosečna starost iznosila je 75,47 godina (min. 65, max. 96, SD 6,86), dominirao je ženski pol (Ž : M = 58%:42%). Pridružene bolesti registrovane su kod 53 (65,4%) bolesnika, od kojih je 24 (29,6%) imalo hipertenziju. E. coli izolovana je kod 12 (46,2%). Pri prijemu, febrilnost je zabeležena kod 60 (75,95%), znaci intoksikacije kod 33 (41,8%), na disuriju se žalilo 23 (29,1%), na polakisuriju 9 (11,4%), na suprapubični bol 8 (10,1%) i na bol u lumbalnoj loži 7 (8,9%) bolesnika. Najčešće upotrebljavani antibiotici bili su cefriakson kod 43 (56,6%) i ciprofloksacin kod 33 (43,3%). Ishod bolesti bio je povoljan kod 79 (97,5%) dok je smrtni ishod nastupio kod 2 (2,5%) bolesnika. Među korisnicima gerontološkog centra česte urinarne infekcije imalo je 9 (22,5%), nokturiju 25 (62,5%) a inkontinenciju 16 (40%). Najčešće pridružene bolesti bile su dijabetes melitus i terapijski zahvati na prostati i mokraćnoj bešici kod 7 (17,5%) i moždani udar kod 5 (12,5%) ispitanika. Zaključak. Dijagnoza uroinfekcija kod starih predstavlja izazov, kako u dijagnostici tako i u lečenju. Potrebno je ažurirati smernice antimikrobnog lečenja kako bi se smanjila nekritična upotreba antibiotika u asimptomatskoj bakteriuriji i sprečilo širenje multirezistentnih mikoorganizama.
Vojnosanitetski Pregled, 2023
Background/Aim. Quantitative hepatitis B virus (HBV) surface antigen (qHBsAg) has become increasi... more Background/Aim. Quantitative hepatitis B virus (HBV) surface antigen (qHBsAg) has become increasingly widespread in the last few years in both diagnostic and therapeutic protocols for HBV infection. Numerous studies have proposed it as a surrogate marker for covalently closed circular DNA (cccDNA). The aim of the study was to determine the correlation between qHBsAg and HBV DNA viremia in untreated patients. Methods. The study included 112 untreated patients diagnosed with chronic HBV infection. Demographic and other data from medical records and laboratory analyses, taken as part of routine chronic HBV infection diagnosis with the determination of qHBsAg and HBV DNA viremia, were recorded for all patients. Results. The average age of the patients included in the study was 48.27 ± 15.14 years; males (58%) were more represented. qHBsAg levels had a high-intensity positive correlation with HBV DNA viremia. The concentration of qHBsAg, HBV DNA viremia, and the concentrations of alanine aminotransferase and aspartate aminotransferase showed statistically significantly higher values in HBV e antigen (HBeAg)-positive than in HBeAg-negative patients. Conclusion. Our study showed that qHBsAg has a highintensity positive correlation with HBV DNA viremia. The use of qHBsAg is essential for determining the phase of chronic HBV infection, assessment of the success and length of treatment, as well as for safe discontinuation of antiviral therapy with a lower risk of relapse.
Medicinski Pregled, 2014
Sažetak Uvod. Hronična hepatitis C virusna infekcija u starijem životnom dobu nije mnogo proučava... more Sažetak Uvod. Hronična hepatitis C virusna infekcija u starijem životnom dobu nije mnogo proučavana iako se očekuje porast prevalencije ove bolesti u starijoj populaciji. Materijal i metode. U radu su prikazane kliničko-epidemiološke karakteristike hroničnog hepatitisa kod 153 bolesnika starosti 65 i više godina, lečenih na Klinici za infektivne bolesti Kliničkog centra Vojvodine u Novom Sadu. Rezultati. Nešto zastupljenije su bile osobe ženskog pola − 55,55%; hepatitis C virusna infekcija je najčešće otkrivena slučajno, prilikom drugih pregleda, i najčešće je stečena postransfuziono-u 42,48% slučajeva. Prosečna dužina trajanja infekcije bila je 28,48 godina; ubedljivo najčešće je bila izazvana genotipom 1 hepatitis C virusa i patohistološkim pregledom biopsije jetre se najčešće radilo o teškoj fibrozi i cirozi − 72,22% slučajeva. Uspeh antivirusne terapije primenjene kod 16 bolesnika iznosio je 62,5%. Zaključak. Antivirusna terapija se kod osoba starijeg životnog doba retko primenjuje, ali uspeh od 62,5% u našem uzorku ukazuje na opravdanu primenu terapije uprkos starosti i komorbiditetima.
Medicina
Background: This study aimed to investigate the clinical form, risk factors, and outcomes of pati... more Background: This study aimed to investigate the clinical form, risk factors, and outcomes of patients with COVID-19 and Clostridioides difficile co-infections. Methods: This retrospective study (2 September 2021–1 April 2022) included all patients with Clostridioides difficile infection (CDI) and COVID-19 infection who were admitted to the Covid Hospital of the University Clinical Center of Vojvodina. Results: A total of 5124 COVID-19 patients were admitted to the Covid Hospital, and 326 of them (6.36%) developed hospital-onset CDI. Of those, 326 of the CDI patients (88.65%) were older than 65 years. The median time of CDI onset was 12.88 days. Previous hospitalizations showed 69.93% of CDI patients compared to 38.81% in the non-CDI group (p = 0.029). The concomitant antibiotics exposure was higher among the CDI group versus the non-CDI group (88.65% vs. 68.42%, p = 0.037). Albumin levels were ≤ 25 g/L among 39.57% of the CDI patients and 21.71% in the non-CDI patients (p = 0.021). ...
Microorganisms
The aim of this study was to investigate the differences of Clostridioides difficile infection (C... more The aim of this study was to investigate the differences of Clostridioides difficile infection (CDI) during the COVID-19 pandemic compared to the pre-COVID-19 era. CDI patients treated at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Serbia during 2017–2019 (n = 304) were compared with COVID-19/CDI patients treated in period September 2021–September 2022 (n = 387). Groups were compared by age, gender, comorbidities, previous medications, laboratory findings, and outcome within 30 days. In the CDI/COVID-19 group, we found: greater percentage of males 59.8% vs. 42.6% (p ≤ 0.001), older age 72.8 ± 9.4 vs. 65.6 ± 11.7 (p ≤ 0.001), higher Charlson comorbidity score (CCS) (3.06 ± 1.54 vs. 2.33 ± 1.34 (p ≤ 0.001), greater percentage of chronic renal failure (33.9% vs. 23.4% (p = 0.003), malignances (24.3% vs. 13.5% (p ≤ 0.001), chronic obstructive pulmonary disease (22.7% vs. 15.5% (p = 0.017), higher usage of macrolide (38.5% vs. 8.6% (p ≤ 0.001), greater percentage of...
Journal of Clinical and Experimental Hepatology, 2014
levels in HBeAg positive chronic HBV infected were 5410.17 IU/ml and 1.86x10 9 IU/ml with a corre... more levels in HBeAg positive chronic HBV infected were 5410.17 IU/ml and 1.86x10 9 IU/ml with a correlation coefficient of À0.184 (P = 0.256). The mean qHBsAg and HBV-DNA levels in HBeAg negative chronic HBV infected were 5229.24 IU/ml and 1.8x10 7 IU/ml with a correlation coefficient of 0.044 (P = 0.583). The HBV-DNA levels were significantly higher in HBeAg positive patients (1.86Â10 9 vs 1.8x10 7 ; P = 0.003). Conclusion: There is no significant correlation between quantitative HBsAg levels and HBV-DNA levels irrespective of the HBeAg status. HBV-DNA levels are significantly higher in HBeAg positive patients.
Medicinski pregled
Infectious diseases are a part of the history of this region. Devastating epidemics of plague, sm... more Infectious diseases are a part of the history of this region. Devastating epidemics of plague, smallpox, and cholera were frequent during the 18th and the 19th centuries. Other infectious diseases were a serious problem as well: alimentary tract infections, scarlet fever, diphtheria, whooping cough. Geographic position, climate, migrations, as well as the tradition and lack of medical staff and medications, affected the frequency and outcome of infections. Patients with infectious diseases were first treated at home. Later, a hospital in Visarion street was opened as an isolation facility and a hospital for homeless patients. The development of science and the education of medical personnel exerted the greatest influence on the control and later treatment of infectious diseases. These measures resulted in the establishment of the first specialized medical institutions in Novi Sad during the cholera outbreak in 1884. After that, temporary pediatric units were organized for the treatm...
Medicinski pregled, 2014
Introduction. Clostridium difficile is the most common infectious cause of nosocomial diarrhea. R... more Introduction. Clostridium difficile is the most common infectious cause of nosocomial diarrhea. Recommended treatments for Clostridium difficile infection include metronidazole and vancomycin. Recent investigation has shown an increasing rate of metronidazole treatment failure, particularly among the elderly. The authors studied the outcome of metronidazole therapy for Clostridium difficile infection in patients over 65 years of age and risk factors associated with metronidazole treatment failure. Material and Methods. This retrospective study was performed at the Department of Infectious Diseases, Clinical Center of Vojvodina from January 2011 to January 2014. The study sample included 112 patients, over 65 years of age, diagnosed with Clostridium difficile infection, who were treated with oral metronidazole 400 mg 3 times per day for 10 days. The efficacy of treatment regimen was assessed by resolution of diarrhea and rates of recurrence within 60 days after completion of therapy ...
Medicinski pregled, 2013
Introduction. Clostridium difficile enterocolitis is a potentially fatal disease showing increasi... more Introduction. Clostridium difficile enterocolitis is a potentially fatal disease showing increasing incidence in hospital environment. Therapeutic approach in the management of Clostridium difficile enterocolitis is highly complex, particularly because of its tendency to relapse and reinfection. The study was aimed at investigating the factors influencing the development of Clostridium difficile enterocolitis and outcomes of enterocolitis after administration of standard antimicrobial therapy combined with probiotic supplement. Material and Methods. A non-comparative prospective observational study encompassed 42 patients (22 males and 20 females) diagnosed with Clostridium difficile enterocolitis and treated at the Department of Infectious Diseases in Novi Sad in the period October 2011 - April 2012. Results. Higher incidence of the disease was found in elderly patients (78.6% of them were over 60 years of age), after antimicrobial therapy (83.8%), after hospitalization (83.3%) and...
Biology of Blood and Marrow Transplantation, 2014
serotherapy exposure good OS (low NRM) was noted in a high-risk group of HCT patients.
Minerva Gastroenterology, 2022
Medical review
Introduction. The end of 20th and beginning of 21st century is marked by the discovery of new, su... more Introduction. The end of 20th and beginning of 21st century is marked by the discovery of new, supercontagious and fast spreading viral diseases. Since 1967, more than 40 new agents have been identified, including human immunodeficiency virus, Ebola, Marburg fever, severe acute respiratory syndrome, hepatitis C, hepatitis E viruses and Zika virus. Modern lifestyle, availability and speed of air traffic, migrations, as well as climate changes, enable faster spreading of infectious diseases from the regions that were hardly reachable. We selected a few diseases that raised the greatest attention among experts and public in general. Ebola. Ebola virus raises anxiety due to high mortality and fast spreading by using inter-human contact. Zika virus. Zika virus, that most often causes mild symptoms, is potentially responsible for microcephaly in neonates. Dengue. Dengue virus is an ?old story?, but in last decades incidence has multiplied by 30. West Nile virus. Although discovered in 193...
Vojnosanitetski pregled
Background/Aim. Hepatic steatosis in patients with chronic hepatitis C occurs in about half of th... more Background/Aim. Hepatic steatosis in patients with chronic hepatitis C occurs in about half of the cases. Its occurrence is influenced by factors of the host and viral factors and its importance lies in the fact that it reduces the success of antiviral therapy based on interferon in the treatment of chronic hepatitis C and that, associated with other factors, exacerbates liver disease. The aim of this study was to determine the prevalence and severity of steatosis in patients with chronic hepatitis C and to determine the factors that affect its occurrence. Methods. The study included 123 patients with chronic hepatitis C with diagnosis of liver steatosis made by liver biopsy and histopathological examination according to which ? 5% of hepatocytes was affected by fatty change. Based on the presence of steatosis, the patients were divided into two groups: 43 patients with steatosis and 80 patients without steatosis. The influence of certain factors on the occurrence of steatosis was e...
Srpski arhiv za celokupno lekarstvo, 2017
Introduction/Objective. Viral gastroenteritides (VGEs) have great infectious potential and may oc... more Introduction/Objective. Viral gastroenteritides (VGEs) have great infectious potential and may occur in all age groups. Loss of fluid due to vomiting and diarrhea represent a special risk, and may result in a more severe clinical presentation in children, the elderly, and people with chronic diseases. The aim of the study was to explore the causes of VGEs among hospitalized patients, as well as to evaluate the severity of clinical symptoms in rotavirus and norovirus infections. Methods. The observational prospective study included 191 patients aged 2?88 years who were treated at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Novi Sad, over a two-year period. Testing of stool samples for viral agents was done by the reverse-transcription polymerase chain reaction method. Positive findings were found in 59 patients. Results. Of 59 patients with confirmed viral gastroenteritis, in 31 (52.5%) it was caused by rotavirus, in 17 (28.8%) by norovirus, three patients (5.1%...
Vojnosanitetski pregled, 2013
Background/Aim. Most infections caused by influenza A (H1N1) 2009 virus are presented by mild res... more Background/Aim. Most infections caused by influenza A (H1N1) 2009 virus are presented by mild respiratory symptoms. However, some patients required admission to the intensive care unit (ICU). In this article we aimed to describe the clinical and laboratory characteristics of the patients with influenza A (H1N1) 2009, antiviral therapy use, the disease outcome and risk factors associated with the severe disease. Methods. The patients with the signs and symptoms of novel influenza A (H1N1) 2009, admitted to the Clinic for Infectious Disease in Novi Sad, were evaluated. The study included 293 patients hospitalized between October 2009 and February 2010. Basic demographic data, underlying medical conditions, clinical signs and symptoms, duration of the disease before the admission, laboratory tests, radiographic findings, treatment, and the final outcome (survived, died) were all noted. Factors associated with severe disease requiring ICU admission were determined by comparing the ICU c...
Medicinski pregled, 2014
Introduction. The aim of the retrospective part of this research was to present the risk factors,... more Introduction. The aim of the retrospective part of this research was to present the risk factors, etiology, clinical picture, therapy and outcome of urinary infections in elderly patients treated at the Department of Infectious Diseases in Novi Sad. The prospective part was aimed at establishing the most common risk factors for urinary infections among users in the Gerontology Center "Novi Sad? and determining the appropriate preventive measures by using an assessment questionnaire. Material and Methods. The retrospective research included 81 patients diagnosed with urinary infection. The patients were over 65 years of age and were treated at the Department of Infectious Diseases in the period from 2010 to September 2012. Within the prospective part of research, a poll was conducted among users of Gerontology Center ?Novi Sad? by applying an "Urination Disorder Test? questionnaire. Results. The average age of participants was 75.47 years (min 65, max 96, SD 6.86), and the ...
Medicinski pregled
The aim of this article was to point to ubiquitous adenoviral infections and to give a literature... more The aim of this article was to point to ubiquitous adenoviral infections and to give a literature overview. Adenoviral infections present with a variety of clinical manifestations, causing many differential diagnosis problems. In our country diagnosis is made using the complement fixation test (CFT), which detects antibodies due to soluble group specific antigen. In acute infections, we need two sera samples given in 2 weeks period with 4-fold rise or fall in titers. Due to many asymptomatic infections which can given increased titer by CFT, many physicians think that patients have a persistent infection. Persistent adenoviral infections need not be accompanied by any special clinical symptomatology. However, adenoviral infections still play an important role in acute respiratory infections. The most severe respiratory infection is pneumonia which can be associated with acute respiratory distress syndrome and death. Disseminated adenoviral diseases appear in 2.5% of all adenoviral i...
Medicinski pregled, 2014
Introduction. Osteoporosis is a chronic, progressive bone disease which leads to a reduction in b... more Introduction. Osteoporosis is a chronic, progressive bone disease which leads to a reduction in bone mineral density and disruption of bone micro-architecture. Patients with osteoporosis have an increased risk of fractures caused by ?small trauma? - stresses which would not normally cause fracture in a non-osteoporotic individual. This study was aimed at determining the incidence of osteoporosis in geriatric population, crucial demographic parameters (gender and age structure) in patients, presence of comorbidities, and the most common drug choice in treatment of osteoporosis. Material and Methods. A retrospective study was conducted in the period from August 1st, 2012 to May 12th, 2014 and it included 526 patients over 65 years of age who were diagnosed to have osteoporosis based on clinical findings (presence/absence of pathological fractures), laboratory tests and osteodensitometry. Data were analyzed by using standard statistical methods and statistical significance was assessed...
Medicinski glasnik
Sažetak Cilj retrospektivnog dela istraživanja bio je da se prikažu faktori rizika, etiologija, k... more Sažetak Cilj retrospektivnog dela istraživanja bio je da se prikažu faktori rizika, etiologija, klinička slika, primenjena terapija i ishod urinarnih infekcija kod starijih osoba koje su lečene na Klinici za infektivne bolesti u Novom Sadu. Cilj prospektivnog dela studije bio je da se primenom upitnika utvrde najčešći faktori rizika za urinarne infekcije među korisnicima Gerontološkog centra "Novi Sad". Materijal i metode. Retrospektivni deo istraživanja obuhvatio je 81 bolesnika sa dijagnozom urinarne infekcije koji su bili stariji od 65 godina i koji su lečeni na Klinici za infektivne bolesti u periodu od 2010. do septembra 2012. Prospektivni deo istraživanja obavljen je anketiranjem korisnika Gerontološkog centra "Novi Sad" pomoću upitnika "Test poremećaja mokrenja". Rezultati. Prosečna starost iznosila je 75,47 godina (min. 65, max. 96, SD 6,86), dominirao je ženski pol (Ž : M = 58%:42%). Pridružene bolesti registrovane su kod 53 (65,4%) bolesnika, od kojih je 24 (29,6%) imalo hipertenziju. E. coli izolovana je kod 12 (46,2%). Pri prijemu, febrilnost je zabeležena kod 60 (75,95%), znaci intoksikacije kod 33 (41,8%), na disuriju se žalilo 23 (29,1%), na polakisuriju 9 (11,4%), na suprapubični bol 8 (10,1%) i na bol u lumbalnoj loži 7 (8,9%) bolesnika. Najčešće upotrebljavani antibiotici bili su cefriakson kod 43 (56,6%) i ciprofloksacin kod 33 (43,3%). Ishod bolesti bio je povoljan kod 79 (97,5%) dok je smrtni ishod nastupio kod 2 (2,5%) bolesnika. Među korisnicima gerontološkog centra česte urinarne infekcije imalo je 9 (22,5%), nokturiju 25 (62,5%) a inkontinenciju 16 (40%). Najčešće pridružene bolesti bile su dijabetes melitus i terapijski zahvati na prostati i mokraćnoj bešici kod 7 (17,5%) i moždani udar kod 5 (12,5%) ispitanika. Zaključak. Dijagnoza uroinfekcija kod starih predstavlja izazov, kako u dijagnostici tako i u lečenju. Potrebno je ažurirati smernice antimikrobnog lečenja kako bi se smanjila nekritična upotreba antibiotika u asimptomatskoj bakteriuriji i sprečilo širenje multirezistentnih mikoorganizama.