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Papers by navanil barua

Research paper thumbnail of Spinal hydatid cyst – A rare case report from North-East India

Journal of spinal surgery, 2023

Research paper thumbnail of A retrospective epidemiological study of the World Health Organization (WHO)-classified primary brain and other Central Nervous System (CNS) tumors from a tertiary health care center in Northeast India

Egyptian Journal of Neurosurgery, Mar 13, 2023

Background Brain and other central nervous systems (CNS) tumors are a heterogeneous group of neop... more Background Brain and other central nervous systems (CNS) tumors are a heterogeneous group of neoplasms that are prevalent in all age groups and gender. The study aimed to investigate the pattern of distribution of World Health Organization (WHO) classified primary brain and other CNS tumors among different age groups and gender at a tertiary care center in Northeast India. This is the first study of CNS tumors from this region of the country. The data obtained can be useful for correct diagnosis, timely treatment, and management of CNS tumors in this area. It can also provide relevant information concerning research and funding for this disease. Data collection was done retrospectively from January 1996 to March 2022. Distribution frequency as per age, gender, histopathology type, and tumor location was estimated. Data analysis was performed using the SPSS software. Results A total of 1441 primary brain and other CNS tumors were examined in the study. There were 232 pediatric cases (16.1%) and 1209 adult cases (83.9%). The ratio of males to females was 1.4. The majority of the cases in the overall cohort were meningiomas (n = 346; 24%). Among the pediatric cohort, the maximum occurrence of gliomas, glioneuronal, and neuronal tumors (n = 68; 29.3%) was seen while meningiomas (n = 336; 27.8%) showed the highest prevalence in the adult cohort. There were 248 other distinct cases of CNS (17.2%) of which 62 (26.7%) were identified within the pediatric cohort and the remaining 186 (15.4%) were detected among the adult population. Most of the tumor sites was supratentorial areas (n = 759; 52.7%) with the next being spinal cord (n = 258; 18%). Conclusion This is the first study from Northeast India that highlights the prevalence of WHO-classified CNS tumors. With newer and advanced health care and diagnostic facilities, there is an increased incidence of CNS tumors in developing countries. Our study may help in understanding the epidemiological aspects and highlight the need for research, funding, and maintenance of a hospital-based tumor registry for this particular ailment.

Research paper thumbnail of Clinical profile, histopathological, immunohistochemical, and molecular analyses and treatment of pilocytic astrocytoma: an eight year study from a tertiary health care centre in North East India

Egyptian Journal of Neurosurgery

Background Pilocytic astrocytoma (PA) is a central nervous system (CNS) World Health Organization... more Background Pilocytic astrocytoma (PA) is a central nervous system (CNS) World Health Organization (WHO) grade 1 glial tumor that is highly prevalent in children and young adults. The main aim of the study was to assess the frequency, clinicopathological features, and treatment of PAs along with their immunohistochemical and molecular analyses in patients from Northeast India. About 144 glial tumors were diagnosed in patients from 3 to 75 yrs of age from January 2015 to March 2022. Nine pediatric PA patients were identified and their clinical data were analyzed. Immunohistochemistry (IHC), fluorescence in-situ hybridization (FISH), and molecular analysis using the real-time polymerase chain reaction (RT-PCR) were performed. Data analysis was performed using the SPSS software. Results The mean age of the glioma patients was 41.7 yrs ± 18.2 with a male/female ratio of 1.3:1. The most common form of the glial tumor was found to be astrocytoma CNS WHO grade 2 (31.9%). The frequency of PA...

Research paper thumbnail of Cervical Trident-Shaped Neurofibroma: A Rare Variant

Asian Journal of Neurosurgery

Spinal nerve root tumors can arise throughout the spine and at multiple levels, likely representi... more Spinal nerve root tumors can arise throughout the spine and at multiple levels, likely representing plexiform neurofibromas that grow from the nerve root into the intraspinal space either intradurally or epidurally and exit through the neural foramen, producing a dumbbell-shaped appearance. Although many cases of dumbbell-shaped extramedullary neurofibromas in the cervical spine have been reported, to the best of our knowledge, there are no reports of trident-shaped extramedullary neurofibromas. A 26-year-old woman presented with swelling over the right side of her neck. Diagnostic workup included magnetic resonance imaging (MRI) and contrast-enhanced computed tomography (CECT) of the neck, which revealed an intradural, extramedullary tumor mass at the right C2–C6 level with an extraspinal extension. Spinal cord compression or canal compromise is the most reliable indication for surgery. The solitary cervical neurofibroma was treated surgically in a single stage through laminoplasty...

Research paper thumbnail of Dumbbell-Shaped Hypoglossal Schwannoma- a Rare Case Report from Northeast India with Review of Literature

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, Mar 1, 2023

Research paper thumbnail of A retrospective epidemiological study of the World Health Organization (WHO)-classified primary brain and other Central Nervous System (CNS) tumors from a tertiary health care center in Northeast India

Egyptian Journal of Neurosurgery

Background Brain and other central nervous systems (CNS) tumors are a heterogeneous group of neop... more Background Brain and other central nervous systems (CNS) tumors are a heterogeneous group of neoplasms that are prevalent in all age groups and gender. The study aimed to investigate the pattern of distribution of World Health Organization (WHO) classified primary brain and other CNS tumors among different age groups and gender at a tertiary care center in Northeast India. This is the first study of CNS tumors from this region of the country. The data obtained can be useful for correct diagnosis, timely treatment, and management of CNS tumors in this area. It can also provide relevant information concerning research and funding for this disease. Data collection was done retrospectively from January 1996 to March 2022. Distribution frequency as per age, gender, histopathology type, and tumor location was estimated. Data analysis was performed using the SPSS software. Results A total of 1441 primary brain and other CNS tumors were examined in the study. There were 232 pediatric cases ...

Research paper thumbnail of Title p-300 wave in patients with post concussion vertigo: A prospective study of 15 cases

Indian Journal of Otolaryngology and Head and Neck Surgery, 1996

P-300 wave was recorded using auditory stimuli in 15 patients presenting with post concussion ver... more P-300 wave was recorded using auditory stimuli in 15 patients presenting with post concussion vertigo. The mean latency of the normal P300 recordings was 316.5 msec while that of the delayed recordings was 392.3 msec. 8 Patients had a bilateral and 4 had an unilateral delay in latency. 5 patients had normal latency bilaterally. The severity of symptoms was directly proportinoal to the delay in latency. This pilot study, though suggestive of a correlation between P300 wave and vertigo is inconclusive because of the limited number of patients studied.

Research paper thumbnail of Clinical profile, treatment, histopathological, immunohistochemical, and molecular analyses of pilocytic astrocytoma- an eight year study from a tertiary health care centre in North East India

Purpose: Pilocytic astrocytoma (PA) is a central nervous system (CNS) World Health Organization (... more Purpose: Pilocytic astrocytoma (PA) is a central nervous system (CNS) World Health Organization (WHO) grade 1 glial tumor that is highly prevalent in children and young adults. The main aim of the study was to assess the frequency, clinicopathological features and treatment of PAs along with their immunohistochemical and molecular analyses. Methods: Approximately, 144 glial tumors were diagnosed in patients from 3 to 75 yrs of age from January 2015 to March 2022. The tumors were classified according to 2021 CNS WHO classification. Nine pediatric PA patients were identified and their clinical data analyzed. Immunohistochemistry (IHC), fluorescence in-situ hybridization (FISH) and molecular analysis using the real time polymerase chain reaction (RT-PCR) were performed for the PAs. Standard deviations were calculated using the Microsoft excel for statistical validations. Results: The mean age of the glioma patients was 41.7 yrs ± 18.2 with a male/female ratio of 1.3:1. The most common ...

Research paper thumbnail of Title p-300 wave in patients with post concussion vertigo: A prospective study of 15 cases

P-300 wave was recorded using auditory stimuli in 15 patients presenting with post concussion ver... more P-300 wave was recorded using auditory stimuli in 15 patients presenting with post concussion vertigo. The mean latency of the normal P300 recordings was 316.5 msec while that of the delayed recordings was 392.3 msec. 6 Patients had a bilateral and 4 had an unilateral delay in latency. 5 patients had normal latency bilaterally. The severity of symptoms was directly proportinoal to the delay in latency. This pilot study, though suggestive of a correlation between P300 wave and vertigo is inconclusive because of the limited number of patients studied.

Research paper thumbnail of Spinal hydatid cyst – A rare case report from North-East India

Journal of spinal surgery, 2023

Research paper thumbnail of A retrospective epidemiological study of the World Health Organization (WHO)-classified primary brain and other Central Nervous System (CNS) tumors from a tertiary health care center in Northeast India

Egyptian Journal of Neurosurgery, Mar 13, 2023

Background Brain and other central nervous systems (CNS) tumors are a heterogeneous group of neop... more Background Brain and other central nervous systems (CNS) tumors are a heterogeneous group of neoplasms that are prevalent in all age groups and gender. The study aimed to investigate the pattern of distribution of World Health Organization (WHO) classified primary brain and other CNS tumors among different age groups and gender at a tertiary care center in Northeast India. This is the first study of CNS tumors from this region of the country. The data obtained can be useful for correct diagnosis, timely treatment, and management of CNS tumors in this area. It can also provide relevant information concerning research and funding for this disease. Data collection was done retrospectively from January 1996 to March 2022. Distribution frequency as per age, gender, histopathology type, and tumor location was estimated. Data analysis was performed using the SPSS software. Results A total of 1441 primary brain and other CNS tumors were examined in the study. There were 232 pediatric cases (16.1%) and 1209 adult cases (83.9%). The ratio of males to females was 1.4. The majority of the cases in the overall cohort were meningiomas (n = 346; 24%). Among the pediatric cohort, the maximum occurrence of gliomas, glioneuronal, and neuronal tumors (n = 68; 29.3%) was seen while meningiomas (n = 336; 27.8%) showed the highest prevalence in the adult cohort. There were 248 other distinct cases of CNS (17.2%) of which 62 (26.7%) were identified within the pediatric cohort and the remaining 186 (15.4%) were detected among the adult population. Most of the tumor sites was supratentorial areas (n = 759; 52.7%) with the next being spinal cord (n = 258; 18%). Conclusion This is the first study from Northeast India that highlights the prevalence of WHO-classified CNS tumors. With newer and advanced health care and diagnostic facilities, there is an increased incidence of CNS tumors in developing countries. Our study may help in understanding the epidemiological aspects and highlight the need for research, funding, and maintenance of a hospital-based tumor registry for this particular ailment.

Research paper thumbnail of Clinical profile, histopathological, immunohistochemical, and molecular analyses and treatment of pilocytic astrocytoma: an eight year study from a tertiary health care centre in North East India

Egyptian Journal of Neurosurgery

Background Pilocytic astrocytoma (PA) is a central nervous system (CNS) World Health Organization... more Background Pilocytic astrocytoma (PA) is a central nervous system (CNS) World Health Organization (WHO) grade 1 glial tumor that is highly prevalent in children and young adults. The main aim of the study was to assess the frequency, clinicopathological features, and treatment of PAs along with their immunohistochemical and molecular analyses in patients from Northeast India. About 144 glial tumors were diagnosed in patients from 3 to 75 yrs of age from January 2015 to March 2022. Nine pediatric PA patients were identified and their clinical data were analyzed. Immunohistochemistry (IHC), fluorescence in-situ hybridization (FISH), and molecular analysis using the real-time polymerase chain reaction (RT-PCR) were performed. Data analysis was performed using the SPSS software. Results The mean age of the glioma patients was 41.7 yrs ± 18.2 with a male/female ratio of 1.3:1. The most common form of the glial tumor was found to be astrocytoma CNS WHO grade 2 (31.9%). The frequency of PA...

Research paper thumbnail of Cervical Trident-Shaped Neurofibroma: A Rare Variant

Asian Journal of Neurosurgery

Spinal nerve root tumors can arise throughout the spine and at multiple levels, likely representi... more Spinal nerve root tumors can arise throughout the spine and at multiple levels, likely representing plexiform neurofibromas that grow from the nerve root into the intraspinal space either intradurally or epidurally and exit through the neural foramen, producing a dumbbell-shaped appearance. Although many cases of dumbbell-shaped extramedullary neurofibromas in the cervical spine have been reported, to the best of our knowledge, there are no reports of trident-shaped extramedullary neurofibromas. A 26-year-old woman presented with swelling over the right side of her neck. Diagnostic workup included magnetic resonance imaging (MRI) and contrast-enhanced computed tomography (CECT) of the neck, which revealed an intradural, extramedullary tumor mass at the right C2–C6 level with an extraspinal extension. Spinal cord compression or canal compromise is the most reliable indication for surgery. The solitary cervical neurofibroma was treated surgically in a single stage through laminoplasty...

Research paper thumbnail of Dumbbell-Shaped Hypoglossal Schwannoma- a Rare Case Report from Northeast India with Review of Literature

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, Mar 1, 2023

Research paper thumbnail of A retrospective epidemiological study of the World Health Organization (WHO)-classified primary brain and other Central Nervous System (CNS) tumors from a tertiary health care center in Northeast India

Egyptian Journal of Neurosurgery

Background Brain and other central nervous systems (CNS) tumors are a heterogeneous group of neop... more Background Brain and other central nervous systems (CNS) tumors are a heterogeneous group of neoplasms that are prevalent in all age groups and gender. The study aimed to investigate the pattern of distribution of World Health Organization (WHO) classified primary brain and other CNS tumors among different age groups and gender at a tertiary care center in Northeast India. This is the first study of CNS tumors from this region of the country. The data obtained can be useful for correct diagnosis, timely treatment, and management of CNS tumors in this area. It can also provide relevant information concerning research and funding for this disease. Data collection was done retrospectively from January 1996 to March 2022. Distribution frequency as per age, gender, histopathology type, and tumor location was estimated. Data analysis was performed using the SPSS software. Results A total of 1441 primary brain and other CNS tumors were examined in the study. There were 232 pediatric cases ...

Research paper thumbnail of Title p-300 wave in patients with post concussion vertigo: A prospective study of 15 cases

Indian Journal of Otolaryngology and Head and Neck Surgery, 1996

P-300 wave was recorded using auditory stimuli in 15 patients presenting with post concussion ver... more P-300 wave was recorded using auditory stimuli in 15 patients presenting with post concussion vertigo. The mean latency of the normal P300 recordings was 316.5 msec while that of the delayed recordings was 392.3 msec. 8 Patients had a bilateral and 4 had an unilateral delay in latency. 5 patients had normal latency bilaterally. The severity of symptoms was directly proportinoal to the delay in latency. This pilot study, though suggestive of a correlation between P300 wave and vertigo is inconclusive because of the limited number of patients studied.

Research paper thumbnail of Clinical profile, treatment, histopathological, immunohistochemical, and molecular analyses of pilocytic astrocytoma- an eight year study from a tertiary health care centre in North East India

Purpose: Pilocytic astrocytoma (PA) is a central nervous system (CNS) World Health Organization (... more Purpose: Pilocytic astrocytoma (PA) is a central nervous system (CNS) World Health Organization (WHO) grade 1 glial tumor that is highly prevalent in children and young adults. The main aim of the study was to assess the frequency, clinicopathological features and treatment of PAs along with their immunohistochemical and molecular analyses. Methods: Approximately, 144 glial tumors were diagnosed in patients from 3 to 75 yrs of age from January 2015 to March 2022. The tumors were classified according to 2021 CNS WHO classification. Nine pediatric PA patients were identified and their clinical data analyzed. Immunohistochemistry (IHC), fluorescence in-situ hybridization (FISH) and molecular analysis using the real time polymerase chain reaction (RT-PCR) were performed for the PAs. Standard deviations were calculated using the Microsoft excel for statistical validations. Results: The mean age of the glioma patients was 41.7 yrs ± 18.2 with a male/female ratio of 1.3:1. The most common ...

Research paper thumbnail of Title p-300 wave in patients with post concussion vertigo: A prospective study of 15 cases

P-300 wave was recorded using auditory stimuli in 15 patients presenting with post concussion ver... more P-300 wave was recorded using auditory stimuli in 15 patients presenting with post concussion vertigo. The mean latency of the normal P300 recordings was 316.5 msec while that of the delayed recordings was 392.3 msec. 6 Patients had a bilateral and 4 had an unilateral delay in latency. 5 patients had normal latency bilaterally. The severity of symptoms was directly proportinoal to the delay in latency. This pilot study, though suggestive of a correlation between P300 wave and vertigo is inconclusive because of the limited number of patients studied.