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Papers by naveen alasyam

Research paper thumbnail of Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits

National Journal of Physiology, Pharmacy and Pharmacology, 2019

Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several di... more Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several diseases. As the treatment of fever was one such remedy, we found that not much work has been done on the antipyretic effect of these plants. Aims and Objective: The aims and objective of this study were to evaluate and compare the antipyretic activity of aqueous leaf extracts of V. negundo and A. paniculata in rabbits. Materials and Methods: Laboratory breed New Zealand strains of rabbits of either sex weighing 1000–1500 g were used in the study. The animals were divided into five groups (n = 6) in both the sets. The rabbits of all the groups were made febrile by administrating misoprostol (prostaglandin E1) subcutaneously in the dose of 100 mcg/kg. For Groups 1 and 2, normal saline 2 ml/kg as control and aspirin 28 mg/kg as standard were given, respectively, in both the sets. V. negundo and A. paniculata in the doses of 200, 400, and 800 mg/kg were given in remaining three groups of both sets, respectively. Rectal temperatures were monitored for every 30 min after treatment started up to 240 min, and its effects were compared to aspirin. Results: Aqueous extracts of V. negundo and A. paniculata produced highly significant (P < 0.001) antipyretic effect in 400 and 800 mg/kg doses. However, the onset of action was fast with V. negundo. Conclusion: The study concludes that aqueous extract of V. negundo has fast onset and sustained antipyretic action in New Zealand rabbits, whereas A. paniculata has delayed onset and sustained antipyretic effect.

Research paper thumbnail of Evaluation of hepatoprotective activity of aqueous extract of Phyllanthus fraternus in Wistar rats

National Journal of Physiology, Pharmacy and Pharmacology, 2019

Background: We hypothesized that carbon tetrachloride-induced hepatotoxicity may be prevented by ... more Background: We hypothesized that carbon tetrachloride-induced hepatotoxicity may be prevented by oral administration of Phyllanthus fraternus extract by inhibiting lipid peroxidation. Aims and Objectives: The present study was undertaken to evaluate the hepatoprotective activity of the aqueous extract of P. fraternus (AEPF) in Wistar rats. Materials and Methods: Five groups of Wistar rats were selected from 30 healthy animals, with six rats in each group. Group A received normal saline 10 ml/kg (p.o). Group B animals were fed with normal saline (10 ml/kg, p.o.). Group C animals were treated with Liv 52-100 mg/kg orally. Groups D and E rats were treated with plant extract orally once daily at the dosage of 250 and 500 mg/kg, respectively. Total duration of experiment is 20 days; CCl4: Olive oil was given i.p on 2 nd , 5 th , and 8 th days for all group of rats except Group A. On the 21 st day, biochemical parameters such as serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), bilirubin, cholesterol, and total protein were estimated from the collected blood. Liver tissues were collected from rats for histopathological examination. Results: P. fraternus exhibited judicious defensive effect by lowering (serum levels of SGOT, SGPT, ALP, bilirubin, and cholesterol) and rising total protein levels. The reduction of necrosis and sinusoids was observed in histopathological examination. Conclusion: The present study results support that the AEPF have a dosedependent hepatoprotective activity.

Research paper thumbnail of Evaluation of Hepatoprotective Activity of Aqueous Extract of Andrographis paniculata in Wistar Rats

International journal of pharmacology and clinical sciences, Jul 1, 2017

Background: The objective of the current study was to evaluate the hepatoprotective activity of t... more Background: The objective of the current study was to evaluate the hepatoprotective activity of the aqueous extract of Andrographis paniculata in wistar rats. Materials and Methods: The animals were divided into six groups with six rats in each group. First group was taken as control, and received 0.9% normal saline 10 ml/kg body weight orally. Second group was taken as CCl 4 control group and treated with normal saline (10 ml/ kg, p.o.) and CCl 4 : olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8 th day) daily for 20 day. The third group rats was treated with Liv 52-100 mg/ kg orally and CCl 4 : olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8 th day) for 20 days .The fourth and fifth groups were taken as test groups and they received crude extract of Andrographis paniculata orally once daily for 20 days at the dosage of 250 and 500 mg/kg respectively. CCl 4 : olive oil was given i.p on 2, 5 and 8 th day. On the 21 st day, blood samples were collected by cardiac puncture method. The blood samples were used to estimate biochemical parameters like serum SGOT,SGPT, ALT, bilirubin and cholisterol and the liver was preserved for histopathological examination. Results: It was found that the Andrographis paniculata exhibited moderate protective effect by lowering the serum levels of SGOT,SGPT,ALT, bilirubin and cholisterol (P<0.001). Histology of liver section of animal treated with the extracts showed the hepatic cell regeneration. Conclusion: Andrographis paniculata has dose dependant hepatoprotective activity.

Research paper thumbnail of Evaluation of antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan induced diabetic albino rats

The Pharma Innovation Journal, Nov 1, 2017

Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic ... more Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic world over. Currently, more attention is being paid to the natural products study as potential antidiabetics. India is considered as the worlds diabetic capital. The study of plants having Antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment. Objective: The present study was aimed to evaluate the antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxaninduced diabetic albino rats model. Methods: Albino rats weighing 150-250 grams were grouped into 5 equal groups taking 6 rats in each. Group A served as control (normal), Group B as diabetic control, received alloxan after overnight fasting. Group C & D was received alloxan + MKLCE suspension at a doses of 250 & 500 mg/kg orally respectively, Group E was given alloxan + standard drug (Glimiperide 2mg/kg) suspension for 21 days & the MKLCE effect on blood sugar was measured at regular intervals. At the end of this research study blood samples were collected from all rats on 0day (initial), on day 7 th , 14 th , 21 st of given test drug MKLCE treatment for biochemical estimation of blood sugar with glucometer & the FBS values were observed. Results: This present research study revealed that MKLCE has antidiabetic effect against alloxan induced diabetic albino rats on i.p. alloxan injection at 120mg/kg.b.w. & confirms that on i.p. alloxan injection causes a significant raise in fasting blood sugar (FBS) in untreated albino rats when compared to control group. Treatment of diabetic rats with MKLCE for 21 days caused a dose dependent fall in FBS levels. Glimiperide treated diabetic rats also showed a significant (P<0.00) fall in FBS levels after 21 days of treatment. Conclusion: It is concluded that MKLCE has shown significant antidiabetic effect at a doses of 250 & 500 mg/kg. b.w. in alloxan induced diabetic albino rats.

Research paper thumbnail of Effectiveness of structured “Om” chanting and listening program on psychological parameters in pre-hypertensive women

National Journal of Physiology, Pharmacy and Pharmacology, 2021

Background: Om chanting was reported to lower blood pressure acting through parasympathetic syste... more Background: Om chanting was reported to lower blood pressure acting through parasympathetic system. It was hypothesized that listening to Om along with chanting may have additional benefits. Aims and Objectives: The study was designed to observe the effectiveness of Om chanting and listening on depression, anxiety, and stress in pre-hypertensive women. Materials and Methods: The present study is an experimental study. Eighty cases of newly diagnosed pre-hypertensive women between the age of 25 and 40 years were included in the study after obtaining written informed consent. They were randomly assigned to waitlist and Om chanting groups with 40 participants in each group. After recording the baseline values, corresponding intervention will be given to the participants of intervention groups for a period of 3 months. Results: There was a significant decrease in the depression, anxiety, and stress scores in the intervention group when compared with the waitlist group. Conclusion: There was a significant decrease in the depression, anxiety, and stress scores followed by the practice of Om chanting. The study recommends further detailed studies in this area to recommend the potential role of Om chanting in clinical practice.

Research paper thumbnail of Evaluation of anticonvulsant activity of alcoholic extract of Mimosa pudica in swiss albino rats

Epilepsy is a central nervous system disorder(neuro logical disorder)in which the nerve cell acti... more Epilepsy is a central nervous system disorder(neuro logical disorder)in which the nerve cell activity i n your brain is disturbed, causing a seizure during which you exper ience abnormal behavior, symptoms and sensation inc luding loss of consciousness. The present study was perfor med to evaluate the anti – convulsant activity of a lcoholic extract of Mimosa pudica (Mimosaceae) against the MES-Indu ce Seizures. A total of 30 Swiss albino rats were divided into five groups containing six in each. Group I – Control Rats (Normal saline 25 ml/kg), Group II – S tandard (Phenytoin 25 mg/kg), Group III – AEMP 50 mg/kg, Gr oup IV – AEMP 100 mg/kg, Group V – AEMP 200 mg/kg. Maximal electroshock seizures (MES) in albino rats were used to study anticonvulsant activity of alcoh olic extract of Mimosa pudica. Alcoholic Extract of Mimosa pudica exhibited a sign ificant (P<0.00) dose dependent protection against tonic extensor phase at all tested doses (5 0, 100 and 200mg/kg ), with maximal ef...

Research paper thumbnail of Evaluation of antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan induced diabetic albino rats

The Pharma Innovation Journal, 2017

Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic ... more Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic world over. Currently, more attention is being paid to the natural products study as potential antidiabetics. India is considered as the worlds diabetic capital. The study of plants having Antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment.Objective: The present study was aimed to evaluate the antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan ‑ induced diabetic albino rats model. Methods: Albino rats weighing 150- 250 grams were grouped into 5 equal groups taking 6 rats in each. Group A served as control (normal), Group B as diabetic control, received alloxan after overnight fasting. Group C & D was received alloxan + MKLCE suspension at a doses of 250 & 500 mg/kg orally respectively, Group E was given alloxan + standard drug (Glimiperide 2mg/kg) suspension for 21 days & the MKLCE effect on blood sugar was measure...

Research paper thumbnail of Evaluation of antidiabetic potential of hydroalcoholic extract of Annona squamosa (HAEAS) leaf in alloxan monohydrate induced diabetic Albino rats

International Journal of Basic & Clinical Pharmacology, 2017

Background: Diabetes is almost growing health concern worldwide and now emerging as an epidemic w... more Background: Diabetes is almost growing health concern worldwide and now emerging as an epidemic world over. Recently, full attention is being paid to the study of natural products as potential antidiabetics. Objective of the study was to evaluate the antidiabetic effect of hydroalcoholic leaf extract of Annona squamosa (HAEAS) plant in alloxan monohydrate induced diabetic albino rats.Methods: Almost a 30 Albino rats with 150- 200 grams weight were weighed and grouped into 5 equal groups taking 6 rats in every group. Group A served as normal control, Group B as diabetic control, received alloxan monnohydrate. Group C and D was received alloxan + HAEAS suspension at 350 and 700 mg/kg doses orally respectively, Group E was given alloxan + standard drug (Glibenclamide 5mg/kg) suspension for 28 successive days and the effect of HAEAS on blood sugar(BS) levels was measured at regular intervals. At the end portion of this investigational research study samples of blood were collected from ...

Research paper thumbnail of Evaluation of Hypoglycemic Property of Gurmar (Gymnema Sylvestre) Leaves Methanolic Extract (GSLME) in Streptozocin (STZ) induced Diabetic Albino Rats

Journal of Medical Science And clinical Research, 2017

Background: Diabetes is almost everywhere a most common growing health issue in the world and is ... more Background: Diabetes is almost everywhere a most common growing health issue in the world and is now emerging as an epidemic world over. currently, so much of importance is being paid to the natural products study as potential antidiabetics. The study of plants which possess Antidiabetic activity may give a new idea in treatment approaches of Diabetes mellitus(DM). Objective: The present research study was aimed to evaluate the Hypoglycemic action of Gymnema Sylvestre (G. sylvestre) plant leaf methanolic extract (GSLME) in streptozocininduced diabetic albino rat model. Methods: Albino rats with a weight of 150-200 grams were weighed & were grouped into 6 equal groups taking 6 rats in each. Group A served as control (normal), Group B as diabetic control, received streptozocin (60mg/kg.b.w.) after overnight fasting. Group C ,D & E was received streptozocin+ GSLME suspension at 100 ,200 & 300 mg/kgdoses orally respectively, Group E was given streptozocin + standard drug (Glibenclamide 5mg/kg.b.w.) suspension for 30 days orally & the GSLME effect on blood sugar(BS) was measured with glucometer at regular intervals. At the end of this research study samples of blood were collected from all rats for biochemical estimation of BS. Results: This present research study has revealed that GSLME has Hypoglycemic effect against streptozocin induced diabetic albino rats on i.p. streptozocin injection at 60mg/kg.b.w. & confirms that on i.p. streptozocin injection causes a significant raise in fasting blood sugar (FBS) in untreated albino

Research paper thumbnail of Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits

National Journal of Physiology, Pharmacy and Pharmacology, 2019

Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several di... more Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several diseases. As the treatment of fever was one such remedy, we found that not much work has been done on the antipyretic effect of these plants. Aims and Objective: The aims and objective of this study were to evaluate and compare the antipyretic activity of aqueous leaf extracts of V. negundo and A. paniculata in rabbits. Materials and Methods: Laboratory breed New Zealand strains of rabbits of either sex weighing 1000–1500 g were used in the study. The animals were divided into five groups (n = 6) in both the sets. The rabbits of all the groups were made febrile by administrating misoprostol (prostaglandin E1) subcutaneously in the dose of 100 mcg/kg. For Groups 1 and 2, normal saline 2 ml/kg as control and aspirin 28 mg/kg as standard were given, respectively, in both the sets. V. negundo and A. paniculata in the doses of 200, 400, and 800 mg/kg were given in remaining three groups of both sets, respectively. Rectal temperatures were monitored for every 30 min after treatment started up to 240 min, and its effects were compared to aspirin. Results: Aqueous extracts of V. negundo and A. paniculata produced highly significant (P < 0.001) antipyretic effect in 400 and 800 mg/kg doses. However, the onset of action was fast with V. negundo. Conclusion: The study concludes that aqueous extract of V. negundo has fast onset and sustained antipyretic action in New Zealand rabbits, whereas A. paniculata has delayed onset and sustained antipyretic effect.

Research paper thumbnail of Evaluation of Anti-Hyperglycemic Activity of Adiantum Philippense Linn, a Pteridophyte in Alloxan Induced Diabetic Rats

Journal of Diabetes & Metabolism, 2012

Nowadays, Tolbutamide, Metformin, Gliclazideetc that are highly preferred as anti-diabetic drugs ... more Nowadays, Tolbutamide, Metformin, Gliclazideetc that are highly preferred as anti-diabetic drugs are mainly sulfonylureas and biguanides which are known to cause various adverse effects [4]. Hence in the recent years medicinal plants have become a subject of interest for drug development owing to their phytochemical constituents and their therapeutic potential. In particular, the angiosperms are given more emphasis but the pteridophytes which are significant group of plant kingdom with 12000 species are not much studied for their antidiabetic activity. Adiantum philippense Linn is commonly known as 'Hanspadi' or 'Walking Maiden hair fern'. It is widely distributed in many parts of India and used as an ornamental plant. It is ethnomedicinally used in bleeding diseases, burning sensation, erysipelas, epileptic fits, dysentery, and elephantiasis [5]. It has been reported that the dried whole plant has been used as a medicine for bronchitis and cough [6]. Adiantum philippense is also reported to have anti-bacterial [7] and anti-fungal activity [8]. Adiantum capillus veneries, a fern of the same genus as that of Adiantum philippense Linn possess antidiabetic potential which is marketed with brand name "Avenca TM ". Belonging to the same genus and family of Pteridophytes, insufficient information was available regarding anti diabetic potential of Adiantum philippense Linn (Adiantum lunulatum Burm f.) which led us to investigate its antihyperglycemic potential on alloxan induced diabetic rats. Materials and Methods Collection and authentication The fern Adiantum philippense Linn (AP) was collected from ChandraprabhaVanrai, Dapoli in the Ratnagiri district of Maharashtra in the end of monsoon and was authenticated by Dr. P.

Research paper thumbnail of Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats

Revista Brasileira de Farmacognosia, 2012

ABSTRACT The present study was carried out to evaluate the hepatoprotective activity of aqueous a... more ABSTRACT The present study was carried out to evaluate the hepatoprotective activity of aqueous and ethanolic leaves extracts of Oxalis corniculata L., Oxalidaceae, against thioacetamide-induced hepatotoxicity. Hepatotoxicity was induced in Wistar rats of either ...

Research paper thumbnail of Association of sleep quality and spatial and verbal memory in young adults

National Journal of Physiology, Pharmacy and Pharmacology, 2019

Background: Sleep is the basic need and essential for survival. Although the exact reason for sle... more Background: Sleep is the basic need and essential for survival. Although the exact reason for sleep is not clear till date, it plays a pivot role in regulating most of the body functions. Sleep quality has an impact on the cognitive functions such as learning and memory. Spatial and verbal memory is important components of cognition. Further, verbal memory is essential for the student population to perform well in their academics. Aims and Objectives: The present study was undertaken to observe the association of sleep quality and cognitive functions in young adults. Materials and Methods: Eighty-two young adults within the age group of 18–24 were part of the study after obtaining the written informed consent. Sleep quality was assessed by the Pittsburgh Sleep Quality Index. Spatial and verbal memory was assessed using spatial and verbal memory test. Pearson correlation coefficient was used to observe the association between the variables. Results: There was a weak positive correlation between the spatial memory and sleep quality (R is 0.1272 and R2 is 0.0162). There was a weak positive correlation between the verbal memory and sleep quality (R is 0.0866 and R2 is 0.0075). Conclusion: The study presents a positive correlation between the sleep quality with the spatial and verbal memory. The study recommends further detailed studies in this area to understand the association between the sleep quality and memory.

Research paper thumbnail of Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits

National Journal of Physiology, Pharmacy and Pharmacology, 2019

Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several di... more Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several diseases. As the treatment of fever was one such remedy, we found that not much work has been done on the antipyretic effect of these plants. Aims and Objective: The aims and objective of this study were to evaluate and compare the antipyretic activity of aqueous leaf extracts of V. negundo and A. paniculata in rabbits. Materials and Methods: Laboratory breed New Zealand strains of rabbits of either sex weighing 1000–1500 g were used in the study. The animals were divided into five groups (n = 6) in both the sets. The rabbits of all the groups were made febrile by administrating misoprostol (prostaglandin E1) subcutaneously in the dose of 100 mcg/kg. For Groups 1 and 2, normal saline 2 ml/kg as control and aspirin 28 mg/kg as standard were given, respectively, in both the sets. V. negundo and A. paniculata in the doses of 200, 400, and 800 mg/kg were given in remaining three groups of both sets, respectively. Rectal temperatures were monitored for every 30 min after treatment started up to 240 min, and its effects were compared to aspirin. Results: Aqueous extracts of V. negundo and A. paniculata produced highly significant (P < 0.001) antipyretic effect in 400 and 800 mg/kg doses. However, the onset of action was fast with V. negundo. Conclusion: The study concludes that aqueous extract of V. negundo has fast onset and sustained antipyretic action in New Zealand rabbits, whereas A. paniculata has delayed onset and sustained antipyretic effect.

Research paper thumbnail of Evaluation of hepatoprotective activity of aqueous extract of Phyllanthus fraternus in Wistar rats

National Journal of Physiology, Pharmacy and Pharmacology, 2019

Background: We hypothesized that carbon tetrachloride-induced hepatotoxicity may be prevented by ... more Background: We hypothesized that carbon tetrachloride-induced hepatotoxicity may be prevented by oral administration of Phyllanthus fraternus extract by inhibiting lipid peroxidation. Aims and Objectives: The present study was undertaken to evaluate the hepatoprotective activity of the aqueous extract of P. fraternus (AEPF) in Wistar rats. Materials and Methods: Five groups of Wistar rats were selected from 30 healthy animals, with six rats in each group. Group A received normal saline 10 ml/kg (p.o). Group B animals were fed with normal saline (10 ml/kg, p.o.). Group C animals were treated with Liv 52-100 mg/kg orally. Groups D and E rats were treated with plant extract orally once daily at the dosage of 250 and 500 mg/kg, respectively. Total duration of experiment is 20 days; CCl4: Olive oil was given i.p on 2 nd , 5 th , and 8 th days for all group of rats except Group A. On the 21 st day, biochemical parameters such as serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), bilirubin, cholesterol, and total protein were estimated from the collected blood. Liver tissues were collected from rats for histopathological examination. Results: P. fraternus exhibited judicious defensive effect by lowering (serum levels of SGOT, SGPT, ALP, bilirubin, and cholesterol) and rising total protein levels. The reduction of necrosis and sinusoids was observed in histopathological examination. Conclusion: The present study results support that the AEPF have a dosedependent hepatoprotective activity.

Research paper thumbnail of Evaluation of Hepatoprotective Activity of Aqueous Extract of Andrographis paniculata in Wistar Rats

International journal of pharmacology and clinical sciences, Jul 1, 2017

Background: The objective of the current study was to evaluate the hepatoprotective activity of t... more Background: The objective of the current study was to evaluate the hepatoprotective activity of the aqueous extract of Andrographis paniculata in wistar rats. Materials and Methods: The animals were divided into six groups with six rats in each group. First group was taken as control, and received 0.9% normal saline 10 ml/kg body weight orally. Second group was taken as CCl 4 control group and treated with normal saline (10 ml/ kg, p.o.) and CCl 4 : olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8 th day) daily for 20 day. The third group rats was treated with Liv 52-100 mg/ kg orally and CCl 4 : olive oil (1:1, 2 ml/ kg, i.p. on 2, 5 and 8 th day) for 20 days .The fourth and fifth groups were taken as test groups and they received crude extract of Andrographis paniculata orally once daily for 20 days at the dosage of 250 and 500 mg/kg respectively. CCl 4 : olive oil was given i.p on 2, 5 and 8 th day. On the 21 st day, blood samples were collected by cardiac puncture method. The blood samples were used to estimate biochemical parameters like serum SGOT,SGPT, ALT, bilirubin and cholisterol and the liver was preserved for histopathological examination. Results: It was found that the Andrographis paniculata exhibited moderate protective effect by lowering the serum levels of SGOT,SGPT,ALT, bilirubin and cholisterol (P<0.001). Histology of liver section of animal treated with the extracts showed the hepatic cell regeneration. Conclusion: Andrographis paniculata has dose dependant hepatoprotective activity.

Research paper thumbnail of Evaluation of antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan induced diabetic albino rats

The Pharma Innovation Journal, Nov 1, 2017

Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic ... more Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic world over. Currently, more attention is being paid to the natural products study as potential antidiabetics. India is considered as the worlds diabetic capital. The study of plants having Antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment. Objective: The present study was aimed to evaluate the antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxaninduced diabetic albino rats model. Methods: Albino rats weighing 150-250 grams were grouped into 5 equal groups taking 6 rats in each. Group A served as control (normal), Group B as diabetic control, received alloxan after overnight fasting. Group C & D was received alloxan + MKLCE suspension at a doses of 250 & 500 mg/kg orally respectively, Group E was given alloxan + standard drug (Glimiperide 2mg/kg) suspension for 21 days & the MKLCE effect on blood sugar was measured at regular intervals. At the end of this research study blood samples were collected from all rats on 0day (initial), on day 7 th , 14 th , 21 st of given test drug MKLCE treatment for biochemical estimation of blood sugar with glucometer & the FBS values were observed. Results: This present research study revealed that MKLCE has antidiabetic effect against alloxan induced diabetic albino rats on i.p. alloxan injection at 120mg/kg.b.w. & confirms that on i.p. alloxan injection causes a significant raise in fasting blood sugar (FBS) in untreated albino rats when compared to control group. Treatment of diabetic rats with MKLCE for 21 days caused a dose dependent fall in FBS levels. Glimiperide treated diabetic rats also showed a significant (P<0.00) fall in FBS levels after 21 days of treatment. Conclusion: It is concluded that MKLCE has shown significant antidiabetic effect at a doses of 250 & 500 mg/kg. b.w. in alloxan induced diabetic albino rats.

Research paper thumbnail of Effectiveness of structured “Om” chanting and listening program on psychological parameters in pre-hypertensive women

National Journal of Physiology, Pharmacy and Pharmacology, 2021

Background: Om chanting was reported to lower blood pressure acting through parasympathetic syste... more Background: Om chanting was reported to lower blood pressure acting through parasympathetic system. It was hypothesized that listening to Om along with chanting may have additional benefits. Aims and Objectives: The study was designed to observe the effectiveness of Om chanting and listening on depression, anxiety, and stress in pre-hypertensive women. Materials and Methods: The present study is an experimental study. Eighty cases of newly diagnosed pre-hypertensive women between the age of 25 and 40 years were included in the study after obtaining written informed consent. They were randomly assigned to waitlist and Om chanting groups with 40 participants in each group. After recording the baseline values, corresponding intervention will be given to the participants of intervention groups for a period of 3 months. Results: There was a significant decrease in the depression, anxiety, and stress scores in the intervention group when compared with the waitlist group. Conclusion: There was a significant decrease in the depression, anxiety, and stress scores followed by the practice of Om chanting. The study recommends further detailed studies in this area to recommend the potential role of Om chanting in clinical practice.

Research paper thumbnail of Evaluation of anticonvulsant activity of alcoholic extract of Mimosa pudica in swiss albino rats

Epilepsy is a central nervous system disorder(neuro logical disorder)in which the nerve cell acti... more Epilepsy is a central nervous system disorder(neuro logical disorder)in which the nerve cell activity i n your brain is disturbed, causing a seizure during which you exper ience abnormal behavior, symptoms and sensation inc luding loss of consciousness. The present study was perfor med to evaluate the anti – convulsant activity of a lcoholic extract of Mimosa pudica (Mimosaceae) against the MES-Indu ce Seizures. A total of 30 Swiss albino rats were divided into five groups containing six in each. Group I – Control Rats (Normal saline 25 ml/kg), Group II – S tandard (Phenytoin 25 mg/kg), Group III – AEMP 50 mg/kg, Gr oup IV – AEMP 100 mg/kg, Group V – AEMP 200 mg/kg. Maximal electroshock seizures (MES) in albino rats were used to study anticonvulsant activity of alcoh olic extract of Mimosa pudica. Alcoholic Extract of Mimosa pudica exhibited a sign ificant (P<0.00) dose dependent protection against tonic extensor phase at all tested doses (5 0, 100 and 200mg/kg ), with maximal ef...

Research paper thumbnail of Evaluation of antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan induced diabetic albino rats

The Pharma Innovation Journal, 2017

Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic ... more Background: Diabetes is a growing health concern in the world and is now emerging as an epidemic world over. Currently, more attention is being paid to the natural products study as potential antidiabetics. India is considered as the worlds diabetic capital. The study of plants having Antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment.Objective: The present study was aimed to evaluate the antidiabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in alloxan ‑ induced diabetic albino rats model. Methods: Albino rats weighing 150- 250 grams were grouped into 5 equal groups taking 6 rats in each. Group A served as control (normal), Group B as diabetic control, received alloxan after overnight fasting. Group C & D was received alloxan + MKLCE suspension at a doses of 250 & 500 mg/kg orally respectively, Group E was given alloxan + standard drug (Glimiperide 2mg/kg) suspension for 21 days & the MKLCE effect on blood sugar was measure...

Research paper thumbnail of Evaluation of antidiabetic potential of hydroalcoholic extract of Annona squamosa (HAEAS) leaf in alloxan monohydrate induced diabetic Albino rats

International Journal of Basic & Clinical Pharmacology, 2017

Background: Diabetes is almost growing health concern worldwide and now emerging as an epidemic w... more Background: Diabetes is almost growing health concern worldwide and now emerging as an epidemic world over. Recently, full attention is being paid to the study of natural products as potential antidiabetics. Objective of the study was to evaluate the antidiabetic effect of hydroalcoholic leaf extract of Annona squamosa (HAEAS) plant in alloxan monohydrate induced diabetic albino rats.Methods: Almost a 30 Albino rats with 150- 200 grams weight were weighed and grouped into 5 equal groups taking 6 rats in every group. Group A served as normal control, Group B as diabetic control, received alloxan monnohydrate. Group C and D was received alloxan + HAEAS suspension at 350 and 700 mg/kg doses orally respectively, Group E was given alloxan + standard drug (Glibenclamide 5mg/kg) suspension for 28 successive days and the effect of HAEAS on blood sugar(BS) levels was measured at regular intervals. At the end portion of this investigational research study samples of blood were collected from ...

Research paper thumbnail of Evaluation of Hypoglycemic Property of Gurmar (Gymnema Sylvestre) Leaves Methanolic Extract (GSLME) in Streptozocin (STZ) induced Diabetic Albino Rats

Journal of Medical Science And clinical Research, 2017

Background: Diabetes is almost everywhere a most common growing health issue in the world and is ... more Background: Diabetes is almost everywhere a most common growing health issue in the world and is now emerging as an epidemic world over. currently, so much of importance is being paid to the natural products study as potential antidiabetics. The study of plants which possess Antidiabetic activity may give a new idea in treatment approaches of Diabetes mellitus(DM). Objective: The present research study was aimed to evaluate the Hypoglycemic action of Gymnema Sylvestre (G. sylvestre) plant leaf methanolic extract (GSLME) in streptozocininduced diabetic albino rat model. Methods: Albino rats with a weight of 150-200 grams were weighed & were grouped into 6 equal groups taking 6 rats in each. Group A served as control (normal), Group B as diabetic control, received streptozocin (60mg/kg.b.w.) after overnight fasting. Group C ,D & E was received streptozocin+ GSLME suspension at 100 ,200 & 300 mg/kgdoses orally respectively, Group E was given streptozocin + standard drug (Glibenclamide 5mg/kg.b.w.) suspension for 30 days orally & the GSLME effect on blood sugar(BS) was measured with glucometer at regular intervals. At the end of this research study samples of blood were collected from all rats for biochemical estimation of BS. Results: This present research study has revealed that GSLME has Hypoglycemic effect against streptozocin induced diabetic albino rats on i.p. streptozocin injection at 60mg/kg.b.w. & confirms that on i.p. streptozocin injection causes a significant raise in fasting blood sugar (FBS) in untreated albino

Research paper thumbnail of Evaluation and comparison of antipyretic activity of aqueous leaf extracts of Vitex negundo and Andrographis paniculata in rabbits

National Journal of Physiology, Pharmacy and Pharmacology, 2019

Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several di... more Background: Vitex negundo and Andrographis paniculata have a multitude of remedies for several diseases. As the treatment of fever was one such remedy, we found that not much work has been done on the antipyretic effect of these plants. Aims and Objective: The aims and objective of this study were to evaluate and compare the antipyretic activity of aqueous leaf extracts of V. negundo and A. paniculata in rabbits. Materials and Methods: Laboratory breed New Zealand strains of rabbits of either sex weighing 1000–1500 g were used in the study. The animals were divided into five groups (n = 6) in both the sets. The rabbits of all the groups were made febrile by administrating misoprostol (prostaglandin E1) subcutaneously in the dose of 100 mcg/kg. For Groups 1 and 2, normal saline 2 ml/kg as control and aspirin 28 mg/kg as standard were given, respectively, in both the sets. V. negundo and A. paniculata in the doses of 200, 400, and 800 mg/kg were given in remaining three groups of both sets, respectively. Rectal temperatures were monitored for every 30 min after treatment started up to 240 min, and its effects were compared to aspirin. Results: Aqueous extracts of V. negundo and A. paniculata produced highly significant (P < 0.001) antipyretic effect in 400 and 800 mg/kg doses. However, the onset of action was fast with V. negundo. Conclusion: The study concludes that aqueous extract of V. negundo has fast onset and sustained antipyretic action in New Zealand rabbits, whereas A. paniculata has delayed onset and sustained antipyretic effect.

Research paper thumbnail of Evaluation of Anti-Hyperglycemic Activity of Adiantum Philippense Linn, a Pteridophyte in Alloxan Induced Diabetic Rats

Journal of Diabetes & Metabolism, 2012

Nowadays, Tolbutamide, Metformin, Gliclazideetc that are highly preferred as anti-diabetic drugs ... more Nowadays, Tolbutamide, Metformin, Gliclazideetc that are highly preferred as anti-diabetic drugs are mainly sulfonylureas and biguanides which are known to cause various adverse effects [4]. Hence in the recent years medicinal plants have become a subject of interest for drug development owing to their phytochemical constituents and their therapeutic potential. In particular, the angiosperms are given more emphasis but the pteridophytes which are significant group of plant kingdom with 12000 species are not much studied for their antidiabetic activity. Adiantum philippense Linn is commonly known as 'Hanspadi' or 'Walking Maiden hair fern'. It is widely distributed in many parts of India and used as an ornamental plant. It is ethnomedicinally used in bleeding diseases, burning sensation, erysipelas, epileptic fits, dysentery, and elephantiasis [5]. It has been reported that the dried whole plant has been used as a medicine for bronchitis and cough [6]. Adiantum philippense is also reported to have anti-bacterial [7] and anti-fungal activity [8]. Adiantum capillus veneries, a fern of the same genus as that of Adiantum philippense Linn possess antidiabetic potential which is marketed with brand name "Avenca TM ". Belonging to the same genus and family of Pteridophytes, insufficient information was available regarding anti diabetic potential of Adiantum philippense Linn (Adiantum lunulatum Burm f.) which led us to investigate its antihyperglycemic potential on alloxan induced diabetic rats. Materials and Methods Collection and authentication The fern Adiantum philippense Linn (AP) was collected from ChandraprabhaVanrai, Dapoli in the Ratnagiri district of Maharashtra in the end of monsoon and was authenticated by Dr. P.

Research paper thumbnail of Evaluation of hepatoprotective activity of aqueous and ethanolic extract of Oxalis corniculata against intoxication of thioacetamide induced rats

Revista Brasileira de Farmacognosia, 2012

ABSTRACT The present study was carried out to evaluate the hepatoprotective activity of aqueous a... more ABSTRACT The present study was carried out to evaluate the hepatoprotective activity of aqueous and ethanolic leaves extracts of Oxalis corniculata L., Oxalidaceae, against thioacetamide-induced hepatotoxicity. Hepatotoxicity was induced in Wistar rats of either ...

Research paper thumbnail of Association of sleep quality and spatial and verbal memory in young adults

National Journal of Physiology, Pharmacy and Pharmacology, 2019

Background: Sleep is the basic need and essential for survival. Although the exact reason for sle... more Background: Sleep is the basic need and essential for survival. Although the exact reason for sleep is not clear till date, it plays a pivot role in regulating most of the body functions. Sleep quality has an impact on the cognitive functions such as learning and memory. Spatial and verbal memory is important components of cognition. Further, verbal memory is essential for the student population to perform well in their academics. Aims and Objectives: The present study was undertaken to observe the association of sleep quality and cognitive functions in young adults. Materials and Methods: Eighty-two young adults within the age group of 18–24 were part of the study after obtaining the written informed consent. Sleep quality was assessed by the Pittsburgh Sleep Quality Index. Spatial and verbal memory was assessed using spatial and verbal memory test. Pearson correlation coefficient was used to observe the association between the variables. Results: There was a weak positive correlation between the spatial memory and sleep quality (R is 0.1272 and R2 is 0.0162). There was a weak positive correlation between the verbal memory and sleep quality (R is 0.0866 and R2 is 0.0075). Conclusion: The study presents a positive correlation between the sleep quality with the spatial and verbal memory. The study recommends further detailed studies in this area to understand the association between the sleep quality and memory.