nazreen banu - Academia.edu (original) (raw)

Papers by nazreen banu

Research paper thumbnail of Magnetic properties of soft ferrites and amorphous ribbons up to radiofrequencies

Journal of Magnetism and Magnetic Materials, 2010

Significant results are reported concerning the magnetic behavior of sintered soft ferrites and v... more Significant results are reported concerning the magnetic behavior of sintered soft ferrites and very thin Co-based amorphous ribbons up to 1 GHz. Conveniently field-annealed amorphous tapes can exhibit, in spite of their metallic character, superior combination of magnetic loss and permeability properties at all frequencies. Such properties are phenomenologically assessed through a physical approach based on the statistical theory of losses and the generalization of the related concept of loss separation, which takes into account different dissipation mechanisms and discriminates between domain wall and rotational processes. The latter, in particular, are described in ferrites in association with spin precession and damping and are given a formulation based on the Landau-Lifshitz-Gilbert equation and the assumption of distributed effective anisotropy fields.

Research paper thumbnail of Inhibition of COX2 with NS398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy

Cell Proliferation, 2007

The use of non-steroidal anti-inflammatory drugs has proved of great interest in the prevention a... more The use of non-steroidal anti-inflammatory drugs has proved of great interest in the prevention and treatment of colorectal cancer, although their precise mechanisms of action remain unclear. Overexpression of cyclooxygenase-2 (COX-2) and subsequent prostaglandin production promote metastasis and have been shown to increase cell motility in vitro . Objective : We have aimed to elucidate whether specific inhibition of COX-2 with NS-398 (NS-398 is a selective inhibitor of COX-2) would be able to inhibit motility of colorectal cancer cells and whether this was modulated through epidermal growth factor receptor (EGFR) transactivation. Materials and Methods : A transwell filter assay was used to study cell motility. Expression of COX-2, EGFR phosphorylation and prostaglandin E 2 (PGE 2 ) receptors were assessed by Western blot analysis and reverse transcriptase-polymerase chain reaction. PGE 2 concentrations after NS-398 treatment were estimated by enzyme immunoassay. Results : Treatment with NS-398 significantly reduced PGE 2 levels and reduced cell migration in the HT29 and HCA7 colorectal carcinoma cell lines and this effect was rescued by addition of PGE 2 . Furthermore, specific inhibition of COX-2 with NS-398 reduced EGFR phosphorylation in colorectal cancer cells. Direct inhibition of EGFR activity with AG1478 reduced PGE 2 -stimulated motility, clearly demonstrating that PGE 2 acts via the EGFR-signalling pathway. The novel combination of NS-398 and AG1478 dramatically reduced migration of colorectal cancer cells. Conclusion : The data presented indicate that the use of NS-398 in chemoprevention and adjuvant therapy for colorectal cancer may work in part, through the inhibition of cell motility. Furthermore, our data

Research paper thumbnail of Galectins–potential targets for cancer therapy

Cancer letters, 2007

Galectins are a family of galactose binding lectins that have become the focus of attention of ca... more Galectins are a family of galactose binding lectins that have become the focus of attention of cancer biologists due to their numerous regulatory roles in normal cellular metabolism and also because of their altered levels in various cancers. They are reportedly similar to several prominent and established modulators of apoptosis. In this review, we present a brief outline of the advancements in the methodology used to detect and identify them and their therapeutic applications in cancer. Their possible interactions with other glycoconjugates are also discussed and a vision for their future use in diagnosis and therapeutics is provided.

Research paper thumbnail of Determination of immune response of imported Newcastle disease virus vaccines in broiler chickens

A study was undertaken to determine the immune response of eight different imported live NDV vacc... more A study was undertaken to determine the immune response of eight different imported live NDV vaccines in broiler chickens in the Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh during the period from July to December 2008. A total of 55 broiler chickens (Ross breed) were divided into eleven groups such as and 11 of which group 1, 3, 5, 7 and 9 were vaccinated primarily with Nobilis ® MA5+Clone30, Avipro ® ND-IB HB1, Cevac ® BIL, Newcastle-Bronchitis Vaccine Fortdodge ® and Avipro ® ND LaSota vaccine respectively at day 5 of age and secondarily with Nobilis ® ND Clone 30, Avipro ® ND LaSota, Cevac ® New L, Newcastle Disease vaccine Fortdodge ® and Avipro ® ND LaSota vaccine respectively at day 21 of age by single eye instillation and 2, 4, 6, 8 and 10 were vaccinated with the same vaccines respectively by double eye instillation following the same schedule. Group 11 was kept as unvaccinated control. Sera samples were collected after 10 days of each vaccination and at day 5, 15, 20, 31 of age from nonvaccinated control and subjected to HI test for the determination of antibody titres. It was observed that after primary vaccination the geometric mean (GM) of HI titres of double eye vaccinated groups differed significantly (P<0.01). Overall analysis of GM of HI titres of double eye vaccinated groups revealed that there were significant increases (P<0.01) in HI titres in groups 8 (301.07±70.10) and 10 (284.24±85.86) compared to other groups. It was observed that secondary vaccination produced higher immune response compared to primary vaccination in case of all the vaccinated groups and double eye vaccination produced higher immune response compared to single eye vaccination in case of all the vaccinated groups. Maternal antibody was high (256.00±140.21) at day 5 of age and persisted to a minimal level (5.27±2.19) until the age of day 20 and almost disappears (≤4±0) at day 31 of age. From the present research it may be concluded that LaSota strain produced higher immune response than Clone 30 and B1 strain and Fortdodge ® and Avipro ® vaccine produced higher immune response than all other vaccines used in this study.

Research paper thumbnail of Magnetic properties of soft ferrites and amorphous ribbons up to radiofrequencies

Journal of Magnetism and Magnetic Materials, 2010

Significant results are reported concerning the magnetic behavior of sintered soft ferrites and v... more Significant results are reported concerning the magnetic behavior of sintered soft ferrites and very thin Co-based amorphous ribbons up to 1 GHz. Conveniently field-annealed amorphous tapes can exhibit, in spite of their metallic character, superior combination of magnetic loss and permeability properties at all frequencies. Such properties are phenomenologically assessed through a physical approach based on the statistical theory of losses and the generalization of the related concept of loss separation, which takes into account different dissipation mechanisms and discriminates between domain wall and rotational processes. The latter, in particular, are described in ferrites in association with spin precession and damping and are given a formulation based on the Landau-Lifshitz-Gilbert equation and the assumption of distributed effective anisotropy fields.

Research paper thumbnail of Inhibition of COX2 with NS398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy

Cell Proliferation, 2007

The use of non-steroidal anti-inflammatory drugs has proved of great interest in the prevention a... more The use of non-steroidal anti-inflammatory drugs has proved of great interest in the prevention and treatment of colorectal cancer, although their precise mechanisms of action remain unclear. Overexpression of cyclooxygenase-2 (COX-2) and subsequent prostaglandin production promote metastasis and have been shown to increase cell motility in vitro . Objective : We have aimed to elucidate whether specific inhibition of COX-2 with NS-398 (NS-398 is a selective inhibitor of COX-2) would be able to inhibit motility of colorectal cancer cells and whether this was modulated through epidermal growth factor receptor (EGFR) transactivation. Materials and Methods : A transwell filter assay was used to study cell motility. Expression of COX-2, EGFR phosphorylation and prostaglandin E 2 (PGE 2 ) receptors were assessed by Western blot analysis and reverse transcriptase-polymerase chain reaction. PGE 2 concentrations after NS-398 treatment were estimated by enzyme immunoassay. Results : Treatment with NS-398 significantly reduced PGE 2 levels and reduced cell migration in the HT29 and HCA7 colorectal carcinoma cell lines and this effect was rescued by addition of PGE 2 . Furthermore, specific inhibition of COX-2 with NS-398 reduced EGFR phosphorylation in colorectal cancer cells. Direct inhibition of EGFR activity with AG1478 reduced PGE 2 -stimulated motility, clearly demonstrating that PGE 2 acts via the EGFR-signalling pathway. The novel combination of NS-398 and AG1478 dramatically reduced migration of colorectal cancer cells. Conclusion : The data presented indicate that the use of NS-398 in chemoprevention and adjuvant therapy for colorectal cancer may work in part, through the inhibition of cell motility. Furthermore, our data

Research paper thumbnail of Galectins–potential targets for cancer therapy

Cancer letters, 2007

Galectins are a family of galactose binding lectins that have become the focus of attention of ca... more Galectins are a family of galactose binding lectins that have become the focus of attention of cancer biologists due to their numerous regulatory roles in normal cellular metabolism and also because of their altered levels in various cancers. They are reportedly similar to several prominent and established modulators of apoptosis. In this review, we present a brief outline of the advancements in the methodology used to detect and identify them and their therapeutic applications in cancer. Their possible interactions with other glycoconjugates are also discussed and a vision for their future use in diagnosis and therapeutics is provided.

Research paper thumbnail of Determination of immune response of imported Newcastle disease virus vaccines in broiler chickens

A study was undertaken to determine the immune response of eight different imported live NDV vacc... more A study was undertaken to determine the immune response of eight different imported live NDV vaccines in broiler chickens in the Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh during the period from July to December 2008. A total of 55 broiler chickens (Ross breed) were divided into eleven groups such as and 11 of which group 1, 3, 5, 7 and 9 were vaccinated primarily with Nobilis ® MA5+Clone30, Avipro ® ND-IB HB1, Cevac ® BIL, Newcastle-Bronchitis Vaccine Fortdodge ® and Avipro ® ND LaSota vaccine respectively at day 5 of age and secondarily with Nobilis ® ND Clone 30, Avipro ® ND LaSota, Cevac ® New L, Newcastle Disease vaccine Fortdodge ® and Avipro ® ND LaSota vaccine respectively at day 21 of age by single eye instillation and 2, 4, 6, 8 and 10 were vaccinated with the same vaccines respectively by double eye instillation following the same schedule. Group 11 was kept as unvaccinated control. Sera samples were collected after 10 days of each vaccination and at day 5, 15, 20, 31 of age from nonvaccinated control and subjected to HI test for the determination of antibody titres. It was observed that after primary vaccination the geometric mean (GM) of HI titres of double eye vaccinated groups differed significantly (P<0.01). Overall analysis of GM of HI titres of double eye vaccinated groups revealed that there were significant increases (P<0.01) in HI titres in groups 8 (301.07±70.10) and 10 (284.24±85.86) compared to other groups. It was observed that secondary vaccination produced higher immune response compared to primary vaccination in case of all the vaccinated groups and double eye vaccination produced higher immune response compared to single eye vaccination in case of all the vaccinated groups. Maternal antibody was high (256.00±140.21) at day 5 of age and persisted to a minimal level (5.27±2.19) until the age of day 20 and almost disappears (≤4±0) at day 31 of age. From the present research it may be concluded that LaSota strain produced higher immune response than Clone 30 and B1 strain and Fortdodge ® and Avipro ® vaccine produced higher immune response than all other vaccines used in this study.