neda abadian - Academia.edu (original) (raw)
Papers by neda abadian
Chemical Papers, 2019
One of the therapeutic approaches in the management of type 2 diabetes is delaying the glucose ab... more One of the therapeutic approaches in the management of type 2 diabetes is delaying the glucose absorption through α-glucosidase enzyme inhibition, which can reduce the occurrence of postprandial hyperglycemia. Based on this thought, a series of novel chloro-substituted 2-(2-methyl-1-phenyl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl) acetamide derivatives 5a-i were synthesized and their α-glucosidase inhibitory activities were evaluated. All the synthesized compounds have shown moderate to excellent in vitro α-glucosidase inhibitory activity with IC 50 values in the range of 111-673 µM) as compared to acarbose, the standard drug (750 ± 9 µM). Compound 5e (111 ± 12 µM), among the series, was the most potent inhibitor of α-glucosidase in a competitive mode of action based on the kinetic study. The molecular docking study of compounds 5e and 5a revealed that they have a lower free binding energy (− 4.27 kcal/mol and − 3.17 kcal/mol, respectively) than acarbose (− 2.47 kcal/mol), which indicates that the target compound binds more easily to the enzyme than acarbose does. The outcomes from the molecular docking studies supported the results obtained from the in vitro assay. In conclusion, the overall results of our study reveal that the synthesized compounds could be a potential candidate in the search for novel α-glucosidase inhibitors to manage postprandial hyperglycemia incidence.
Journal of Food Protection, 2009
Efficacy of commercial detergent and disinfectants to eliminate microorganisms associated with fr... more Efficacy of commercial detergent and disinfectants to eliminate microorganisms associated with fresh vegetables eaten raw in Iran, including radish, parsley, basil, coriander (cilantro), Allium porrum (leek), and peppermint were studied. The raw vegetables were subjected to a triple wash treatment of washing in tap water for mud removal, washing in water containing a detergent (dishwashing liquid) or disinfectant individually, and rinsing in tap water. The population of total mesophilic microbes on the surface of untreated vegetables ranged from 105 to 106 CFU/g. Washing in tap water or treatment with detergent (333 ppm for 10 min) or benzalkonium chloride (92 ppm for 15 min) reduced the total microbial count, most probable number (MPN) of coliforms, MPN of fecal coliforms, and MPN of fecal streptococci by about 1.2 to 2.3 log. No significant differences in microbial populations were found on vegetables after decontamination with tap water, detergent, or benzalkonium chloride (P >...
Natural Product Research, 2011
The essential oil obtained from the flowering parts of Anthemis altissima L. var. altissima was a... more The essential oil obtained from the flowering parts of Anthemis altissima L. var. altissima was analysed by gas chromatography and gas chromatography mass spectroscopy. In this study, 34 compounds representing 98.76% of the essential oil were identified. The main components were α-terpineol (26.42%), β-pinene (9.23%), cis-chrysanthenyl acetate (6.30%), globulol (5.36%), n-tricosane (4.41%), terpinen-4-ol (4.08%) and 1,8 cineole (3.84%). Antibacterial activities
Medicinal Chemistry Research, 2012
In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core... more In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3ylidene) analogs of 2-thiazolylimino-5-arylidene-4-thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as Helicobacter pylori strains. Biological data indicated that 5-nitrofuran analog 5a and 5-nitroimidazole analog 7a containing no substitutions on the thiazole ring were the most potent compounds.
Journal of Biological Sciences, 2007
Applied Microbiology and Biotechnology, 2007
Biosurfactants (BS) are surface-active compounds abundantly produced by a variety of microorganis... more Biosurfactants (BS) are surface-active compounds abundantly produced by a variety of microorganisms. They have been receiving great attention due to their unique properties, including higher biodegradability, lower toxicity, and versatile biological functions, compared to synthetic surfactants 1-3). However, the structural variety of biosurfactants available is still limited: this has prevented a wide range of BS applications. Succinoyl trehalose lipids (STLs) are promising glycolipid BS, since they are efficiently produced from n-alkanes by Rhodococcus bacteria and recovered by precipitation 4,5). Among STL producers hitherto reported, Rhodococcus sp. SD-74 gives the best yield (40 g/L) from n-hexadecane under the high osmotic conditions. The strain mainly produces two types of homologues, STL-1 and STL-2, together with minor components 6). STLs have one or two succinic acids on the trehalose moiety in addition to two fatty acids, and thus behave as anionic surfactants depending on pH of the aqueous solution. Ishigami et al. previously reported that a mixture of STLs show potential emulsifying and dispersing activities 7) , reflecting the unique hydrophobic structure. These STLs were also demonstrated to show growth inhibition against influenza virus and cell-differentiation induction towards human lukemia cells 8,9). In spite of these attractive properties, the detailed structure of STL-1 or STL-2 has not yet been determined. Moreover, there is no available information on the surface activity of the pure compound. It is of great important to obtain these data not only for a better understanding of the 97
Chemical Papers, 2019
One of the therapeutic approaches in the management of type 2 diabetes is delaying the glucose ab... more One of the therapeutic approaches in the management of type 2 diabetes is delaying the glucose absorption through α-glucosidase enzyme inhibition, which can reduce the occurrence of postprandial hyperglycemia. Based on this thought, a series of novel chloro-substituted 2-(2-methyl-1-phenyl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl) acetamide derivatives 5a-i were synthesized and their α-glucosidase inhibitory activities were evaluated. All the synthesized compounds have shown moderate to excellent in vitro α-glucosidase inhibitory activity with IC 50 values in the range of 111-673 µM) as compared to acarbose, the standard drug (750 ± 9 µM). Compound 5e (111 ± 12 µM), among the series, was the most potent inhibitor of α-glucosidase in a competitive mode of action based on the kinetic study. The molecular docking study of compounds 5e and 5a revealed that they have a lower free binding energy (− 4.27 kcal/mol and − 3.17 kcal/mol, respectively) than acarbose (− 2.47 kcal/mol), which indicates that the target compound binds more easily to the enzyme than acarbose does. The outcomes from the molecular docking studies supported the results obtained from the in vitro assay. In conclusion, the overall results of our study reveal that the synthesized compounds could be a potential candidate in the search for novel α-glucosidase inhibitors to manage postprandial hyperglycemia incidence.
Journal of Food Protection, 2009
Efficacy of commercial detergent and disinfectants to eliminate microorganisms associated with fr... more Efficacy of commercial detergent and disinfectants to eliminate microorganisms associated with fresh vegetables eaten raw in Iran, including radish, parsley, basil, coriander (cilantro), Allium porrum (leek), and peppermint were studied. The raw vegetables were subjected to a triple wash treatment of washing in tap water for mud removal, washing in water containing a detergent (dishwashing liquid) or disinfectant individually, and rinsing in tap water. The population of total mesophilic microbes on the surface of untreated vegetables ranged from 105 to 106 CFU/g. Washing in tap water or treatment with detergent (333 ppm for 10 min) or benzalkonium chloride (92 ppm for 15 min) reduced the total microbial count, most probable number (MPN) of coliforms, MPN of fecal coliforms, and MPN of fecal streptococci by about 1.2 to 2.3 log. No significant differences in microbial populations were found on vegetables after decontamination with tap water, detergent, or benzalkonium chloride (P >...
Natural Product Research, 2011
The essential oil obtained from the flowering parts of Anthemis altissima L. var. altissima was a... more The essential oil obtained from the flowering parts of Anthemis altissima L. var. altissima was analysed by gas chromatography and gas chromatography mass spectroscopy. In this study, 34 compounds representing 98.76% of the essential oil were identified. The main components were α-terpineol (26.42%), β-pinene (9.23%), cis-chrysanthenyl acetate (6.30%), globulol (5.36%), n-tricosane (4.41%), terpinen-4-ol (4.08%) and 1,8 cineole (3.84%). Antibacterial activities
Medicinal Chemistry Research, 2012
In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core... more In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3ylidene) analogs of 2-thiazolylimino-5-arylidene-4-thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as Helicobacter pylori strains. Biological data indicated that 5-nitrofuran analog 5a and 5-nitroimidazole analog 7a containing no substitutions on the thiazole ring were the most potent compounds.
Journal of Biological Sciences, 2007
Applied Microbiology and Biotechnology, 2007
Biosurfactants (BS) are surface-active compounds abundantly produced by a variety of microorganis... more Biosurfactants (BS) are surface-active compounds abundantly produced by a variety of microorganisms. They have been receiving great attention due to their unique properties, including higher biodegradability, lower toxicity, and versatile biological functions, compared to synthetic surfactants 1-3). However, the structural variety of biosurfactants available is still limited: this has prevented a wide range of BS applications. Succinoyl trehalose lipids (STLs) are promising glycolipid BS, since they are efficiently produced from n-alkanes by Rhodococcus bacteria and recovered by precipitation 4,5). Among STL producers hitherto reported, Rhodococcus sp. SD-74 gives the best yield (40 g/L) from n-hexadecane under the high osmotic conditions. The strain mainly produces two types of homologues, STL-1 and STL-2, together with minor components 6). STLs have one or two succinic acids on the trehalose moiety in addition to two fatty acids, and thus behave as anionic surfactants depending on pH of the aqueous solution. Ishigami et al. previously reported that a mixture of STLs show potential emulsifying and dispersing activities 7) , reflecting the unique hydrophobic structure. These STLs were also demonstrated to show growth inhibition against influenza virus and cell-differentiation induction towards human lukemia cells 8,9). In spite of these attractive properties, the detailed structure of STL-1 or STL-2 has not yet been determined. Moreover, there is no available information on the surface activity of the pure compound. It is of great important to obtain these data not only for a better understanding of the 97