nikhil patel - Academia.edu (original) (raw)

Papers by nikhil patel

Informatics, 2021

Despite the popularity of commercially available wearable activity monitors (WAMs), there is a pa... more Despite the popularity of commercially available wearable activity monitors (WAMs), there is a paucity of consistent methodology for analyzing large amounts of accelerometer data from these devices. This multimethod study aimed to inform appropriate Fitbit wear thresholds for physical activity (PA) outcomes assessment in a sample of 616 low-income, majority Latina patients with obesity enrolled in a behavioral weight-loss intervention. Secondly, this study aimed to understand intervention participants’ barriers to Fitbit use. We applied a heart rate (HR) criterion (≥10 h/day) and a step count (SC) criterion (≥1000 steps/day) to 100 days of continuous activity monitor data. We examined the prevalence of valid wear and PA outcomes between analytic subgroups of participants who met the HR criterion, SC criterion, or both. We undertook qualitative analysis of research staff notes and participant interviews to explore barriers to valid Fitbit data collection. Overall, one in three partic...

PSN: Exchange Rates & Currency (Comparative) (Topic), 2016

While the trade channel indicates that an exchange rate depreciation will stimulate domestic econ... more While the trade channel indicates that an exchange rate depreciation will stimulate domestic economic activity, the financial channel can have the opposite effect. When banks and non-banks have foreign currency liabilities, an exchange rate depreciation has valuation effects that can lead to a tightening in domestic financial conditions. Using trade-weighted exchange rates and new BIS-constructed debt-weighted exchange rates to separate these influences, this article finds that the financial channel partly offsets the trade channel for emerging market economies but the effect is weaker for advanced economies.

International Journal of Otorhinolaryngology and Head and Neck Surgery, 2018

Background: Microscopes have ruled ear surgeries for years. The invention of endoscope and its us... more Background: Microscopes have ruled ear surgeries for years. The invention of endoscope and its use in otorhinolaryngology have become an important alternative for use. Importance of endoscope lies in giving the operating surgeon a wider exposure of the EAC and access in various hidden areas without need of a post auricular incision. Aim of this study is to analyze the outcome of endoscopic transcanal tympanoplasty.Methods: This prospective study was conducted in the Department of ENT, B.J. Medical College, Ahmedabad, from July 2015 to July 2017. Thirty patients with tympanic membrane perforation (tubotympanic type) were included in study. Patients were followed up for a mean duration of 12 months and the outcome was analyzed. Results: The patients included in the study ranged in the age group of 15-55 years. Out of them 16 were males and 14 were females. All of them underwent endoscopic transcanal tympanoplasty. 2 out of 30 patients had graft failure while others had good graft upt...

The project is designed to develop a robotic vehicle that is controlled by a cell phone. DTMF com... more The project is designed to develop a robotic vehicle that is controlled by a cell phone. DTMF commands from a phone are sent to another cell phone which is mounted on the robot. These commands are fed to a microcontroller of 8051 family to operate the vehicle movement through motor interface.

Monetary Economics: Central Banks - Policies & Impacts eJournal, 2017

Drawing on a recent survey of emerging market economy central banks, this note highlights the dif... more Drawing on a recent survey of emerging market economy central banks, this note highlights the different channels through which the influence of macroprudential measures can extend beyond national borders, and discusses the need and scope for international cooperation of macroprudential measures.

Journal of Clinical Oncology, 2021

127Background: Liquid biopsy (LB) offers a non-invasive alternative for obtaining genomic signatu... more 127Background: Liquid biopsy (LB) offers a non-invasive alternative for obtaining genomic signature of malignancies to develop a tailor-made treatment plan. We evaluated the feasibility and impact ...

ERN: Central Banks - Policies (Topic), 2019

Foreign exchange intervention is an important tool for central banks in many emerging market econ... more Foreign exchange intervention is an important tool for central banks in many emerging market economies (EMEs). Drawing on a recent survey of 21 EME central banks as well as inputs from their contributions published in this volume, this paper summarises the main issues with regard to FX intervention. It focusses on the goals, channels, effectiveness and the different methods and tactics used by central banks. It leverages data from similar surveys conducted in the past to illustrate how central banks’ views and conduct have evolved over the years along each of these dimensions. Full Publication: Reserve Management and FX Intervention

Methods in molecular biology, 2020

Innate lymphoid cells (ILCs) are a recently identified family of immune cells mostly present at b... more Innate lymphoid cells (ILCs) are a recently identified family of immune cells mostly present at barrier surfaces. They play an important role in the induction, regulation, and resolution of inflammatory responses. Environmental signals play an important role in development and function of ILCs. G-protein coupled receptors (GPCRs) sense and mediate cellular responses to the environmental signals. ILCs express several G-protein coupled receptors, which play a critical role in migration of these cells to appropriate sites. Here, we describe a method to test the migration of ILCs toward 7α,25-hydroxycholesterol, which is mediated by cell surface-expressed GPR183. A similar strategy can be employed to test the role of other GPCRs in mediating the migration of ILCs toward other chemotactic ligands.

Future wireless networks must be able to coordinate services within a diverse-network environment... more Future wireless networks must be able to coordinate services within a diverse-network environment. One of the challenging problems for coordination is vertical handoff, which is the decision for a mobile node to handoff between different types of networks. While traditional handoff is based on received signal strength comparisons, vertical handoff must evaluate additional factors, such as monetary cost, security, power consumption, network conditions, and user preferences. In this paper, several optimizations are proposed for the execution of vertical handoff decision algorithms, with the goal of maximizing the quality of service experienced by each user.

Cells, 2021

The zebrafish provided an excellent platform to study the genetic and molecular approach of cellu... more The zebrafish provided an excellent platform to study the genetic and molecular approach of cellular phenotype-based cardiac research. We designed a novel protocol to develop the transparent transgenic zebrafish model to study annexin-5 activity in the cardiovascular function by generating homozygous transparent skin Casper(roy−/−,nacre−/−); myl7:RFP; annexin-5:YFP transgenic zebrafish. The skin pigmentation background of any vertebrate model organism is a major obstruction for in vivo confocal imaging to study the transgenic cellular phenotype-based study. By developing Casper(roy−/−,nacre−/−); myl7; annexin-5 transparent transgenic zebrafish strain, we established time-lapse in vivo confocal microscopy to study cellular phenotype/pathologies of cardiomyocytes over time to quantify changes in cardiomyocyte morphology and function over time, comparing control and cardiac injury and cardio-oncology. Casper contributes to the study by integrating a transparent characteristic in adult ...

Anesthetic Management in Pediatric General Surgery, 2021

SSRN Electronic Journal, 2020

Cancers, 2020

This meta-analysis aims to identify the diagnostic accuracy of mutations in the Kirsten Rat Sarco... more This meta-analysis aims to identify the diagnostic accuracy of mutations in the Kirsten Rat Sarcoma (KRAS) oncogene in the diagnosis of pancreatic ductal adenocarcinoma (PDAC). The survival of PDAC remains poor often due to the fact that disease is advanced at diagnosis. We analysed 22 studies, with a total of 2156 patients, to identify if the detection of KRAS mutations from pancreatic exocrine secretions yields sufficient specificity and sensitivity to detect patients with PDAC amongst healthy individuals. The majority of the studies were retrospective, samples were obtained endoscopically or surgically, and included comparator populations of patients with chronic pancreatitis and pre-malignant pancreatic lesions (PanIN) as well as healthy controls. We performed several analyses to identify the diagnostic accuracy for PDAC among these patient populations. Our results highlighted that the diagnostic accuracy of KRAS mutation for PDAC was of variable sensitivity and specificity when...

Annals of Medicine and Surgery, 2020

Background: The application process for Core Surgical Training (CST) in the United Kingdom (UK) i... more Background: The application process for Core Surgical Training (CST) in the United Kingdom (UK) is competitive and hence, careful preparation is required for trainees to obtain their posts of choice. There are multiple resources for preparation for selection including face-to-face courses and online question banks, however there is a paucity of webinars to educate trainees. With the cancellation of such courses due to social distancing restrictions caused by the Covid-19 pandemic, this cross-sectional study aims to evaluate the usefulness of a webinar to educate trainees on CST selection in the UK. Materials and methods: A free online webinar was held on a single day by a second year core surgical trainee and was attended by 111 junior doctors. Beforehand, all attendees were invited to complete a survey on Google Forms (Google, USA) to ascertain their level of experience with webinars, obtain demographic information and elicit their level of knowledge about CST selection using a 1-5 Likert scale. Results: Most attendees were in Foundation Year 2 (38.7%) and many had not previously attended a webinar as part of CST application preparation (93.7%). Over half of respondents (55.0%) preferred a webinar over a faceto-face tutorial, appreciating the flexibility, convenience and zero financial cost associated. Many candidates received minimal advice on CST application by their Foundation School (47.7%) and 50.5% of respondents rated their confidence on the application process at '3 out of 5.' Conclusion: Our study suggests webinars have been underused in preparation for CST applications. Traditional courses and advice from colleagues are more popular ways in which applicants prepare for selection. However, given the degree of uncertainty surrounding the return of face-to-face courses due to the Covid-19 pandemic, preparation for CST application may become increasingly reliant on online materials, which may result in an increased demand for high quality, engaging and informative webinars.

This dissertation benefitted from many individuals' contributions along the way. I would like to ... more This dissertation benefitted from many individuals' contributions along the way. I would like to express my deep appreciation and gratitude to those who inspired and helped me through this long process. First of all, I wish to thank my advisor Dr. Cem Karayalcin for his support and guidance throughout the Ph.D. program. He has spent a lot of time discussing research with me and going over the ideas. I am proud to call him my advisor.

BMJ Open, 2019

ObjectiveTo prospectively evaluate safety and efficacy of the ultrathin strut biodegradable polym... more ObjectiveTo prospectively evaluate safety and efficacy of the ultrathin strut biodegradable polymer-coated Supraflex sirolimus-eluting stent (S-SES) in ‘real world’ patient population requiring percutaneous coronary intervention (PCI).MethodsNational, prospective, multicentre, single-arm, all-comers, observational registry of 469 patients treated with S-SES from July 2015 and November 2016 in 11 centres in UK. Primary endpoint was target lesion failure (TLF) at 12 months (cardiac death, target vessel myocardial infarction (MI) or clinically driven target lesion revascularisation (TLR)). Secondary endpoints included safety and performance outcomes at 12 months—overall stent thrombosis (ST), all-cause mortality, any MI, target vessel failure (TVF) and major adverse cardiac events (MACE—composite of cardiac death, MI, emergent or repeat revascularisation).ResultsAt 12 months, the primary endpoint occurred in 11 (2.4%) of 466 patients, consisting of 4 (0.9%) cardiac deaths, 3 (0.6%) tar...

AMA Journal of Ethics, 2015

SSRN Electronic Journal, 2018

BIS Working Papers are written by members of the Monetary and Economic Department of the Bank for... more BIS Working Papers are written by members of the Monetary and Economic Department of the Bank for International Settlements, and from time to time by other economists, and are published by the Bank. The papers are on subjects of topical interest and are technical in character. The views expressed in them are those of their authors and not necessarily the views of the BIS. This publication is available on the BIS website (www.bis.org).

Abu Dhabi International Petroleum Exhibition & Conference, 2018

Pore pressure and wellbore stability estimation in real-time has become a mandatory service in an... more Pore pressure and wellbore stability estimation in real-time has become a mandatory service in any situation where drilling hazards are expected and particularly in the cases of deep water, exploration, geologically complex and extended reach settings. The basic workflow assumes that under-compaction is the primary cause of abnormal pore pressure generation (Eaton 1975), where an increase in formation pressure is associated with a response in sonic, density and resistivity logs, and models are defined based on this assumption. However, structural deformities, dipping beds or alternate pressure mechanisms could result in a wrong prediction of pore pressure based on what is observed in the shales above, or what is predicted from the standard models. Besides increasing the Eaton exponent or creating different normal compaction trend lines (Malinverno et al., 2004; Sayers et al., 2006) or using an unloading parameter (Bowers 1995), there is the need to define an integrated approach using multiple data sources to construct and constrict the model. Advanced mud gas interpretation and cavings (pieces of rock not drilled by bit or reamers) analysis have become important tools in real time pore pressure and wellbore stability monitoring and are used to determine the approach to a structural deformity (faults/fractures) or the presence of elevated pressures at the crest of a permeable formation, either due to lateral transfer or gas buoyancy. Analysis of cavings shape, structure and mode of generation helps to determine the current borehole condition and whether the mud weight (MW) needs to be raised to control the problem, or just modifying the drilling parameters would suffice. The presence of connection gas peaks aids the pore pressure analyst to estimate the pore pressure across a permeable formation by associating its magnitude and its relationship to dynamic (equivalent circulating density - ECD) and static (equivalent static density - ESD) environments. The use of Managed Pressure Drilling (MPD) to maintain a constant backpressure across the annulus, negates this fluctuating static to dynamic environment and hence affects the use of mud gas behavior to determine if the prevailing MW column is sufficient to provide static overbalance, but workflows to address this issue have been defined over the years. Although, the industry is currently beginning to use these secondary indicators into their workflows, there is no standard that incorporates these sources into a single, cohesive workflow. This paper presents an integrated approach to pore pressure prediction and managing drilling risk by incorporating multiple sources of information beyond classical log-based techniques. It demonstrates the value of advanced mud gas interpretation, drilling mechanics interpretation, cavings and drilling parameter analysis to optimize the pore pressure model in real-time and enhance the traditional techniques.