oksan derinoz - Academia.edu (original) (raw)

Papers by oksan derinoz

Renal Failure, Feb 8, 2013

To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and seru... more To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and serum as a follow-up marker for the discrimination of prerenal acute kidney injury (AKI) from intrinsic AKI in critically ill pediatric patients with established AKI at the time of patient presentation. This was a prospective cohort study of a heterogeneous group of critically ill children in the pediatric intensive care unit (PICU). Serum creatinine (SCr) values were obtained daily as part of routine patient care. AKI was defined as a 50% or greater increase in SCr from baseline and classified as prerenal and intrinsic AKI. A total of 32 critically ill children (mean age: 105 ± 71.7 months, 56% female) with established AKI were included to the study. Area under curve (AUC) for urine and serum NGAL to distinguish prerenal AKI from intrinsic AKI was 0.94, 95% confidence interval (CI): 0.869-1.02 (p < 0.001) and 0.86, 95% CI: 0.71-1.02 (p = 0.002), respectively. In a heterogeneous group of critically ill children with established AKI, we found that NGAL in both urine and serum at the time of patient presentation discriminated intrinsic AKI from prerenal AKI.

Anadolu kliniği tıp bilimleri dergisi, Jan 29, 2022

Button battery ingestion (BBI) is an increasingly common pediatric condition, both nationwide and... more Button battery ingestion (BBI) is an increasingly common pediatric condition, both nationwide and worldwide. Management algorithms, including treatment with honey or sucralfate within the first 12 hours, should be prepared for use in the emergency care of patients with suspected BBI without initial complications. In this report, we present three pediatric patients who presented to the emergency department with different symptoms and complications and were diagnosed with BBI.

DergiPark (Istanbul University), Sep 1, 2007

A Am ma aç ç: : Bu çal›flman›n amac›, Gazi Üniversitesi T›p Fakültesi Çocuk Acil Servisi'ne baflv... more A Am ma aç ç: : Bu çal›flman›n amac›, Gazi Üniversitesi T›p Fakültesi Çocuk Acil Servisi'ne baflvuran ilaç zehirlenmesi olgular›n›n demografik özellikleri, kulland›klar› ilaçlar›n türleri ve hastane maliyetleri incelenerek ülke ekonomisine getirdi¤i yükün saptanmas› ve al›nacak önlemlerin planlanmas›d›r. G Ge er re eç ç v ve e Y Yö ön nt te em m: : ‹laç zehirlenmesi nedeniyle baflvuran olgular›n dosyalar›nda yer alan epikrizler ve Avicenna Hastane Bilgi Yönetim Sistemi'nde yer alan hastane maliyetleri incelenmifltir. B Bu ul lg gu ul la ar r: : Ergenlik dönemdeki olgular, çocuk psikiyatrisi taraf›ndan de¤erlendirilen ve intihar giriflimi olduklar› düflünülen olgular olup oyun çocuklu¤u dönemindekiler ise kaza sonucu ilaç zehirlenmesi olarak de¤erlendirilmifl olgulard›r. Olgular›n iki y›ll›k toplam hastane maliyetleri 45608 YTL'dir. ‹ntihar giriflimi oldu¤u düflünülen olgular›n ortalama hastane maliyetleri 405,1±240,8 YTL, kaza oldu¤u düflünülen olgu-lar›n ise 245,7±169 YTL'dir. Ç Ç› ›k ka ar r› ›m ml la ar r: : Çal›flmam›z›n sonuçlar› çocukluk ça¤› zehirlenmelerinde koruyucu önlemlerin gelifltirilmesinde ve hastane maliyetlerinin azalt›lmas›nda en etkili yöntemin e¤itim oldu¤unu ve bu sayede çocukluk ça¤› zehirlenmelerinin ülke ekonomisine getirdi¤i yükün azala-ca¤›n› göstermifltir. Ayr›ca çocuklar› zehirlenmelerden korumak için cezalar›n a¤›rlaflt›r›lmas›n› da içeren ülke politikas›n›n gelifltirilmesinin gerekti¤ini düflünmekteyiz.(Türk Ped Arfl 2007; 42: 103-6) A An na ah ht ta ar r k ke el li im me el le er r: : Çocuk, acil, ilaç, zehirlenme, maliyet.

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2010

Nörojenik pulmoner ödem (NPÖ), santral sinir sistemini etkileyen herhangi bir hastalığın ardından... more Nörojenik pulmoner ödem (NPÖ), santral sinir sistemini etkileyen herhangi bir hastalığın ardından meydana gelen klinik bir durumdur. Çocukluk çağında nadir görülür. Bu yazıda ateşli silah yaralanması ardından NPÖ gelişen 12 yaşında erkek olgu, literatürde ateşli silah yaralanması ardından NPÖ gelişen çocuk olgu sayısı çok az olduğu için sunulmuştur. NPÖ, klinik bir tanıdır. Kafa travması ile sıklıkla karşılaşan çocuk hekimlerinin, açık veya kapalı kafa travması sonrası hastalarda açıklanamayan solunum sıkıntısı, takipne, hipoksemi meydana gelm-esi durumunda NPÖ akıllarına gelmelidir.

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2008

In a patient that admitted to the hospital with the complaints of nause, vomitting, polydipsia, w... more In a patient that admitted to the hospital with the complaints of nause, vomitting, polydipsia, with findings of hyperglisemia, ketonemia and acidemia, the first diagnosis to be considered is diabetic ketoacidosis. However, intoxications can mimic many diseases. Lactic acidosis, uremia, intoxications with salicylates, methanol, ethylene glycole and paraaldehyde may present clinically as Diabetic ketoacidosis. This may delay the patient's diagnosis and treatment. Therfore; patients with unexplained clinical findings should be investigated for these intoxications. In this paper, we presented a 3-year-old girl patient, who was refered to our hospital with the diagnosis of diabetic ketoacidosis and was diagnosed salicylate intoxication afterwards.

Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2008

Alcohol consumption has increased among adolescents in concordance with problems related to schoo... more Alcohol consumption has increased among adolescents in concordance with problems related to school friends and family environment and nbsp; also as a result of their curiosity Since alcohol intoxication cases increase in emergency services pediatrician rsquo;s knowledge of clinical and metabolic complications is getting more important We present here 4 cases to underline the classical approach to alcohol intoxication Turk Arch Ped 2008; 43: 143 5 Key words: Alcohol alcohol intoxication adolescent

Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2007

Aim: The aim of this study is to determine the demographic characteristics the types of utilized ... more Aim: The aim of this study is to determine the demographic characteristics the types of utilized drugs and the hospital costs of the drug intoxication cases who attended to the Gazi University Medical Faculty Pediatric Emergency Service to determine the burden on the national economy and to plan the prevention nbsp; Material and Method: The epichrises of the cases attended because of drug intoxication were evaluated using the hospital records and the hospital costs were evaluated using the Avicenna Hospital Information Management System Results: The adolescent cases are those evaluated by child psychiatry and thought to be suicideal attempts and the young children cases are those evaluated as accidental drug intoxication The total two year’s hospital cost of the cases is 45608 0 YTL The mean hospital cost of the suicidal attempt cases is 405 1±240 8 YTL and the mean cost of the accidental poisoning cases is 245 7±169 0 YTL p lt;0 001 Conclusions: The results of our study shows that ...

The Turkish Journal of Pediatrics, 2016

Listeria monocytogenes is an important cause of life-threatening bacteremia and meningoencephalit... more Listeria monocytogenes is an important cause of life-threatening bacteremia and meningoencephalitis in neonates, pregnant women, the elderly, and immunocompromised individuals. However, it is an uncommon cause of illness in immunocompetent children beyond the neonatal period. Ampicillin with or without an aminoglycoside remains the best treatment for listeriosis. Here, we report a rare case of Listeria meningitis and bacteremia in a 7-month-old immunocompetent girl, which was refractory to ampicillin plus gentamicin treatment and successfully treated by the addition of TMP/SMX.

Journal of Clinical Research in Pediatric Endocrinology, 2017

What this study adds? What is already known on this topic? Objective: The aim of the present stud... more What this study adds? What is already known on this topic? Objective: The aim of the present study was to document ovarian cyst frequency and characteristics as well as distribution of these parameters with respect to age in children and adolescents. Methods: We retrospectively analyzed the medical records of 1009 girls between the ages of 5-18 years who presented to our pediatric emergency department (PED) with pelvic pain and therefore underwent pelvic ultrasound examination between June 2011 and May 2014. Results: In total, 132 of 1009 girls (13.1%) were identified as having ovarian cysts ≥1 cm in diameter. The frequency of ovarian cysts was found to be 1.8% (6/337) in children aged 5-9 years and 18.8% (126/672) in those aged 10-18 years. All the cysts detected in children aged 5-9 years were small (<3 cm) and simple with age-specific frequencies ranging between 1.5-2.7%. With the onset of adolescence, ovarian cyst frequency started to increase with age and ranged between 3.8-31.3% throughout adolescence. Age of peak ovarian cyst frequency was 15 years with a rate of 31.3%. Large ovarian cysts (>5 cm) were identified in 19 adolescents (15.1%) with most occurring during middle adolescence. Of the 19 adolescents, five were found to have cyst-related significant ovarian pathologies including cystadenoma (n=3) and ovarian torsion (n=2). Conclusion: In children aged 5-9 years, ovarian cysts were infrequent and small (<3 cm). Peak ovarian cyst frequency was detected at the age of 15 years. All patients diagnosed with cyst-related significant ovarian pathologies were adolescents having a cyst >5 cm in diameter with a complex appearance in most.

TURKISH JOURNAL OF MEDICAL SCIENCES, 2016

The rats were separated into four groups: 1) the control group (n = 12), which was raised under s... more The rats were separated into four groups: 1) the control group (n = 12), which was raised under standard care; 2) the early handling (EH) group, which was raised using an EH model (n = 16); 3) the early deprivation (ED) group, which was raised using an ED model (n = 13), and 4) the ambivalent mother (AM) group, which spent 3 h/day with a "fake mother" (n = 17). When they became adults, their anxiety levels, depressive-like behaviors, and memory functions were measured using the elevated plus maze test, the forced swim test, and the novel object recognition test, respectively. Their neurodevelopment was evaluated by measuring the brainderived neurotrophic factor (BDNF) levels in the prefrontal cortex, the dentate gyrus, and the cerebellum via ELISA. Results: The rats in the ED and AM groups exhibited less anxiety and depressive-like behavior than those in the control and EH groups, particularly in females. There was no significant difference between the groups in memory function or brain BDNF levels. Conclusion: Severe and ambivalent early adverse life events may decrease anxiety and depressive-like behavior in adult rats.

Turkiye Klinikleri Journal of Surgical Medical Sciences, 2007

Turkiye Klinikleri Journal of Pediatrics, 2016

Turkiye Klinikleri Journal of Surgical Medical Sciences, 2007

Turkiye Cocuk Hastalıkları Dergisi, Jun 10, 2012

Asphyxia is one of the causes of unintentional injury. It causes death in young children when the... more Asphyxia is one of the causes of unintentional injury. It causes death in young children when the airways become blocked. Here is presented 4 month-old baby in the Pediatric Emergency Department who has complaints of cyanosis and inability to breath and is diagnosed suffocation due to plastic bag. This is very important to ask mechanical factors that may cause airway obstruction in a patient with unexplained clinical status with history, physical examination and laboratory results. Asphyxiation with plastic bag is not common in children and it is due to shopping bags found in homes. In conclusion, suffocation can be prevented with training of families.

Gazi Medical Journal, 2010

Turkiye Klinikleri Journal of Pediatrics, 2011

European Journal of Paediatric Neurology, 2015

Objective The objective of this study is to determine the prevalance, indications, aid to the dia... more Objective The objective of this study is to determine the prevalance, indications, aid to the diagnosis and the treatment and the excessive and irrelevant use of the cranial computed tomography (CCT) in children with acute neurological complaints. Methods The records of the patients, who presented to Pediatric Emergency Department of Gazi University Medical Faculty between June 2012 to June 2013 with acute neurological complaints and had CCT, were reviewed retrospectively. Results During one year, 34.575 patients were admitted to our emergency department. Ranging in age from one month to eighteen years, 146 girls and 240 boys, 460 had CCT scan, 386 patients were included. The indications for CCT are trauma 78.4%, seizure 6.9%, unconsciousness 4.1%, headache 3.1% and the others 7.2% respectively. The results of CCT scans of 156 40.4% were reported abnormal (110 of these patients have significant findings such as brain edema, fractures and/or haemorrhage). MRI scan was performed to 27 of these patients who has normal CCT, 11 of them parenchymal haemorrhage, axonal damage, mass, sinusitis, ventricular dilatation and gliotic signal changes were reported. Only 120 (31%) patients were hospitalized and 11 (2.8%) of them had emergent neurosurgical intervention. Conclusion Although CCT is still commonly used in the evaluation of acute neurological conditions at pediatric emergency departments, the number of patients who have urgent neurosurgical intervention is very low. As a result, if CCT scan is not supported with clinical findings and neurological examination, the use of CCT scan can be excessive and irrelevant.

The Turkish journal of pediatrics

Isoniazid is an effective antituberculosis drug. Isoniazid poisoning produces a characteristic cl... more Isoniazid is an effective antituberculosis drug. Isoniazid poisoning produces a characteristic clinical syndrome that occurs 30 to 120 minutes after ingestion and includes seizures, metabolic acidosis, and in severe cases, coma. Rhabdomyolysis is one of the reported complications of isoniazid poisoning, but relevant data are limited. Parenteral pyridoxine is the antidote of isoniazid. In this case, a 16-year-old male patient admitted to the Pediatric Emergency Department two hours after isoniazid poisoning. For treatment, intramuscular pyridoxine was used, but he developed serious rhabdomyolysis.

Pharmacology Biochemistry and Behavior, 2014

The Journal of Infection in Developing Countries, 2014

Introduction: The aim of this survey was to investigate the current knowledge, attitudes, and pra... more Introduction: The aim of this survey was to investigate the current knowledge, attitudes, and practices of febrile children’s caregivers about fever, antipyretic usage, and temperature measurement methods in a tertiary care hospital. Methodology: A 41-item questionnaire was administered to a convenience sample of febrile children’s caregivers in face-to-face interviews by two research assistants from January 2012 through June 2012 in an urban region of Turkey. Results: A total of 1,032 caregivers completed the interview. Approximately one-third of caregivers considered a temperature of less than 37.8°C (100°F) to be a fever, and 13% of all respondents would give antipyretics for a body temperature ≤ 37.8°C. Furthermore, 76% of parents would wake their children from sleep to administer antipyretics. Although a high proportion (89.5%) of respondents believed that fever had harmful effects, 10.5% considered fever to be beneficial. Alternating use of acetaminophen and ibuprofen (44%) an...

Renal Failure, Feb 8, 2013

To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and seru... more To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and serum as a follow-up marker for the discrimination of prerenal acute kidney injury (AKI) from intrinsic AKI in critically ill pediatric patients with established AKI at the time of patient presentation. This was a prospective cohort study of a heterogeneous group of critically ill children in the pediatric intensive care unit (PICU). Serum creatinine (SCr) values were obtained daily as part of routine patient care. AKI was defined as a 50% or greater increase in SCr from baseline and classified as prerenal and intrinsic AKI. A total of 32 critically ill children (mean age: 105 ± 71.7 months, 56% female) with established AKI were included to the study. Area under curve (AUC) for urine and serum NGAL to distinguish prerenal AKI from intrinsic AKI was 0.94, 95% confidence interval (CI): 0.869-1.02 (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) and 0.86, 95% CI: 0.71-1.02 (p = 0.002), respectively. In a heterogeneous group of critically ill children with established AKI, we found that NGAL in both urine and serum at the time of patient presentation discriminated intrinsic AKI from prerenal AKI.

Anadolu kliniği tıp bilimleri dergisi, Jan 29, 2022

Button battery ingestion (BBI) is an increasingly common pediatric condition, both nationwide and... more Button battery ingestion (BBI) is an increasingly common pediatric condition, both nationwide and worldwide. Management algorithms, including treatment with honey or sucralfate within the first 12 hours, should be prepared for use in the emergency care of patients with suspected BBI without initial complications. In this report, we present three pediatric patients who presented to the emergency department with different symptoms and complications and were diagnosed with BBI.

DergiPark (Istanbul University), Sep 1, 2007

A Am ma aç ç: : Bu çal›flman›n amac›, Gazi Üniversitesi T›p Fakültesi Çocuk Acil Servisi'ne baflv... more A Am ma aç ç: : Bu çal›flman›n amac›, Gazi Üniversitesi T›p Fakültesi Çocuk Acil Servisi'ne baflvuran ilaç zehirlenmesi olgular›n›n demografik özellikleri, kulland›klar› ilaçlar›n türleri ve hastane maliyetleri incelenerek ülke ekonomisine getirdi¤i yükün saptanmas› ve al›nacak önlemlerin planlanmas›d›r. G Ge er re eç ç v ve e Y Yö ön nt te em m: : ‹laç zehirlenmesi nedeniyle baflvuran olgular›n dosyalar›nda yer alan epikrizler ve Avicenna Hastane Bilgi Yönetim Sistemi'nde yer alan hastane maliyetleri incelenmifltir. B Bu ul lg gu ul la ar r: : Ergenlik dönemdeki olgular, çocuk psikiyatrisi taraf›ndan de¤erlendirilen ve intihar giriflimi olduklar› düflünülen olgular olup oyun çocuklu¤u dönemindekiler ise kaza sonucu ilaç zehirlenmesi olarak de¤erlendirilmifl olgulard›r. Olgular›n iki y›ll›k toplam hastane maliyetleri 45608 YTL'dir. ‹ntihar giriflimi oldu¤u düflünülen olgular›n ortalama hastane maliyetleri 405,1±240,8 YTL, kaza oldu¤u düflünülen olgu-lar›n ise 245,7±169 YTL'dir. Ç Ç› ›k ka ar r› ›m ml la ar r: : Çal›flmam›z›n sonuçlar› çocukluk ça¤› zehirlenmelerinde koruyucu önlemlerin gelifltirilmesinde ve hastane maliyetlerinin azalt›lmas›nda en etkili yöntemin e¤itim oldu¤unu ve bu sayede çocukluk ça¤› zehirlenmelerinin ülke ekonomisine getirdi¤i yükün azala-ca¤›n› göstermifltir. Ayr›ca çocuklar› zehirlenmelerden korumak için cezalar›n a¤›rlaflt›r›lmas›n› da içeren ülke politikas›n›n gelifltirilmesinin gerekti¤ini düflünmekteyiz.(Türk Ped Arfl 2007; 42: 103-6) A An na ah ht ta ar r k ke el li im me el le er r: : Çocuk, acil, ilaç, zehirlenme, maliyet.

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2010

Nörojenik pulmoner ödem (NPÖ), santral sinir sistemini etkileyen herhangi bir hastalığın ardından... more Nörojenik pulmoner ödem (NPÖ), santral sinir sistemini etkileyen herhangi bir hastalığın ardından meydana gelen klinik bir durumdur. Çocukluk çağında nadir görülür. Bu yazıda ateşli silah yaralanması ardından NPÖ gelişen 12 yaşında erkek olgu, literatürde ateşli silah yaralanması ardından NPÖ gelişen çocuk olgu sayısı çok az olduğu için sunulmuştur. NPÖ, klinik bir tanıdır. Kafa travması ile sıklıkla karşılaşan çocuk hekimlerinin, açık veya kapalı kafa travması sonrası hastalarda açıklanamayan solunum sıkıntısı, takipne, hipoksemi meydana gelm-esi durumunda NPÖ akıllarına gelmelidir.

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2008

In a patient that admitted to the hospital with the complaints of nause, vomitting, polydipsia, w... more In a patient that admitted to the hospital with the complaints of nause, vomitting, polydipsia, with findings of hyperglisemia, ketonemia and acidemia, the first diagnosis to be considered is diabetic ketoacidosis. However, intoxications can mimic many diseases. Lactic acidosis, uremia, intoxications with salicylates, methanol, ethylene glycole and paraaldehyde may present clinically as Diabetic ketoacidosis. This may delay the patient's diagnosis and treatment. Therfore; patients with unexplained clinical findings should be investigated for these intoxications. In this paper, we presented a 3-year-old girl patient, who was refered to our hospital with the diagnosis of diabetic ketoacidosis and was diagnosed salicylate intoxication afterwards.

Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2008

Alcohol consumption has increased among adolescents in concordance with problems related to schoo... more Alcohol consumption has increased among adolescents in concordance with problems related to school friends and family environment and nbsp; also as a result of their curiosity Since alcohol intoxication cases increase in emergency services pediatrician rsquo;s knowledge of clinical and metabolic complications is getting more important We present here 4 cases to underline the classical approach to alcohol intoxication Turk Arch Ped 2008; 43: 143 5 Key words: Alcohol alcohol intoxication adolescent

Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2007

Aim: The aim of this study is to determine the demographic characteristics the types of utilized ... more Aim: The aim of this study is to determine the demographic characteristics the types of utilized drugs and the hospital costs of the drug intoxication cases who attended to the Gazi University Medical Faculty Pediatric Emergency Service to determine the burden on the national economy and to plan the prevention nbsp; Material and Method: The epichrises of the cases attended because of drug intoxication were evaluated using the hospital records and the hospital costs were evaluated using the Avicenna Hospital Information Management System Results: The adolescent cases are those evaluated by child psychiatry and thought to be suicideal attempts and the young children cases are those evaluated as accidental drug intoxication The total two year’s hospital cost of the cases is 45608 0 YTL The mean hospital cost of the suicidal attempt cases is 405 1±240 8 YTL and the mean cost of the accidental poisoning cases is 245 7±169 0 YTL p lt;0 001 Conclusions: The results of our study shows that ...

The Turkish Journal of Pediatrics, 2016

Listeria monocytogenes is an important cause of life-threatening bacteremia and meningoencephalit... more Listeria monocytogenes is an important cause of life-threatening bacteremia and meningoencephalitis in neonates, pregnant women, the elderly, and immunocompromised individuals. However, it is an uncommon cause of illness in immunocompetent children beyond the neonatal period. Ampicillin with or without an aminoglycoside remains the best treatment for listeriosis. Here, we report a rare case of Listeria meningitis and bacteremia in a 7-month-old immunocompetent girl, which was refractory to ampicillin plus gentamicin treatment and successfully treated by the addition of TMP/SMX.

Journal of Clinical Research in Pediatric Endocrinology, 2017

What this study adds? What is already known on this topic? Objective: The aim of the present stud... more What this study adds? What is already known on this topic? Objective: The aim of the present study was to document ovarian cyst frequency and characteristics as well as distribution of these parameters with respect to age in children and adolescents. Methods: We retrospectively analyzed the medical records of 1009 girls between the ages of 5-18 years who presented to our pediatric emergency department (PED) with pelvic pain and therefore underwent pelvic ultrasound examination between June 2011 and May 2014. Results: In total, 132 of 1009 girls (13.1%) were identified as having ovarian cysts ≥1 cm in diameter. The frequency of ovarian cysts was found to be 1.8% (6/337) in children aged 5-9 years and 18.8% (126/672) in those aged 10-18 years. All the cysts detected in children aged 5-9 years were small (<3 cm) and simple with age-specific frequencies ranging between 1.5-2.7%. With the onset of adolescence, ovarian cyst frequency started to increase with age and ranged between 3.8-31.3% throughout adolescence. Age of peak ovarian cyst frequency was 15 years with a rate of 31.3%. Large ovarian cysts (>5 cm) were identified in 19 adolescents (15.1%) with most occurring during middle adolescence. Of the 19 adolescents, five were found to have cyst-related significant ovarian pathologies including cystadenoma (n=3) and ovarian torsion (n=2). Conclusion: In children aged 5-9 years, ovarian cysts were infrequent and small (<3 cm). Peak ovarian cyst frequency was detected at the age of 15 years. All patients diagnosed with cyst-related significant ovarian pathologies were adolescents having a cyst >5 cm in diameter with a complex appearance in most.

TURKISH JOURNAL OF MEDICAL SCIENCES, 2016

The rats were separated into four groups: 1) the control group (n = 12), which was raised under s... more The rats were separated into four groups: 1) the control group (n = 12), which was raised under standard care; 2) the early handling (EH) group, which was raised using an EH model (n = 16); 3) the early deprivation (ED) group, which was raised using an ED model (n = 13), and 4) the ambivalent mother (AM) group, which spent 3 h/day with a "fake mother" (n = 17). When they became adults, their anxiety levels, depressive-like behaviors, and memory functions were measured using the elevated plus maze test, the forced swim test, and the novel object recognition test, respectively. Their neurodevelopment was evaluated by measuring the brainderived neurotrophic factor (BDNF) levels in the prefrontal cortex, the dentate gyrus, and the cerebellum via ELISA. Results: The rats in the ED and AM groups exhibited less anxiety and depressive-like behavior than those in the control and EH groups, particularly in females. There was no significant difference between the groups in memory function or brain BDNF levels. Conclusion: Severe and ambivalent early adverse life events may decrease anxiety and depressive-like behavior in adult rats.

Turkiye Klinikleri Journal of Surgical Medical Sciences, 2007

Turkiye Klinikleri Journal of Pediatrics, 2016

Turkiye Klinikleri Journal of Surgical Medical Sciences, 2007

Turkiye Cocuk Hastalıkları Dergisi, Jun 10, 2012

Asphyxia is one of the causes of unintentional injury. It causes death in young children when the... more Asphyxia is one of the causes of unintentional injury. It causes death in young children when the airways become blocked. Here is presented 4 month-old baby in the Pediatric Emergency Department who has complaints of cyanosis and inability to breath and is diagnosed suffocation due to plastic bag. This is very important to ask mechanical factors that may cause airway obstruction in a patient with unexplained clinical status with history, physical examination and laboratory results. Asphyxiation with plastic bag is not common in children and it is due to shopping bags found in homes. In conclusion, suffocation can be prevented with training of families.

Gazi Medical Journal, 2010

Turkiye Klinikleri Journal of Pediatrics, 2011

European Journal of Paediatric Neurology, 2015

Objective The objective of this study is to determine the prevalance, indications, aid to the dia... more Objective The objective of this study is to determine the prevalance, indications, aid to the diagnosis and the treatment and the excessive and irrelevant use of the cranial computed tomography (CCT) in children with acute neurological complaints. Methods The records of the patients, who presented to Pediatric Emergency Department of Gazi University Medical Faculty between June 2012 to June 2013 with acute neurological complaints and had CCT, were reviewed retrospectively. Results During one year, 34.575 patients were admitted to our emergency department. Ranging in age from one month to eighteen years, 146 girls and 240 boys, 460 had CCT scan, 386 patients were included. The indications for CCT are trauma 78.4%, seizure 6.9%, unconsciousness 4.1%, headache 3.1% and the others 7.2% respectively. The results of CCT scans of 156 40.4% were reported abnormal (110 of these patients have significant findings such as brain edema, fractures and/or haemorrhage). MRI scan was performed to 27 of these patients who has normal CCT, 11 of them parenchymal haemorrhage, axonal damage, mass, sinusitis, ventricular dilatation and gliotic signal changes were reported. Only 120 (31%) patients were hospitalized and 11 (2.8%) of them had emergent neurosurgical intervention. Conclusion Although CCT is still commonly used in the evaluation of acute neurological conditions at pediatric emergency departments, the number of patients who have urgent neurosurgical intervention is very low. As a result, if CCT scan is not supported with clinical findings and neurological examination, the use of CCT scan can be excessive and irrelevant.

The Turkish journal of pediatrics

Isoniazid is an effective antituberculosis drug. Isoniazid poisoning produces a characteristic cl... more Isoniazid is an effective antituberculosis drug. Isoniazid poisoning produces a characteristic clinical syndrome that occurs 30 to 120 minutes after ingestion and includes seizures, metabolic acidosis, and in severe cases, coma. Rhabdomyolysis is one of the reported complications of isoniazid poisoning, but relevant data are limited. Parenteral pyridoxine is the antidote of isoniazid. In this case, a 16-year-old male patient admitted to the Pediatric Emergency Department two hours after isoniazid poisoning. For treatment, intramuscular pyridoxine was used, but he developed serious rhabdomyolysis.

Pharmacology Biochemistry and Behavior, 2014

The Journal of Infection in Developing Countries, 2014

Introduction: The aim of this survey was to investigate the current knowledge, attitudes, and pra... more Introduction: The aim of this survey was to investigate the current knowledge, attitudes, and practices of febrile children’s caregivers about fever, antipyretic usage, and temperature measurement methods in a tertiary care hospital. Methodology: A 41-item questionnaire was administered to a convenience sample of febrile children’s caregivers in face-to-face interviews by two research assistants from January 2012 through June 2012 in an urban region of Turkey. Results: A total of 1,032 caregivers completed the interview. Approximately one-third of caregivers considered a temperature of less than 37.8°C (100°F) to be a fever, and 13% of all respondents would give antipyretics for a body temperature ≤ 37.8°C. Furthermore, 76% of parents would wake their children from sleep to administer antipyretics. Although a high proportion (89.5%) of respondents believed that fever had harmful effects, 10.5% considered fever to be beneficial. Alternating use of acetaminophen and ibuprofen (44%) an...