om shah - Academia.edu (original) (raw)
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Sanjay Gandhi Postgraduate Institute of Medician Sciences, Lucknow
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Background: Rheumatic fever (RF) is an inflammatory disease of the heart after a pharyngitis by G... more Background: Rheumatic fever (RF) is an inflammatory disease of the heart after a pharyngitis by Group-A beta haemolytic streptococci. The pathogenetic mechanisms highlight a complex interplay of immunological, genetic and environmental factors. Immunity gene polymorphisms, in relation to susceptibility to RF, have been studied by many investigators, and IL-1 α has been the focus of attention. Aims & Objectives: To investigate the association of ILI-α 889C/T, gene polymorphism with clinical outcomes of rheumatic heart disease. Materials and Methods: A cohort of 157 patients of established rheumatic heart disease and 200 controls (HS) were enrolled. Genotyping was done for all cases and controls regarding IL-1 α gene. Results: 58.6% of RHD patients had ILI-α 889T allele, as compared to 49.5% for HC and was not
Background: Rheumatic fever (RF) is an inflammatory disease of the heart after a pharyngitis by G... more Background: Rheumatic fever (RF) is an inflammatory disease of the heart after a pharyngitis by Group-A beta haemolytic streptococci. The pathogenetic mechanisms highlight a complex interplay of immunological, genetic and environmental factors. Immunity gene polymorphisms, in relation to susceptibility to RF, have been studied by many investigators, and IL-1 α has been the focus of attention. Aims & Objectives: To investigate the association of ILI-α 889C/T, gene polymorphism with clinical outcomes of rheumatic heart disease. Materials and Methods: A cohort of 157 patients of established rheumatic heart disease and 200 controls (HS) were enrolled. Genotyping was done for all cases and controls regarding IL-1 α gene. Results: 58.6% of RHD patients had ILI-α 889T allele, as compared to 49.5% for HC and was not